Live Longer World
Aastha Jain
The science of aging is moving rapidly and making progress at defeating age-related diseases and aging itself. Live Longer World takes you right where the action is happening! Through conversations with scientists, entrepreneurs, investors and other advocates revolutionizing the field of longevity science, we tell you how you can be disease-free, reverse aging, and maximize longevity in the future. https://livelongerworld.substack.com/
Michael Levin & Pamela Lyon | Rethinking Cognition for Longevity
What if our cells have memory and cognition, which changes how medicine is done?In this conversation with Dr. Pamela Lyon and Dr. Michael Levin, we discuss:- Cognition and creativity is not merely associated with the brain and nervous system- Implications of this view of cognition for regenerative medicine and longevity- Is stress response the source of our creativity?Episode Show Notes: https://livelongerworld.com/p/plyonFind me: https://x.com/aasthajs My longevity products: https://www.livelon
Mar 20, • 1:11:57
Boost Mitochondria with Sunlight & Infrared light | Glen Jeffery
We’re only just waking up to the benefits of sunlight and red light for mitochondrial health, lowering blood glucose, and potentially treating Parkinson’s disease and cancer.Dr. Glen Jeffery is at the leading edge of this research. We discuss:- Health benefits of sunlight and red light- Harmful effects of blue light & LEDs- In the 2nd half of the podcast, I ask him rapid fire practical questions that everyone wants to know about light, ranging from how much sunlight should one get to what ti
Mar 7, • 1:37:53
Keto Diet & Metabolic Therapy for Cancer | Dr. Thomas Seyfried
Dr. Thomas Seyfried challenges the existing paradigm that says cancer is a genetic disease. He says that instead cancer is caused by damage to the mitochondria. Understanding this completely overturns the management and prevention of cancer. He is a Professor of biology, genetics, and biochemistry at Boston College. He has over 150 peer-reviewed publications and is also the author of books such as, ‘Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer’. WE DISCUSS:
Jan 27, • 1:21:56
Denis Noble & Michael Levin | What Biology needs to Advance Longevity
Denis Noble and Michael Levin - two great minds in biology come together on Live Longer World. Denis Noble is a renowned biologist and pioneer in systems biology, known for his groundbreaking work on the electrical activity of the heart and his influential contributions to the understanding of biological systems. Denis is an advocate for taking a systems integrative approach to biology, as opposed to the reductionist gene-centric view that has dominated the field due to Neo-Darwinism. The gene
Oct 24, 2024 • 1:08:00
Michael Levin & Mustafa Djamgoz | Bioelectricity and Cancer
This interview is part of my series with Dr. Michael Levin where we interview significant people in the history of developmental bioelectricity. Dr. Mustafa Djamgoz was one of the first people to study the role of ion channels and bioelectricity in cancer, which he initially documented in a 1995 paper. His research showed that there was an uptake in voltage-gated sodium channels in all types of cancer metastasis, except prostate cancer, highlighting the significant role of studying ion channels
Oct 3, 2024 • 59:33
Genes are NOT the "blueprint of life" | Dr. Alfonso Martinez Arias
Dr. Alfonso Martinez Arias is a development biologist and the author of the book The Master Builder: How the New Science of the Cell Is Rewriting the Story of Life. He also co-authored the biology textbook Principles of Development, which was awarded the Royal Society of Biology book prize. Episode Show Notes: https://livelongerworld.com/p/aarias OVERVIEW: Each of our cells has the same DNA. Yet they somehow differentiate into different body parts - eyes, ears, skin, and so on. There is no in
Sep 19, 2024 • 1:20:50
The Evolutionary Theory of Cancer | Dr. Charley Lineweaver
The following is a fascinating interview with Dr. Charley Lineweaver, who worked with Paul Davies on his work on cancer which we discuss. Episode Show Notes: https://livelongerworld.com/p/clineweaver Topics include: - the evolutionary and atavistic theory of cancer - the incorrectness of the somatic mutation theory of cancer - a novel take on attacking the weakness of cancer - how embryogenesis could be viewed as cells reverting to old memory - the origins of multicellularity - “Cancer cannot
Sep 4, 2024 • 1:05:12
Michael Levin & Ken Robinson | Bioelectricity in the era of the Genetic Code
This is the third in my series with Dr. Michael Levin where we interview significant people in the history of developmental bioelectricity. Ken Robinson has a long list of accomplishments in the bioelectricity field, covering the role of electric fields in guiding cell migration and more generally the function of electrogenic epithelia in embryogenesis. This is about a ~1 hour conversation in which he talks about his background, the history of the field, and his time in Lionel Jaffe's lab. Episo
Jul 11, 2024 • 1:01:26
Michael Levin & Min Zhao | Bioelectricity in Wound Repair
This is the second of several interviews Michael Levin and I will do with significant people in the history of developmental bioelectricity. Min Zhao's work is focused on the role of ion currents and applied electric fields in cell migration and wound repair. Episode Show Notes: https://livelongerworld.com/p/mzhao Find me: https://x.com/aasthajs Background on the bioelectricity series & 1st episode with Dr. Richard Nuccitelli: https://youtu.be/DtUqOwTRvz0?si=3OJryM0yJjzfQtfo TIMESTAMPS: 0:00 Mi
Jun 25, 2024 • 56:52
Glyphosate Toxicity & Deuterium's Role in Cancer, Celiac, Aging | Dr. Stephanie Seneff
Stephanie Seneff is the pioneer in raising concerns around glyphosate, a chemical and active ingredient in RoundUp and other pesticides, which has practically infiltrated our food system, water bodies, and soil. Glyphosate has been linked to several diseases including liver disease, autoimmunity, neurological disorders, reproductive issues, microbiome problems, and more. Dr. Stephanie Seneff has spent 10+ years researching glyphosate’s harmful impact on our health, and documented her findings in
May 30, 2024 • 1:18:39
Michael Levin & Richard Nuccitelli | History of Bioelectricity & Solving Cancer
This is the first of several interviews Michael Levin and I will do with significant people in the history of developmental bioelectricity. Richard Nuccitelli is a legend, having invented (with Lionel Jaffe, in 1974) the Vibrating Probe - a technique that allowed the non-invasive sensing of ion currents around living tissues. This is about a ~1 hour conversation in which he talks about his background, the history of the field, and his current clinical work on the bioelectrics of cancer. Episode
May 2, 2024 • 1:04:53
FDA History and Breast Cancer Drug Controversy | Dr. Mikkael Sekeres
Dr. Mikkael Sekeres is the author of the book The Drugs and FDA. He served as the chair of the Oncology Drugs Advisory Committee of the FDA, and was on the jury for the controversial trial of the breast cancer drug Avastin. We discuss: - The history of the FDA, - The trial of Avastin which got FDA approval in 2008 and revoked in 2011 - FDA's funding mechanisms - FDA ties to big pharma - What can be improved about the FDA and the criticisms it receives Episode Show Notes: https://livelongerworld
Apr 24, 2024 • 1:05:01
#27 Women's Reproductive Aging, Menopause, & Hormone Replacement Therapy | Dr. Jennifer Garrison
Dr. Jennifer Garrison is a an Assistant professor at the Buck Institute for research on aging where she studies women's reproductive aging. In today’s conversation we discussed menopause and it’s effect on women’s health, hormone replacement therapy, and how increasing the number of quality eggs a woman has at age 40 by just 1% can be a game changer. Episode Show Notes: https://livelongerworld.com/p/jgarrison Find the previous podcast episodes & subscribe to be notified: https://livelongerworl
Nov 8, 2023 • 1:03:06
#26 Scaling Laws in Longevity & Aging | Dr. Geoffrey West, Author of book Scale
Dr. Geoffrey West is the author of the bestselling book Scale, the Universal Laws of Life Growth and Death in Organisms, cities and Companies. He is a physicist who got fascinated by the field of aging and longevity and asked the question of why we live as long as we do and no longer. In today's episode, we dive into his research on the scaling laws in biology and longevity. Episode Show Notes: https://livelongerworld.substack.com/p/gwest Find the previous podcast episodes & subscribe to be noti
Jun 29, 2023 • 2:03:25
#25 Caloric Restriction Deep-Dive & Longevity Secrets of Long-Lived Animals | Dr. Steven Austad
All platforms / Episode Transcript: https://livelongerworld.substack.com/p/saustad Dr. Steven Austad is a professor in the Healthy Aging department at the University of Alabama and also scientific director of the American Federation for Aging research. He has a fascinating entry into the world of aging research - it all began with training lions! There are many open questions on the caloric restriction research for enhancing longevity and we dive into that. Further, a lot of Dr. Austad’s wor
Aug 4, 2022 • 1:08:36
#24 Dr. Dominic D'Agostino | Modified Ketogenic Diet for Optimal Health & Exercise (Part 2)
All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom2 Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition. This is Part 2 of a 2 part conversation with Dom. He has so much knowledge to share and in
Jun 28, 2022 • 1:09:41
#23 Dominic D'Agostino | Ketogenic Diet for Brain Health and Longevity (Part 1)
All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom1 Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition. This is Part 1 of a 2 part conversation with Dom. He has so much knowledge to share and in
Jun 9, 2022 • 56:35
#22 The Cancer Diet Connection & Otto Warburg - Nobel Prize Scientist under Hitler | Sam Apple, Author of Ravenous
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/sapple Sam Apple is the author of Ravenous: Otto Warburg, The Nazis, and the Search for the Cancer-Diet Connection. Otto Warburg was a Nobel-Prize winning German scientist during the era of Hitler and the Nazi’s and he was the first person to put the metabolic story of cancer on the map. The famous “Warburg Effect” that shows how cancer cells have an increase in glucose uptake even in the presence of oxygen, is named aft
May 24, 2022 • 1:03:21
#21 Selenium's Dual Role in Health & Aging in the Womb | Dr. Vadim Gladyshev
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev Dr. Vadim Gladyshev is a professor at Harvard Medical school and a Director of redox medicine at Brigham and Women’s hospital, where he runs his own lab. We had a brilliant discussion which started off by talking about his work on selenium. Selenium is found is Brazil nuts and we discussed its connection to aging and cancer prevention, and also some of the harmful effects it can have. Dr. Gladyshev calls it t
May 10, 2022 • 1:00:16
#20 Cardiovascular Disease Risk Assessment & Ketogenic Diets for Heart Health | Dr. Ethan Weiss
Dr. Ethan Weiss is a cardiologist and his special interests include preventive cardiology, genetics of coronary disease, risk assessment, and heart disease in the young. In today’s conversation we spoke about misconceptions people have about heart disease, genetic factors involved in heart disease, how to understand cholesterol and triglycerides in the context of heart disease, ketogenic diets for preventative cardiology and so much more. If you want to understand how to think about your ris
May 3, 2022 • 1:11:50
#19 Michael Levin | Can Bioelectrical Signals Reverse Aging?
Dr. Michael Levin is an American developmental and synthetic biologist at Tufts University where he heads his own lab. He also directs the Tufts Center for Regenerative and Developmental Biology. His groundbreaking research focuses on bioelectrical signals that dictate the collective intelligence of cells and direct it to form tissues and organs. His work on bioelectric signals has important applications for how we understand cancer, regenerative medicine and even aging. In fact, he is collabo
Apr 19, 2022 • 1:00:27
#18 Longevity Supplements - Interventions Testing Program Results | Dr. Richard Miller
Dr. Richard Miller runs one of the labs for the Interventions Testing Program or the ITP, which is largely considered the gold standard for testing longevity drugs. This was one of the best conversations I’ve had on longevity supplements that affect lifespan and those that might me subject to mere hype. Dr. Miller is rigorous in his approach and states the data clearly. He also has opinions on lifespan vs. healthspan that are unique from those of most others and worth paying attention to. I genu
Apr 12, 2022 • 1:21:40
#17 Epigenetic Reprogramming, Yamanaka Factors, Cryonics & COVID Lab Leak | Yuri Deigin
Yuri Deigin is the founder and CEO of YouthBio Therapeutics which is a company that is working on Epigenetic reprogramming or using the Yamanka factors to achieve partial reprogramming. Epigenetic reprogramming has been in the news lately because of several companies being started in the space, with some notable ones being Altos Labs funded by Jeff Bezos and NewLimit founded by Brian Armstrong, CEO of Coinbase. If you’re not familiar with this trending, hyped (rightly so this time - it is pre
Mar 8, 2022 • 1:02:51
#16 Cancer, Cellular Senescence & Senolytics | Dr. Peter Adams
Dr. Peter Adams, Professor at Sanford Burnham Prebys Medical Discovery Institute, is an expert in the biology of aging and cancer. The Peter Adams Lab is focused on the Epigenetics of Cancer & Aging and their goal is to contribute to development of epigenetic-based interventions that promote healthy aging and suppression of disease, including cancer. You will hear about some of these contributions in this conversation. In today’s episode, you will learn: Cellular Senescence and it’s dual role
Mar 1, 2022 • 1:09:30
#15 Parkinson's Disease & Mitochondrial Dysfunction | Andy Lee, COO Vincere Biosciences
My guest today is Andy Lee who is the Chief Operating Officer at Vincere Biosciences. Vincere is working to stop Parkinson’s disease by creating small molecules or drugs that target mitochondrial dysfunction. There is increasing evidence that a dysfunctional mitochondria can lead to the onset of Parkinson’s disease. In today’s conversation, we discussed the science behind a dysfunctional mitochondria and mitophagy, the relationship between the mitochondria and Parkinson’s disease, and whether c
Feb 22, 2022 • 50:23
#14 Dr. Bjorn Schumacher | DNA Damage & Aging, p53 & Cancer, and DNA repair in Reproductive Cells
My guest today is Dr. Bjorn Schumacher whose work focuses on the central role of DNA damage in the aging process. We discussed DNA damage accumulation with age, how DNA repair mechanisms play a role, how DNA damage in the reproductive cells can tell us a lot about aging, human fertility and reproductive capacity. We also discussed the role of p53 in cancer suppression, a new biological age clock being developed in his lab and how we should protect our skin from aging and thereby control DNA dama
Feb 15, 2022 • 55:48
#13 Dr. David Gems | Hyperfunction & Programmatic Theory of Aging and Critique of the Hallmarks of Aging
My guest today is Dr. David Gems who runs the C. Elegans Aging lab at the University College London. We had a fascinating discussion talking about emerging paradigms in the theories of aging. We discussed the hyperfunction theory or the programmatic theory of aging which gives a better integrated understanding of the different theories of aging that have been presented such as damage accumulation, evolutionary, antagonistic pleiotropy. It has been assumed that molecular damage is always the caus
Feb 8, 2022 • 1:24:58
#12 Dr. Bruce Ames | Longevity Micronutrients, Triage Theory, and Vitamin D for Healthy Aging
My guest today is Dr. Bruce Ames who has received several awards and accolades for developing the Ames test which is used to detect carcinogens in commercial products. He showed how there were carcinogens in products such as hair dyes and children’s pajamas! Later, Dr. Bruce Ames turned to studying micronutrients and how deficiency of important vitamins and minerals leads to accelerated aging. He came up with the Micronutrient triage theory, which says that when nutrient intake is insufficien
Feb 1, 2022 • 27:43
#11 Dr. Brian Kennedy | Aging Networks & Biomarkers, AKG, Spermidine and Longevity of Bats
My guest today is Dr. Brian Kennedy who is the Director for the Center of Healthy Aging at the National University of Singapore. He is also the former President and CEO of the Buck Institute of Research on Aging. Dr. Kennedy is well-known in the field of longevity & beyond and has been involved in critical aging research. Dr. Kennedy's lab is working on different small molecules and natural products that could boost longevity. In today's discussion, we spoke about the network concept of the ha
Jan 25, 2022 • 58:26
#10 Dr. Collin Ewald | Collagen Protein & Extracellular Matrix During Aging
My guest today is Dr. Collin Ewald who is a professor at the Health Sciences department at ETH Zurich. His lab focuses on understanding the extracellular matrix (ECM) and how it changes with age. Collin explains the role of the ECM in tissue repair, muscle strength, and overall longevity. In fact, Collin’s lab is also working on establishing the ECM as a biomarker for health and disease risk. So, studying the ECM can indeed tell us a lot about the aging process and ways to intervene. Think of th
Jan 18, 2022 • 1:02:15
#09 Dr. Irina & Michael Conboy | Tissue Rejuvenation Via Plasma Dilution, Neutral Blood Exchange and Parabiosis
My guests in today's episode are Dr. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley. Their groundbreaking research focuses on tissue rejuvenation via plasma dilution and heterochronic parabiosis, where the Conboys took a young mouse and an older mouse and sutured them together, such that the animals shared blood and environment. The old mice became rejuvenated & younger. They’ve also pioneered a process called the Neutral Blood Exchange or
Jan 11, 2022 • 50:04
#08 Nir Barziali | Metformin, TAME Trial & Centenarian Longevity Research
Dr. Nir Barzilai is well-known in the field of longevity and beyond and is the director and chair of several institutes focused on Aging research. Just to name a few, he is the director of the Institute for Aging Research at the Albert Einstein College of Medicine and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. Dr. Barzilai’s research interests are in the biology and genetics of aging, so he has done extensive work studying cent
Jan 4, 2022 • 1:01:51
#07 2021 Best of Live Longer World | Longevity Science
The final 2021 episode of the Live Longer World podcast is a rather special one. I've compiled some of the best & most informative parts of each of my previous episodes and highlighted them in this finale episode. Think of it as a tour showcasing some of the work being done in the field of longevity. Some topics included in the clips are Inflammaging, SystemsAge Clock, Reprogramming, Atherosclerosis, Brain Aging and more. And if a particular topic or clip captures your attention, you can of c
Dec 21, 2021 • 54:27
#06 Morgan Levine | Epigenetic Clocks, SystemsAge Clock and Epigenetic Reprogramming
Dr. Morgan Levine is an Assistant Professor of Pathology and Epidemiology at the Yale School of Medicine. Morgan runs the lab for Aging in Living Systems at Yale. Her labs works on Epigenetic Clocks, Epigenetic reprogramming, cellular aging trajectories, and in trying to understand the causes of Alzheimer’s disease. I can’t even begin to tell you how much I learned in today’s conversation! We extensively discussed Morgan’s work on developing a new Epigenetic clock called the SystemsAge clock, wh
Nov 30, 2021 • 1:15:33
#05 Matt Kaeberlein | Aging Interventions - Rapamycin, mTOR, CR, Sirtuins, NAD+ & Dog Aging Project
Dr. Matt Kaeberlein is a Professor of Pathology, Adjunct Professor of Genome Sciences, and Adjunct Professor of Oral Health Sciences at the University of Washington. His research interests are focused on basic mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. Matt has been around the field of aging for a long time and knows more about the work in the aging field than perhaps anyone else. This was a comprehensive conversa
Nov 17, 2021 • 1:33:31
#04 Dave Gobel, Founder & CEO of Methuselah Foundation | Longevity Funding, Regenerative Medicine & Longevity Escape Velocity
My guest today is David Gobel who is the co-founder & CEO of the Methuselah foundation. Methuselah foundation has donated several million dollars for the advancement of longevity research and regenerative medicine. Their goal is to make make 90 the New 50 by 2030. I’m definitely rooting for that! Dave was an entrepreneur before he decided to jump into the field of longevity. In my conversation with him, we discuss how he got excited about longevity research, companies funded by Methuselah includ
Nov 11, 2021 • 58:30
#03 Carolina Oliveira, the founder & CEO of OneSkin Technologies | Skin Aging, OneSkin, and Building a Longevity Company
Carolina Reis Oliveira is the founder & CEO of OneSkin Technologies. OneSkin is pioneering technologies aimed at extending human healthspan. Their first product is a topical supplement designed to extend your skinspan by improving skin health and skin strength. Their proprietary peptide, OS-01, has been shown to rejuvenate your skin on a molecular level and effectively treat the negative implications of aging. Carolina holds her Ph.D. in Immunology at the Federal University of Minas Gerais in co
Nov 3, 2021 • 1:00:01
#02 Dr. Jean Hebert | Brain Aging, Tissue Replacement, and Radical Strategy to Fight Aging (Potentially Forever!)
Jean M. Hébert, PhD, is a Professor of Neuroscience and Genetics at the Albert Einstein College of Medicine in New York. Dr. Hebert was fascinated from a young age by how a single cell forms the whole human body following an innate genetic program and he got excited by how knowledge of this process might be used to improve our biological fates and defeat aging. He is a molecular geneticist by training and obtained his Ph.D. from the University of California, San Francisco, before specializing in
Oct 26, 2021 • 1:04:57
#01 Reason, the Founder & CEO of Repair Biotechnologies | How to Fight Aging, NAD+ Boosters, Senolytics & Curing Atherosclerosis
Reason is the founder and CEO of Repair Biotechnologies. Repair Biotechnologies is a biotech company focused on developing therapies that treat medical conditions arising due to accumulation of excessive cholesterol. They have developed a unique Cholesterol Degrading Platform to reverse the damage that leads to heart disease and atherosclerosis. More than 5 million people die every year due to atherosclerosis and Repair Biotechnologies is trying to solve this problem. Reason is perhaps most well
Oct 12, 2021 • 1:04:47