End stage Hashimoto's is defined as complete thyroid gland destruction. This state is IRREVERSIBLE which is why it is such a big deal! But how do you know if you are in this stage of your disease? And what does it mean for you if you are? Once you reach end stage Hashimoto's your thyroid is non functional and it also means that you are 100% reliant upon thyroid medication. This changes how you look at treatment because you don't really need to focus on the immune aspect of Hashimoto's any longer. Here are 5 signs that indicate you are in this position: