Biochemist Kati Karikó spent decades experimenting with mRNA, convinced that she could solve the problems that had kept it from being used as a therapeutic. Her tireless, methodical work was dismissed and she was ridiculed. But that work laid the foundation for the rapid development of COVID-19 vaccines that saved millions of lives, and was recognized by a Nobel Prize in 2023. Kati shares her secret weapon for dealing with stress and naysayers. Plus, neurologist David Langer describes Kati’s exacting research style, and her daughter, Olympic gold medalist Susan Francia, reveals the life lessons that led them both to the winner’s circle.“The Leap” is a 10-episode audio series that profiles scientists willing to take big risks to push the boundaries of discovery. It premieres on Science Friday’s podcast feed every Monday until July 21. “The Leap” is a production of the Hypothesis Fund, brought to you in partnership with Science Friday.Transcript will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.