The phrase “go with your gut” is often used to say one should follow their intuition in the face of a big decision. Recent research in the journal Nature Mental Health shows the gut really could have a big impact on mental health and decision-making.This study shows a clear link between people who handle stressful situations well and certain biological signatures in their microbiomes. Certain metabolites and gene activity in study participants were associated with high emotional regulation and cognition. These more resilient participants also had reduced inflammation and improved gut barrier integrity.The study builds on previous research that shows the brain and the gut are closely linked, and that a dysregulation in one can lead to a dysregulation in the other. Lead author Dr. Arpana Church, co-director of UCLA’s Microbiome Center and associate professor of medicine, joins Ira to talk about the study. They also discuss how probiotics could someday be a promising treatment for mental health conditions.Transcripts for each segment will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.