Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors: – SEMrush: https://www.semrush.com/partner/lex/ to get a free month of Guru – Pessimists Archive: https://pessimists.co/ – Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get $200 off – BetterHelp: https://betterhelp.com/lex to get 10% off EPISODE LINKS: Manolis Website: http://web.mit.edu/manoli/ Manolis Twitter: https://twitter.com/manoliskellis Manolis YouTube: https://www.youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA Manolis Wikipedia: https://en.wikipedia.org/wiki/Manolis_Kellis PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: – Check out the sponsors above, it’s the best way to support this podcast – Support on Patreon: https://www.patreon.com/lexfridman – Twitter: https://twitter.com/lexfridman – Instagram: https://www.instagram.com/lexfridman – LinkedIn: https://www.linkedin.com/in/lexfridman – Facebook: https://www.facebook.com/LexFridmanPage – Medium: https://medium.com/@lexfridman OUTLINE: Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. 00:00 – Introduction 08:05 – Molecular basis for human disease 32:04 – Deadliest diseases 37:47 – Genetic component of diseases 46:38 – Genetic understanding of disease 1:02:25 – Unified theory of human disease 1:08:26 – Genome circuitry 1:33:29 – CRISPR 1:45:06 – Mitochondria 1:53:10 – Future of biology research 2:22:46 – The genetic circuitry of disease