Aldo de Pape speaks with Patrick Joyce and Dr. Jeffrey Koury about the challenges and opportunities in the field of decentralized science. They discuss the need for a new economic model in science due to the replication crisis, personal frustrations in academia, and the impact of financial pressures on research integrity. The discussion also covers the role of the ResearchHub and its foundation in incentivizing quality research, the importance of decentralization in scientific publishing, and the evolving landscape of funding and peer review. They reflect on their journey, the community they are building, and the importance of aligning business models with scientific values.Relevant links https://www.researchhub.com/https://www.researchhub.foundation/Sound bites"50 to 85% of experiments are irreproducible.""We need to fix the incentives in science.""The economy of science is extremely competitive."Chapters00:00 Introduction to Decentralized Science01:31 The Need for a New Economic Model in Science04:07 Personal Frustrations in Academia10:17 The Impact of Financial Pressure on Research12:11 The Journey of Research Hub17:56 Decentralization in Scientific Publishing22:18 Peer Review and Funding in a Decentralized World26:48 The Role of the Research Hub Foundation30:19 Incentives and Goodheart's Law34:38 Evaluating Other Decentralized Science Solutions39:49 Building a Business Model that Serves Science45:37 Reflections on the Journey51:11 Recommended Readings and InspirationsKeywordsDecentralized Science, Research Hub, Economic Model, Peer Review, Funding, Open Science, Scientific Publishing, Innovation, Academic Frustration, Science Communities