This Week in Virology
Vincent Racaniello
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
Dickson Despommier, parasitologist without borders
The entire TWiV team comes together to pay tribute to Dickson Despommier, then reviews antibodies to H5N1 virus in veterinarians working with dairy cattle, Elisabeth Bik donates prize money for data integrity analyses, measles outbreak in Texas, and use of an alternative genetic code by human microbiome phages. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, Brianne Barker, Daniel Griffin, Angela Mingarelli, and Jolene Ramsey Subscribe (free): Apple Podcasts, RSS, email Becom
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and Vincent Racaniello reminiscence about Dickson before discussing discharging Ebola patients, another announcement of emergency measures to control polio spread and the third nOPV2 vaccination campaign in Gaza in less than 6 months, the measles outbreak in the US, vaccination campaign for chickens against high pathogenic avian flu before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, w
HPV or not to B
TWiV reviews a facility accident that killed monkeys, new bird blu genotype found in Nevada dairy cattle, Argentina plans to leave WHO, yellow fever on the rise, dynamics of HPV infections in women, and Epstein-Barr virus protein targets B cell receptor for degradation. Hosts: Vincent Racaniello, Alan Dove, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 Accident kills monkeys at
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss confirmation of Robert F Kennedy as HHS sectary, mpox, Ebola, how the American people support vaccine development and administration, the measles outbreak in the US-Texas, Georgia and influenza: the number of human infections, high avian flu in mammals, house cats and dairy cows before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, a
The pandemic duo
TWiV reviews freezes and unfreezes of US government grants, how prior COVID-19 vaccination prevents over-reaction of the innate immune response during infections, and how bat genomes illuminate adaptations to viral tolerance and disease resistance. Hosts: Vincent Racaniello and Alan Dove Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 NIH freezes (ScienceAdviser) Is your research on Trump’s hit list? (
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss changes in access to public health information and aid mechanisms such as the return of MMWR, the largest tuberculosis outbreak in the US ever, lack of USAID in fighting Marburg and Ebola outbreaks in Africa, discussing if avian influenza virus is airborne, how eggs are effected and the emergence of second spillover into dairy cattle, how the difference between nOPV2 and Sabin OPV2 is a minor reduction in the association o
Viruses making waves
TWiV notes the HHS communication pause, and describes research showing that rotavirus viroporin activity is necessary for intracellular calcium signals that contribute to viral pathogenesis, and control of human orthrflavivirus vaccine challenge by T cells in the absence of neutralizing antibodies. Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at Mic
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss changes in access to public health information, the Marburg and Ebola outbreaks in Africa, the largest tuberculosis outbreak in the US ever, the politicization of polio vaccine campaigns in Pakistan, effect of high pathogenic influenza in animals and on the economy before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, provides inform
The tau of herpesvirus
TWiV explains a new blood test for head and neck cancer, Japanese regulators approve tecovirimat for mpox, an entry receptor for enterovirus D68, and anti-herpetic tau preserves neurons via a DNA sensing pathway in Alzheimer’s disease. Hosts: Vincent Racaniello, Kathy Spindler, Brianne Barker, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and co-host Vincent Racaniello lament about the public changes from withdrawing from the WHO to health and scientific communication pauses by the Trump Administration after a brief discussion of Marburg in Tanzania and mpox in England before reviewing cats and bird flu, the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Cent
The birds and the Bs
TWiV explains Guillain-Barré Syndrome associated with RSV vaccines, outbreaks of metapneumovirus in China and India, editors resign to protest Elsevier’s use of AI in publishing, global distribution and diversity of wild bird associated pathogens, and broadly inhibitory anti-neuraminidase antibody from human memory B cells. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses current and past outbreaks of “vaccine” preventable diseases including whooping cough, polio and measles with your co-host Vincent Racaniello and the recent increase in norovirus outbreaks, if alcohol-based hand sanitizers aid in the spread of norovirus before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Me
More than 2024 viruses
TWiV reviews some of their favorite virology stories from 2024. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at Micr
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses how vaccination and vaccine hesitancy affects public health and disease spread in terms of mpox, the first human death from H5N1 in US, why one should not feed their pets raw pet food and the metapneumonia outbreak in China before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, how nirmatrelvir-ritonavir/Paxlovid reduces adverse outcomes of COVID in patients wi
Seek and ye shall find, coronaviruses and phage
TWiV discusses an outbreak of influenza H5N1 that killed over half of the great cats at a Washington sanctuary, origin and cross-species transmission of bat coronaviruses in China, and the diverse and abundant phages that enter cells via receptors encoded on conjugative plasmids. Hosts: Vincent Racaniello, Rich Condit, and Jolene Ramsey Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the recent increase in norovirus outbreaks, human cases of H5N1 avian influenza, before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, how effective Molnupiravir is and provides information for Columbia University Irving Medical Center’s long COVID treatment center. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode
TWiV 1179: Dark matter and warning signs
TWiV reviews RFK Jr’s demand to revoke polio vaccine, Wuhan lab samples do not include close relatives to SARS-CoV-2, using artificial intelligence to discover the RNA virosphere, and biomarkers that discriminate early and late phases of respiratory virus infections from a SARS-CoV-2 human challenge study. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin deep dives into the whooping cough epidemic and bird flu in big cats, and in conjunction with your host Vincent Racaniello discusses the recent case of paralytic poliomyelitis in Israel, measles outbreaks and HHS campaign for vaccine safety campaign before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, if the COVID mRNA vaccine is effective against symptomatic SARS-CoV-2 infection and hospitalization in children,
TWiV 1177: Going to school for flu
At the School for Influenza in Brisbane, TWiV speaks with Kirsty, Erik and Rebecca about their careers and their research. Host: Vincent Racaniello Guests: Kirsty Short, Erik Karlsson, and Rebecca Cox Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Diabetes, obesity, and COVID-19 severity (Diab Care) Rice farming and zoonosis in Cambodia (One Health) Influenza correlates of protection (mBio) Timestamps by Jolen
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin continues his discussion of whether the mysterious respiratory illness in the Congo is malaria, and in conjunction with your host Vincent Racaniello discusses how routine childhood immunizations especially that against poliovirus are threatened by Robert F Kennedy Jr and Aaron Siri, the origin of the SAR-CoV-2 virus and retraction of Didier Raoult’s research, then returns to discussing the first case of severe disease following H5N1 infection in humans
TWiV 1175: A hitchiker's guide to virology
TWiV reviews the appearance of poliovirus in Europe, mystery disease in DRC, global burden of Chikungunya, viruses of parasitic nematodes that induce antibody responses in vertebrate hosts, and picobirnaviruses, do they infect eukaryotes or prokaryotes? Hosts: Vincent Racaniello, Alan Dove, and Jolene Ramsey Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2025 Write your senators about RFK Jr Support science education at MicrobeTV Poliovirus in
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin deep dives into whether the mysterious respiratory illness in the Congo is malaria, and in conjunction with your host Vincent Racaniello discusses the failure of the poliovirus eradication campaign with virus circulation detected throughout Europe and how we should focus on disease control not virus circulation, then returns to discussing avian influenza in raw milk and the early stoppage of the mpox antiviral Tecovirimat before reviewing the recent st
Holy Cow! Convergent evolution!
TWiV reviews nominees to head NIH, FDA, and CDC, cervical cancer decline following HPV vaccination, local dengue in Texas, human isolate of H5N1 virus is transmissible and virulent in animal models, and shared mechanisms of immune evasion among animal and bacterial viruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, Brianne Barker, and Jolene Ramsey Subscribe (free): Apple
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin summarizes influenza and RSV circulation in the US, the benefit of administering oseltamivir early and if influenza vaccination reduces secondary household infections, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how 1st or 2nd trimester SARS-CoV-2 infections may shorten newborn telomeres, what are B1 cells, if IgG4 responses are critical for protection elicited by mRNA vaccines, if there is a difference
The born immunity
TWiV reviews susceptibility to vaccine-preventable infections in asylum seekers, the economic power of vaccines, French university tries to bury its investigation of a faculty member’s ethical lapses, transmission dynamics of SARS-CoV-2 in New Zealand before and after COVID-19, and a germ line encoded antibody that recognizes a broad array of enveloped viruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS,
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin dives into H5N1/influenza and RSV circulation in the US, whether or not H5N1 is “adapting” for human-human transmission, why drinking raw milk may NOT be the best idea despite RFK Jr endorsement, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how if I encounter no one I can infect no one, the efficacy of COVID-19 boosters, how vaccines are the ‘seat belt’ of public health, the results of two PLACEBO contro
Can anyone hook me up with a duck?
TWiV travels to Brisbane, Australia for the Options XII for the control of influenza conference, and meets up with Stephanie Gras and Jenna Guthmiller to talk about their careers and their research. Hosts: Vincent Racaniello, Kathy Spindler, and Steph Langel Guests: Stephanie Gras and Jenna Guthmiller Subscribe (free): Apple Podcasts,
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin briefly discusses the E.coli outbreak associated with onions from McDonald’s before deep diving into the announcement of Robert F Kennedy Jr. nomination for Secretary of Human and Health Services with highlights from MicrobeTV’s own Vincent Racaniello and Paul Offit (Beyond the Noise), the global measles outbreak, underutilization of influenza antivirals for children and teens, the $350 million 2025 order for mpox vaccination, before reviewing the recen
Virus cloak and entry
TWiV reveals a novel H5N1 reassortant virus in Cambodia, circulating vaccine derived poliovirus type 2 in more countries, circulation in the blood of humans of infectious parvovirus B19 coated with active proteases, and B cell receptor dependent enhancement of dengue virus infection. Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin apprises us about the first case of highly pathogenic influenza in Canda, children dying of influenza infection and novel genetic reassortments of the virus, the Marburg virus outbreak in Rwanda, number of mpox infections, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how scientific mistrust has affected COVID-19 vaccine administration, resolution of the FDA hold on Novovax’s combination influenza and COV
What doesn't kill us primes our macrophages
TWiV notes the passing of virologist Diane Griffin, first H5N1 influenza virus in US pigs, Innate immune control of influenza virus interspecies adaptation via IFITM3, and antiviral trained innate immunity in alveolar macrophages after SARS-CoV-2 infection reduces secondary influenza A virus disease. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, RSS
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin informs us about the World Health Organization research and development plan to combat endemic pathogens including hepatitis C virus, RSV and dengue virus, another case of mpox in Britian, the Marburg virus outbreak in Rwanda, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, if there is a benefit to additional COVID vaccinations after the initial series, ISDA guideline for using anti-SARS-CoV-2 monoclonal an
Hepadnaviridae in the heartland
From the 2024 International Hepatitis B virus meeting in Chicago, TWiV speaks with Mala Maini and John Tavis about their careers, the replication and transmission of HBV, and the HBV Foundation. Hosts: Vincent Racaniello and Rich Condit Guests: Mala Maini and John Tavis Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin informs us about “walking pneumonia”, the phase of the polio supplemental immunization campaign in Gaza, mpox circulation, the Marburg virus outbreak in Rwanda, the beginning of influenza season, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, contrasting public health concerns between the US and the UK, if mRNA boosters affect mucosal immunity against SARS-CoV-2 infection, where to find PEMGARDA, a reminde
Baby you can drive my gene
TWiV reviews continuing expansion of poliovirus type 2, removal of influenza B/Yamagata from the vaccine, Nobel Prize for miRNAs, protective immune response with a adenovirus-associated virus vector expressing a computationally designed hemagglutinin, and viral gene drive during herpes simplex 1 infection in mice. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts,
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin informs us about mpox circulation, the Marburg virus outbreak in Rwanda, new recommendations for the RSV and pneumococcal vaccines by the CDC, the beginning of influenza season, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, contrasting public health concerns between the US and the UK, what the risk of SARS-CoV-2 transmission is when indoors, the difference between NVX-CoV2327 and BNT162b2 for adolescents,
Eliminating cervical cancer, and endometrial immunity
Vincent travels to the Karolinska Institute in Stockholm to meet up with Niklas Björkström and Joakim Dillner to review their research on the endometrial immune system, and the plan to eliminate cervical cancer in Sweden. Host: Vincent Racaniello Guests: Niklas Björkström and Joakim Dillner Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Endometrial immune system variation (Sci Immunol) Immune defense in th
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin informs us about mpox circulation and new vaccine approval, the Marburg virus outbreak in Rwanda, and the largest outbreak of whooping cough in a decade before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, immunity among those over 65th following the 3rd dose of the COVID-19 mRNA vaccine, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, how well the SARS-CoV-2 rapid antigen t
Superworm liquefaction and a pandemic prophylactic
TWiV reviews Marburg virus outbreak in Rwanda, cryo-EM based discovery of a parvovirus causing black wasting disease in farmed beetles, and a mosaic nanoparticle experimental vaccine that elicits cross-reactive sarbecovirus responses in pre-vaccinated animals. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Marburg virus disease, Rwanda (WHO) Suspecte
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin updates us about polio SIA campaign in Gaza, the durability of protection following administration of GSK’s recombinant antigen RSV vaccine, mpox in an Ugandan jail, the Marburg virus outbreak in Rwanda, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, immunogenicity, reactogenicity and safety of different COVID-19 vaccine platforms, disease severity in those not previously vaccinated with those vaccinated b
Spillover in stall A
TWiV reviews mask effectiveness against respiratory infections, EEE death in NY State, viruses with zoonotic potential in farmed fur animals, and genetic tracing of market wild life and viruses at the Huanan Seafood Market, the epicenter of the COVID-19 pandemic. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Review confirms mask effectiveness (original
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the Marburg virus outbreak in Rwanda, the lack of immune durability following pertussis vaccination, recommendations for maternal vaccination and antibody therapy to protect against infant RSV, vaccine security for Mpox, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how to put on and take off PPE to avoid contamination, where to find PEMGARDA, a reminder of how and when to use steroids to treat
Viruses that (can) make you well
From the Viruses of Microbes meeting in Cairns, Australia, TWiV speaks with Krystyna and Rob about their research on using bacteriophages to treat bacterial infections. Hosts: Vincent Racaniello and Jolene Ramsey Guests: Krystyna Dabrowska and Rob Lavigne Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Viruses of Microbes 2024 Immune responses to phages (Front Immunol) Engineering bacteriolytic enzymes (Fron
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin deep dives into the durability of the antibody response following mpox vaccination, vaccine security, global mpox circulation, the origins of SARS-CoV-2, including a list TWiV episodes and combatting scientific misinformation, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-C
Hotel California for Phage
TWiV reviews polio vaccination campaign in Gaza, viruses with zoonotic potential in farmed fur animals, low HPV vaccination in North Texas associated with high rates of cervical cancer, a large flavivirus genome that does not encode error correction machinery, and antiphage defense through inhibition of virion assembly. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Jolene Ramsey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin dives into West Nile virus in New Jersey, poliovirus vaccination campaign in Gaza and Afghanistan, California dengue virus infections, children dying from flu, mpox vaccination procurement and antiviral usage, flu circulation in US, before reviewing the recent statistics on SARS-CoV-2 infection, finding a new wasterwater dashboard, if the monovalent XBB.1.5 COVID-19 vaccine is effective against circulating SARS-CoV-2 isolates, the need for nasal mucosal
Mary Estes, a gutsy virologist
From the annual meeting of the American Society for Virology, Kathy and Brianne speak with Mary Estes about her career and the research of her laboratory on viruses that infect the gastrointestinal tract, including rotavirus and norovirus. Hosts: Kathy Spindler and Brianne Barker Guest: Mary Estes Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Diarrhea induced by rotavirus NSP4 (Science) Minimal infective d
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin dives into “pandemic potential” viruses isolated from farmed fur animals, how the mRNA and pox vectored vaccines against mpox spar against each other, how telehealth does managing mpox, and if prophylactic use of the anti-RSV monoclonal for infants is cost-effective before reviewing the recent statistics on SARS-CoV-2 infection, if viral load correlates to one vaccination status, where to find PEMGARDA, does administration of molnupiravir reduce symptom
Breastmilk paradox for norovirus
TWiV reviews multi-country outbreak of Mpox, first face covering ban in Nassau County NY, case of polio in India, more in US accept vaccine misinformation, other wartime diseases in Gaza besides polio, a new scientist run virus genome database, Mpox epidemiology and vaccine effectiveness in England, and metabolic immaturity and breastmilk bile acid metabolites determine heightened newborn vulnerability to norovirus diarrhea. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (f
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses seasonal influenza vaccine recommendations from the CDC, polio vaccine campaign securing mpox vaccine for Africa, and donating to reduce food insecurity in mpox affected areas before reviewing the recent statistics on SARS-CoV-2 infection, where to find PEMGARDA, when to use convalescent plasma, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against
Heartbeats and hoofbeats
TWiV reviews a case of polio in Gaza, more Mpox, COVID-19 boosters, effectiveness of Ebola virus vaccine, measles cases across the US, an endogenous retroviral envelope protein that regulates human cardiomyocyte development, and submergence of an encephalitic alphavirus caused by receptor shifts. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Se
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses Dr. Fauci’s case of West Nile virus, polio vaccine campaign develops in Gaza, disease that associates with Oropouche virus, mpox: vaccines, clinical trial for mpox antiviral and the WHO strategic preparedness and response plan before reviewing the recent statistics on SARS-CoV-2 infection, how to obtain free COVID tests, EUA for updated Novavax COVID vaccine, ISDA support of and where to find PEMGARDA, breakthrough infections when administerin
SARS-CoV-2 gone wild, with a side of rice
TWiV discusses WHO declaration of Mpox as a public health emergency of international concern, Sweden reports first case of clade 1b outside of Africa, can household pets be productively infected with monkeypox virus, widespread exposure to SARS-CoV-2 in wildlife communities, and modulation of plant defenses by insect salivary GAPDH benefits viral transmission. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podca
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses global transmission of mpox, the different clades of the virus and associated pathogenesis, vaccination vs antiviral therapy against mpox and the US’s aid response for controlling the African outbreak before reviewing the recent statistics on SARS-CoV-2 infection, authorization and approval of updated COVID vaccines, the economic benefit of an annual COVID vaccine and if the first updated vaccines against XBB.1.5 were effective, where to find
Being green with the Red Queen
TWiV discusses the spread of monkeypox virus clade 1b in Africa, COVID drops to tenth leading cause of death in the US, response to detection of poliovirus in Gaza, mechanism of MIS-C after SARS-CoV-2 infection, neonatal Fc receptor is a pan-arterivirus receptor, and antiviral immunity in plants mediated by protein arginine methyltransferase 6. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a pa
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehe
Long COVID with Dr. Judith Bruchfeld
Vincent travels to the Karolinska Institute in Stockholm on 31 May 2024 to meet with Dr. Judith Bruchfeld and discuss her research on the etiology and treatment of Long COVID. Hosts: Vincent Racaniello Guest: Judith Bruchfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Immune system perturbations in Long COVID (J Immunol) Post-COVID immune system perturbations (J Immunol) Systems disregulation in Long CO
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehe
Dengue is not BANAL
TWiV discusses a twice-yearly antiviral for prevention of AIDS, the WHO pandemic plan, West Nile resurgence in the US, the BANAL SARS-CoV-2 related viruses reproduce in human cells but do not transmit among animal hosts, and an amino acid change in dengue virus that enhances midgut replication in mosquitoes but reduces pathogenicity in humans. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TW
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses how the pandemic may have effected our trust in physicians and hospitals and if waiting longer to make strain selection for the seasonal influenza vaccine would be advantageous before reviewing the recent statistics on SARS-CoV-2 infection, how different CVODI-19 vaccines effect the cardiovascular system, if the a third of either COVID-19 mRNA vaccine is effective, where to find PEMGARDA, if convalescent plasma, what do when healthcare workers
Resistance is not always futile
TWiV reviews whats going on with measles and its global resurgence, poliovirus found in Gaza, vaccine hesitancy in a community, 14 year old dies of Nipah, selection of SARS-CoV-2 viruses resistant to nirmatrelvir, and protective but non-neutralizing antibodies from survivors of Crimean-Congo hemorrhagic fever virus. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Brianne Barker, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses Merck’s RSV preventative monoclonal antibody Clesrovimab before reviewing the recent statistics on SARS-CoV-2 infection, if previous SARS-COV-2 infections predict the outcome of subsequent infections, if using COVID rapid diagnostic tests is cost effective, if the protein based vaccine NVX-CoV2327 elicits a durable immune response, if combination treatment of vaccine and antiviral drugs effectively protect against hospitalization, where to fin
Gain of function makes us safer
TWiV reviews cases of measles in Brooklyn NY and Washington DC, stalling of global childhood vaccination, licenses H5N1 vaccines protect against circulating strains, viruses traveling without passports. OC43 SARS-CoV- 2 spike replacement virus as an improved BSL-2 proxy virus for SARS-CoV-2 neutralization assays, and deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove,
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr, Daniel Griffin reviews President Biden’s case of COVID, reviews recent statistics on SARS-CoV-2 infection, discusses post-acute sequelae after infection during pregnancy, the use of nirmatrelvir-ritonavir for post-exposure prophylaxis, where to find Pemgarda, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment, effectiveness of Ensitrelvir in reducing severe outcomes in outpatients at high risk for COVID-19, effectiveness of combined nirmatr
Mootant influenza H5N1 virus
TWiV reviews the potential impact on science of the Supreme Court ruling in the Chevron decision, measles in New Hampshire and Vermont, new who proposed terminology for respiratory pathogen transmission, and pathogenicity and transmission of bovine H5N1 influenza virus. Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Articles on Chevron decision
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses H5N1 influenza in the bird and cow communities of Colorado and Michigan and dengue in New York and the US before reviewing the recent statistics on SARS-CoV-2 infection, the absence of association with proton pump inhibitors and COVID-19 severity in children, where to find PEMGARDA, the effectiveness of molnupiravir and dexamethasone, convalescent plasma, what to do when healthcare workers succumb to SARS-CoV-2 infection, a resource of long CO
You never forget the first time you flu
TWiV reviews measles in Kenya, a trial for a intranasal COVID vaccine, dengue in the Florida Keys and in Central/South America, Spain connecting government with scientists, T cell activation and viral RNA fragments persist for up to 2 years after SARS-CoV-2 infection, and durable cross-reactive and protective antibodies against avian N2 neuraminidases elicited by A(H2N2) and A(H3N2) influenza pandemics. Hosts: Vincent Racaniello and Alan Dove Subscribe (free): Apple Podcasts, Google Podcasts, R
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the fourth US case of H5N1 human infection and reminds the audience of the definition of “pasteurization” before reviewing the recent statistics on SARS-CoV-2 infection, where to find PEMGARDA, the effectiveness of molnupiravir and dexamethasone, convalescent plasma, what to do when healthcare workers succumb to SARS-CoV-2 infection, how an EEG can be used to look for signatures of cognitive decline after SARS-CoV-2 infection and what we obser
Giving prions the (zinc) finger
TWiV discusses secret anti-vax campaign run by Pentagon to undermine China during pandemic, NY governor’s subways mask ban proposal, Colorado bat facility sparks outbreak fears, House budget billls suggest ban on gain of function research, evolution of STAT2 resistance to flavivirus NS5, and brainwide silencing of prion protein by AAV-mediated delivery of an epigenetic editor. Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove Subscribe (free): Apple Podcasts, Google Podcasts, RSS, em
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses RSV vaccination recommendations and revisions to guidelines before reviewing the recent statistics on SARS-CoV-2 infection, data suggesting that individuals with high HLA-DQA2 expression (MHC class II) are better at preventing the onset of a sustained viral infection, how moderate coffee intake can reduce risk of COVID-19 severity but cannabis use resulted in more severe disease but reduced risk of mortality, where to find PEMGARDA, if statin
Can pig flu viruses go viral?
TWiV reviews criticism of NIAID monkeypox virus experiments by House Republicans, spread of wild poliovirus across Afghanistan and Pakistan, plan to overhaul NIH by House lawmakers, and the potential pandemic risk of circulating swine H1N2 influenza viruses. Hosts: Vincent Racaniello, Dickson Despommier, Brianne Barker, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server 2024 International
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews the recent statistics on SARS-CoV-2 infection, before discussing methods for sterilizing filtering facepieces, an update to the fall COVID boosters, the emergency use application of a pre-exposure prophylactic and where to find it and drug interaction database, convalescent plasma, the effectiveness of the monoclonal antibody sotrovimab against Omicron variants, what to do when healthcare workers succumb to SARS-CoV-2 infection, the need for bet
Europic 2024 in Jyväskylä, Finland
Vincent travels to Europic 2024 in Jyväskylä, Finland to speak with Tapani Hovi and Caroline Tapparel about their careers and their research on enteroviruses and elimination of poliomyelitis. Host: Vincent Racaniello Guests: Tapani Hovi and Caroline Tapparel Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Survival of influenza virus on banknotes (Appl Environ Micro) Variant EV-A71 in immunosuppressed patient (Cell Rep) Rhinoviruses
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses expanded use of the RSV vaccine by GSK, how the youngest member of the MicrobeTV family was hospitalized with RSV, why we are seeing more RSV infections than before the pandemic and how administration of monoclonal antibody therapy does not prevent infection but disease, before reviewing the weekly US COVID update, how SARS-CoV-2 affects neurodevelopment of the fetus and probability of preeclampsia, if giving Paxlovid prevents long COVID, and
How the pandemic began in Nature, in 5 key points
TWiV rebuts a recent opinion piece which falsely claims that the COVID-19 pandemic began in a lab (it began in Nature). This material has been extracted from TWiV 1121. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Brianne Barker, and Jolene Ramsey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server SARS-CoV-2 origin discussions previously on TWiV: TWiV 1019: Eddie Holmes on SARS-CoV-2 origins TWiV 1017: F
SARS-CoV2 still didn't come from a lab
TWiV rebuts a recent opinion piece which falsely claims that the COVID-19 pandemic began in a lab (it began in Nature), followed by a discussion of Paride bacteriophage, which has the unsual property of being able to kill dormant, antibiotic-tolerant cells by direct lytic replication. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Brianne Barker, and Jolene Ramsey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reports the third case of influenza H5N1 infection in a human, this time with respiratory symptoms, an H5 avian influenza virus wastewater dashboard, FDA approves Moderna’s mRNA vaccine for respiratory syncytial virus, vaccine advisors to FDA recommend switching from the XBB.1.5 variant to JN.1 for fall COVID-19 vaccine formulations, weekly US COVID update, a controlled human exhaled breath aerosol experimental study on the relative efficacy of masks an
Gene editing latent herpes
TWiV reviews viral shedding and antibody responses of men with acute monkeypox virus infection, and gene editing for latent herpes simplex virus infection reduces viral load and shedding. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress 2024 International HBV Meeting Michelson Prizes: Next Generation Gra
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin delves into highly pathogenic H5N1 infection of hunting dogs, dairy cattle, humans and alpacas before reviewing the recent statistics on SARS-CoV-2 infection, risks factors associated with the development of severe COVID-19 in pediatric patients, virus transmission on commercial airline flights, the guidelines for spring administration of COVID vaccines boosters, the emergency use application of a pre-exposure prophylactic, a drug interaction database,
Pol dances with the RNA that brought it
TWiV discusses presence of infectious avian H5N1 influenza virus in raw milk from infected dairy cows. dynamics of measles immunity from birth and following vaccination, and a mechanism for cis-preferential reverse transcription revealed by deep mutational scanning of hepatitis B virus. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this epi
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin delves highly pathogenic H5N1 biology including its circulation in New York City, being able to infect cells within mammary glands and why testing is not supported before reviewing the recent statistics on SARS-CoV-2 infection, how vaccination reduced deaths and hospitalizations associated with COVID-19 and how to take off PPE to reduce virus transmission, discussing the guidelines for spring administration of COVID vaccines boosters, the emergency use
Calling the CoPs on flu
TWiV reviews results of a phase 3 trial of a self-amplifying mRNA COVID-19 vaccine, and the finding that baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology. Hosts: Dickson Despommier, Alan Dove and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Michelson Prizes: Next Generation
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin delves into discussing drinking “raw” milk possessing H5N1 influenza virus, if the virus can reproduce in the human gut, and the meaning of finding viral RNA in wastewater samples before reviewing the recent statistics on SARS-CoV-2 infection, the guidelines for spring administration of COVID vaccines boosters, withdrawal of AstraZeneca’s SARS-CoV-2 vaccine from the European market, discusses the emergency use application of a pre-exposure prophylactic,
Influenza virus H5N1 in cows' milk with Richard Webby
Richard Webby joins TWiV to review the history of avian H5N1 influenza virus, the recent change in epidemiological patterns, infection of dairy cattle in the US, and the risk of an outbreak in humans. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Guest: Richard Webby Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Webby research laboratory H5N1 virus in dairy cattle an
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin deep dives into infections of dairy cattle with high pathogenic influenza H5N1, how long virus has been circulating and if known anti-influenza antivirals can reduce secondary attack rates, before reviewing the recent statistics on SARS-CoV-2 infection, the guidelines for spring administration of COVID vaccines boosters, whether COVID booster takes associates with long COVID prevalence, discusses the emergency use application of a pre-exposure prophylac
Taming of the flu
TWiV reviews viruses in the news: Chinese scientist who released the SARS-CoV-2 genome sequence sleeps in the street, a case of measles in Haifa, spread of waterborne infectious diseases in Gaza, interstate spread of avian influenza A(H5N1) in dairy cattle, and an orangutan heals himself with medicinal plants, followed by identification of a cell receptor for parechoviruses, and blockade of necroptosis prevents lung injury in severe influenza. Hosts: Vincent Racaniello, Dickson Despommier, and A
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin begins with discussing if the antibiotic neomycin is really a pan-antiviral countermeasure, then reviews the recent statistics on SARS-CoV-2 infection before deep diving into if shedding and the rapid antigen test results correlate, the guidelines for spring administration of COVID vaccines boosters, whether COVID booster associates with the long COVID prevalence, discusses the emergency use application of a pre-exposure prophylactic, revised guidelines
A protein flew out and a bat flu in
TWiV reviews avian H5N1 influenza virus in the US, measles at highest levels in England, positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution, and cross-species spill-over potential of the H9N2 bat influenza A virus. Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.or
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles, and H51 influenza infection of birds, poultry and cows before and SARS-CoV-2 circulation, before discussing if the original monovalent SARS-CoV-2 vaccine was effective in children and adolescents, how to use words to properly describe respiratory pathogens the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic, re
Uncoating some envelopes
It has been a long time since TWiV has released an all listener email episode, and if you have been waiting for one, then this episode is for you! (and everyone else of course). Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier (blog post) International Confe
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles before addressing results of Pfizer’s phase 3 RSV vaccine clinical trial for adults under 60, RSV, influenza and SARS-CoV-2 circulation, differences between rural and urban communities dealing with SARS-CoV-2 infections, the latest statistics on influenza and COVID-19 circulation, restates the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application o
All the T and B in China
TWiV reviews influenza H5N1 in North American cows and in birds throughout New York City, polio health emergency extended, ChatGPT to control vaccine hesitancy, increasing viral hepatitis worldwide, dengue public health alert in Puerto Rico, cherry trees drowning in Washington DC, death of iron lung Paul, origin and dispersal history of hepatitis B virus in Eastern Eurasia, and antibody-independent protection against heterologous SARS-CoV-2 challenge. Hosts: Vincent Racaniello, Alan Dove, Rich C
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles before addressing results of Pfizer’s phase 3 RSV vaccine clinical trial for adults under 60, RSV, influenza and SARS-CoV-2 circulation, differences between rural and urban communities dealing with SARS-CoV-2 infections, the latest statistics on influenza and COVID-19 circulation, restates the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application o
Jason 'Spike' McLellan
Vincent travels to the University of Texas in Austin to speak with speak with Jason McLellan about his career and his research on the SARS-CoV-2 spike protein, including the effect of adding two proline residues, its effect on other viral spike glycoproteins, and general approaches to vaccine design. Hosts: Vincent Racaniello and Rich Condit Guest: Jason McLellan Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Serv
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles and influenza before addressing Vincent’s comment on measles inclusion in the clinical respiratory PCR panel, the latest statistics on influenza and COVID-19 circulation, if inflammatory cytokines and anti-viral antibody function synergistically, if administration of peptide agonists of the glucagon-like or sodium-glucose pump can reduce disease severity, restates the guidelines for spring administ
It's not over 'til it's Offit
Paul Offit joins TWiV to discuss his latest book, “Tell Me When It’s Over”, an insider’s guide to deciphering COVID myths and navigating our post-pandemic world. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Guest: Paul Offit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier Tell Me When It’s Ov
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles influenza and SARS-CoV-2, before discussing the development of new monoclonal antibody therapy, if vaccines and antivial drugs can used effectively together. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound including that after administration of the “oral remdesivir”, revised guidelines SARS-CoV-2 treatment and how
Volker Lohmann, as persistent as his viruses
Vincent travels to the University of Heidelberg to speak with Volker Lohmann about his career and the research of his laboratory on hepatitis C virus, hepatitis A virus, and norovirus. Host: Vincent Racaniello Guests: Volker Lohmann Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier HCV human challenge studies (Lanc
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin deep dives into recent domestic and global measles and mpox outbreaks, before reviewing recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2, discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of c
Tiny cells and giant viruses in a castle
Vincent travels to the fifth Giant Virus Meeting in Tegernsee, Germany and speaks with Sheree Yau and Victoria Queiroz about their research on picoeukaryotes (tiny algal cells) and their viruses, pithoviruses, and an educational kit for virology classes. Host: Vincent Racaniello Guests: Sheree Yau and Victoria Queiroz Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a membe
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin highlights measles outbreaks throughout the continental US, reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing if vaccination protected children from the development of long COVID or cardiovascular diseases associated with virus infection, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use st
Monkeys fly and mice exaggerate
TWiV reviews heterosexual transmission of clade I Mpox virus, continued circulation of oropouche virus in South America, herpesviruses in South American fur seals and sea lions, sex-specific differences in physiological responses to SARS-CoV-2 infection, underdetected dispersal and extensive local transmission drove the 2022 mpox epidemic, and a humanized mouse model for adenovirus-associated virus gene therapy. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Angela Mi
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, effectiveness of the new SARS-CoV-2 vaccines and the combination of vaccination and antiviral therapy against the development of disease, continues to dispel the myth of viral rebound, how to pay for paxlovid, the lack of evidence supporting ivermec
Reservoir bats and jumbo phage
TWiV discusses effectiveness of this season’s flu vaccine, efficacy of Pfizer RSV vaccine, nOPV2 in the US, dengue in Peru, measles in Michigan and Indiana, how coordinated inflammatory responses dictate control of Marburg virus by reservoir bats, and tRNA acquisition in phages driven by degradation of host translational machinery. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, Brianne Barker, and Jolene Ramsey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patr
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing new vaccine guidelines released by the advisory committee on immunization practices, and reviews the CDC guidelines for quarantine/ isolation following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, the role of IFN-g in long COV
Skeeter poo and obelisks too
TWiV reviews resurgence of Lassa fever in West Africa, at least 3 paralytic cases of cVDPV2 in Zimbabwe, CWD from eating prion-laden plants, measles in New Orleans and Broward County Florida, failure of Florida Surgeon General to support vaccination, a measles variant in Switzerland, SARS-CoV-2 persistent infections, leaky blood-brain-barrier for long COVID brain fog, West Nile virus transmitted among mosquitoes by the excreta, and viroid-like colonists of human microbiomes. Hosts: Vincent Racan
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus before discussing uptake of the RSV vaccine Abrysvo or the monoclonal anti-RSV antibody nirsevimab to prevent severe disease following RSV infection in infants 8 months or younger before going over this week’s influenza virus and SARS-CoV-2 virus statistics, including all circulating variants in the US, examines if self-testing is more accurate than clinician administered Binax
Shoot out at the Circle-T ranch
TWiV reviews a fatal Alaskapox case, MERS in Kenya, diagnostic tests for Nipah and Lassa diseases, HPV vaccination rates in the US, cases of measles in Arizona and Minnesota, hepatitis C virus-derived RNA circles in infected cells, and prevention of respiratory virus transmission by resident memory CD8+ T cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episod
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the use of monoclonal antibody therapy to prevent RSV hospitalization of infants and use of GSK’s RSV vaccine Arexy to prevent severe disease following RSV infection in adults between 50-59 years before he reviews recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses if how the influenza vaccine is manufactured can reprogram the antibod
Should old infections be forgot
TWiV reviews rhinovirus complications in infants, a new influenza antiviral drug, Oropouche fever in Brazil, measles in Maryland and Ohio, effect of eliminating non-medical vaccine exemptions in NY, foot-and-mouth disease in Europe, severe primary and secondary dengue infections, and therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Angela Mingarelli Subscribe (fr
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the how the pandemic influenced the healthcare job market and why people conceal their infectious diseases before he reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses if susceptibility and disease severity are inheritable traits, if vaccination during pregnancy protects neonates or leads to adverse effects, the effectiv
When macrophages go to alimentary school
TWiV reviews measles outbreaks in England and Europe, 2 fatal Nipah virus cases in Bangladesh, yellow fever outbreak in Sudan, and discuss how the type of immunodeficiency influences the outcome of SARS-CoV-2 infection, and programming of alveolar macrophages by intestinal bacteria that influences severity of respiratory viral infection. Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the how the pandemic influenced the healthcare job market before he reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses the safety of the prefusion RSV vaccine, if high or moderate dose of the quadrivalent influenza vaccine is better for protection against hospitalization, summarizes the new WHO COVID guidelines, revisits
AI builds better viruses
TWiV reviews global measles outbreaks, toilet-generated aerosols that spread viruses, highly effective prevention of invasive cervical cancer by HPV vaccination, and design of improved adenovirus-associated viral vectors using machine learning. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, before discussing viral transmission to adults in healthcare setting, the recently EUA approved protein based COBREVAX vaccine, reviews quarantine guidelines, the use of simnotrelivr for mild to moderate COVID-19, how viral RNA may persist in your cell culture dish following antiviral thera
I opened the pig sty and in flew enza
TWiV reviews the latest virology news, how infection with a plant virus causes insect to grow long wings, and reverse zoonoses of 2009 H1N1 pandemic influenza viruses in US swine. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Brianne Barker, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant posi
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US before discussing vaccine effectiveness in children and adolescents, how the pandemic impacted the socioemotional development of infants and toddlers, continues to dispel the myth of viral rebound, how to pay for Paxlovid, reviews quarantine guidelines, when to use steroids and the benefits of convalescent plasma, examines the
Rock of phages
TWiV reveals how viruses participate in the organomineralization of travertines, and how neutralizing antibodies evolve to exploit vulnerable sites in the hepatitis C virus envelope glycoprotein E2 and mediate clearance of infection. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafe
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent measles outbreaks, prequalification of nOPV2 by the WHO and most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US before discussing COVID-19 deaths linked to SNPs in C-reactive protein, spread of recent viral variants, how early vaccination reduced hospitalization of those infected with XBB.1.5, reviewed quarantine guidelines, how oral antivirals reduce hospitalizations, d
EtOH and viruses at McGill
Vincent travels to McGill University in Montreal, Canada to join Angela for a discussion of the careers and the research of two faculty members, Corinne Maurice and Jesse Shapiro, and their PhD trainees Anshul Sinha and Sana Naderi. Hosts: Vincent Racaniello and Angela Mingarelli Guests: Corinne Maurice, Jesse Shapiro, Anshul Sinha and Sana Naderi Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV sto
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin highlights global circulation of Mpox virus, reviews the most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US, and discusses the clinical outcome of hospitalized children under 5 years infected with SARS-CoV-2, the perinatal and neonatal outcomes including adverse effects of SARS-CoV-2 infection and virus transmission in Italy between early 2020 and 2022, the guidelines to improve home
Fit viruses, parasites, sick chickens
For the last episode of 2023, TWiV describes how ancient chicken remains reveal the increase of fitness and virulence of Marek’s disease virus, and the diversity and dissemination of Leishmania virus in the pathogenic protozoan Leishmania braziliensis. Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, Brianne Barker and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the outcomes of SARS-CoV-2, influenza and respiratory syncytial virus infection in pediatric communities under the age of 18 years, the treatment of infants with the human monoclonal anti-respiratory syncytial virus antibody to prevent hospitalizations, most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US, how the SARS-CoV-2/COVID-19 pandemic affected school attendance and chi
Taming the shrew and barring Epstein-Barr virus
TWiV explains a study showing that ost traits shape virome composition and virus transmission in wild bats, rodents, and shrews, and development of a gB nanoparticle vaccine that elicits a protective neutralizing antibody response against Epstein-Barr virus. Hosts: Vincent Racaniello, Dickson Despommier, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the annual economic burden of respiratory syncytial virus in adults in the US, recombinant or standard-dose influenza vaccine in adults under 65 years of age, maternal vaccine effectiveness against influenza-associated hospitalizations and emergency department visits in iInfants, influenza positive tests reported to CDC by US clinical laboratories, update on COVID-19, risk of severe maternal morbidity associated with SARS-CoV-2 infection during
Giant viruses and virophages with Matthias Fischer
Vincent visits the Max Planck Institute for Medical Research in Heidelberg, Germany to speak with Matthias Fischer about his career and his research on giant viruses, virophages, and their plankton hosts. Host: Vincent Racaniello Guest: Matthias Fischer Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA (pdf) C. roenbergensis gia
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses monkeypox and chickenpox co-infection in southern Nigeria, vaccine effectiveness against influenza A, SARS-CoV-2 neutralizing antibody titers in maternal blood, umbilical cord blood, and breast milk, COVID-19 rapid antigen tests with self-collected vs health care worker–collected nasal and throat swab specimens, four methods for monitoring SARS-CoV-2 and Influenza A virus activity in schools, efficacy and safety of Baricitinib for the treatmen
European CDC with Eeva Broberg
From the European Society for Clinical Virology meeting in Milan, Vincent speaks with Eeva Broberg about her career and her work at the European Centre for Disease Prevention and Control. Hosts: Vincent Racaniello and Heli Harvala Guest: Eeva Broberg Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBE
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses developmental impairment in children exposed during pregnancy to maternal SARS-COV2, vagus nerve dysfunction in the post-COVID-19 condition, and humoral immunity to an endemic coronavirus is associated with postacute sequelae of COVID-19 in individuals with rheumatic diseases, incidence and burden of long COVID in Africa. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Developmen
Heads or tails, you win a phage lunch
On this all-bacteriophage episode, TWiV explains the ‘vampire phage’, and and how mammalian cells internalize phage particles and utilize them to enhance cell growth and survival. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Jolene Ramsey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses a microbiologist who was harassed during COVID pandemic sues university, use of inactivated poliovirus vaccine for poliovirus outbreak response, safety and immunogenicity of bivalent rsvpref vaccine coadministered with seasonal inactivated influenza vaccine in older adults, coffee as a dietary strategy to prevent SARS-CoV-2 infection, enrollment of pediatric patients in COVID-19 interventional trials, vaccination, immunity, and the changing im
Cat coronavirus gains function in Cyprus
TWiV reviews ban on gain-of-function research by the House, chronic wasting disease in Tennessee deer, nOPV2 causing paralysis in children, and an outbreak of feline infectious peritonitis in Cyprus caused by a new recombinant coronavirus. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses progress toward measles elimination, risk of severe coronavirus disease 2019 despite vaccination in patients requiring treatment with immune-suppressive drugs, symptoms, viral loads, and rebound among COVID-19 outpatients treated with nirmatrelvir/ritonavir compared to propensity score matched untreated individuals, late administration and corticosteroid usage explain inefficacy in COVID-19 convalescent plasma trial, higher-dose fluvoxamine an
Childhood paralysis with Kevin Messacar
Kevin Messacar visits the Incubator to discuss his career as a pediatric infectious disease physician, and his work on enteroviruses that are associated with acute flaccid myelitis and other diseases. Host: Vincent Racaniello Guest: Kevin Messacar Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/F
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses coverage with selected vaccines and exemption from school vaccine requirements among children in kindergarten, seasonality of endemic COVID-19, mRNA SARS-CoV-2 vaccination before vs during pregnancy and omicron infection among infants, extracting symptoms from free-text responses using ChatGPT among COVID-19 cases in Hong Kong, SARS-CoV-2 virologic rebound with nirmatrelvir–ritonavir therapy, optimization of antiviral therapy in immunocompromi
Seasonal COVID and a niche for cervical cancer
TWiV reveals a prediction of the expected endemic seasonality of COVID-19, based on circulation of human coronaviruses, and ecological clearance of vaccine-targeted human papillomaviruses and an increase in circulation of non-targeted virus types. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Sc
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses CDC expanding testing of international air traveler samples to include flu, RSV, and other respiratory viruses, missed opportunities for preventing congenital syphilis, intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and omicron BA.2 variant in Hong Kong, T-cell immunity against severe acute respiratory syndrome coronavirus 2 measured by an interferon-γ release assay is strongly associated with patient out
Keeping poliovirus out and Ebolavirus in
On this episode of TWiV we discuss unusual properties of monoclonal antibodies: one that that binds the receptor attachment site and blocks infection with all three poliovirus serotypes, and others that inhibit Ebolavirus spread from cell to cell. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Caf
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses health worker–perceived working conditions and symptoms of poor mental health, Mpox neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination, newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy, duration of SARS-CoV-2 culturable virus shedding in children, prescribing outcomes in outpatients treated with nirmatrelvir–ritonavir for COVID-19 in an interdisciplinary community clinic, Nir
CMV-based HIV vaccine with Klaus Früh
Klaus Früh visits the Incubator to discuss his career and his work on cytomegalovirus-vectored vaccines which are unique in their ability to persistently maintain an immune shield of effector memory T cells, including highly unconventional MHC-II and MHC-E restricted CD8+ T cells. Host: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Klaus Früh Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Micro
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses health worker–perceived working conditions and symptoms of poor mental health, Mpox neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination, newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy, duration of SARS-CoV-2 culturable virus shedding in children, prescribing outcomes in outpatients treated with nirmatrelvir–ritonavir for COVID-19 in an interdisciplinary community clinic, Nir
Vermont viridae
Vincent travels to the University of Vermont to speak with Jason, Emily, Jessica, and Dimitry about their careers and their work on SARS-CoV-2, hantaviruses, poliovirus, influenza virus, and the involvement of viruses in the autoimmune disease multiple sclerosis. Host: Vincent Racaniello Guests: Jason Botten, Emily Bruce, Jessica Crothers, and Dimitry Krementsov Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Serve
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses high Influenza incidence and disease severity among children and adolescents aged Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode High Influenza incidence and disease severity among children and adolescents aged Neurologic effects of SARS-CoV-2 transmitted among dogs (EID) Effectiveness of mRNA vaccines against Omicron XBB infection in Singaporean children (JAMA) Effectiveness
Bird flu in Baltimore
From the Centers for Excellence in Influenza Research and Response meeting in Baltimore, Vincent speaks with Ron Fouchier, Rafael Medina, and Louse Moncla about recent changes in the epidemiology of avian H5N1 influenza virus and the threat to humans and other animals. Host: Vincent Racaniello Guests: Ron Fouchier, Rafael Medina, and Louise Moncla Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV sto
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses disease severity of RSV compared with COVID-19 and Influenza among hospitalized adults aged ≥60 years, antiviral efficacy of Molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19, Nirmatrelvir-Ritonavir and COVID-19 mortality and hospitalization among patients with vulnerability to covid-19 complications, antibiotic use among hospitalized patients with COVID-19 in the United States, one week of oral Cam
Like SARS-CoV-2 in the headlights
TWiV reviews the 2023 Nobel Prize in Physiology or Medicine awarded to Katalin Karikó and Drew Weissman for their identification nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19, and accelerated mutation of SARS-CoV-2 in white-tailed deer. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Disc
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the effectiveness of maternal mRNA COVID-19 vaccination during pregnancy against COVID-19–associated hospitalizations in infants aged Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Effectiveness of maternal mRNA COVID-19 vaccination during pregnancy against COVID-19–associated hospitalizations in infants (CDC) COVID-19 vaccination recommendations and practices for women of repr
Long COVID's book of homeostatic cats
TWiV explains how immune profiling was used to identify distinguishing features of Long COVID, and how a co-opted feline endogenous retroviral envelope promotes cell survival by controlling copper transport and homeostasis in cats. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Spike shirts at vaccinated.us (p
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses a molnupiravir-associated mutational signature in global SARS-CoV-2 genomes, inhaled fluticasone furoate for outpatient treatment of COVID-19, optimal duration of systemic corticosteroids in COVID-19 treatment, early antibody treatment, inflammation, and risk of post-COVID conditions, autonomic dysregulation in long-term patients suffering from post-COVID-19 syndrome assessed by heart rate variability, and multiorgan MRI findings after hospita
Long COVID and avian flu in ferrets
TWiV explains a study of postacute sequelae of COVID-19 at 2 years, and respiratory droplet transmission of human-isolated avian H3N8 influenza virus between ferrets. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA (pdf) 4:20 Postacute sequelae of C
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses wastewater surveillance data as a complement to emergency department visit data for tracking the incidence of influenza A and RSV, chatbot-delivered online intervention to promote seasonal Influenza vaccination during the COVID-19 pandemic, temporal assessment of disparities in California COVID-19 mortality by industry, modeling the impact of a high-uptake bivalent booster scenario on the COVID-19 burden and healthcare costs in New York City,
Less Lassa, CRISPR RNA viruses
TWiV reviews a Lassa virus mRNA vaccine that confers protection against disease without inducing neutralizing antibodies, and a CRISPR-based method for engineering the genome of RNA viruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Brianne Barker, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the immunogenicity and reactogenicity of coadministration of COVID-19 and Influenza vaccines, interim effectiveness estimates of 2023 southern hemisphere influenza vaccines in preventing Influenza-associated hospitalizations, genome-wide association study of susceptibility to RSV hospitalization in young children Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Immunogenicity and
Marion Koopmans on COVID-19, Mpox, H5N1, polio and One Health
From the European Society for Clinical Virology meeting in Milan, Vincent speaks with Marion Koopmans about COVID-19, Mpox, H5N1 and polio, and the promise of a One Health approach to prevent outbreaks, epidemics, and pandemics. Host: Vincent Racaniello Guest: Marion Koopmans Click arrow to play Download TWiV 1043 (45 MB .mp3, 62 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepre
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses China’s health authorities fighting surge in cases of Mpox unknown origin, analysis of seasonal variation of antibiotic prescribing for respiratory tract diagnoses in primary care practices, prevalence and associated outcomes of co-infection between SARS-CoV-2 and influenza, comparison of bivalent and monovalent mRNA vaccine boosters, optimal duration of systemic corticosteroids in COVID-19 treatment, acute blood biomarker profiles predict cog
Novel oral polio vaccine? with Raul Andino and Kostya Chumakov
Vincent speaks with Raul and Kostya about the development of novel oral polio vaccine from the Sabin type 2 strain, its deployment in over 600 million children, and whether it can lead to eradication of poliomyelitis. Host: Vincent Racaniello Guests: Raul Andino and Kostya Chumakov Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/F
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the public health significance of finding autochthonous melioidosis cases in the continental United States, human neural larva migrans caused by Ophidascaris robertsi ascarid, Project nextgen awards over $1.4 billion to develop the future of COVID-19 vaccines and therapeutics, excess all-cause mortality in China after ending the zero COVID policy, international pediatric COVID-19 severity over the course of the pandemic, differences in SARS-Co
Landmines for phages, a mouthful of redondoviruses
TWiV describes how a viral capsid protein activates a bacterial innate immune system that interferes with protein synthesis, and human-associated redondoviruses that infect the commensal protozoan Entamoeba gingivalis. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Jolene Ramsey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant po
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses modeling poliovirus transmission and responses in New York State, FDA approves first vaccine for pregnant individuals to prevent RSV in infants, prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices, Nirmatrelvir resistance – de novo E166V/L50V mutations in an immunocompromised patient treated with prolonged nirmatrelvir/ritonavir monotherapy leading to clinical and viro
Antibodies, the good (CoV), the bad (Ad), the beautiful
TWiV reviews evidence that symptomatic adenovirus infection leads to thrombocytopenia, thrombosis, and production of anti-platelet factor 4 antibodies similar to the rare disorder seen after immunization with adenoviral vectored COVID-19 vaccines, and a monoclonal antibody isolated from a SARS survivor, following vaccination with a SARS-CoV-2 spike mRNA vaccine, that neutralizes a broad collection of ACE2-binding sarbecoviruses. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy S
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses Florida local transmission of dengue cases reported in Broward and Miami-Dade counties, infants admitted to US intensive care units for RSV infection during the 2022 seasonal peak, long-term risk of death and readmission after hospital admission with COVID-19 among older adults, safety profile and clinical and virological outcomes of Nirmatrelvir-Ritonavir treatment in patients with advanced chronic kidney disease and COVID-19, Fluvoxamine vs
Poxvirus wars, warp speed COVID-19 vaccine rollout
TWiV dissects a study of COVID-19 vaccination which shows that the timing of initial rollout affects disease outcomes more substantially than final coverage or degree of socioeconomic disparity, and discovery of a novel cellular defense comprising a nuclease that is activated by poxvirus infection and cleaves a specific tRNA molecule to inhibit protein synthesis. Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email B
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the immunogenicity, safety, and preliminary efficacy evaluation of OVX836, a nucleoprotein-based universal influenza A vaccine candidate, association between nose picking and SARS-CoV-2 incidence, a cohort study in hospital health care workers; effect of COVID-19 vaccination and booster on maternal-fetal outcomes, dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA, does monoclonal antibody treatment
Toppling the anti-vaxxer pyramid with "flu-shot cheerleader" Desiree Townsend
Vincent speaks with Desirée Townsend about how she felt used and indoctrinated by the anti-vaxx movement, the science surrounding her autoimmune disorder, and why she is no longer the “flu shot cheerleader,” but a cheerleader for flu shots. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Desiree on Instagram and LinkedIn ‘Flu-shot cheerleader’ speaks out (NBC) ‘Flu-shot cheerleader’ back with a warning (NBC) Timestamps by Jolene. Th
Freediving with nanobodies and interferon
TWiV notes the passing of Harald zur Hausen, dengue breaking records in the Americas, inhibition of SARS-CoV-2 infection and inflammation by modulation of type I IFN, and an armed nanobody that protects mice against influenza A and B disease. Hosts: Vincent Racaniello, Kathy Spindler, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Position in Rosenfeld Labo
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses predicting COVID-19 incidence using wastewater surveillance data, use of wastewater metrics to track COVID-19 in the US, wastewater-based epidemiology predicts COVID-19-induced weekly new hospital admissions in over 150 USA counties, association between duration of SARS-CoV-2 positivity and long COVID, rapid direct detection of SARS-CoV-2 aerosols in exhaled breath at the point of care, effectiveness of oral Nirmatrelvir/Ritonavir vs. intraven
Death on the West Nile
TWiV notes the passing of virologist Michael BA Oldstone, a study to assess the performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 infection, and the presence of antibodies to type I interferons in ~40% of patients with West Nile virus encephalitis. Hosts: Vincent Racaniello, Rich Condit, and Alan Dove Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepr
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the use of RSV vaccines in older adults: recommendations of the advisory committee on immunization practices, case report of leprosy in Central Florida, blood group A enhances SARS-CoV-2 infection, predicting COVID-19 incidence using wastewater surveillance data, a common allele of HLA associated with asymptomatic SARS-CoV-2 infection, prevalence of low-frequency, antiviral resistance variants in SARS-CoV-2 isolates in Ontario, Canada, viral r
David Tuller on Long COVID and ME/CFS
David Tuller returns to TWiV to provide an update on ME/CFS, the PACE trial, developments related to the NICE guidelines, and how similar practices and ideologies are being applied to long COVID. Host: Vincent Racaniello Guest: David Tuller Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server David Tuller at virology blog CFS, a long tangled tale (virology blog) Request for Correction of Prevalence Rates Cited i
Asymptomatic SARS-CoV-2 infection and T cells
TWiV reviews approvals of the first gene therapy for severe hemophilia A in adults and a monoclonal antibody to prevent RSV respiratory disease in babies and toddlers, and a common allele of HLA that mediates asymptomatic SARS-CoV-2 infection through pre-existing T cell immunity due to previous exposure to common cold coronaviruses. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States, Omicron subvariant BA.5 efficiently infects lung cells, COVID-19 scent dog research highlights and synthesis during the pandemic of December 2019, T-Cell Immunity against SARS-CoV-2 measured by an interferon-γ release assay is strongly associated with patient outcomes in vaccinated persons hospitalized with Delta or Omicron variants, a common allele of HLA i
Debunking RFK Jr.’s vaccine funk with Dan Wilson
Dan Wilson returns to TWiV to debunk vaccine misinformation by RFK Jr. during his recent appearance on the Joe Rogan Experience. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Dan Wilson Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Joe Rogan’s worst misinformation yet, with RFK Jr. (YouTube) Every first vaccine has been tested in placebo-controlled tr
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the new risk assessment for the H5N1 avian flu viruses, the development of monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 exposure in animals, repeated antibiotic exposure and risk of hospitalization and death following COVID-19 infection, COVID-19 rebound study: a prospective cohort study to evaluate viral and symptom rebound differences in participants treated with Nirmatrelvir plus Ritonavir versus untreated controls, exa
The Chumakoviridae
Vincent speaks with Kostya Chumakov about his career: raised by two virology parents in Moscow, trained in virology by Vadim Agol, then moving to the US FDA where he developed a molecular test for measuring production consistency of oral poliovirus vaccine. Host: Vincent Racaniello Guest: Kostya Chumakov Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Mikhail Chumakov (Wikipedia) MAPREC (WHO pdf) Kostya Chum
Covering science with Katherine Wu
Katherine joins TWiV to discuss her career in science writing, from not liking science at all, to a PhD in microbiology and immunology, and writing for Nova, the NY Times, and The Atlantic, and how the COVID-19 pandemic has impacted her craft. Host: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guest: Katherine Wu Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server All Katherine’s articles at The Atlant
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses autochthonous leprosy in the United States, a systematic review to identify novel clinical characteristics of Mpox virus infection and therapeutic and preventive strategies to combat the virus, two-year duration of immunity of inactivated poliovirus vaccine, evaluation of novel oral polio vaccine type 2 SIA impact in a large outbreak of circulating vaccine-derived poliovirus in Nigeria, performance of rapid antigen tests to detect symptomatic
Nextstrain with Trevor Bedford
From ASV 2023 in Athens, Georgia, Vincent, Kathy and Brianne speak with Trevord Bedford about his career, the development of Nextstrain.org for real-time tracking of pathogen evolution, and evolution of SARS-CoV-2 from January 2020 through Omicron. Host: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guest: Trevor Bedford Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Nextstrain Household influenza
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses guidance on measles during the summer travel season, the Infectious Diseases Society of America guidelines on the diagnosis of COVID-19: antigen testing, SARS-CoV-2 variants and age-dependent infection rates among household and nonhousehold contacts, effect of COVID-19 vaccination on household transmission of SARS-COV-2 in the Omicron era, incidence of myopericarditis after mRNA COVID-19 vaccination, intrinsic and effective severity of COVID-1
Eddie Holmes on SARS-CoV-2 origins
From ASM Microbe in Houston, Texas, Vincent speaks with Eddie Holmes about the evidence that SARS-CoV-2 spilled over into humans in the Huanan Market in Wuhan, absence of evidence for other origins, and his work on the virosphere. Host: Vincent Racaniello Guest: Eddie Holmes Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Huanan Seafood Market early COVID-19 epicenter (Science) SARSr-CoV-2 in Malayan Pangoli
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the CDC vaccine advisory group recommending the newly approved RSV vaccines, association of culturable-virus detection and household transmission of SARS-CoV-2, prevention of COVID-19 following a single intramuscular administration of Adintrevimab, real-world effectiveness of Nirmatrelvir/Ritonavir on COVID-19, and COVID-19 convalescent plasma outpatient therapy to prevent outpatient hospitalization. Subscribe (free): Apple Podcasts, Google Po
From Nature, not a lab
Vincent travels to the University of Pennsylvania to meet up with Susan, Rick, Gigi and David to discuss the origin of SARS-CoV-2, how the FBI might have reached its conclusion on the matter, and public and political perception of scientific risk. Host: Vincent Racaniello Guests: Susan Weiss, Rick Bushman, Gigi Gronvall, and David Joanson Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Huanan Seafood Market
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses surveillance to track progress toward poliomyelitis eradication, genetic stabilization of attenuated oral vaccines against poliovirus types 1 and 3, evaluation of Oseltamivir used to prevent hospitalization in outpatients with Influenza, viral emissions into the air and environment after SARS-CoV-2 human challenge, has COVID-19 threatened routine childhood vaccination, successful treatment of persistent symptomatic COVID-19 infection with exte
Soldiers & Scientists at USAMRIID
Vincent and Rich travel to Ft. Detrick to visit USAMRIID and speak with Todd, Crystal, John and Jay about their careers, their research, and the mission of the US Army Medical Institute of Infectious Diseases. Host: Vincent Racaniello and Rich Condit Guests: Todd Bell, Crystal Burke, John Dye, and Jay Hooper Opinions, interpretations, conclusions, and recommendations are those of the panelists and no official endorsement by the U.S. Army should be inferred. Subscribe (free): Apple Podcasts, Go
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses estimates of SARS-CoV-2 seroprevalence and incidence of primary SARS-CoV-2 infections among blood donors, by COVID-19 vaccination status, smart thermometer–based participatory surveillance to discern the role of children in household viral transmission during the COVID-19 pandemic, COVID-19 vaccine mandates, changing severity and epidemiology of adults hospitalized with COVID-19 in the United States after introduction of COVID-19 vaccines, eff
Bird flu around the world
TWiV reviews remarkable changes in the epidemiology of avian H5N1 influenza virus leading to previously uninfected areas, involvement of previously unaffected wild birds, and devastating outbreaks in farmed poultry, and isolation of a monoclonal antibody against the influenza virus neuraminidase that inhibits infection with a wide range of A and B isolates. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts,
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the potential for recurrent Mpox outbreaks among gay, bisexual, and other men who have sex with men, association between SARS-CoV-2 variants and frequency of acute symptoms, prospective study of key correlates for household transmission of SARS-CoV-2, Pfizer’s PAXLOVID™ receiving FDA approval for adult patients at high risk of progression to severe COVID-19, efficacy and safety of antimicrobial stewardship prospective audit and feedback in pat
Aquatic viruses
Vincent travels to Québec City, Canada and the 11th Aquatic Virus Workshop, where he speaks with Fred Aylward and Jed Furman about the research of their laboratories on the ecology and evolution of aquatic viruses and their microbial communities. Host: Vincent Racaniello Guests: Fred Aylward and Jud Fuhrman Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server 11th Aquatic Virus Workshop Endogenization of giant vi
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the CDC HIV surveillance report, FDA voted in favor of approving the Abrysvo vaccine, canine olfactory detection of SARS-CoV-2-infected humans, safety of the BNT162b2 COVID-19 vaccine in children aged 5 to 17 years, and statement on the antigen composition of COVID-19 vaccines. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode HIV surveillance report (CDC) FDA voted in favor of appr
Nidovirus on the water
Vincent travels to Montreux, Switzerland and the 16th International Nidovirus Symposium, where he speaks with Maria von Kerkhove, the face of COVID-19 for the World Health Organization, and Kanta Subbarao, Director of the WHO Collaborating Centre on Influenza in Melbourne. Host: Vincent Racaniello Guests: Kanta Subbarao and Maria von Kerkhove Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Nidovirus Symposiu
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses variant specific clinical performance of a SARS-CoV-2 rapid antigen test with focus on omicron VOC, ventilation in buildings, COVID-19 mortality among selective serotonin reuptake inhibitor users, risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses, trajectories of the evolution of post COVID-19 condition, and efficacy of cognitive behavioral therapy targeting severe fat
Fragile DNA, viruses, cancer
TWiV explains genetic changes in nOPV2 strains that paralyzed children, outbreak of raccoon distemper in Toronto, EcoHealth Alliance gets its NIH grant back, and breakage at chromosomal fragile sites caused by the EBNA1 protein of Epstein-Barr virus as a mechanism for carcinogenesis. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Register for ASV 2023 Res
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses immunogenicity and tolerability of a bivalent virus-like particle norovirus vaccine candidate in children from 6 months up to 4 years of age, influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults, COVID-19 surveillance after expiration of the public health emergency declaration, provisional mortality data, targeted vaccine messaging to promote COVID-19 vaccines for children and youth,
COVID T vax and a virus from the blue
TWiV reveals plankton-infecting relatives of herpesviruses in the sunlit oceans, and a vaccine encoding non-spike T cell antigens that protects animals from severe SARS-CoV-2 infection. Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Register for ASV 2023 Research assistant position at FDA (pdf) MicrobeTV Discord Server Mirusviruses link herpesvirus to giant vi
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the U.S. Food and Drug Administration approving Arexvy: the first respiratory syncytial virus (RSV) vaccine approved for use in the United State, association between SARS-CoV-2 and metagenomic content of samples from the Huanan Seafood Market, researchers disagree over how bad it is to be reinfected and whether COVID-19 can cause lasting changes to the immune system, virtual care and emergency department use during the COVID-19 pandemic among
Going clinically viral
Vincent and Kathy travel to Atlanta for APHL ID Lab Con, a conference focused on the latest developments in detection and characterization of infectious diseases of public health concern, and speak with Megan, Ryan, and Kirsten about the workings of public health and clinical laboratories. Hosts: Vincent Racaniello and Kathy Spindler Guests: Megan Crumpler, Ryan Relich, and Kirsten St. George Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses completeness and spin of medRxiv preprints and associated published abstracts of COVID-19 randomized clinical trials, lessons learned from a COVID-19 dog screening pilot in California K-12 schools, SARS-CoV-2 reinfection and severity of the disease, effectiveness of COVID-19 bivalent vaccine, Molnupiravir and risk of post-acute sequelae of COVID-19, risk of new-onset long Covid following reinfection with SARS-CoV-2, low vitamin D levels associ
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses an update on vaccine-derived poliovirus outbreaks, how the dream of wiping out polio might need a rethink, risk of death in patients hospitalized for COVID-19 vs seasonal Influenza in fall-winter, French Mpox cluster includes fully vaccinated patients, two individuals with potential Mpox virus reinfection, epidemiologic and clinical features of Mpox-associated deaths, FDA authorizes changes to simplify use of bivalent mRNA COVID-19 vaccines, S
Live from New York, 1k epitopes of virology
The entire TWiV team gathers at a theatre in New York City to celebrate a milestone in science podcasting, to reminisce how they joined the show, and to play a game of TWiV Jeopardy. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, Brianne Barker, Daniel Griffin, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode TWiV #1: West Nile virus TWiV #100: TWiV catches a big fish TWi
Vaccinated to the nines
TWiV notes Ashish Jha’s call for doctors to combat a vacuum of medical information while ignoring our contributions, China CDC’s surveillance of SARS-CoV-2 at the Huanan Seafood Market, and an experimental infectious attenuated COVID-19 vaccine that elicits superior mucosal and systemic immunity in hamsters. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links fo
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the White House COVID adviser calling on doctors to combat a vacuum of medical information, adeno-associated virus type 2 in US children with acute severe hepatitis, genomic investigations of unexplained acute hepatitis in children, surveillance of SARS-CoV-2 at the Huanan seafood market, vaccine effectiveness against hospitalization among adolescent and pediatric SARS-CoV-2 cases between May 2021 and January 2022 in Canada, effectiveness of B
Inside Omicron with Mohsan Saeed
Mohsan joins TWiV to discuss the work of his laboratory showing that spike and nsp6 are determinants of Omicron attenuation, and why the work was widely misinterpreted by the press and the public. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Guest: Mohsan Saeed Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server • Spike and nsp6 determinants of Omicron attenuation (Nature) •China
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses how antibiotics don’t reduce risk of death from viral respiratory infections, norovirus infections continue to rise in the US, ABO blood types and SARS-CoV-2 infection assessed using seroprevalence data in a large population-based sample, maternal third dose of BNT162b2 mRNA vaccine and risk of infant COVID-19 hospitalization, association of treatment with Nirmatrelvir and the risk of Post–COVID-19 condition, mechanically ventilated patients w
Viral origin stories
TWiV discusses genetic evidence of susceptible wildlife in SARS-CoV-2 positive samples at the Huanan Wholesale Seafood Market, polio cases in African linked to a new polio vaccine that was designed to not cause the disease, and structural conservation of hepatitis B virus capsid proteins over millions of years despite a shift from a naked to an enveloped capsid. Click arrow to play Download TWiV 995 (74 MB .mp3, 123 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patr
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the detection of circulating vaccine-derived poliovirus type 2 in Burundi and the Democratic Republic of the Congo, the novel oral polio vaccine type 2 story, prior COVID-19 infection associated with increased risk of newly diagnosed erectile dysfunction, adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection, correlates of protection against COVID-19 infection and intensity of symptomatic disease in vacci
COVID-19 drives autoimmunity
TWiV reveals how treatment with remdesivir for COVID-19 resolved a chronic poliovirus infection in an immunocompromised patient, and the finding that infection with SARS-CoV-2 leads to an increase in new and preexisting autoantibodies. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server •Janet Sinsheimer on TWiV 653 •Clearance of chronic poliovirus infection by remdesivir (Front Immunol)
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses clearance of longstanding, immune-deficiency-associated, vaccine-derived poliovirus infection following remdesivir therapy for chronic SARS-CoV-2 infection, SARS-CoV-2 exposure in New York City rats, clinical characteristics and outcomes of children with SARS-CoV-2 infection during the Delta and Omicron variant-dominant periods in Korea, exhaled breath aerosol shedding of SARS-CoV-2 variants, outpatient treatment of COVID-19 and the developmen
The cancer mRNA shot
On this episode of TWiV, the observation that the 1918 influenza virus is not lethal in nonhuman primates and implications for studies on viral virulence, and mRNA vaccines that control and resolve human papillomavirus-associated cancers in mice. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server •1918 influenza virus not lethal in nonhuman primates (J Virol) •mRNA vaccines control HPV-as
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses confronting the evolution and expansion of anti-vaccine activism in the USA in the COVID-19 era, the effectiveness of maternal Influenza vaccination in Peru, characteristics and predictors of persistent symptoms post-COVID-19 in children and young people, parental nonadherence to health policy recommendations for prevention of COVID-19 transmission among children, community-onset bacterial coinfection in children critically ill with SARS-CoV-2
Antibody cross-reactivity is metal
TWiV to explains a study on presence of COVID-19 vaccine mRNA in the blood, and the isolation of cross-protective monoclonal antibodies against common endemic respiratory viruses. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server •Paul Berg obituary •Spike mRNA in blood (J Path Micro Imm) •Spike mRNA in blood (Biomedicine) •Cross-protective mAbs against respiratory viruses (Nat Comm) •RS
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses FDA authorizing the first over-the-counter at-home test to detect both influenza and COVID-19, monoclonal antibody for the prevention of respiratory syncytial virus infection in infants and children, epidemiologic characteristics of SARS-CoV-2 recombinant variant XBB.1.5, COVID-19 vaccines vs pediatric hospitalization, maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life, immunoglobulin,
Convalescing with Casadevall
Arturo Casadevall returns to TWiV to explain the use of convalescent serum to treat COVID-19 patients, and the need to support virology at a time when more regulation of experiments is envisioned. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Guest: Arturo Casadevall Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Register for ASV 2023 MicrobeTV Discord Server Early treatment of COVID-19 with convalescent plasma (NEJM) Neut
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the efficacy and safety of two RSV vaccines in older adults, health care vaccine mandate remains as some push for an end, past SARS-CoV-2 infection protection against re-infection, a third vaccine dose equalizes the levels of effectiveness and immunogenicity of heterologous or homologous COVID-19 vaccine regimens, Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ.1.1 in a non-human primate model, effect of higher-dose Ivermectin
Bambi's revenge
TWiV reviews an outbreak of Marburg hemorrhagic fever in Equatorial Guinea, wild poliovirus type 3 shedding from a laboratory in the Netherlands, and white-tailed deer as a reservoir for previous SARS-CoV-2 variants of concern. Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server •Marburg virus disease outbreak in Equatorial Gui
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi’s cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants, yes masks red
One flu vaccine for them all with Scott Hensley
Scott returns to TWiV to explain the development of an experimental mRNA vaccine that encodes hemagglutinin antigens against all known influenza A virus subtypes and influenza B virus lineages, and why he is worried about avian H5N1 influenza virus. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Guest: Scott Hensley Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Research assistant position at FDA (pdf) •Register
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the consistency of COVID-19 trial preprints with published reports and impact for decision making, the negative effect of preexisting immunity on Influenza vaccine responses transcends the impact of vaccine formulation type and vaccination history, highly pathogenic avian influenza A(H5N1) virus infection in farmed minks in Spain, Peru confirms H5N1 avian flu in marine mammals, prior vaccination enhances immune responses during SARS-CoV-2 break
Tastes like chikungunya
TWiV explains the recent meeting of the National Science Advisory Board for Biosecurity (NSABB) where stricter guidelines for research involving human, animal, and plant pathogens were considered, and how the consumption of viruses by small protists returns energy to food chains. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Research assistant
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses prevalence and clinical outcomes of respiratory syncytial virus versus influenza virus in adults hospitalized with acute respiratory Illness, reconsideration of antinucleocapsid IgG antibody as a marker of SARS-CoV-2 infection postvaccination for mild COVID-19 patients, assessment of COVID-19 as the underlying cause of death among children and young people aged 0 to 19 years in the US, information for persons who are immunocompromised regarding
One COVID vaccine for them all with Paul Offit
Paul Offit returns to TWiV to unpack the recent FDA Advisory Panel on COVID vaccines, with discussions on giving everyone the same bivalent vaccine, simplifying the immunization schedule, and how to know when the vaccine should be updated. Hosts: Vincent Racaniello and Rich Condit Guest: Paul Offit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA briefing document (pdf) Effectiveness of bivalent booster against severe infection (N
Flushing out the viroids
TWiV gives an update on poliovirus in wastewater, and reveals a vast world of viroids that infect a wide range of host species in diverse ecosystems. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Research assistant position at FDA (pdf) •Register for ASV 2023 •MicrobeTV Discord Server •Nick Muzyczka passes •CDC planning wastewater testing for polio (CDC) •Wastew
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses co-detections of other respiratory viruses among children hospitalized with COVID-19, preprint review should form part of PhD programs and postdoc training, early and increased Influenza activity among children, COVID-19 vaccines versus pediatric hospitalization, SARS-CoV-2 variant-related abnormalities detected by prenatal MRI, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the Omicron variant and severe
Ageing is infectious
TWiV covers a study of SARS-CoV-2 persistence at multiple sites in the human body, and the role of endogenous retroviruses in ageing and senescence. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Brianne Barker, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Research assistant position at FDA (pdf) •Register for ASV 2023 •MicrobeTV Discord Server •Persistence of SARS-CoV-2 (Nature) •Endogenous retro
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses China reporting almost 60,000 Covid-related deaths after abrupt shift in policy, detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination, effect of Fluvoxamine vs placebo on time to sustained recovery in outpatients with mild to moderate COVID-19, hyperimmune globulin for severely immunocompromised patients hospitalized with COVID-19, long COVID outcomes at one year after mil
Crossing the Ts with Daniela Weiskopf
Daniela joins TWiV to discuss her career and her research on T cells, their role in infection with SARS-CoV-2, T cell epitopes and why a variant that evades T cell immunity is not likely to emerge. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Guest: Daniela Weiskopf Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Research assistant position at FDA (pdf) •Register for ASV 2023 •Cross reactive T cells to SARS-CoV-2 (Scienc
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses poliovirus returns to New York wastewater, COVID-19 is more widespread in animals than we thought, increasing ventilation reduces SARS-CoV-2 airborne transmission in schools, the use of carbon dioxide monitoring to assess ventilation at a national infectious diseases conference, effectiveness of the bivalent mRNA vaccine in preventing severe COVID-19 outcomes, 7-month duration of SARS-CoV-2 mucosal immunoglobulin-A responses and protection, and
Crouching virus, hidden triggers with Felicia Goodrum
Felicia joins TWiV to discuss her career and her research on human cytomegalovirus, which infects most of us for our entire lives yet mainly causes disease in the immunosuppressed. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Guest: Felicia Goodrum Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Research assistant position at FDA (pdf) •The loss of binary (Curr Clin Micro Rep) •Virology in Peril (mBio) •Letters read on T
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave, virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants, antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants, comparative effectiveness of third doses of mRNA-based COVID-19 vaccines in US veterans, time to negative PCR conversion among high-risk patients with mild-to-mode
Another year is viral
In the first epitope of 2023, TWiV reviews our coverage of virology in 2022, including favorite story arcs, episodes, show titles, and much more. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Our favorite 2022 virology stories: •Vincent: Paul Offit on bivalent boosters (TWiV 917, 942, Special) •Dickson: Interviews with Paul Offit and Andy
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses modelling the adjustment of COVID-19 response and exit from dynamic zero-COVID in China, canine real-time detection of SARS-CoV-2 infections in the context of a mass screening event, two masks can be worse than one: N95 respirator failure caused by an overlying face mask, airflow patterns in double-occupancy patient rooms may contribute to roommate-to-roommate transmission of severe SARS-CoV-2, clinical validation of a novel T-Cell receptor seq
Carl Zimmer on COVID-19
Carl Zimmer visits the Incubator to record a wide-ranging conversation about COVID-19, including origins, vaccines, public health responses, and impact on society. Host: Vincent Racaniello Guest: Carl Zimmer Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
A spillover waiting in the wings
TWiV reviews eukaryotic viruses recovered from ancient permafrost, a mistake made by scientists on Omicron origins, and close relatives of MERS-CoV from bats that bind ACE2 for entry into cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV Positions with the Mosq
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses how immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection, prevalence of SARS-CoV-2 and influenza coinfection and clinical characteristics among children and adolescents aged Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Immunological dysfunction persists for 8 months following SARS-CoV-2 infection (Nature) Prevalence of SARS-CoV
1918 influenza with Jeffery Taubenberger
Vincent travels to the NIH campus to speak with Jeffery Taubenberger about his career, the 1918 influenza pandemic, deciphering the genome sequence of the virus from tissues of disease victims and using it to rescue infectious virus. Host: Vincent Racaniello Guest: Jeffery Taubenberger Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV Influenza 1918 pandem
Asking Esper Kallas for some I.D.
Brazilian infectious diseases physician Esper Kallas returns to TWiV to discuss the state of viral diseases in his country, including those cause by Zika, dengue, and yellow fever viruses, MPOX, and SARS-CoV-2. Hosts: Vincent Racaniello and Alan Dove Guest: Esper Kallas Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV International Scientific Coordinator
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses Dr. Griffin discusses progress toward poliomyelitis eradication in Afghanistan, reduced risk for Mpox after receipt of 1 or 2 doses of JYNNEOS vaccine compared with risk among unvaccinated persons, reduced airborne transmission of SARS-CoV-2 BA.1 Omicron virus in Syrian hamsters, authorized updated (Bivalent) COVID-19 vaccines for children down to 6 months of age, low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by parental
Feline coronavirus with Gary Whittaker
Vincent travels to Cornell University to speak with Gary Whittaker about regulation by proteolytic processing of the fusion activity of the spike protein of SARS-CoV-2, and feline coronavirus transmission, replication and disease. Hosts: Vincent Racaniello Guest: Gary Whittaker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 spike and its furin cleavage site (Lancet Microbe) TMPRSS2 inhibitor blocks SARS-CoV-2 reproduction
TWiV Special: Bivalent boosters with Paul Offit
Paul Offit returns to TWiV to discuss why the bivalent booster dosing story should be a cautionary tale of how not to move forward in this pandemic. Hosts: Vincent Racaniello and Rich Condit Guest: Paul Offit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Antibody responses to bivalent booster (bioRxiv) Immunogenicity of bivalent vaccine (bioRxiv) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology q
Chiara Mingarelli takes the pulse of the universe
Astrophysicist Chiara Mingarelli joins TWiV to discuss her career and her work using pulse timing arrays to study the gravitational wave background, ripples in the fabric of spacetime that are caused by events such as the merging of black holes. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Angela Mingarelli Guest: Chirara Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses Mpox (formerly monkeypox) in women: epidemiological features and clinical characteristics of mpox cases in Spain, April to November 2022, triage of patients with Ebola virus disease, SARS-CoV-2 serology and self-reported infection among adults, serological markers of SARS-CoV-2 infection; anti-nucleocapsid antibody positivity may not be the ideal marker of natural infection in vaccinated individuals, sensitivity of anti-SARS-CoV-2 nucleocapsid
Getting funky with Dan Wilson
Dan Wilson of Debunk the Funk joins TWiV to explain why he decided to take on science misinformation and how he critiques people who promulgate incorrect information. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guest: Dan Wilson Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV International Scientific Coordinator Positio
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses effectiveness of influenza vaccination of pregnant women for prevention of maternal and early infant Influenza-associated hospitalizations in South Africa, a multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes, single and 2-dose vaccinations with modified vaccinia Ankara-Bavarian Nordic induce durable B cell memory responses comparable to replicating smallpox vaccines, whether the risk of still and preterm bi
Pass the RNA and have some venison pi
The TWiV team reveals a variant SARS-CoV-2 that emerged in deer with deer-to-human transmission, and hybrid virus particles produced by co-infection with influenza virus and respiratory syncytial virus particles. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV T
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses human monkeypox virus infection in women and non-binary individuals during the 2022 outbreaks, changes in population immunity against infection and severe disease from SARS-CoV-2 Omicron variants in the United States, updates on COVID-19–related mortality, impact of community masking on COVID-19, effectiveness of the COVID-19 vaccines against hospitalization with Omicron sub-lineages BA.4 and BA.5 in England, cardiovascular outcomes after Tixag
A domesticated viral envelope with Cedric Feschotte and John Anthony Frank
Cedric and John join TWiV to discuss their research showing that a human protein derived from an ancient retrovirus infection can protect against infection by other retroviruses. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guest: Cedric Feschotte and John Anthony Frank Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV Cedric on TWiV 935 Anti
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the four things to know about RSV, the burden of respiratory syncytial virus in healthy term-born infants in Europe, the diagnostic accuracy of rapid diagnostic tests for Ebola virus disease, evaluating the accuracy of self-collected swabs for the diagnosis of monkeypox, tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations, acute and postacute sequelae associated with SARS-CoV-2 reinfection, clinical cours
Speculating sarbecovirus spillovers with Michael Letko
Michael Letko joins TWiV to discuss his research on understanding cell receptors required for sarbecovirus entry, including an ACE2-dependent isolate from Russian bats that is resistant to vaccine-induced antibodies. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Michael Letko Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us)
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses high demand for Amoxicillin causing shortages amid child RSV surge, epidemiologic and clinical features of children and adolescents aged Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode High demand for Amoxicillin causing shortages amid RSV surge (Washington Post) Epidemiologic and clinical features of children & adolescents with monkeypox (CDC) Low risk of SARS-Cov2 transmission b
Jake Scott put the ID in COVID-19
Infectious Disease physician Jake Scott joins TWiV to provide a west coast clinical perspective on the evolution of the COVID-19 pandemic with respect to the impact of vaccines, antivirals, variants of concern and mortality. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Jake Scott Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code Micr
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses Influenza incidence and vaccine effectiveness during the southern hemisphere influenza season in Chile, Nirsevimab for prevention of RSV infection in healthy late-preterm and term infants, severe Monkeypox in hospitalized patients, reinfections with different SARS-CoV-2 Omicron subvariants, impact of community masking on COVID-19 in Bangladesh, unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses, ant
Prion diseases with Richard Knight
From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Richard Knight about prion diseases and the outbreak of bovine spongiform encephalitis that led to cases of variant Creutzfeldt-Jakob disease in humans. Host: Vincent Racaniello Guest: Richard Knight Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode National CJD Research and Surveillance Unit Clinical diagnosis of human prion disease
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses progress toward poliomyelitis eradication in Pakistan, polio by the numbers , influenza and COVID-19 vaccination coverage among health care personnel, phase 1/2a safety and immunogenicity of an adenovirus 26 vector RSV vaccine encoding prefusion F in adults 18–50 years and RSV seropositive children 12–24 months, receipt of first and second doses of JYNNEOS vaccine for prevention of Monkeypox, distinguishing SARS-CoV-2 persistence and reinfecti
Breathless with David Quammen
David Quammen returns to TWiV to discuss how he wrote his new book ‘Breathless’, a story about the science and the scientists behind the race to understand the pandemic coronavirus SARS-CoV-2. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: David Quammen Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Boston Quammens (TWiV 408) Breathless by David Quammen Spillover by David Quammen Song of the Dodo
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the prediction of upcoming global infection burden of influenza seasons after relaxation of public health and social measures during the COVID-19 pandemic, severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters, and how successful immunomodulators for treatment of COVID-19 have opened the pathway for comparative trials. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links
Poo versus flu
Angela Mingarelli joins TWiV to discuss whether the gut microbiota of bats confers tolerance to influenza virus infection in mice, and primate hemorrhagic fever-causing arteriviruses that can reproduce in human cells and might be capable of infecting humans. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assis
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses a healthcare-associated infection with Monkeypox virus, air and surface sampling for monkeypox virus in a UK hospital, misrepresentation and nonadherence regarding COVID19 public health measures, tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine, clinical, virologic, and immunologic evaluation of symptomatic rebound following Nirmatrelvir/Ritonavir treatment, early outpatient treatment with Eem
Hacking through Borneo with Kathryn Hanley
Kathryn Hanley joins TWiV to discuss her career and the research in her laboratory on the molecular biology, evolution and ecology of emerging RNA viruses and their insect vectors. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guest: Kathryn Hanley Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position at FDA (pdf) Support MicrobeTV with a Spike t-shirt (Vaccinated.us) One bite is all it takes (TWiV
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses high points of the multi-national monkeypox outbreaks, monkeypox virus genome mutations, possible occupational infection of healthcare workers with monkeypox virus, rates of monkeypox cases by vaccination status, protection of SARS-CoV-2 infection against reinfection, Paxlovid significantly reduces COVID-19 hospitalizations and deaths, and rebound in COVID19 with and without Paxlovid treatment. Subscribe (free): Apple Podcasts, Google Podcasts,
Public Health with Laurie Garrett: Wastewater Testing
Laurie Garrett discusses the role of wastewater testing in public health and her idea of a device that could be used by anyone to analyze water samples. This podcast is not an episode of TWiV, but I thought it would be of interest to listeners. Laurie Garrett and Vincent Racaniello Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) Coliform testing of water in Florida (YouTube) Decl
Omicron boosters with Paul Offit
Paul Offit returns to TWiV for a discussion of SARS-CoV-2 bivalent boosters containing ancestral and Omicron spike mRNAs, including their composition, why they are being recommended by CDC, and who would benefit the most from them. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Paul Offit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position at FDA (pdf) Su
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses increased acute respiratory illnesses among children and adolescents, estimates of monkeypox incubation period, generation time, and reproduction number, rapid increase in suspected SARS-CoV-2 reinfections, interim infection prevention and control recommendations for healthcare personnel during COVID-19, SARS-CoV-2 secondary attack rates in vaccinated and unvaccinated household contacts during replacement of delta with omicron variant, breakthr
Eddie Holmes in on viral origins
Eddie Holmes joins TWiV to discuss his role in the first release of the SARS-CoV-2 genome sequence, what really happened during the infamous Fauci teleconference, and evidence that the virus came from Nature and not from a lab. Hosts: Vincent Racaniello and Dickson Despommier Guest: Eddie Holmes Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position at FDA (pdf) Support MicrobeTV with a Spike t-shirt (Vaccinated
From lizards to Lassa with Tom Monath
Tom Monath joins TWiV to discuss his wide-ranging career that includes medicine, field work and vaccine development while working for the US government, the US military, and multiple biotechnology companies. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guest: Tom Monath Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position at FDA (pdf) Support MicrobeTV with a Spike t-shirt (Vaccinat
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin reviews the public health response to poliovirus in New York, impact of mandatory influenza vaccination, monkeypox in a young infant, health care worker exposure to monkeypox virus, monkeypox testing delays, transmission potential of monkeypox virus, TPOXX trial for monkeypox, detection of SARS-CoV-2 subgenomic mRNA, mucosal IgA against SARS-CoV-2, BNT262b2 against Omicron, awareness and use of SARS-CoV-2 antivirals, comparable outcomes for Bebtelovimab
Pediatric hepatitis with Emma Thomson
From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Emma Thomson about the recent outbreak of pediatric hepatitis of unknown etiology and the finding that it is linked to infection by adenovirus-associated virus 2. Hosts: Vincent Racaniello Guest: Emma Thomson Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Thomson laboratory Emma on TWiV 188 and TWiV 341 AAV2-associated pediatric
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses detection of a highly divergent type 3 vaccine-derived poliovirus in a child with a severe primary immunodeficiency disorder, severe respiratory illnesses associated with rhinoviruses and/or enteroviruses including EV-D68, effects of vaccination and previous infection on Omicron infections in children, COVID-19-associated hospitalizations among vaccinated and unvaccinated adults 18 years or older in 13 US states, effectiveness of COVID-19 vacci
Mobile DNA with Cedric Feschotte
Vincent travels to Cornell University to speak with Cedric about his career and his research on mobile genetic elements such as transposons and endogenous viruses and how they have shaped the evolution of nearly all organisms. Hosts: Vincent Racaniello Guest: Cedric Feschotte Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Feschotte laboratory Field guide to transposable elements (Ann Rev Genetics) Timestamps by Jolene. Thanks! Intr
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses variant influenza virus infections: recommendations for identification, treatment, and prevention for summer and fall 2022, low levels of monkeypox virus neutralizing antibodies after MVA-BN vaccination in healthy individuals, using the right tools at the right time for SARS-COV-2 infection, onset and window of SARS-COV-2 infectiousness and temporal correlation with symptom onset, transmission of SARS-COV-2: a review of viral, host, and environ
Island-hopping bats
TWiV discusses a new henipavirus from fruit bats in Madagascar, and attenuation of SARS-CoV-2 Omicron disease in mice caused by genome mutations outside of the spike protein coding region. Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position at FDA (pdf) Beijerinck virology prize (KNAW) Nipah virus vaccine (TWiV 618) Novel henipa
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses vaccine effectiveness against influenza illness in children, clinical manifestations of infection with poliovirus, spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory mice, concordance of SARS-CoV-2 results in self-collected nasal swabs vs swabs collected by health care workers in children and adolescents, probable animal-to-human transmission of SARS-CoV-2 causing a pet shop-related outbreak, laboratory-confirmed
Driven to immunodistraction
TWiV reviews the genetic characterization of a new strain of type 2 oral polio vaccine and its implications for eradication, and how a polymorphism in humans comprising a single amino acid change in an antibody molecule regulates vaccine elicitation of broadly neutralizing antibodies against influenza virus HA. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links f
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses antibody response against nonpoliovirus enteroviruses, clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain, object and surface contamination with monkeypox virus, monkeypox virus infection in humans across 16 countries, clinical characteristics of ambulatory and hospitalized patients with monkeypox virus infection, compassionate use of Tecovirimat for the treatment of monkeypox infection, monitorin
Empathyology with Andy Slavitt
Andy Slavitt joins TWiV to discuss his book, Preventable and how failures in leadership, politics, and selfishness doomed the U.S. response to SARS-CoV-2. Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker Guest: Andy Slavitt Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode In the Bubble podcast Preventable (Amazon) Letters read on TWiV 929 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Best big
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the public health response to a polio case in a unvaccinated NY state resident, human to dog transmission of monkeypox virus, Tecovirimat and the treatment of monkeypox, detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium, what to do if you are exposed to SARS-CoV-2 and isolation and precautions for people with COVID-19, risk of SARS-CoV-2 infection in health care workers, effectiveness of H
Merchlinsky vs monkeypox
Michael Merchlinsky joins TWiV to discuss the development of two smallpox antiviral drugs and two smallpox vaccines and their uses during the monkeypox outbreak. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Michael Merchlinsky Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Michael on Anything but academic (TWiM 145) Development of Tecoviromat (TPOXX) (Antiviral Res) Use of Jynneos vaccine (MM
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses guidance for prevention and treatment of monkeypox, post-infectious symptoms among children and adolescents, profiling post-infectious syndromes of different variants, comparison of vaccine Ankara vs intradermal routes of administration, infection in vaccinated individuals treated with or without PAXLOVID, duration of symptoms with positive rapid antigen after infection, epidemiologic characteristics of monkeypox, and sequelae of post-acute inf
First kisses and second doses
TWiV discusses monkeypox virus, poliovirus in NY, Marburg virus in Ghana, ancient herpes simplex virus type 1 genomes, and immunogenicity of different combinations of SARS-CoV-2 vaccines. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode How monkeypox virus spreads (CDC) Vaccination against monkeypox virus (CDC) Monkeypox case trends (CDC) Polio in
TWiV clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses Tecovirimat for treatment of monkeypox, the safety and acceptance of vaccination after multisystem inflammatory syndrome, variants in solid organ transplant recipients, masks for prevention of respiratory virus infections, pre-exposure prophylaxis with Evusheld, the association between Evusheld administration and infection, if repeat administration of casirivimab and imdevimab is well-tolerated, viral and symptom rebound in untreated infection
If a bat pees in a forest, does anyone care?
From The Third International Symposium on Infectious Diseases of Bats in Ft. Collins, Colorado, TWiV speaks with Vincent Munster and Raina Plowright about their careers and their research on bats, bat viruses, bat ecology and spillover events. Hosts: Vincent Racaniello and Brianne Barker Guests: Vincent Munster and Raina Plowright Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Novel Hendra virus variant in Australia (Emerg Inf Dis)
TWiV clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses monkeypox infection in humans across 16 countries, pregnancy outcomes after SARS-CoV-2 infection by trimester, vaccination intent and belief, antiviral drug treatment for non-severe disease, the association of smoking with infected hospitalized patients, the association of Paxlovid on negative conversion rates among high-risk patients with COVID-19, safety and efficacy of Molnupiravir, usage of enoxaparin for primary thromboprophylaxis, statin
Science will break your heart
From ASV 2022 in Madison, Wisconsin, TWiV speaks with Pamela Bjorkman and Andy Mehle about their careers and their research on influenza virus, HIV-1, SARS-CoV-2, and influenza virus. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guests: Pamela Bjorkman and Andy Mehle Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Bjorkman laboratory Mehle laboratory Finding the groove (Nat Immunol) Structure of HLA-A2 (
COVID-19 clinical update #124 with Dr. Daniel Griffin
In COVID-19 clinical update #124, Dr. Griffin discusses the results of a variant vaccine booster trial, the neutralization of variant sub-lineages by Novavax, the CDC’s recommendation of Novavax’s COVID-19 vaccine in adults, Paxlovid in patients who are immunocompromised and hospitalized, and inhaled fluticasone for outpatient treatment. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Variant vaccine boosters trial (medRxiv) Novavax
Motivated by volatiles
TWiV reviews the FDA decision to update COVID-19 vaccine boosters in the fall, the meaning of fatigue with respect to long COVID, and a skin volatile induced by flavivirus reproduction that attracts mosquitoes to the infected host. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 vaccine booster composition (FDA) Settling in for the long haul (Crooke
COVID-19 clinical update #123 with Dr. Daniel Griffin
In COVID-19 clinical update #123, Dr. Griffin discusses rapid diagnostic testing in response to the monkeypox outbreak, leading causes of death in the US during the COVID-19 pandemic, antibody evasion by subvariants, broadly-neutralizing antibodies against emerging variants, factors associated with severe outcomes among hospitalized immunocompromised adults, measurement of the burden of hospitalizations during the pandemic, parental vaccine hesitancy in diverse communities, evaluating saliva sam
Boosters on, Paul Offit
Paul Offit returns to TWiV to discuss why, during the recent FDA advisory committee meeting, he voted against releasing revised COVID-19 vaccines containing an Omicron component, and the reasons why children must be vaccinated against the disease. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Paul Offit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode 28 June 2022 VRBPAC meeting materials (FDA)
COVID-19 clinical update #122 with Dr. Daniel Griffin
In COVID-19 clinical update #122, Dr. Griffin discusses vaccine availability and coverage among children, post-infection health impairments in children and adolescents, infection detection using salvia and nasopharyngeal samples, effectiveness of vaccines during delta dominance, durability of vaccine against severe outcomes, concern in the postvaccination era, infection rebound after Paxlovid & Molnupiravir, lack of improvement after adding ivermectin to standard care, duration of shedding of vi
Mouse mouth to mouse mom
TWiV discusses the recent decision by an FDA advisory committee to update COVID vaccines for the fall, the monkeypox virus outbreak, and the finding that enteric viruses infect the salivary glands and are transmitted through saliva. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Postdoctoral position in the Kielian Laboratory (pdf) COVID
COVID-19 clinical update #121 with Dr. Daniel Griffin
In COVID-19 clinical update #121, Dr. Griffin discusses age as a risk factor for severe disease, updated vaccine boosters for the fall, pediatric infection and antibody seroprevalence in Arkansas over the first year of the COVID-19 pandemic, all-cause maternal mortality in the United States before and during the pandemic, and the effect of 2-week interruption in methotrexate treatment and how it impacts vaccine immunity. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patr
Twinkle twinkle little SARS
TWiV explains the meaning of vaccine-derived poliovirus found in London sewage, risk of long COVID after infections with Delta or Omicron variants of SARS-CoV-2, and enhancers of innate immune signaling as broad-spectrum antivirals. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Poliovirus in UK sewage (ProMedMail and Science) Poliovirus erad
COVID-19 clinical update #120 with Dr. Daniel Griffin
In COVID-19 clinical update #120, Dr. Griffin discusses outcomes of SARS-CoV-2 reinfection, CDC recommendation for vaccines in young children, neurodevelopment outcomes in infants of mothers testing positive for COVID during pregnancy, efficacy of monoclonal antibodies and antivirals in hamsters, rebound phenomenon after PAXLOVID in high-risk persons, hospitalization for infection after PAXLOVID treatment, and risk of long COVID with different variants. Subscribe (free): Apple Podcasts, Google P
Antibody can get vaccinated now
TWiV provides an update on hepatitis of unknown etiology in children, an experimental nanoparticle vaccine for Epstein-Barr virus, and minimal impact of bamlanivimab therapy on antiviral antibodies induced by vaccination. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Hepatitis of unknown etiology (MMWR) Clinical recognition of monkeypox (CDC) Epstein-Barr
COVID-19 clinical update #119 with Dr. Daniel Griffin
In COVID-19 clinical update #119, Dr. Griffin reviews tixagevimab for infection prevention, ivermectin for outpatient infection treatment, symptom rebound after PAXLOVID treatment, bamlanivimab minimally impacting immune response to vaccination, in-hospital mortality among infection patients, residual viral antigen in patients following infection, usage of Casirvimab/Imdevimab and Remdesivir in infected patients with depleted B-cells, and rheumatic symptoms following infection. Subscribe (free):
Art of science
From ASM Microbe 2022 in Washington DC, Vincent and Michael speak with science artists Michele Banks and Jane Hartman about their work and their inspiration. Hosts: Vincent Racaniello and Michael Schmidt Guests: Michele Banks and Jane Hartman Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Trilobite Glassworks (Jane Hartman) Artologica (Michele Banks) Science art with Michele Banks (TWiV 352) Timestamps by Jolene. Thanks! Intro mu
When the cats and mice are away, the viruses play
TWiV discusses the situation with monkeypox, risk factors for SARS-CoV-2 infections of cats and dogs, and a lineage-tracing mouse model for studying papillomavirus infections. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monkeypox update (CDC) SARS-CoV-2 infection of cats and dogs (Emerg Inf Dis) Mouse papillomavirus identification (Vet Patrol) Mouse model for papillomav
COVID-19 clinical update #118 with Dr. Daniel Griffin
In COVID-19 clinical update #118, Dr. Griffin discusses management of hair loss after infection, FDA announcements on vaccine schedule and recommendations, Moderna announcement on bivalent booster candidate, association between vaccination and infection during pregnancy, population-level implications of Israel’s booster campaign, PAXLOVID outcomes during recent infection surge, efficacy and safety of Tixagevimab-cilgavimab, diagnostic accuracy of infection by canines, efficacy of colchicine in h
Long COVID, giant viruses, and smallish pox
TWiV reviews human monkeypox infections, evidence for human Mimivrus infections, and incidence of long COVID in post-vaccine SARS-CoV-2 infections. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monkeypox update (ProMedMail) Multi-country monkeypox outbreak (WHO) Monkeypox new global threat (Science) Monkeypox outbreak 9 US states (MMWR) Mimivirus in h
COVID-19 clinical update #117 with Dr. Daniel Griffin
In COVID-19 clinical update #117, Dr. Griffin discusses duration of virus shedding, association between pre-exposure to steroids and infection outcome, post-infection subtypes, rehabilitation for post-acute infection, Tixagevimab/Cilgavimab for infection prevention, antibody prophylaxis and vaccination in kidney transplant recipients, remdesivir and bebtelovimab fact sheets for providers, the updated guidelines on treatment with Famotidine, Paxlovid rebound symptom characterizations, antigen tes
50 years of reverse transcriptase
Vincent travels to Cold Spring Harbor Laboratory to speak with David Baltimore, John Coffin, and Harold Varmus about the discovery in 1970 of retroviral reverse transcriptase and its impact on life sciences research. Hosts: Vincent Racaniello Guests: David Baltimore, John Coffin, and Harold Varmus Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Fifty Years of Reverse Transcriptase (Cold Spring Harbor Laboratory) 50th Anniversary of R
COVID-19 clinical update #116 with Dr. Daniel Griffin
In COVID-19 clinical update #115, Dr. Griffin discusses croup association with infection surge, rhinovirus co-circulation in children, shedding following vaccination, high vaccine efficacy in children 6 mo-5 yr, vaccine protection for hospitalized patients, convalescent plasma as post-exposure prophylaxis, real-world effectiveness of PAXLOVID, effectiveness of PAXLOVID in reducing hospitalization, infection rebound after PAXLOVID, relapse of symptomatic infection after PAXLOVID, remdesivir and b
Monkeypox clinical update with Dr. Daniel Griffin
In this special episode, Dr. Griffin answers questions about the recent cases of monkeypox including their origin, clinical presentation, diagnosis, treatment, and overall risk. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monkeypox multi-country outbreak risk assessment (pdf, ECDC) Monkeypox update (ProMedMail) Monkeypox virus genome sequences (Nextstrain) Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to
Autoantibodies drive severe COVID-19
TWiV reviews recent cases of monkeypox, presence of SARS-CoV-2 RNA but not infectious virus in feces, and the association of autoantibodies to interferons with severe COVID-19. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monkeypox in MA (ProMed Mail) Possible monkeypox in NYC (NY Times) Occupational monkeypox, Wisconsin (Emerg Inf Dis)
COVID-19 clinical update #115 with Dr. Daniel Griffin
In COVID-19 clinical update #115, Dr. Griffin reviews cross-variant immunity without vaccination, EUA for boosters in 5-11 year olds, B.1.1.529 attack rate, scent dogs, Omicron and pets, Paxlovid, Veklury, Fluvoxamine, antigen positivity after isolation, inflammasome activation and severe disease, and GI persistence and fecal shedding. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Limited cross-variant immunity without vaccination
Burning down the mouse
TWiV celebrates 900 episodes, Vincent gives the Richard R. Ernst lecture, and we discuss why inflammasome activation in infected macrophages drives severe COVID-19. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Richard R. Ernst Lecture Infected macrophages drives severe COVID-19 (Nature) Timestamps by Jolene. Thanks! Weekly Picks Brianne – The
COVID-19 clinical update #114 with Dr. Daniel Griffin
In COVID-19 clinical update #114, Dr. Griffin discusses early treatment with ivermectin, procalcitonin not a reliable biomarker, vaccine in 6-11 year olds, FDA limits use of Janssen vaccine, does site of vaccine booster matter, sniffer dogs, monoclonals for hospitalized patients, risk assessment for public events, Paxlovid eligibility, and persistence of pediatric anosmia. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Effects of ea
Immunity is skin deep
TWiV explains why the concept of herd immunity might not apply to COVID-19, and the observation that smallpox vaccination causes an increase in skin bacteria that promote pathology and influence the immune response. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Herd immunity may not apply to COVID-19 (J Inf Dis) Smallpox vaccination increases skin bacteria
COVID-19 clinical update #113 with Dr. Daniel Griffin
In COVID-19 clinical update #113, Dr. Griffin discusses tocilizumab use in hospitalized Patients, IL-6 inhibitors and mortality, Baricitinib in hospitalized patients, post-infection neurological sequelae, comparative effectiveness of Pfizer and Moderna vaccines, phase 2/3 study of Paxlovid, infection relapse following Paxlovid, pre-hospital administration of Remdesivir, and hospitalization with different variants. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of T
Memory B cells, the way we were
TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost. Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Climate change and viral zoonosis risk (Nature) COVID-19 mRNA boost effect on memory B cells (Nature) Letters read on TWiV 896 Ti
COVID-19 clinical update #112 with Dr. Daniel Griffin
In COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines in US, FDA approval of first treatment for young children, phase 2 data for Sabizabulin, and post infection inflammation. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Seroprevalence of Infection-Induced Antibodies (CDC) Authorization for
Dinner with the TMPRSS family
TWiV explains what is known about cases of acute, severe hepatitis of unknown origin in children, and discovery of an inhibitor of TMPRSS2 protease that blocks SARS-CoV-2 infection. Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Severe hepatitis in children (WHO) TMPRSS2 inhibitor (Nature) Omicron less dependent on TMPRSS2 (TWiV 879) Letters read on TWiV 894 T
Yellow fever virus escapes antibodies
Kartik, Denise, and Gorka join TWiV to discuss their finding that changes in the surface glycoprotein of South American yellow fever virus lead to reduced neutralization by antibodies induced by the vaccine, which is derived from an African isolate. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Guests: Kartik Chandran, Denise Haslwanter, and Gorka Lasso Cabrera Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Prome
COVID-19 clinical update #111 with Dr. Daniel Griffin
In COVID-19 clinical update #111, Dr. Griffin discusses vaccine coverage and mortality in Hong Kong, immune response to boosters in kids, hospitalization of kids, breath based diagnostic test, viral co-infections, bivalent mRNA vaccine, intramuscular Evusheld, and global long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine coverage and mortality, Hong Kong (MMWR) Kids behind on routine vaccinations (Politico) Immune
LLOV in the time of Ebola
Elke, Adam, and Gabor join TWiV to discuss their work on Lloviu virus, a filovirus, including recovery of infectious virus from a DNA copy of the genome and from Schreiber’s bats in Hungary. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guests: Elke Muhlberger, Adam Hume, and Gabor Kemenesi Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Elke on TWiV 200 and Threading the NEIDL Infectious Lloviu virus fro
Looking into a booster crystal ball
This episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval between vaccination and infection influences the quality of the antibody response. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode What next for COVID-19 boosters? (NE
COVID-19 clinical update #110 with Dr. Daniel Griffin
In COVID-19 clinical update #110, Dr. Griffin covers hospital admissions during variant outbreaks, viral load in vaccinated and unvaccinated individuals, predictive capacity of symptoms in children, comparison of antigen tests, incidence of myocarditis after vaccination, steroids during replication phase, Paxlovid efficacy and safety, fluvoxamine, sabizabutin, colchicine, and prevalence of infection in Africa. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV!
Molnupiravir with Richard Plemper
Richard joins TWiV to discuss the SARS-CoV-2 antiviral drug Molnupiravir , including how it was discovered, its mechanism of action, whether it is a mutagen for cells, and the future of drugs for treatment of COVID-19. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Guest: Richard Plemper Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Richard on TWiV 636 Molnupiravir in ferrets (Nat Micro) Oral prodrug of Remdesivir in ferr
Bonfire of the monocytes
TWiV explains why this season’s influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a major contributor to severe COVID-19. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Seasonal influenza vaccine effectiveness (MMWR) Properties of a dominant H3N2 vari
COVID-19 clinical update #109 with Dr. Daniel Griffin
In COVID-19 clinical update #109, Daniel Griffin discusses cardiac complications after infection or vaccination, long COVID in children, fourth vaccine dose in Israel, no need for fourth vaccine dose in EU, dexamethasone dosing, immunomodulation therapy, MIS outcomes in children, US long COVID effort launched, and herd immunity. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Cardiac complications after infection or vaccination (MMW
Russian bats and Ankara vectors
TWiV reveals an ACE2-dependent sarbecovirus from Russian bats that is not inhibited by anti-SARS-CoV-2 antibodies, and a modified vaccinia virus Ankara vectored vaccine that protects nonhuman primates from Delta infection. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Sarbecovirus from Russian bat (bioRxiv) MVA vectored COVID vaccine (Sci Immunol) Letters read on TWiV 885 T
Cytokines and viral mimicry
Vincent and Amy explain how asthmatic bronchial smooth muscle increases rhinovirus replication in the bronchial epithelium, and mimicry of IL-17 by the ORF8 protein of SARS-CoV-2. Hosts: Vincent Racaniello and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Asthmatic bronchial smooth muscle and rhinovirus (Cell Rep) SARS-CoV-2 ORF8 mimics IL-17 (mBio) Letters read on TWiV 884 Timestamps by Jolene. Thanks! Weekly Picks
COVID-19 clinical update #108 with Dr. Daniel Griffin
In COVID-19 clinical update #107, Daniel Griffin reviews vaccine booster doses, at-home testing, transmission in ferrets, improving indoor air quality, trials of BCG, ivermectin, and fluvoxamine, vaccination during pregnancy, mRNA vaccines and Fc functions, anti-platelet and aspirin therapy and a trial of prone positioning. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA authorizes second booster (FDA) Second booster and mortal
Elispot on about T cells and lipids
Vincent and Brianne review the need to better understand T cell responses to SARS-CoV-2 infection to better inform public health decisions, and how IL-1 and IL-1ra are important regulators of the inflammatory response to RNA vaccines. Hosts: Vincent Racaniello and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Understanding T cell responses during COVID-19 (Science Immunol) IL-1 and IL-1ra are keys to inflammation af
50 ways to zap your virus
TWiV describes the identification of a monoclonal antibody that provides broad protection against a variety of hantaviruses, and development of an oral remdesivir-like antiviral that ameliorates viral disease in mice. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monoclonal antibody provides broad hantavirus protection (Sci Transl Med) Prometheus Project
COVID-19 clinical update #107 with Dr. Daniel Griffin
In COVID-19 clinical update #107, Daniel Griffin discusses Moderna vaccine results in children, hospitalization by ethnicity, BA.2 severity in children, placentitis and thrombohematoma during pregnancy, predictive value of symptoms for diagnosis, Evusheld activity against BA.1 and BA.2, Remdesivir resistance, Ivermectin with and without strongyloidiasis, inhaled ciclesonide, home telemonitoring, pulse oximetry for remote monitoring, effectiveness of anti-platelet therapy, and deaths in Zambia. S
Indolent, resistant, and losing our TMPRSS
TWiV reviews the emergence of remdesivir-resistant SARS-CoV-2 during treatment of a persistently infected immunocompromised patient, and how altered TMPRSS2 utilization by the Omicron variant influences infectivity and fusion. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2022 Emergence of remdesivir resistance (Nature Comm) How to stall a cop
Shape matters sometimes
TWiV revisits chronic wasting disease of cervids and the ability of the prions to infect meadow voles and raccoons, and the suggestion that stochastic assembly of influenza virus particles may play a role in phenotypic diversity. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode CWD in meadow voles and raccoons (Emerg Inf Dis) Unusual infectious agents (Virol
COVID-19 clinical update #106 with Dr. Daniel Griffin
In COVID-19 clinical update #106, Daniel Griffin covers failure of ivermectin to improve hospitalization, increased hospitalization of children with Omicron, seroconversion of children versus adults, effectiveness of Pfizer mRNA vaccine in children, high vaccine effectiveness in Finland against Omicron, distinct long COVID clinical phenotypes, and estimating worldwide excess mortality. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode
Spillover market with Michael Worobey
Michael Worobey joins TWiV to explain evidence that SARS-CoV-2 emerged via the wildlife trade and that the Huanan market was the unambiguous epicenter of the COVID-19 pandemic. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Michael Worobey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Early COVID-19 cases in Wuhan (TWiV 833) Huanan market was epicenter of COVID-19 (Zenodo) Two spillover events lau
Animal house
TWiV discusses the virome of game animals in China, and the finding that binding of sarbecoviruses to ACE2 is an ancestral and evolvable trait. Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode WHO declaration of COVID-19 pandemic Virome of China game animals (Cell) ACE2 binding is ancestral and evolvable (Nature) Letters read on TWiV 875 Timestamps by Jolene. Thanks!
COVID-19 clinical update #105 with Dr. Daniel Griffin
In COVID-19 clinical update #105, Daniel Griffin discusses changes in brain structure after infection, dementia in patients with pneumonia, Paxlovid in children, mask effectiveness in schools, host factors and severe disease, post-acute symptoms, and the mission of CEPI. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Infection and changes in brain structure (Nature) Dementia among pneumonia survivors (Open Forum Inf Dis) Narrative
Pig viruses and big viruses
TWiV reviews the six known coronaviruses that infect pigs and what can be learned about human infections, and how the giant Mimivirus DNA genome is organized into a nucleocapsid. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Click arrow to play Download TWiV 873 (128 MB .mp3, 107 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ABRCMS ePoster Spring Symposium for Emerging Scientists Porcine coronaviruses (
COVID-19 clinical update #104 with Dr. Daniel Griffin
In COVID-19 clinical update #104, Daniel Griffin reviews effectiveness of mRNA vaccines among children, number of children affected by disease, accuracy of rapid antigen tests, CDC guidance for prevention strategies, monoclonal antibody effectiveness, predicting progression to severe respiratory failure from pneumonia, risk of long COVID after two vaccine doses, and peripheral neuropathy in long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links f
If the ACE2 fits, ferret
TWiV discusses whether or not Omicron should be designated a new serotype of SARS-CoV-2, and the finding that amino acid changes that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ABRCMS ePoster Spring Symposium for Emerging Scientists ASV Annual Meeting Registration (ASV) Microbiology & Immunology
COVID-19 clinical update #103 with Dr. Daniel Griffin
In COVID-19 clinical update #102, Daniel Griffin covers immunocompromised people, hospitalization of children, vaccine usage update, Omicron and cross-reactive neutralizing antibodies, reinfection prevents disease in hamsters, repeated infections with endemic coronaviruses, global burden of antimicrobial resistance, ivermectin not protective in hamsters, and Omicron evades therapeutic monoclonals. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for th
Epstein-Barr virus and MS, a perfect storm
TWiV reviews epidemiological and experimental evidence that infection with Epstein-Barr virus leads to the production of antibodies against a viral protein that cross-react with a human protein, leading to multiple sclerosis. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ABRCMS ePoster Spring Symposium for Emerging Scientists ASV Annual Meeting Registrat
COVID-19 clinical update #102 with Dr. Daniel Griffin
In COVID-19 clinical update #102, Daniel Griffin reviews children and COVID, effectiveness of maternal vaccination, vaccines for immunocompromised, primary care physicians and vaccination rates, booster safety among adults, placentitis, azithromycin, oral Nirmatrelvir, Omicron antibody evasion, EUA for bebtelovimab, IL-1 blocking agents, thromboprophylaxis, effectiveness of vaccines against long COVID, and risks of mental health outcomes. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, e
I love the smell of vaccines in the morning
TWiV reviews an experimental, intranasally administered SARS-CoV-2 vaccine that utilizes adenovirus vectors to deliver three viral proteins and induces immunity to ancestral and variant isolates. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Dorothy Horstmann (Wikipedia) Intranasal SARS-CoV-2 experimental vaccine (Cell) t-SNE (Wikipedia) Timestamps by Jolene. T
EV antibodies rEVolutionize our thinking
Amy returns to TWiV to discuss her work on the identification of cross-reactive antibody responses among diverse enteroviruses, and the implications for our understanding of viral pathogenesis and seroprevalence studies. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit Brianne Barker, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ABRCMS ePoster Spring Symposium for Emerging Scientists Cross-reactive ente
COVID-19 clinical update #101 with Dr. Daniel Griffin
In COVID-19 clinical update #101, Daniel Griffin discusses children and COVID, human challenge study results, effectiveness of mask use, Omicron boost in macaques, mucosal vaccine candidate, long-term cardiovascular outcomes, and global vaccine perceptions. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Children and COVID state data (AAP) Human challenge study (Res Sq) Effectiveness of mask use (MMWR) Omicron boost in macaques (bi
Sea Sawdust
Mark Martin returns to TWiM for a discussion of the frightening global burden of bacterial antibiotic resistance, and a solution to the problem of daylight nitrogen fixation in a cyanobacterium, despite the incompatibility of nitrogenase with oxygen produced during photosynthesis. Become a patron of TWiM. Links for this episode: Global bacterial antimicrobial resistance (Nat Micro) Cancer moon shot (NCI) When antibiotics don’t work (TED) Cyanobacterium buoyancy (Nat Micro) Music used on TWi
A game of thrones
Monica, John, David, and Marc join TWiV to discuss their work on identifying cryptic SARS-CoV-2 lineages in New York City wastewater, and understanding whether they were shed from humans or other animals. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guests: John Dennehy, Marc Johnson, Davida Smyth, and Monica Trujillo Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 in NYC wastewater (TWiV 737) Cryptic SARS-Co
Does this challenge study pass the smell test?
TWiV reviews the results of a study in which 36 volunteers were infected with SARS-CoV-2, and what was learned about the kinetics of virus reproduction in the nose and throat, development of symptoms, and reliability of lateral flow antigen assays. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Columbia University BSL-3 Manager po
COVID-19 clinical update #100 with Dr. Daniel Griffin
In COVID-19 clinical update #100, Daniel Griffin, from Accra, Ghana, reviews the challenges in evaluating Omicron severity, over 800 deaths in children, Pfizer vaccine EUA application for under 5 year olds, false positives from soft drinks, Novavax vaccine EUA application, childhood experiences and vaccine hesitancy, fourth vaccine dose in Israel, effects of antivirals and monoclonals against Omicron, and multiple factors associated with PASC. Subscribe (free): Apple Podcasts, Google Podcasts, R
Rough draft of Omicron origins
Nels joins TWiV to discuss hypotheses for the origins of Omicron, including that it came from mice or arose during chronic infection of an immunocompromised patient. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Nels Elde Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Columbia University BSL-3 Manager position Did Omicron come from mice? (J Genet Genomics) Persistent SARS
Evading a Toll on the road to RNA vaccines
TWiV reviews a seminal paper showing that chemically modified bases in RNAs suppress recognition by Toll-like receptors, a finding that that was essential for the development of COVID-19 mRNA vaccines. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Columbia University BSL-3 Manager position RNA modifications suppress innate recog
COVID-19 clinical update #99 with Dr. Daniel Griffin
In COVID-19 clinical update #99, Daniel Griffin discusses Omicron disease severity, neurologic manifestations in children, testing outcomes during multiple infections, boosters improve VE and VD, booster efficacy for ED and UC encounters, vaccines induce cross-protective T cell memory, and indications for monoclonal antibody therapy.C Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Omicron disease severity (MMWR) Neurologic manifest
The vax of life with John Mascola
John Mascola joins TWiV to discuss the history and mission of the NIH Vaccine Research Center, how it prepared for devising pandemic vaccines, and development of the COVID-19 vaccines. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Guest: John Mascola Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Accelerated COVID-19 vaccine development (Immunity) Letters read on TWiV 858 Timestamps by Jolene. Thanks! Weekly
Not just antibody, Jon Yewdell
Jon Yewdell returns to TWiV to discuss how antibodies are made, vaccination against SARS-CoV-2, antigenic variation of the virus, booster shots, and more. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guest: Jon Yewdell Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Jon Yewdell on TWiV 208, 467, 597, 620 Letters read on TWiV 857 Timestamps by Jolene. Thanks! Weekly Picks Jon – The Premonition by Michael L
COVID-19 clinical update #98 with Dr. Daniel Griffin
In COVID-19 clinical update #98, Daniel Griffin reviews COVID-19 in South Africa, recognition of Omicron by ancestral T cells, booster effectiveness against disease, infection and vaccination in pregnant women, early Remdesivir to prevent progression to severe disease, management of hospitalized adults, Tocilizumab in hospitalized patients, vaccination and long COVID, and the true toll of the pandemic. Click arrow to play Download TWiV 853 (58 MB .mp3, 48 min) Subscribe (free): iTunes, Google Po
T time with Alessandro Sette
Alessandro Sette returns to TWiV to discuss the observation that SARS-CoV-2 vaccination induces T cells that are able to cross-recognize variants Alpha to Omicron. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Alessandro Sette Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Travel Award Applications (ASV) 3:20 Impact of variants on T cells (Cell Rep Med) Timestamps by Jolene. Thanks! Letters read on TWiV 8
Omicron is evasive
TWiV reviews findings that increased fitness of the Omicron variant is due to immune evasion, not an increase in intrinsic transmissibility, and determination of infectious viral load in patients infected with wild type, Delta and Omicron viruses reveals lack of correlation with RNA loads determined by RT-PCR, similar levels of shedding among Delta and Omicron, and greatly reduced shedding in vaccinated people. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brian
COVID-19 clinical update #97 with Dr. Daniel Griffin
In COVID-19 clinical update #97, Daniel Griffin covers immunity after infection recognized by CDC, outcomes before and after Omicron, infectious viral load in Delta vs Omicron, PCR vs rapid antigen tests, booster interval shortened to 5 months, risk factors for severe outcomes in vaccinated, cross-reactive memory T cells, vaccine effectiveness vs MIS-C, and Rivaroxiban for thromboprophylaxis. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode
Tree man syndrome
A TWiV threesome explains the observation that humans with inherited T cell CD28 deficiency are susceptible to severe warts driven by human papilloma virus infection, but are otherwise healthy. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Travel Award Applications (ASV) CD28 deficiency and severe warts (Cell) Vincent interviews Harald zur Hausen (virology
Questions are tricky
The TWiV team reviews the observation that infection with the SARS-CoV-2 Omicron variant causes reduced reproduction and pathogenesis in mice and hamsters. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Brianne Barker, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Travel Award Applications (ASV) Omicron infection in mice and hamsters (Res Square) Letters read on TWiV 851 Timestamps by
COVID-19 clinical update #96 with Dr. Daniel Griffin
In COVID-19 clinical update #96, Daniel Griffin reviews Omicron in South Africa, rapid antigen tests, viral coinfections, isolation and quarantine, saliva preferred for Omicron, risk factors for severe disease in vaccinated, Paxlovid dosing, and long COVID. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Variant proportions (CDC) Omicron in South Africa (JAMA) Transmission of SARS-CoV-2 (Ann Int Med) Diagnostics for COVID-19 (Lancet) Compar
Arc of the epitope
TWiV kicks off 2022 with a review of the virology highlights of 2021, from three virologists, one immunologist, a science writer, and a partridge in a pear tree. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID vaccines: TWiV 708, 715, 718, 844 Non-CoV papers: TWiV 763, 784, 819, 822, 740, 848 Immune correlates of protection: TWiV 791, 799, 835,
On Dasher, on Dancer, on Corona and Lassa
For the final episode of 2021, TWiV reviews an experimental infectious attenuated Lassa fever vaccine based on a codon-deoptimized glycoprotein gene, and SARS-CoV-2 infection of free-ranging white-tailed deer. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Codon-deoptimized Lassa fever vaccine (mBio) Attenuation of dengue virus by codon deoptimizat
COVID-19 clinical update #95 with Dr. Daniel Griffin
In COVID-19 clinical update #95, Daniel Griffin discusses new CDC guidelines for isolation and quarantine, EUA for Molnupiravir, children and COVID, vaccine safety in 5-11 year olds, Omicron outbreaks in Nebraska and Denmark, Baylor's COVID vaccine, and COVID-OUT for ivermectin. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Isolation and quarantine guidance (CDC) EUA for Molnupiravir (FDA) Children and COVID state data (AAP) Vaccine sa
Beta was stirring, and now in a mouse
TWiV explores the impact of the intestinal virome on seroconversion after rotavirus vaccination, and implications of the ability of the SARS-CoV-2 beta variant to infect wild-type laboratory mice. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Impact of enteric virome on rotavirus vaccine (Cell Host Micr) Beta variant infects wild type mice (Sig Transd Ta
COVID-19 clinical update #94 with Dr. Daniel Griffin
In COVID-19 clinical update #94, Daniel Griffin reviews the FDA EUA for Paxlovid, test to stay in school, immunity after infection, variants and therapeutics, quarantine and isolation guidelines, Molnupiravir in non-hospitalized patients, and convalescent serum in outpatients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA EUA for Paxlovid (pdf) Children and COVID-19 (pdf) Evaluation of test
Paul Offit on children, COVID, and boosters
Paul Offit returns to TWiV to discuss new CDC guidance on J&J vaccine, why children should be immunized against COVID-19, and whether or not booster doses are scientifically justified. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Guest: Paul Offit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Paul Offit on TWiV 720 Are COVID-19 vaccine boosters needed? (virology blog) Letters read on TWiV 844 Timestamps by Jolene. Tha
COVID-19 clinical update #93 with Dr. Daniel Griffin
In COVID-19 clinical update #93, Dr. Griffin summarizes Omicron fitness, S-gene target failure, monoclonal efficacy against Omicron, vaccination, monoclonals, and disease in children, persistence of memory B cells in the elderly, infection and vaccine induced immunity, protection against severe illness and death by a third mRNA vaccine dose, high flow oxygen versus intubation, and therapeutic anticoagulation. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts,
The clot thickens
TWiV reviews the results of serum neutralization assays which show that a third vaccine dose restores neutralization of the Omicron variant, and interaction of platelet factor 4 with the adenovirus capsid, suggesting a mechanism for thrombosis with thrombocytopenia syndrome. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Third vaccine dose improves Omicron neutralization (medRxiv
Unmasking immunity
TWiV provides an update on immunity to Omicron, results of a randomized controlled trial of face masks, and a study of correlates of protection against respiratory syncytial virus infection in the upper and lower respiratory tract of nonhuman primates. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Omicron escape from serum antibodies (pdf) Pfizer/BioNTech update
COVID-19 clinical update #92 with Dr. Daniel Griffin
In COVID-19 clinical update #92, Dr. Griffin reviews emerging data on the Omicron variant, much information about monoclonal antibody treatment, including expansion of EUA for Lilly’s cocktail, FDA EUA for pre-exposure prophylaxis, outcomes after treatment, and investigation of subcutaneous or intramuscular administration; effect of adding immunomodulatory agents to usual care on thromboembolic events, and long COVID following infection in previously vaccinated individuals. Hosts: Daniel Griffin
The long and the short of it: get vaccinated
TWiV reviews the impact of vaccination on SARS-CoV-2, the latest information on Omicron, West Nile virus transmission by organ transplantation, and why a 16 week interval between doses of BNT162b2 vaccine is better than a shorter interval. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Coronavirus in the US (NY Times) Omicron variant (NY Times) West Nile virus transmissi
The magic virus bus
The New York City Virus Hunters join TWiV to reveal how local students engage in safe virus surveillance and conduct science research right in their neighborhoods, followed by an update on variant of concern Omicron. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guests: Teresa Bautista, Isabel Francisco, Jesus Gonzales, Joel Gonzalez, Florian Krammer, and Christine Marizzi, Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for t
COVID-19 clinical update #91 with Dr. Daniel Griffin
In COVID-19 clinical update #91, Dr. Griffin discusses final results of molnupiravir trial, Omicron variant of concern, outcomes in B-cell depleted patients, recovery in T-cell depleted macaques, peptide for induction of T cell immunity, high respiratory viral RNA loads in infants, IgA and T cells transferred to breast milk after vaccination, sensitivity and specificity of ID NOW, post-acute sequelae at 12 months, disease in low and middle income countries. Hosts: Daniel Griffin and Vincent Raca
OMG, Omicron!
TWiV reveals all that we know so far about the variant of concern B.1.1.529, also called Omicron, and describes a study on the ability of the alpha, beta, and delta variants to reproduce in cells in culture and induce membrane fusion. Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Omicron genome changes (Covariants) Omicron shared changes with other variants (Covariant
Giving thanks for antibodies
TWiV reviews why children should be vaccinated against COVID-19, increased risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated but not recovered individuals, and immune correlates of protection from the mRNA-1273 vaccine efficacy trial. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 vaccines for children (Science)
COVID-19 clinical update #90 with Dr. Daniel Griffin
In COVID-19 clinical update #90, Dr. Griffin covers FDA expansion for booster doses, 3 more at home antigen tests approved by FDA, immune correlates analysis of mRNA-1273 vaccine, risk for stillbirth, PROVENT prophylaxis trial results, fluvoxamine recommendations, advice on molnupiravir, automated text messaging service for monitoring illness, and long COVID-19 after vaccination and infection. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Beco
Grand theft kinesin
TWiV reviews Michael Worobey’s dissection of the early COVID-19 cases in Wuhan, and the discovery that herpesviruses assimilate cellular kinesin to produce motorized virus particles. Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Early COVID-19 cases in Wuhan (Science) Herpesviruses assimilate kinesin (Nature) Letters read on TWiV 833 Timestamps by Jolene. Thanks! Weekly Picks Kathy
Heavy metal flu fighters
TWiV reviews the vials labeled smallpox that were not, re-emergence of enterovirus D68 in Europe, efficacy of inactivated SARS-CoV-2 vaccine, and cellular correlates of protection for an oral influenza virus vaccine. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Smallpox vials contain vaccinia virus (6abc.com) European re-emergence of enterovirus D68 (Eurosurvei
COVID-19 clinical update #89 with Dr. Daniel Griffin
In COVID-19 clinical update #89, Dr. Griffin reviews upcoming meeting on FDA emergency use authorization for molnupiravir, 25% of US cases in children, reinfection associates with presence of antibodies, national surveillance for acute flaccid myelitis in the US, and monoclonal antibody treatment of infection in vaccinated, high-risk individuals. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Sco
A culture of resistance
TWiV explains that a recent report suggesting that the SARS-CoV-2 spike protein inhibits V(D)J recombination in vitro would not impact immunity after infection or vaccination, and describes the isolation of remdesivir resistant mutants in cells in culture, and the emergence of amino acid changes in the spike protein identical to those in variants of concern, in the absence of immune selection. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Click arrow to play Download TWi
Antiviral and cytotoxically empowered for COVID-19
A TWiV duo reviews how SARS-CoV-2 attacks the olfactory mucosa but spares the olfactory bulb, vaccination with BNT162b2 induces virus-specific stem cell memory T cells, and development of an oral protease inhibitor for the treatment of COVID-19. Hosts: Vincent Racaniello and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode How SARS-CoV-2 attacks olfactory mucosa (Cell) SARS-CoV-2-specific stem cell memory T cells after mRNA va
COVID-19 clinical update #88 with Dr. Daniel Griffin
In COVID-19 clinical update #88, Dr. Griffin covers vaccine protection among US veterans, absence of long COVID in vaccinated who are infected, single dose of REGEN-COV monoclonal antibody cocktail provides long term protection, and Pfizer protease inhibitor Paxlovid is 89% effective in preventing hospitalization or death. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine protection of US v
A shot to save the world with Greg Zuckerman
Greg Zuckerman joins TWiV to discuss his book that explores the race to produce COVID-19 vaccines, with insights into the companies, scientists, and executives involved and the rivalries, ambitions, ego, and a desire to save the world. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Greg Zuckerman Click arrow to play Download TWiV 824 (76 MB .mp3, 127 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode
COVID-19 clinical update #87 with Dr. Daniel Griffin
In COVID-19 clinical update #87, Dr. Griffin reviews PCR cycle threshold and RNA copy number, rapid antigen tests, hospitalization rate after infection or vaccination, allergies and vaccination, community transmission and viral RNA load, early treatment with sotrovimab, meta-analysis of tocilizumab treatment, antibiotic overuse, and guidelines on the use of anticoagulation for thromboprophylaxis. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email B
COVID-19 Q&A with Dr. Daniel Griffin
In this special live-streamed episode of TWiV, Dr. Daniel Griffin fields questions on SARS-CoV-2 and COVID-19 from listeners. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Immunogoblins in the nose and lungs
TWiV explores the properties of the spike glycoproteins of an influenza B virus discovered in the Wuhan spiny eel, and protection against SARS-CoV-2 infection one year after mRNA-1273 vaccination of nonhuman primates. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode HA and NA of Wuhan spiny eel influenza virus (Nat Comm) Protection one year after mRNA-1273 vaccinat
COVID-19 clinical update #86 with Dr. Daniel Griffin
In COVID-19 clinical update #86, Dr. Griffin discusses virologic features of infection in children, antibody tests should not be used to asses level of protection, test-to-stay programs in schools, FDA authorizes Moderna boosters, results of TOGETHER trial for fluvoxamine, statins and 28 day mortality, and cognitive function in patients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode 115,000 heal
Viking variola variants
Rich reviews the history of smallpox and the discovery of variola viral genomes in ancient DNA from human remains throughout Northern Europe, which pushes back the earliest date of smallpox virus infection to ~600–1050 CE, overlapping the Viking Age. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Variola virus genomes from Viking era (Science) Hidden histo
Public clonotype #1
A TWiV trio reveal the isolation of novel paramyxoviruses from rodents and bats in Arizona, and isolation of naive B cells from seronegative donors that produce germline encoded antibodies which engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses from bats. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Bat and rodent paramyxoviruses fro
COVID-19 clinical update #85 with Dr. Daniel Griffin
In COVID-19 clinical update #85, Dr. Griffin reviews cases and deaths by vaccination status, mRNA vaccine effectiveness in 12-18 year olds, standard and extended dosing of mRNA vaccines, immune responses after vaccination, Moderna booster dose approved, giving monoclonals at home, no benefit from colchicine, and IFN does not help remdesivir. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Guidelin
How to stall a copy machine
TWiV explains how remdesivir inhibits the SARS-CoV-2 RNA polymerase: the drug is incorporated into the growing RNA chain and causes synthesis to stall when the drug clashes with an amino acid in the active site. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode How remdesivir stalls the SARS-CoV-2 polymerase (Nat Comm) Movie of polymerase stalling (Nat Comm) Second mechanis
Thor's hammer
The TWiVers review phase 3 efficacy and safety results for the Novavax COVID-19 vaccine, effects on the neonatal immune system caused by maternal infection with SARS-CoV-2, and NHC, the metabolite of molnupiravir, causes mutations in cellular DNA. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Efficacy and safety of Novavax vaccine (medRxiv) A flo
COVID-19 clinical update #84 with Dr. Daniel Griffin
In COVID-19 clinical update #84, Dr. Griffin discusses childrens’ antibody response to vaccination, phase 3 results of Novavax vaccine, heterologous vaccination, antithrombotic therapy, EUA for molnupiravir, phase 3 results of AZD7442, serum ferritin levels and outcomes, heparin therapy, and WHO strategy for global vaccination. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Antibody profiles af
Long COVID and ME/CFS with David Tuller
David Tuller returns to TWiV to revisit his work to expose the methodological and ethical problems with the PACE trial, and the post-acute sequelae to SARS-CoV-2 infection, also known as long COVID. Host: Vincent Racaniello Guest: David Tuller Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Call me David Tuller (TWiV Special) David writes at virology blog Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology que
MIS-C with Moshe Arditi and Ivet Bahar
Moshe and Ivet join TWiV to discuss their finding that MIS-C is a consequence of a superantigen in the spike protein of SARS-CoV-2 that causes activation of a skewed population of T cell receptor bearing lymphocytes, leading to hyperinflammation. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit and Kathy Spindler Guests: Moshe Arditi and Ivet Behar Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MIS-C in US children (NEJM) Superant
COVID-19 clinical update #83 with Dr. Daniel Griffin
In COVID-19 clinical update #83, Daniel Griffin discusses upcoming FDA discussions on vaccines, strategies to prevent transmission at youth camps, outbreaks at summer camps, impact of vaccination on transmission, AZD7442 request for EUA filed, EUA issued for home antigen test, phase 3 data on AZD1222 vaccine, 6 month effectiveness of Pfizer/BioNTech vaccine, estimates of durability of immunity against reinfection, Molnupiravir interim results, optimal time for monoclonal antibody infusion, IVIG
COVID-19 at the European Society for Clinical Virology
From the 2021 online meeting of the European Society for Clinical Virology, Vincent speaks with meeting speakers on COVID-19 vaccines, immunity, how countries responded to the pandemic, and how to prepare for the next one. Host: Vincent Racaniello Guests: Sarah Gilbert, Florian Krammer, Fausto Baldanti, Thea Fischer, Ron Fouchier, and Catherine Moore Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Correlate of protection needed for COVID-
Bespoke capsids delivered
TWiV considers lessons learned from COVID-19 about emergency drug use during a pandemic, and selection of AAV capsids to produce vectors that efficiently deliver genes to muscle cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Emergency drug use during a pandemic (Cell) Muscle-directed AAV capsids (Cell) Designer AAV muscles up (Cell) Letters rea
COVID-19 clinical update #82 with Dr. Daniel Griffin
In COVID-19 clinical update #82, Daniel Griffin reviews vaccines for 5-12 years old, safety of a third vaccine dose, Oklahoma reinfection data, Regencov outcomes, Pfizer protease inhibitor, impact of Tocilizumab, and incidence of long COVID. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Data on Pfizer-BioNTech in 5-12 year olds (Pfizer) Safety of additional vaccine dose (MMWR) Oklahoma reinfe
Opening Pandora's box
TWiV reviews how a novel technology enabled development of COVID-19 mRNA vaccines, and discovery of a proton gradient and an incomplete TCA cycle in a giant. virus. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode mRNA vaccines, a novel technology (Cell) Proton gradient in giant virus (ISME J) Tomograms of Pandoravirus massiliensis Pandoraviruses are not alive (viro
Vampire vax
TWiV reveals isolation from bats in Laos of a SARS-CoV-2 like virus with a spike protein that allows entry into human cells, and exploration of a herpesvirus vector for immunization of vampire bats against rabies virus. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 like viruses from Laotian bats (Res Sq) Herpesvirus in rabies endemic vampire
Clinical update #81 with Dr. Daniel Griffin
In COVID-19 clinical update #81, Daniel Griffin discusses vaccine boosters, vaccination during pregnancy, mRNA vaccine comparison, J&J vaccine booster, EUA expansion for Lilly monoclonals, remdesivir reduces risk of hospitalization, and anticoagulation regimens. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pfizer phase III results in 5-11 year olds (Pfizer) FDA authorizes booster (FDA) V-safe
The shot yearned 'round the world with Chadi Saad-Roy and Caroline Wagner
Chadi and Caroline join TWiV to describe the potential epidemiological and evolutionary impacts of vaccine nationalism, and their modeling which emphasizes the importance of rapid equitable vaccine distribution for global control of the pandemic. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit and Brianne Barker Guests: Chadi Saad-Roy and Caroline Wagner Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine nationalism and contr
COVID-19 clinical update #80 with Dr. Daniel Griffin
In COVID-19 clinical update #80, Daniel Griffin reviews infections in children, masking, testing to limit transmission, high barrier for monoclonal antibody escape, are boosters needed, use of steroids, grants for long COVID, and how the pandemic unfolds in Africa. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Hospitalization pre- and post-vaccines (Res Sq) Infection in children (medRxiv) Update
Delta and boosters
The TWiVotopes review current evidence which does not show the need for widespread COVID-19 booster vaccination, and results of experiments to examine the replication and immune evasion of the SARS-CoV-2 delta variant. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV Vaccine Town Halls Vaccine boosters not needed (Lancet) Delta variant replication and immune evasi
A tangled web of viruses with Mya Breitbart
Virus hunter Mya Breitbart joins TWiV to describe her laboratory’s work on viruses in spiders, insects, millipedes, freshwater springs, seawater, plants, human feces and much more. Hosts: Vincent Racaniello, Alan Dove, and Dickson Despommier Guest: Mya Breitbart Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Viruses of spinybacked orbweavers (J Gen Virol) Viruses of terrestrial arthropods (PeerJ) Pepper mild mottle virus in sewage (PLoS Pat
COVID-19 clinical update #79 with Dr. Daniel Griffin
In COVID-19 clinical update #79, Daniel Griffin discusses clinical management guidelines, ER visits and hospitalization among children, infection and vaccine induced seroprevalence in the US, antibodies in Kenyan blood donors, infections after vaccination, anticoagulation for thromboprophylaxis, baracitinib efficacy, long-term symptoms in adults, and sustained symptoms after severe disease. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Becom
Another epitope with Shane Crotty
Shane Crotty returns to TWiV to review the immunology of COVID-19, including differences between infection and vaccination, increased breadth of antibodies after infection followed by vaccination, the roles of T cells, and whether booster vaccinations are needed. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Shane Crotty Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV Vaccine Town Halls SARS-CoV-2 immu
We can hear the coffin
The meteorologicomaniacs discuss the COVID-19 pandemic global death toll, effectiveness of vaccines against the delta variant, and how analysis of ancient viral DNA reveals that two pathogenic human viruses were brought into Mexico during the transatlantic slave trade. Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV Vaccine Town Halls COVID-19 exces
COVID-19 clinical update #78 with Dr. Daniel Griffin
In COVID-19 clinical update #78, Daniel Griffin covers ivermectin, convalescent plasma, disease in pregnant women, children and COVID, delta outbreak in an elementary school, validation of at-home antigen test, shedding in infected vaccinated people, mRNA vaccine antibody responses compared, AZD7442, fluvoxamine, one year outcomes in hospitalized patients, and post-vaccination disease. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a pat
A very model of a modern TWiV
TWiV reviews models for determining correlates of neutralizing antibody protection against COVID-19, and for identifying key vector and host species that drive transmission of zoonotic pathogens. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Correlate of protection needed for COVID-19 vaccines (Nat Med) Neutralizing antibodies predict protection against symptomatic
Rats, more coronaviruses!
The TWiV team explains what the Biden report on SARS-CoV-2 origins did not: evidence that the virus came from Nature, not a lab; and reveals new coronaviruses in rodents that inhabit populated areas in southern China. Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Biden preliminary report on virus origins (NY Times) Window on SARS-CoV-2 origins closin
COVID-19 clinical update #77 with Dr. Daniel Griffin
In COVID-19 clinical update #77, Daniel Griffin discusses children becoming increasingly infected, virological characteristics of infections in vaccinated health care workers, transmission dynamics among close contacts, licensing of Pfizer mRNA vaccine, cost of hospitalization of unvaccinated patients, 29 times higher hospitalization rates in unvaccinated patients, boost in neutralizing antibody potency and breadth by third vaccine dose, and use of J&J vaccine as second dose. Hosts: Daniel Griff
The vary hungry spike with Paul and Theodora
Paul and Theodora return to TWiV to explain their research on determining the number of neutralizing epitopes on the SARS-CoV-2 spike that are recognized by antibodies, and engineering of a polymutant spike with twenty amino acid changes that demonstrates the high genetic barrier to escape from convalescent serum. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guests: Paul Bieniasz and Theodora Hatiziiouannou Subscribe (free): iTunes, Google Podcasts, RSS, email
COVID-19 clinical update #76 with Dr. Daniel Griffin
In COVID-19 clinical update #76, Daniel Griffin covers association of age and pediatric household transmission, rapid antigen testing in remote communities, shedding of infectious virus in vaccinated individuals, FDA amendment of mRNA vaccine EUA to allow a third dose, new vaccine mandate for NY state, full vaccination suppresses selection of variants, effectiveness of mRNA vaccines in nursing homes, sustained effectiveness of mRNA vaccines against hospitalization, and no benefit from early conv
PAMS spray SARS-CoV-2
TWiV summarizes cases of arbovirus disease during 2019 in the US, and explains a study that estimates infectiousness throughout the SARS-CoV-2 course of infection. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Halls (ASV) Arboviral illness, US, 2019 (MMWR) Estimating SARS-CoV-2 infectiousness (Science) Timestamps by Jolene. Thanks! Weekl
COVID-19 clinical update with Dr. Daniel Griffin
In COVID-19 clinical update #75, Daniel Griffin reviews vaccine effectiveness against transmission, modeling effectiveness of daily antigen tests, updated CDC guidance for fully vaccinated, risk of infection with time after mRNA vaccination, reduced risk of infection after vaccination, therapeutic anticoagulants in critically ill patients, and 6 month outcomes in hospitalized patients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a pat
Transmission with Jeffrey Shaman
Jeffrey Shaman returns to TWiV to explain how epidemiologists measure SARS-CoV-2 movement among humans, including calculation of the reproductive index, secondary transmission, and what factors affect transmission. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guest: Jeffrey Shaman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode A guide to R (Nature) Epidemiology of three SARS-CoV-2 VOC (medRxiv) Impact of delta variant in In
A mad virologists' T party
TWiV reviews SARS-CoV-2 infection of wild white-tailed deer in the US, mRNA vaccine-mediated protection by spike-specific T cells before detection of neutralizing antibodies, and recovery from SARS-CoV-2 infection in T-cell depleted rhesus macaques. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 in wild deer (bioRxiv) Rapid T cell induction
COVID-19 clinical update #74 with Dr. Daniel Griffin
In COVID-19 clinical update #74, Daniel Griffin covers infections in vaccinated individuals, expansion of Regeneron monoclonal antibody cocktail for prophylaxis, neutralization of variants by antibodies produced by infection or vaccination, longer hospital stays associated with remdesivir treatment, and post-acute sequelae of infection and impact on quality of life 1-6 months after illness. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become
Does delta mean a change?
TWiV reviews a leaked CDC document on virulence and spread of the delta variant, and how anti-alphavirus antibodies that do not neutralize infection can nevertheless protect mice from disease. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode NYC first to require vaccination proof (Reuters) Leaked internal CDC document (WaPo) Manuscripts on increased virulence (one, t
neuroCOVID with Kiran Thakur, MD
Kiran joins TWiV to discuss the findings of a team at Columbia University Medical Center on COVID-19 neuropathology, and the conclusion that SARS-CoV-2 does not reproduce in the central nervous system. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guest: Kiran Thakur Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 neuropathology (Brain) Infections in vaccinated people (MMWR) Infections in vaccinated
COVID-19 clinical update #73 with Dr. Daniel Griffin
In COVID-19 clinical update #73, Daniel Griffin reviews updated mask guidance from CDC, infections in public school district employees, effectiveness of vaccines against delta variant, antibody response after third vaccine dose in kidney transplant recipients, protection afforded by mRNA vaccines fully vaccinated people with and without prior infections, correlates of protection in nonhuman primates, lack of effectiveness of doxycycline, neurological manifestations of COVID-19, and infection in
You make mucus and you move it
TWiVsters review off-season epidemics of respiratory syncytial virus in Australia after easing of COVID-19 restrictions, and impaired innate immune responses in upper respiratory tract cells from patients with severe COVID-19. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Off-season RSV in Australia (medRxiv) Impaired innate immunity in severe COVID-19 (Cell) Letter
COVID-19 Q&A with Dr. Daniel Griffin
In this special episode, Daniel Griffin answers listener questions on COVID-19 vaccines, vaccine misinformation, long COVID, masking and distancing, school safety, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Letters read on TWiV 785 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Virtually live from ASV
Moriah and Joseph join the nearly complete TWiV team to discuss their work on genetic variation and adaptability in herpes simplex virus, and how rotavirus infection disrupts intracellular calcium homeostasis. Live streamed during the 2021 annual meeting of the American Society for Virology. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Brianne Barker Guests: Joseph Hyzer and Moriah Szpara Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV
COVID-19 clinical update #72 with Dr. Daniel Griffin
In COVID-19 clinical update #72, Daniel Griffin covers long term symptoms in children, outcomes for MIS-C, recent guidance from the American Academy of Pediatrics, a large well traced outbreak of delta variant, low dose mRNA vaccination generates durable T cell memory and antibodies, protective immunity in recovered patients, assessment of BinaxNOW, no effect of oral azithromycin, post-discharge symptoms in Nigeria, and therapeutics for low and middle income countries. Hosts: Daniel Griffin and
An antibody for all sarbecoviruses
On this episode, broadening of immune responses to SARS-CoV-2 after mRNA vaccine booster to ChAdOx1 nCoV-19, five-fold underestimation of the number of cases in the US during the first six months of the pandemic, and a monoclonal antibody that broadly neutralizes many different sarbecoviruses. Hosts: Vincent Racaniello and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Immune responses after heterologous COVID-19 vaccine boost
My genome is left to tell the tale
The Team with Invincible Values discusses whether dogs or cats passively carry SARS-CoV-2 on hair and foot pads, maternal to fetal transfer of antibodies in infected or vaccinated pregnant women, and evidence that retroviruses infected cetaceans before and after they moved into the oceans. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 on dogs and cats (
COVID-19 clinical update #71 with Dr. Daniel Griffin
In COVID-19 clinical update #71, Daniel Griffin reviews updated school and child care guidance from CDC, transmission in schools, accuracy of lateral flow assays, update to J&J/Janssen vaccine EUA to include GBS, interim immunogenicity of Ad.26.CoV2.s, effectiveness of mRNA vaccines to prevent hospitalization, Bamlanivimab plus Etesevimab for mild or moderate disease, and a meta-analysis of ivermectin results. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts
Evolving boosterism
TWiV reviews evidence that COVID-19 mRNA vaccination of both uninfected and previously infected persons elicits cross-variant neutralizing antibodies, and directed evolution of a bacterial protein to form a virus-like capsid that specifically packages its encoding mRNA. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode mRNA vaccine boosts cross-variant neutralizing Ab (Science) mRNA vacc
COVID-19 clinical update #70 with Dr. Daniel Griffin
In COVID-19 clinical update #70, Daniel Griffin discusses efficacy of portable air cleaners, vaccine induced serum neutralizing antibodies against variants, prevention and attenuation of disease with mRNA vaccines, ivermectin to prevent hospitalization, IL-6 antagonists and mortality, and impact of vaccination on long COVID. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Efficacy of portable air
SARS-CoV-2 fitness with Ron Fouchier
Ron Fouchier explains why increased transmission of SARS-CoV-2-variants has not been demonstrated, and their ability to displace ancestral variants is due to greater fitness, much like influenza virus antigenic variation leads to better fitness and replacement of previously circulating variants. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guest: Ron Fouchier Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Ron Fouchier on TW
Yes! We have no pangolins
TWiV reviews an analysis of animal sales from Wuhan wet markets before the COVID-19 pandemic, control of dengue by release of Wolbachia-infected mosquitoes, and fatal dengue acquired in Florida. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Animal sales from Wuhan markets before COVID-19 (Sci Rep) Dengue control by Wolbachia-infected mosquitoes (NEJM) Fatal dengue in Florida (NEJM) L
COVID-19 clinical update #69 with Dr. Daniel Griffin
In COVID-19 clinical update #69, Daniel Griffin covers effectiveness of mRNA vaccines against the delta variant, depression among public health workers, correlates of protection against asymptomatic and symptomatic infection, BNT162b2 in ChAdOx-1-S primed individuals, prior infection rescues B and T cell responses to variants after vaccination, effect of vaccination on household transmission, germinal responses induced by mRNA vaccines, phase 3 results of Novavax vaccine, and long COVID as our
Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences
Kristian Andersen and Robert Garry join TWiV to discuss recovery of deleted deep sequencing data from early in the Wuhan SARS-CoV-2 epidemic, and whether they shed light on the early phase of the outbreak. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guests: Kristian Andersen and Robert Garry Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Andersen laboratory Recovery of deleted deep sequencing data (bioRxiv) Animal sales f
Laurie Garrett, pandemic prophet
Laurie Garrett, author of The Coming Plague, joins TWiV for a wide-ranging discussion of infectious disease and public health, including emerging infections, the role of wildlife markets in spillovers, and missteps in handling the COVID-19 pandemic. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guest: Laurie Garrett Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Lauriegarrett.com The Coming Plague Betrayal of Trust Trump sab
COVID-19 clinical update #68 with Dr. Daniel Griffin
In COVID-19 clinical update #68, Daniel Griffin discusses children acquiring infection at birthday parties, immunogenicity of vaccines in solid organ transplant patients, reinfection rates in recovered patients, lack of efficacy of azithromycin, bacterial and fungal infections in hospitalized patients, effect of monoclonal antibody treatment on clinical outcomes of ambulatory patients, and reduction in mortality of hospitalized patients treated with remedesivir. Hosts: Daniel Griffin and Vincent
Borna hundred million years ago
A TWiV trio reveals the 100 million year old history of bornavirus infections hidden as EVEs in vertebrate genomes, and identification of novel bat coronaviruses that provide evolutionary insight into the origins of SARS-CoV-2. Hosts: Vincent Racaniello, Alan Dove, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV Vaccine Town Hall 2:05 100 million year old bornavirus infections (PNAS) Bornaviruses across geological times
COVID-19 clinical update #67 with Dr. Daniel Griffin
In COVID-19 clinical update #67, Daniel Griffin reviews antibodies to the virus early in the US, serology testing of blood donations, MIS-C in children under 21, myocarditis in competitive athletes, ER visits for suspected suicide attempts, delta variant in Scotland, Novavax vaccine phase 3 results, vaccine coverage in pregnant women, early monoclonal administration reduces hospitalization and mortality, casirivimab and imdevimab recovery trial results, and CDC guidance on postacute sequelae. Ho
MIS-C and leaky gut
On this episode of TWiV, Novavax COVID-19 vaccine demonstrates 90% overall efficacy, preventing an antigenically disruptive change during growth of influenza virus vaccine in chicken eggs, and MIS-C is driven by loss of the gut mucosal barrier. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Click arrow to play Download TWiV 769 (68 MB .mp3, 114 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV Vaccine Town Hall 2:05 Nov
Can nanobody stop these variants?
TWiV describes how human behavior, not increased transmissibility, led to increased spread of a SARS-CoV-2 variant throughout Europe in summer 2020, and nanobodies from camelid mice and llamas that efficiently neutralize variants of concern. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV Vaccine Town Hall Spread of SARS-CoV-2 variant in summer 2020 (Nature) Nan
COVID-19 clinical update #66 with Dr. Daniel Griffin
In COVID-19 clinical update #66, Daniel Griffin covers treatment guidelines from IDSA, hospitalization of adolescents, estimating epidemiological dynamics from viral load distributions, incidence of infection according to baseline antibody status, assessment of reinfection in Italy, need for vaccination in previously infected individuals, assessment of protection against reinfection, antimicrobial use in hospitalized patients, effect of single dose ivermectin, and a trial of aspirin in hospitali
The CORONA project with David Fajgenbaum
David joins TWiV to relate how his near-death experience with Castleman’s disease motivated him to found the Center for Cytokine Storm Treatment & Laboratory and the CORONA project to identify and track all treatments reported for COVID-19 in an open-source data repository. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guest: David Fajgenbaum Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode CORONA project Center for Cytokine S
Potpourri of COVID-19
TWiV reviews the new nomenclature for SARS-CoV-2 variants, effectiveness of Pfizer/BioNTech vaccine against variants, modified Moderna vaccine against variants, impact of COVID-19 interventions on influenza in China and the US, and binding of RaTG13 spike protein to ACE2 of multiple species. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Updated nomenc
COVID-19 clinical update #65 with Dr. Daniel Griffin
In COVID-19 clinical update #65, Daniel Griffin summarizes effects of non-pharmaceutical interventions, updated summer camp guidance from CDC, serology testing not recommended by FDA, antigen tests during a music event, inhibition of vaccine immunogenicity by methotrexate, phase 3 trial results for colchicine, and small airway disease as a post-acute sequelae. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for thi
Cap-snatch fever
TWiV explains how cap-snatching, the priming of viral mRNA synthesis with fragments of host mRNAs, can lead to the synthesis of novel viral proteins. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Cap-snatching makes new ORFs (Cell) Cap-snatching leads to novel proteins (Cell) Letters read on TWiV 763 Timestamps by Jolene. Thanks! Weekly Picks Kathy – Flat pasta that turns into s
SARS-CoV-2 origins with Robert Garry
Robert Garry joins TWiV to explain how the molecular biology of SARS-CoV-2 shows that it came from Nature and not a lab, including the receptor binding domain, the furin cleavage site, and the two lineages circulating in Wuhan wildlife markets. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Robert Garry Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode The proximal origin of SARS-CoV-2 (Nature
COVID-19 clinical update #64 with Dr. Daniel Griffin
In COVID-19 clinical update #64, Daniel Griffin covers new guidance from NY on day camps, mitigation and infection rates in schools, testing to sustain in person instruction, Moderna mRNA vaccine highly effective in adolescents, longer storage of Pfizer vaccine, FDA EUA for sotrovimab, and persistent illness in UK children. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Guidance on child camps
SARS-CoV-2 origins with Peter Daszak, Thea Kølsen Fischer, Marion Koopmans
Peter Daszak, Thea Kølsen Fischer, and Marion Koopmans, members of the WHO team investigating the origins of SARS-CoV-2 join TWiV to explain the work done by the committee during phase one, their conclusions, and the extent of work that remains to be done in phase two. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Peter Daszak, Thea Kølsen Fischer, and Marion Koopmans Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pete
Pork dogs and an evolutionary pickle
TWiV examines spillovers of porcine and canine coronaviruses into humans in Haiti and Malaysia, and how antigenic evolution of measles virus is constrained by multiple co-dominant epitopes on the viral glycoproteins. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV vaccine town halls 15:10 Porcine deltacoronavirus in Haitian children (medRxiv) Canin
COVID-19 clinical update #63 with Dr. Daniel Griffin
In COVID-19 clinical update #63, Daniel Griffin reviews cases at child care facilities, estimates of mRNA vaccine effectiveness, risk of reinfection in university students, enhanced antibody generation with extended interval of mRNA vaccination, no benefit of convalescent plasma in hospitalized patients, and risk of clinical sequelae after acute infection. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this ep
Supershedders and super vaccines
TWiV reveals that 2% of SARS-CoV-2−positive individuals carry 90% of the virus circulating in a college campus, and a nanoparticle vaccine that induces cross-reactive immunity against multiple pandemic and pre-emergent coronaviruses. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV vaccine town halls 2% of SARS-CoV-2 positives carry most viral RNA (PNAS) Pan-coron
Precluding problematic polio prophylaxis
TWiV returns to the 2012 brouhaha over transmission experiments with avian H5N1 influenza virus, re-examines the claim of SARS-CoV-2 RNA integration into human DNA, and reviews the engineering and testing of a genetically stable version of the attenuated type 2 Sabin poliovirus vaccine. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV vaccine town ha
COVID-19 clinical update #62 with Dr. Daniel Griffin
In COVID-19 clinical update #62, Daniel Griffin covers outdoor transmission of the virus, safe use of NSAIDS, expansion of Pfizer/BioNTech vaccine to include 12-15 year olds, post-disease Mucormycosis, and hydroxychloroquine treatment associated with increased mortality. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Moderna vaccine safe, effective in teens (AAP news) Review of outdoor transmiss
Tuesday two: SARS-CoV-2 and TLR2
TWiV discusses the finding that the envelope (E) protein of SARS-CoV-2 is sensed by toll-like receptor 2 on cells, leading to the production of inflammatory cytokines that cause damage to cells and tissues in COVID-19. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV vaccine town halls Michelson Prizes FDA authorizes Pfizer/BioNTech mRNA vaccine for adolescents (
The ferret nose where the virus goes
TWiV revisits Brazil’s rejection of Sputnik vaccine, examines influenza transmission via the air from the nasal epithelium of ferrets, and a history of accidental releases of polioviruses and their relevance for eradication of poliomyelitis. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV vaccine town halls Sputnik Light Ferret airborne transmissi
COVID-19 clinical update #61 with Dr. Daniel Griffin
In COVID-19 clinical update #61, Daniel Griffin reviews a modeling of future hospitalizations and deaths by vaccination rates and non pharmaceutical intervention scenarios, performance evaluation of rapid antigen tests, children making up a growing share of new cases, antibody response to mRNA vaccine in solid organ transplant recipients, and outcomes in hospitalized patients treated with tocilizumab. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, em
Sputnik spat and furin in ferrets
TWiV examines the claim by Brazil’s ANVISA that the Sputnik vaccine contains replication-competent adenovirus, and a role for the furin cleavage site in SARS-CoV-2 spike for efficient reproduction in the respiratory tract, evasion of antiviral IFITM proteins, and transmission in ferrets. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV vaccine town halls Brazil rejects Gamaleya
To err is viral
The TWiVmeisters discuss how copy-back defective viral genomes might modulate the clinical outcome of respiratory syncytial virus infection, and detection of antibodies to henipa- and filo-like viruses in Trinidad bats. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine education town halls (ASV) RSV cpDVG may influence clinical outcome (Nat Micro
COVID-19 clinical update #60 with Dr. Daniel Griffin
In COVID-19 clinical update #60, Daniel Griffin summarizes CDC guidance for summer camps, how to protect yourself when fully vaccinated, updated recommendation for J&J vaccine, declining global case fatality rate, and characterization of post-acute sequelae. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Summer camp guidance (CDC) Protect yourself when fully vaccinated (CDC) Updated recommendat
SARS-CoV-2 gets a sense of humoral
A TWiV trio explains a method for sequencing single genomes of SARS-CoV-2 and its use to explore in-host evolution drive by antibody responses, and incidence of cerebral venous thrombosis in COVID-19 patients and vaccine recipients. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode In-host SARS-CoV-2 evolution drive by antibody (PLoS Path) COVID-19 and CVT (OSF) CoronaVac underperforms
COVID-19 clinical update #59 with Dr. Daniel Griffin
Daniel Griffin discusses a front-line health care worker survey, pre-exposure seropositivity and subsequent infection in healthy young adults, fitted filtration efficiency of double masking, BinaxNow rapid in-home antigen test, postvaccination infections in a nursing facility, safety of mRNA vaccine in pregnant women, case control study of Bamlanivimab, no evidence for brain infection in patients with neurolgical symptoms, and mortality among US patients hospitalized with COVID-19. Hosts: Daniel
Encephalitis viruses dine on caveolae
Team TWiV explains how alphaviruses like Western equine encephalitis virus cross into the brain from capillaries by caveolin-mediated transcytosis, and reveal scientists’ incentives and attitudes towards public communication. Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Viral brain entry by transcytosis across endothelial cells (mBio) Scientists attitudes to
Gorilla COVID with Nadine Lamberski
Nadine Lamberski joins TWiV to discuss an outbreak of COVID-19 among gorillas at the San Diego Zoo, and the use of a spike protein-based vaccine to immunize the animals. Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker Guest: Nadine Lamberski Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Gorillas receive COVID-19 vaccine (Nat Geo) COVID-19 vaccine for great apes and mink (Zoetis) Letters read on TWiV 745 Timestam
COVID-19 clinical update #58 with Dr. Daniel Griffin
In COVID-19 clinical update #58, Daniel Griffin provides the latest update on the J&J vaccine pause, healthcare worker deaths, children and COVID, physical inactivity associated with higher risk, using monoclonal antibodies for prophylaxis, and shows us how to properly wear a face mask. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Healthcare worker deaths (Guardian) Children and adolescent di
Shape-shifting viruses
The TWiVsters explain how the shape of pleomorphic virus particles – spherical or filamentous – determines the probability of virus attachment and fusion, and resistance to selective pressure such as antibodies that block cell entry. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pleomorphic virus particles and cell entry (Nat Micro) Letters read on TWiV 743 Time
De-fusing COVID-19
TWiV reviews a drug screen for inhibitors of syncytium formation, the fusing of cells caused by SARS-CoV-2, which reveals that the process is regulated by a calcium-activated ion channel and scramblase that is inhibited by the anti-parasite drug Niclosamide. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode TMEM16 inhibitors block SARS-CoV-2 driven syncytium formation (Natu
COVID-19 clinical update #57 with Dr. Daniel Griffin
In COVID-19 clinical update #57, Daniel Griffin covers children and MIS-C, school opening plans, transmission event with masks, fomite transmission, diagnostic test performance, AZ vaccine and blood clots, and long COVID and the effect of vaccines. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Children with MIS-C (JAMA) Transmission with masks (Op For Inf Dis) Accuracy of diagnostic tests (J Cli
Complementation will get you everywhere
The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode NIDO 2021 Symposium ASV hosts f
COVID-19 convalescent plasma with Arturo Casadevall
Arturo Casadevall joins TWiV to discuss the use of convalescent plasma to treat COVID-19, including a history of the process, how plasma is prepared and tested, why it is difficult to conduct randomized clinical trials, how this treatment has fared and his hopes for the future. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Guest: Arturo Casadevall Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Victory for Scientif
COVID-19 clinical update #56 with Dr. Daniel Griffin
In COVID-19 clinical update #56, Daniel Griffin note increasing hospitalization in children and young adults, Pfizer vaccine efficacy results in 12-15 year olds, rapid self administered nucleic acid and antigen tests, mRNA vaccine efficacy in real world conditions, and improvement of long COVID after vaccination. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pfizer mRNA vaccine is 100% effective
SARS-CoV-2 in NYC wastewater
John, Monica, and Davida join TWiV to discuss development of a method to detect SARS-CoV-2 in raw sewage from all 14 of New York City’s treatment plants, and its use to determine the presence of the genome throughout the pandemic and detection of genome mutations from variants of concern. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: John Dennehy, Davida Smyth, and Monica Trujillo Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TW
Rhapsody in T with Alessandro Sette
Alessandro Sette joins TWiV to discuss the role of T cells in COVID-19, the finding that amino acid changes in SARS-CoV-2 variants of concern have a negligible impact on T cell reactivity in convalescent patients and vaccinees, and whether a next generation vaccine should include more viral proteins than spike. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Alessandro Sette Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for thi
COVID-19 clinical update #55 with Dr. Daniel Griffin
In COVID-19 clinical update #55, Daniel Griffin reviews recommendations for keeping transmission low in school settings, optimal testing strategies for schools and businesses, impact of vaccines on asymptomatic infections, vaccine safety in PASC patients, and early use of aspirin associated with decreased mortality. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 in primary and secondary
Weiss hath no furin like a virus scorned
Susan Weiss returns to TWiV to discuss coronavirus entry into cells and the role of spike protein cleavage by proteases, why lab escaped hypotheses for SARS-CoV-2 are unlikely, and modulation of innate immune responses during infection. Hosts: Vincent Racaniello, Rich Condit, Alan Dove, Brianne Barker, and Amy Rosenfeld Guest: Susan Weiss Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode CoV pathogenesis in CNS (J Neuro Pharm) SARS-CoV-2 ind
COVID-19 clinical update #54 with Dr. Daniel Griffin
In COVID-19 clinical update #54, Daniel Griffin covers effectiveness of 3 vs 6 ft physical distancing, effectiveness of masks, physical distancing, and eye shields, second vaccine dose completion, alleviation of COVID-19 symptoms after vaccination, vaccine trials in children, and IDSA approval of a mAb cocktail. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Effectiveness of 3 ft vs 6 ft (CID)
Citizen science with Forest Rohwer and Maria-Isabel Rojas
Forest and Maria-Isabel join TWiV to discuss their their project to engage thousands of citizens to swab inanimate surfaces in the San Diego area, then send the samples to the Rohwer Lab for nucleic acid analysis. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Forest on TWiV 391 Swabbing surfaces in San Diego (10News) Nido21 meeting Molnupiravi
The kids aren't alright
On a TWiV tetramer, we review the ongoing outbreaks of Ebolavirus disease in DRC and Guinea, evidence that SARS-CoV-2 infections in children are far more prevalent than are being detected, and recent long COVID estimates from the UK. Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Ebolavirus disease outbreak continues in Africa (ProMedMail) List of Ebolavirus outbreaks (W
COVID-19 clinical update #53 with Dr. Daniel Griffin
In COVID-19 clinical update #53, Daniel Griffin reviews underreporting of infections and long term disease in children, a blood test for T cells, results of phase 3 trials for monoclonal antibodies, preliminary findings on an oral antiviral, clinical trial of ivermectin, and recommendations for upcoming gatherings. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 seroprevalence in EUA
A floret of spikes with Matt Frieman
Matt Frieman returns to TWiV to discuss the COVID-19 pandemic from the point of view of a coronavirologist, including his work with Novavax on their spike protein-based vaccine. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Matt Frieman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Phase 1-2 trial of Novavax protein vaccine (NEJM) MERS-CoV spike nanoparticle vaccine in mice (Vaccine)
Cover your nose and mouse
TWiV notes the passing of Mavis Agbandje-McKenna, and reviews data on maximizing fit for cloth and medical procedure masks, SARS-CoV-2 total and subgenomic viral load in hospitalized patients, and effect of changes in spike protein on efficacy in a mouse model of infection. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Mavis Agbandje-McKenna dies (U
COVID-19 clinical update #52 with Dr. Daniel Griffin
In COVID-19 clinical update #52, Daniel Griffin reviews differences in attack rates between children and adults, J&J vaccine phase III data, G6PD deficiency and vaccines, NIH halts convalescent plasma trial, dexamethasone in hospitalized patients, data on tocilizumab, and long COVID in children. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 attack rates in children and adults (Clin In
Molecular animator Janet Iwasa
Janet Iwasa joins TWiV to recount how she became a molecular animator, including a pivot during her Ph.D. thesis research, the value of animations in science, and their latest animation of SARS-CoV-2 entry into cells. Hosts: Vincent Racaniello, Rich Condit, Brianne Barker and Kathy Spindler Guest: Janet Iwasa Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode The Animation Lab SARS-CoV-2 animation Documents for J&J COVID-19 vaccine review (F
Eva Harris and Janet Smith clip flavivirus wings
Eva Harris and Janet Smith join TWiV to discuss how an antibody against dengue virus NS1 protein blocks endothelial dysfunction and the potential of treating infections by multiple flaviviruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Eva Harris and Janet Smith Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Eva Harris on TWiV 228 Zika virus in Nicaragua (virology blog) How an antibody block NS1-mediate
COVID-19 clinical update #51 with Dr. Daniel Griffin
In COVID-19 clinical update #51, Daniel Griffin reviews use of two masks, effectiveness of testing in nursing homes, updates on vaccines, use of nonsteroidal anti-inflammatory drugs, little effect of vitamin D and remdesivir in clinical studies, and a long COVID research initiative from NIH. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Updated NYC mask guidance (NYC Health) Two masks recommend
COVID-19 palliative care with Ginger Campbell, MD
Ginger Campbell joins TWiV to discuss palliative care for COVID-19 patients, and how to approach the disease from a goals of care perspective. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guest: Ginger Campbell, MD Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Brain Science Podcast Dr. Campbell’s video on palliative care (YouTube) Resources on palliative care (WHO) Interviews with Paul Offit (one, two) B
More coronaviruses in the pipeline
The entire TWiV team assembles to discuss resurgence of COVID-19 in Manaus, Brazil, discovery of SARS-CoV-2 related viruses in bats in Southeast Asia, and increased Ct values after administration of mRNA vaccine. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Resurgence of COVID-19 in Manaus (Lancet) SARS-CoV-2 related viruses in Sout
COVID-19 clinical update #50 with Dr. Daniel Griffin
In COVID-19 clinical update #50, Daniel Griffin discusses CDC guidance on school opening, decreased viral load after vaccination, randomized clinical trial of vitamin D treatment, a study of zinc plus vitamin C, anticoagulation therapy effect on mortality, and multi system inflammatory phase in children. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Guidance on school openings (CDC) Calcifediol
With vaccines, Offit is on it
Paul Offit joins TWiV to discuss all things vaccine, including how COVID-19 vaccine development was accelerated, whether the vaccines are safe and efficacious, the difference between an EUA and a licensed vaccine, sterilizing immunity, herd immunity, and much more. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Paul Offit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine education cent
COVID-19 clinical update #49 with Dr. Daniel Griffin
In COVID-19 clinical update #49, Daniel Griffin discusses CDC guidelines on mask use, drop in test frequency in the US, resurgence of COVID-19 in Brazil, possible impact of Pfizer vaccine on viral load, EUA for bamlanivimab and etesevimab administered together, and preliminary results of Tocilizumab in hospitalized patients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Resurgence of COVID-19 i
Recombining vaccine schedules
TWiV explores single dose administration and timing of second dose of AZD1222 COVID-19 vaccine, safety and efficacy of Sputnik V, and control of coronavirus recombination by a viral proofreading exonuclease. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode AZD1222 single dose efficacy and booster timing (Lancet preprint) Safety and efficacy of Sputnik V vaccine (Lance
Paul and Theodora, pandemic explorers
Theodora and Paul return to TWiV to explain how they quickly pivoted their retrovirus laboratories towards SARS-CoV-2, their work on the antibody response to infection and its durability, and the emergence of variants with increased resistance to neutralization. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guests: Paul Bieniasz and Theodora Hatziioannou Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Evolution
COVID-19 clinical update #48 with Dr. Daniel Griffin
In COVID-19 clinical update #48, Daniel Griffin reviews effect of spike amino acid changes on neutralization with monoclonal antibodies, Sputnik V safety and efficacy results, increased reactogenicity after a single vaccine dose in seropositive individuals, single dose vaccination in seropositive health care workers, and results of three clinical trials on the use of anticoagulants. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron
Fauci ouchy
TWiV explains why hydroxychloroquine failed in humans despite showing antiviral effects in cells, and reviews the published data on the Pfizer/BioNTech mRNA vaccine. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode TMPRSS2 is why hydroxychloroquine failed (PLoS Path) Safety and efficacy of BNT162b2 mRNA vaccine (NEJM) Letters read on TWiV 715 Timestamps by Jolene. T
The shape of spike with Jason McLellan
Jason McLellan joins TWiV to reveal all we know about the SARS-CoV-2 spike protein, followed by Novavax and J&S phase 3 results and a discussion of variants of concern: neutralization by vaccine-induced antibodies, transmission, and virulence. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld Guest: Jason McLellan Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Prefusion spike structure (Science) Neutr
COVID-19 clinical update #47 with Dr. Daniel Griffin
In COVID-19 clinical update #47, Daniel Griffin reviews phase 3 results for Novavax and J&J vaccines, transmission in K-12 settings in Wisconsin, data on Lilly and Regeneron monoclonal antibody therapy, and a study of colchicine for treatment of disease. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Novavax vaccine phase 3 results (Novavax) J&J vaccine phase 3 results (J&J) COVID-19 and transm
Deutscher Virus Wahnsinn
Gisa, Steffi, and César join TWiV to discuss their careers, their research, and the COVID-19 pandemic in Germany. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Gisa Gerold, Stefanie Becker, and César Muñoz-Fontela Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode German Society for Virology Ticks in Germany and TBEV (Sci Rep) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions a
The New Heal
The TWiVers review Biden’s national strategy for the COVID-19 responses and pandemic preparedness, and an evaluation of the BinaxNOW rapid antigen test for SARS-CoV-2 infection. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Biden’s COVID-19 strategy (pdf) CDC evaluation of BinaxNOW antigen test (MMWR) FDA instructions for BinaxNOW test (pdf) Adam Nee
COVID-19 clinical update #46 with Dr. Daniel Griffin
In COVID-19 clinical update #46, Daniel Griffin discusses the BinaxNow rapid antigen test, efficacy of Bamlanivimab in nursing homes, associations of serum vitamin D concentrations with in-hospital mortality and need for invasive mechanical ventilation, trials of IL-6 receptor antagonists, effects of anticoagulants on in-hospital mortality, and symptom persistence in outpatients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of
COVID cherry picking
In this episode, President Biden elevates his science advisor to his Cabinet, a review of the current flu season, the scientific goals of the WHO-convened Global Study of the Origins of SARS-CoV-2, and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode President’s science advisor to Cabinet (NY Times) Letter from Biden to Lander (pdf) Weekly flu (CDC) We
Alpaca llama full of nanobodies
The TWiVy team deconstructs CoronaVac, the inactivated SARS-CoV-2 vaccine produced by Sinovac Biotech, and production of multivalent camelid nanobodies that block infection with the virus and suppress selection of neturalization-resistant variants. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode David Kessler to head Operation Warp Speed (NY Times) Ph
COVID-19 clinical update #45 with Dr. Daniel Griffin
In COVID-19 clinical update #45, Daniel Griffin discusses J&J Ad26 vaccine results, reactogenicity after the second dose of mRNA vaccines, expansion of vaccine eligibility, and the finding that encephalitis after SARS-CoV-2 infection is a cytokine release syndrome. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode J&J Ad26 vaccine phase 1/2 results (NEJM) SARS-CoV-2 encephalitis is a cytokine relea
Do as Dr. Fauci says
TWiV answers listener questions about pandemic response, excess deaths in 25-44 year olds, vaccines, vaccines, and vaccines. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Poems are at Twiverse 2020 US traffic deaths (Car & Driver) National Vaccine Injury Compensation Program (HRSA) Jet injector (Wikipedia) Letters read on TWiV 706 Timestamps by Jolene. Thanks! We
Rocky Mountain COVID with Emily Travanty
Emily Travanty from the Colorado Department of Public Health and Environment joins TWiV to discuss how her laboratory was the first in the US to detect the SARS-CoV-2 variant VOC 202012/01. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Emily Travanty Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode VOC detected in Colorado (WaPo) US has sequenced only 50,000 SARS-CoV-2 genomes (CDC) Human
COVID-19 clinical update #44 with Dr. Daniel Griffin
In this COVID-19 clinical update, Daniel Griffin summarizes current status of vaccination in the US, discusses a study on convalescent sera from Argentina, use of remdesivir in patients with kidney disease, and provides further considerations on the use of Ct values in patient management. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Argentine study on plasma therapy (NEJM) Ct values and clinic
Does dose matter?
On this episode, a discussion of why modifying the dose schedule of the mRNA vaccines in the US is not a good idea, evidence that lower Ct values on hospital admission is associated with higher mortality, and dose-dependent response to SARS-CoV-2 infection of ferrets. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position Follow authorized
Year of the Pandemic
For this first episode of 2021, the complete TWiV team reviews compelling virology stories of 2020, and thanks the multitude of guests who have helped us to navigate the pandemic, and our many listeners who turn to us for scientific facts. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Poems are at Twiverse This little virus went to ma
COVID-19 clinical update #43 with Dr. Daniel Griffin
In Daniel Griffin’s final clinical report for 2020, he summarizes what we have learned about the clinical management of COVID-19 patients in the past year. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Attributes and predictors of long COVID-19 (medRxiv) Letters read on TWiV 701 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@mi
'Twas COVID and the aerosols
TWiV reviews additional data on the UK variant of SARS-CoV-2, the distinct variant spreading in South Africa, association of afucosylated antiviral IgG with severe COVID-19, approval of AstraZeneca vaccine in the UK, and winners of the pandemic poem contest. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position PHE update #2 (pdf) South Af
Arboviruses at ASTMH
From the 2020 online meeting of the American Society for Tropical Medicine and Hygiene, Vincent speaks with Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira about their careers and their research on arthropod-borne viruses. Host: Vincent Racaniello Guests: Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode RNAi in arbo
COVID-19 clinical update #42 with Dr. Daniel Griffin
Daniel Griffin provides his weekly clinical report on COVID-19, including his own experience with vaccination, guidelines for vaccine distribution, reasons for under-utilization of monoclonal antibody therapy, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Phased allocation of COVID-19 vaccines (ACIP slides) How CDC is making COVID-19 vaccine recommendations (CDC) Letters read on
The sky is NOT falling
TWiV reviews the latest data on the UK variant of SARS-CoV-2, including some properties of the variant and why it is being closely studied, development of liver cancer in a participant in a adenovirus-associated virus gene therapy trial, and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position 3:39 NERVTAG m
Tear down that SARS-CoV-2 manuscript
TWiV explains that COVID-19 is not harmless for young adults, FAA approval for Pfizer mRNA vaccine, lack of justification for the claim of reverse transcription of SARS-CoV-2 RNA and integration into the human genome, and lack of evidence for increased transmission by new variants in the UK. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode BSL-3 labora
COVID-19 clinical update #41 with Dr. Daniel Griffin
Daniel Griffin provides his weekly clinical report on COVID-19, including thoughts on the first immunizations with Pfizer mRNA vaccine, the anticipated EUA for the Moderna vaccine, whether the vaccine prevents infection, not just disease, monoclonal antibody therapy, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA EUA for Pfizer mRNA vaccine (FDA) Ellume at-home SARS-CoV-2 anti
Mitigating COVID-19
On this episode, TWiV makes Bloomberg Business News 2020 Jealousy List, crushing of CDC revealed by insiders, seasonal influenza during the COVID-19 pandemic, FDA briefing documents from Moderna, and three-quarters attack rate of SARS-CoV-2 during an unmitigated epidemic in Brazil. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position TWiV
Vax to the future
On this episode, FDA EUA for Pfizer mRNA vaccine, efficacy of AstraZeneca ChAdOx1 COVID-19 vaccine, and an orally administered drug that blocks SARS-CoV-2 transmission in ferrets. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode BSL-3 laboratory assistant manager position FDA advisory committee votes in favor of EUA for Pfizer vaccine (NY Times) Sanof
COVID-19 clinical update #40 with Dr. Daniel Griffin
Daniel Griffin provides his weekly clinical report on COVID-19, including the anticipated EUA for the Pfizer mRNA vaccine, mitigation strategies in early care and education settings, expressive aphasia, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Mitigation strategies in early care and education settings (MMWR) WHO solidarity trial results (NEJM) Letters read on TWiV 692 Timesta
SciArt with Laura Splan
SciArtist Laura Splan joins TWiV to reveal her transdisciplinary work that intersects science, technology, design and culture, then we discuss an inverse correlation between mumps virus antibodies induced by MMR vaccine and COVID-19 severity, and whether ivermectin is indicated for treatment of COVID-19. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Laura Splan Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this epis
This is your brain on SARS-CoV-2
TWiV reviews the difficulties in predicting species susceptibility to SARS-CoV-2 infection by only examining the ACE2 protein, and the olfactory mucosa as a portal of entry into the central nervous system in COVID-19 patients. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guest: Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode NYC will create pandemic response institute (NY Bus J) Comparison of ACE2
COVID-19 clinical update #39 with Dr. Daniel Griffin
Daniel Griffin provides his weekly clinical report on COVID-19, including analysis of vitamin D levels in patients, information on Moderna and Pfizer vaccines, distribution plans suggested by ACIP, and more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vitamin D levels in COVID-19 patients (Nature) ACIP recommendations for distribution of COVID-19 vaccine (MMWR) Updated CDC guidance on when t
We put COVID-19 papers through a sieve
TWiV 688: We put COVID-19 papers through a sieve December 2, 2020 On this episode, UK grants EUA for Pfizer vaccine, advice for CDC on who to immunize first, news from Das Coronavirus, SARS-CoV-2 protease regulates innate responses, and viral mRNAs are not an indication of viral replication. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode UK grants EUA for Pfizer v
Peter Hotez sticks to the vax
Peter Hotez joins TWiV to discuss the COVID-19 pandemic, including why it went out of control in the US, the hijacking of public health practices by anti-science extremist groups, prospects for control, and whether we will be prepared for the next one. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Peter Hotez Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Peter Hotez on TWiP 29 and TWiV S
COVID-19 clinical update #38 with Dr. Daniel Griffin
Daniel Griffin provides his weekly clinical report on COVID-19, including new post-exposure guidelines from CDC, clinical trials of Remdesivir and convalescent plasma, FDA EUA for baricitinib and Regeneron’s monoclonal antibody and more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode WHO Solidarity trial for Remdesivir and other drugs (medRxiv) EUA for Baricitinib (FDA) EUA for Casirivimab and
Pandemicky
The TWiVers analyze efficacy of the AstraZeneca/Oxford adenovirus vectored vaccine, SARS-CoV-2 did not infect miners who became ill 8 years ago after cleaning bat guano from a cave in Yunnan Province, and induction of antigen-specific germinal center responses and production of neutralizing antibody by SARS-CoV-2 mRNA vaccine but not purified protein. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, emailBecome a patron o
Persistence of SARS-CoV-2 immune memory
Daniel Griffin provides a clinical report on COVID-19, and Shane Crotty explains a study of antibodies, B cells and T cells in patients which suggests that immunological memory to SARS-CoV-2 might be long-lived. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Shane Crotty Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA authorizes Lucira mini home testing kit (FDA) 60 day outcomes
Two COVID-19 mRNA vaccines
On this episode of TWiV, mRNA vaccines from Moderna and Pfizer show over 90% efficacy, prothrombotic auto-antibodies in serum of COVID-19 patients, and the whereabouts of SARS-CoV-2 in the human body. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Efficacy of Moderna and Pfizer mRNA vaccines Longer shelf life of Moderna vaccine (Moderna) Prothrombotic antibodies
Kate Rubins from the International Space Station
From Expedition 64 of International Space Station, Flight Engineer Kate Rubins joins TWiV to discuss experiments that she is working on, including cell cultures, genome sequencing, and plant growth. Hosts: Vincent Racaniello and Rich Condit Guest: Kate Rubins Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Crowley, coats, and cross-reactive antibodies
Daniel Griffin provides a clinical report on COVID-19, Kathleen Crowley explains the role of Environmental Health & Safety departments, update on SARS-CoV-2 transmission in farmed mink, and the presence of pre-existing antibodies to SARS-CoV-2 in unexposed individuals. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Kathleen A. Crowley Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for th
Long-term COVID and ME/CFS
Mady, Fiona, and David join TWiV to discuss patients with long-term COVID and similarities and differences with ME/CFS. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guests: Mady Hornig, Fiona Lowenstein, and David Tuller Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Body Politic Survivor Corps Long-haulers redefining COVID-19 (Ed Yong) I’m 26. Coronavirus sent me to the hospital (Fiona Lowenstein) We need to talk about wha
Mink, mutation, and myocytes
Daniel Griffin provides a clinical report on COVID-19, Slovlakia’s plan to test all adults for SARS-CoV-2 infection, viral variants arising in Danish mink and their potential threat to humans, why it is unethical to carry out challenge trials, Nipah virus dynamics in bats and spillovers into humans, and direct cardiac damage by spike-mediated cardiomyocyte fusion. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Amy Rosenfeld S
Fishing for viruses with Nels Elde
Nels joins TWiV to reveal the discovery of a picornavirus of zebrafish by measuring immune responses in the host, genome sequence analysis of the White House COVID-19 outbreak, and a six-fold higher SARS-CoV-2 exposure rate than reported cases in German children. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guest: Nels Elde Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Zebrafish virus discovery by visualization (Curr Biol) V
Does antibody really know what time it is?
Daniel Griffin provides a clinical report on COVID-19, then we discuss rapid deployment of SARS-CoV-2 testing by research laboratories in San Francisco, longitudinal observation of antibodies to SARS-CoV-2 in patients, and listener questions on vaccines, loss of smell, face masks, and more. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Daniel’s COVID-19 graph (Twitter) Cornell U containment victory (Bloomberg) Regeneron mAb trial paused
Tragic gene flow from Neanderthals
In this episode we explain how regions of the human genome associated with severe COVID-19 are identified, the finding that one of these regions was inherited from Neanderthals, and prolonged SARS-CoV-2 reproduction in an immunocompromised patient. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, emailBecome a patron of TWiV! Links for this episode Genome wide association study of severe COVID-19 (NEJM) Major genetic risk
Forget what you've herd about immunity
Daniel Griffin provides a clinical report on COVID-19, then we discuss Bill Foege’s letter to CDC director Robert Redfield, the false promise of herd immunity for COVID-19, secret blueprints for SARS-CoV-2 vaccine trials released, and neuropilin-1 as a possible entry protein for the virus. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, emailBecome a patron of TWiV! Links for this epi
In the company of coronaviruses with Lisa Gralinski
Lisa joins TWiV to discuss her research on the pathogenesis of SARS-CoV, MERS-CoV, and SARS-CoV-2, including work on vaccines and an antiviral, then we review the SARS-CoV-2 spike protein as a potential analgesic, and listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Lisa Gralinski Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-like bat CoV with potential for human emergence (Nat Med
Wake up and smell the pandemic
Daniel Griffin provides a clinical report on COVID-19, we debunk the Great Barrington Declaration, and discuss smell and taste changes as early indicators of the pandemic, vascular disease and thrombosis in SARS-CoV-2 infected humans and rhesus macaques, and the ability of the swine pathogen SADS-CoV to infect human respiratory tract cells. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Daniel’s COVID-19 testing strategy calculator (and med
Black in Microbiology with Ari Kozik and Kishana Taylor
Ari and Kishana, two of the founders of Black in Microbiology, join TWiV to discuss the goals of the organization, then we review pauses of J&J and Lilly COVID-19 vaccine trials, preclinical studies of Regeneron's SARS-CoV-2 monoclonal antibody cocktail, reinfection of a patient in Nevada, and listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Ari Kozik and Kishana Taylor Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of T
Prizes, polio, and a pandemic puzzle
Daniel Griffin provides a clinical report on COVID-19, then Amy joins us to discuss the 2020 Chemistry Nobel Prize for gene editing using CRISPR/Cas9, continuing circulation of poliovirus in Afghanistan, inborn errors of interferon in patients with severe COVID-19, and listener questions. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Guests: Daniel Griffin and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASH guideli
Coronavirus vaccine preparedness with Kizzmekia Corbett
Kizzmekia Corbett joins TWiV to review her career and her work on respiratory syncytial virus, influenza virus, and coronaviruses and coronavirus vaccines, including her role in development and testing of a spike-encoding mRNA vaccine, and then we review the Nobel Prize for discovery of hepatitis C virus. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Kizzmekia Corbett Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this
Presidential COVID-19 with Dr. Daniel Griffin
Daniel Griffin discusses President Trump's case of COVID-19, including the clinical course, the medications he received and why, and expectations for the next few weeks. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Regeneron CoV-2 mAb cocktail results (Regeneron) Rethinking COVID-19 test sensitivity (NEJM) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
All the wrong COVID-19 moves
Daniel Griffin provides a clinical report on COVID-19, including a discussion of the role of vitamin D in COVID-19, Michael and Christopher explain why we have made all the wrong moves during the pandemic, evidence that the D614G amino acid change improves transmission in hamsters, and listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guests: Daniel Griffin, Michael B. Yaffe, and Christopher D. Barrett Subscribe (free): iTunes, Google Podcasts,
Mice, bats, and coronaviruses with Tony Schountz
Tony Schountz joins TWiV to explain the work of his laboratory showing that deer mice can be infected with and transmit SARS-CoV-2, and how his colony of Jamaican fruit bats is being used to understand their response to virus infections. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Tony Schountz Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 infection of deer mice (bioRxiv) Infection of Jamaic
Building a better virus trap
Daniel Griffin provides a clinical report on COVID-19, review of the phase I and II trials of the Russian prime-boost vaccine, a mouse model that recapitulates age-dependent severe disease, and listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Safety and immunogenicity of Russian COVID-19 vaccine (Lancet) 'Questionable' data in
A far-UVC light bulb went off for David Brenner
David Brenner joins TWiV to explain how far-UVC lights could provide protection from SARS-CoV-2 and other airborne viruses in public places, solutions to face mask fogging, transmission during airplane flights, and listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: David Brenner Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Far-UVC light inactivates viruses (paper one and two) Tips to avoi
This half-week in coronavirology
Daniel Griffin provides a clinical report on COVID-19, superspreading potential of SARS-CoV-2 in Hong Kong, structure of virion glycoprotein of a commmon cold coronavirus reveals changes driven by prolonged circulation in humans, and listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Increased risk for COVID-19 during
TWiV is for the dogs
On this mid-week edition, does it matter that SARS-CoV-2 is mutating, seasonal coronavirus immunity is short-lived, another bogus claim that the virus was produced in a laboratory (it came from Nature), and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Coronavirus is mutating (Nature) Seasonal CoV immunity is short (Nat Med) Sorry, no
The joy of vax
Daniel Griffin provides a clinical report on COVID-19, including vaccines, Alan summarizes a vaccine webinar on the most advanced US trials, a nidovirus from snapping turtles, longevity of memory B cells in recovered patients, and listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Young adults with COVID-19 (JAMA) Le
Principals of Principles, Fifth Edition
The authors of the textbook Principles of Virology gather to reveal new additions to the fifth edition, including a new author, study questions, and a chapter on therapeutic viruses. Host: Vincent Racaniello Guests: Jane Flint, Anna Marie Skalka, Glenn F. Rall, and Theodora Hatziioannou Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Purchase PoV 5e Volumes 1 + 2 (link) Purchase PoV 5e Volume 1 (link) Purchase PoV 5e Volume 2 (link) Intro
SWAG with Ralph Baric
Ralph Baric returns to TWiV to provide an update on the COVID-19 resurgence in the US, monoclonal antibodies, antiviral drugs, vaccines, immunity and reinfection, reopening schools, and what will happen this fall. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Guest: Ralph Baric Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Broadly neutralizing sarbecovirus mAbs (bioRxiv) Evaluation of mRNA-1273 in nonhuman primates (NEJM) Bioavailab
In case of emergency finish the trial
Daniel Griffin provides a clinical report on COVID-19, then we discuss decline of virus-specific bone marrow B cells within a year after influenza vaccination, the push to release SARS-CoV-2 vaccines before completion of phase 3 trials, and absence of evidence for infectious virus in aerosols. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this ep
Sloppy coronavirus immunity with Christian Drosten
Christian Drosten returns to TWiV to provide an update on the COVID-19 situation in Germany, and general thoughts on testing, immunity, vaccines, therapeutics, epidemiology, reopening schools, and what will happen this fall. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Christian Drosten Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Christian previously on TWiV 601 Plague percolation phenomenon (Nature) TMPRSS2 inhibit
Everyone needs a H.E.A.R.T.
Daniel Griffin provides a clinical report on COVID-19, then we discuss CDC softening testing guidelines, Moderna vaccine phase I results in older people, Abbott's $5 rapid antigen test, and reinfection with a distinct SARS-CoV-2 isolate, followed by listener email. Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Rich Condit Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode CDC told to soften SARS-CoV-2 tes
Shane Crotty on SARS-CoV-2 immunity
Immunologist Shane Crotty joins TWiV to discuss the antibody and T cell responses to infection with SARS-CoV-2, followed by answers to listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Shane Crotty Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Ahead of the Curve by Shane Crotty SARS-CoV-2 T cell epitopes (Cell) Cross-reactive CoV T cell epitopes (Science) Knowns and unknowns about SAR
TWiV 656: See, it can be done!
Daniel Griffin provides a clinical report on COVID-19, surgeons Lisa Smith and David Bruce detail how they have helped their Chattanooga community during the pandemic, then we discuss racial and ethnic disparities among COVID-19 cases, no more premarket review of laboratory developed tests by FDA; and emergency use authorization of convalescent plasma is on hold. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guests: Daniel Griffin, Lisa A. Smith, and W. David Bru
Minority health with Robert Fullilove
Sociomedical scientist Robert Fullilove joins TWiV to discuss disparities in minority health; FDA announces an EUA on Yale's SalivaDirect, protection of the upper and respiratory tract of mice after intranasal inoculation with an adenovirus-vectored SARS-CoV-2 spike gene, and listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Robert Fullilove Click arrow to play Download TWiV 652 (69 MB .mp3, 114 min)Subscribe (free): iTunes, Google Podcasts,
TWiVering with excitement
Daniel Griffin provides a clinical report on COVID-19 and the convalescent plasma trial, then we answer listener questions about the Russian vaccine, choir practice, face masks (wear them!), Mina testing, transmission, and much more. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Daniel's recommendations for COVID-19 testing (pdf) E
Back to school with COVID-19
Alfonso, Ken, Mary and Janet join TWiV to explain their modeling of school reopening strategies during the SARS-CoV-2 pandemic. Hosts: Vincent Racaniello and Rich Condit Guests: Alfonso Landeros, Ken Lange, Mary E. Sehl, and Janet Sinsheimer Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode School reopening strategies (medRxiv) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@m
The rules of contagion with Adam Kucharski
Epidemiologist Adam Kucharski joins TWiV to discuss SARS-CoV-2, including R0, incubation period, herd immunity, asymptomatic infection, superspreaders, children as drivers of pandemics, and how this one will end. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Adam Kucharski Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode The Rules of Contagion (Amazon affiliate link) Overdispersion in SARS-CoV-2 transmissi
FDA rules with Denise Esposito
Daniel Griffin provides a clinical report on COVID-19, then former FDA Chief of Staff to the Commissioner Denise Esposito joins us to explain the challenges in approving vaccines, antiviral drugs, and diagnostic tests during a pandemic, followed by answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Denise Esposito Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links f
Virology is infinite
In this mid-week episode of Earth's Virology Podcast, we analyze SARS-CoV-2 transmission among youths at a summer camp, adaptation to mice by passage, the importance of T cells for recovery from COVID-19, and listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Travis County indicators dashboard SARS-CoV-2 transmission at an overnight camp (MMWR) Ada
Ohio State viral
Vincent visits Ohio State University (March 2020) and speaks with Shan-Lu, David, Amanda, Mark, Matt, Chris, and Qiuhong about their careers and their work on retroviruses, hepatitis C virus, coronaviruses, paramyxoviruses, and environmental viruses. Host: Vincent Racaniello Guests: Shan-Lu Liu, David Bisaro, Amanda Panfill, Mark Peeples, Matt Sullivan, Chris Walker, Qiuhong Wang Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode New virus requ
Life is for learning
Daniel Griffin provides a clinical report on COVID-19, followed by a review of the findings that children shed as much SARS-CoV-2 viral RNA from the respiratory tract as older patients, the lineage giving rise to SARS-CoV-2 has been circulating in bats in China for decades, and answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Becom
Testing is our way out of this crisis
In this mid-week TWiV, children under 10 do transmit SARS-CoV-2, why hydroxychloroquine does not work for treating COVID-19, scale-up of diagnostic testing, explanation of LAMP testing, and listener questions. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Children do transmit infection (Emerg Inf Dis) NIH RADx initiative (NEJM) Rockefeller Foundation testing plan HCQ observation
Virocentricity II with Eugene Koonin
From the NIH campus (recorded February 2020) Vincent and Rich meet with Eugene Koonin to discuss his theories on the evolutionary origins of viruses. Hosts: Vincent Racaniello and Rich Condit Guest: Eugene Koonin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Virocentricity with Eugene Koonin (TWiV 275) Origin of viruses (Nat Rev) Multiple origins of capsid proteins from cells (PNAS) Origins and evolution of global RNA virome (mBio) Evolut
Lions and tigers and zookeepers (oh my)
Daniel Griffin provides a clinical report on COVID-19, followed by a review of the State Department document on the Wuhan BSL-4 laboratory, the report on infection of tigers and lions in the Bronx Zoo, and, answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode State Dept. memo on Wuhan BSL-4 lab (pdf) Bios
Don't let perfect be the enemy of good
In this mid-week edition, identifying flawed research before it becomes dangerous, Michigan governor tells America to mask-up, Pfizer mRNA vaccine gets $1.95 billion from Warp Speed, preliminary phase I/II results of the ChAdOx1 SARS-CoV-2 vaccine, answers to listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Click arrow to play Download TWiV 644 (69 MB .mp3, 115 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links
Bernie Moss, the real Poxdoc
From the NIH campus (recorded February 2019) Vincent and Rich meet with Bernie Moss to hear about his training and his remarkable 50-year-plus career working on poxviruses. Hosts: Vincent Racaniello and Rich Condit Guest: Bernie Moss Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Link for this episode Reflections on Bernie Moss' career (JBC) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Bringin' in 50 keys of spike mRNA
Daniel Griffin provides a clinical update on COVID-19, then we discuss phase I preliminary results of the SARS-CoV-2 mRNA vaccine, factors associated with death in 17 million patients, and answer listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Travis County virtual Town Hall SARS-CoV-2 mRNA
COVID-19 with Dr. Anthony Fauci
Dr. Anthony Fauci joins TWiV to discuss SARS-CoV-2 transmission, testing, immunity, pathogenesis, vaccines, and preparedness. Hosts: Vincent Racaniello and Rich Condit Guest: Dr. Anthony Fauci Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Dr. Fauci was previously on TWiV 219 Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Test often, fast turnaround, with Michael Mina
Michael Mina joins TWiV to reveal why frequent and rapid SARS-CoV-2 testing is more important than accuracy, how a daily $1 rapid test could control the pandemic, and why group testing works. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guests: Michael Mina Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Michael Mina on Immune 26 White House bypasses CDC (NY Times) Test sensitivity is secondary to frequency an
Virology Nobel Prizes with Erling Norrby part 2
Vincent and Erling resume their discussion of virology Nobel Prizes, focusing on awards for research on tumor viruses, bacteriophages, virus structure, reverse transcriptase, hepatitis B virus, HIV-1, human papillomaviruses and much more. Host: Vincent Racaniello Guest: Erling Norrby Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Nobel Prizes and Life Sciences by Erling Norrby Nobel Prizes and Nature’s Surprises by Erling Norrby Nobel Prize
Do, there is no try
Daniel Griffin provides a clinical update on COVID-19, then Viviana Simon joins to review serological assays developed at Mt. Sinai for SARS-CoV-2 infection, tracking the outbreak in NYC, and listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guests: Viviana Simon, Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Serological assay for SARS-CoV-2 infection (Nat Med) E
Clearing the fog of ignorance
In this episode, approval of an Ad5 vectored SARS-CoV-2 vaccine for the military in China, description and clinical trials of a Novavax vaccine joining Operation Warp Speed, prevalence of SARS-CoV-2 in Spain, shedding and transmissibility of the virus, and listener email. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode China approves COVID-19 vaccine for military (CNN) Ad5-vectore
Georgia State viral
From Georgia State University, Vincent speaks with Chris, Andrew, Priya, and Richard about their careers and their work on Ebolaviruses, rotavirus, and antiviral drug development. Host: Vincent Racaniello Guests: Chris Basler, Andrew Gewirtz, Priya Luthra, and Richard Plemper Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Mutant Ebolavirus lacks virulence (Cell Rep) Blocking Ebolavirus replication by depleting nucleoside pools (Antiviral Re
Mask hysteria
Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 shedding in children, how to resume school safely, the need for widespread testing and wearing face masks, and much more, including listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Infectious SARS-CoV-2 in nasopharynx
1000 hours of the sunlight of TWiV
TWiV reviews a new H1N1 swine influenza virus from China with pandemic potential, Ad5 vectored SARS-CoV-2 oral vaccine candidate, Operation Warp Speed vaccine candidates, FDA guidance on vaccine approval, and answer listener email. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode New swine flu with pandemic potential (BBC, PNAS) Oral SARS-CoV-2 vaccine candidate (Clin
Singapore viral
From DukeNUS Medical School, Vincent speaks with Ashley, Sheemei, Eng Eong and Dahai about their careers and their research on flaviviruses and sensing of viral RNA. Host: Vincent Racaniello Guests: Sheemei Lok, Dahai Luo, Eng Eong Ooi, and Ashley St. John Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Dengue virus and endothelial permeability (J Clin Invest) Dengue virus morphological switch (PLoS Path) Symptomatic yellow fever vaccine
Countering a miasma of anti-think
Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 infections in non-humans, vesicular stomatitis in Kansas horses, and answer listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Dexamethasone for COVID-19 (medRxiv) Proning trial for COVID-19 (Lancet) Tocilizumab f
Lots of eggs in the spike basket
Vincent, Rich, and Brianne discuss a study estimating the fraction of symptoms and severe disease after SARS- CoV-2 infection, cellular immune responses without seroconversion during interfamilial infections, and answer listener email. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Probability of symptoms and severe COVID-19 (aRxiv) Cellular immune response without seroconversion (
Singapore Environmental Health Institute
From the Environmental Health Institute in Singapore, Vincent speaks with Director Lee Ching Ng about their work to control viral infectious diseases, including the controlled release of mosquitoes containing Wolbachia endosymbionts to inhibit viral transmission. Host: Vincent Racaniello Guest: Lee Ching Ng Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV!
Coronavirus update, pandemic sitrep
Daniel Griffin provides a clinical update on COVID-19, including analysis of the dexamethasone trial, and then we discuss two Ebolavirus outbreaks in DRC, clinical and virological aspects of asymptomatic SARS-CoV-2 infections, age-dependent effects on transmission, and answer listener email. Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode De
Physical distance for COVID-19
Vincent and Rich discuss the SARS-CoV-2 D614G amino acid change in the spike glyprotein, duration of infectious virus shedding from patients, virus transmission among hamsters infected in the laboratory, and tackle listener email. Hosts: Vincent Racaniello and Rich Condit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Austin TX key indicators for staging D614 amino acid change (Scripps) Virus shedding in hospitalized patients (medRxiv) H
Singapore National Centre for Infectious Diseases
Vincent visits the National Centre for Infectious Diseases and speaks with Executive Director Leo Yee-Sin and Consultant Nancy Tee about the main hub for both clinical treatment of infectious diseases and outbreak management in Singapore. Host: Vincent Racaniello Guests: Leo Yee-Sin and Nancy Tee Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode National Centre for Infectious Diseases National Public Health Laboratory Intro music is by Rona
Ralph Baric and fancy ferrets
Daniel Griffin provides a clinical update on COVID-19, then Ralph Baric joins TWiV to discuss SARS-CoV-2 transmission, vaccines, diagnostic tests, and a new animal model from his laboratory that does not use transgenic mice. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin, Chuck Knirsch, and Ralph Baric Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Mouse-adapted SARS-CoV-2 model (bioRxiv) SARS-CoV-2
Fred Murphy, virologist for all seasons
Vincent and Rich visit Fred Murphy to hear about his wide-ranging career in virology, spanning many institutions, involving dangerous viruses like rabies virus, Ebolavirus (he took that famous iconic image), Marburg virus, Lassa virus, coronaviruses, and later writing a history of the field. Hosts: Vincent Racaniello and Rich Condit Guest: Frederick A. Murphy Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Link for this episode (UTMB) Intro music is by Ronald Je
SeXX matters with Sabra Klein
Daniel Griffin provides a clinical update on COVID-19, then Sabra Klein joins us to discuss the effect of sex, gender, and age on viral infectious disease, including COVID-19. Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker Guests: Daniel Griffin, Chuck Knirsch, and Sabra Klein Click arrow to play Download TWiV 624 (91 MB .mp3, 152 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode
Bats and coronaviruses with Peter Daszak
Peter Daszak joins TWiV to explain the work of EcoHealth Alliance in surveillance of bats in China for SARS-related coronaviruses to provide the information needed to prevent future pandemics, and why NIH recently withdrew financial support for their work. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Peter Daszak Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Bats are reservoirs of SARSr-CoV (Science
Nonhuman primate model for COVID-19 with Emmie de Wit
Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Emmie de Wit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Respiratory disease in macaques inoculated with SARS-CoV-2 (Nature) Clinical benefit of remdesivir in SARS-CoV-2 infected macaques (bioRxiv) Remdesi
An era of COVID-19 poppycock
Daniel Griffin provides a clinical update on COVID-19, then we review an Ad5 vectored SARS-CoV-2 vaccine, reports on remdesivir and hydroxychloroquine, a drug repurposing study, why some patients infect many others, reducing viral transmission, and much more, including listener email. Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patro
Antibodies and T cells in COVID-19 patients
Jon Yewdell returns to explain studies on detection of antibodies and T cell epitopes in patients who have recovered from COVID-19. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Jon Yewdell Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode T cell targets in COVID-19 patients (Cell) SARS-CoV-2 seroconversion in humans (Nat Med) Convergent antibody responses to SARS-CoV-2 infection (bioRxiv) Timestamps by Jolene. Thanks!
Recombination led to emergence of SARS-CoV-2
Raul Rabadan joins TWiV to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Raul Rabadan Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Rabadan Laboratory Understanding Coronavirus (Amazon) Topological Data Analysis for Genomics and Evolution (Amazon) Recombination and mutation shaped SARS-CoV-2 (bioRxiv
Nipah virus at 20
From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine. Hosts: Vincent Racaniello Guests: John Mackenzie, Jon Epstein, Eun-Chung Park, and Linfa Wang Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and co
Coronavirus Times
Daniel Griffin provides a clinical update on COVID-19, then we review TETRIS by Paterson NJ, modeling the effects of intervention in the US on cases and deaths, mixing PCR and serology data, and much more, including listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Playing tennis safely (USTA) Scienti
Singing about coronavirus
Vincent, Kathy and Rich discuss COVID-19 research paper overload, Moderna's mRNA vaccine Phase I results, increase of ACE2 RNA by cigarette smoke, and answer listener questions. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Drowning in COVID-19 papers (Science) CORD-19 2019 NCRC AI powered literature review SciSight Graphical guide to CoV vaccines (Nature) Moderna Phase I result
Peter Daszak of EcoHealth Alliance
Vincent speaks with Peter Daszak, President of EcoHealth Alliance, a global nonprofit organization dedicated to protecting wildlife and public health from the emergence of disease. Hosts: Vincent Racaniello Guests: Peter Daszak Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. 20% off The Invisible ABCs for TWiV listeners! Use promo code: ABC20 at checkout. Send your virology questions and comments to twiv@microbe.tv
COVID Tetris - Test, trace, isolate
Daniel Griffin provides a clinical update on COVID-19, then we review results showing requirement for the furin site in the SARS-CoV-2 spike for replication, US state vaccine exemptions, concerns with a rapid diagnostic test, and answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Triple
Jenner, vaccines, and COVID-19
Vincent, Kathy and Rich explain the Jenner Institute's SARS-CoV-2 vaccine, the NIH decision to stop the Remdesivir study, and answer listener questions. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 brings out dark side of science (Mother Jones, Wired) Jenner Institute COVID-19 vaccine (BioSpace) Recombineering (Nucleic Acids Res) Vaccines lecture (YouTube) ChAdOx1 MERS
CEPI, preventing the next pandemic
From the Nipah Virus International Conference in Singapore, Vincent speaks with Richard Hatchett, CEO of CEPI, about its mission to stimulate and accelerate the development of vaccines against emerging infectious diseases. Hosts: Vincent Racaniello Guests: Richard Hatchett and Linfa Wang Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Corona and crowns
Daniel Griffin provides a weekly clinical update on COVID-19, then Michael Schmidt discusses how dentistry can be safely practiced during a pandemic, followed by answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Michael Schmidt Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode OSHA guidance for dentistry COVID0-19 challenges for dentistry (J Den
Coronavirus FAQ
The TWiV team summarizes serology-based tests for SARS-CoV-2, lack of effect of ACE inhibitors or ARBs on COVID-19 severity, and answers listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA revises statement on antibody tests (FDA) Serology-based tests for SARS-CoV-2 (Center for Health Security) ACE inhibitors, ARBs not linked to COVID-19 severit
TWiV 609: A coronavirus chronology with Susan Weiss
Susan Weiss recalls some of her 40 years of research on coronaviruses, including mouse hepatitis virus, MERS-CoV, and now SARS-CoV-2. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Susan Weiss Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Coronaviruses by Susan Weiss (YouTube) Forty years with coronaviruses (JEM) No credible evidence that SARS-CoV-2 came from a lab (Emerg
Daniel Griffin's COVID-19 clinical report
Daniel Griffin updates the clinical situation with COVID-19 patients, followed by analysis of the remedesivir clinical trial results, and answers listener questions. Hosts: Vincent Racaniello and Rich Condit Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pulmonary embolism in COVID-19 (Emerg Inf Dis) Patch Study Remdesivir in adults with severe COVID-19 (Lancet) ACTT remdesivir trial (NIAID) Commentary on remdesivi
Coronavirus epidemiology with Jeff Shaman
Jeff Shaman returns to TWiV to explain why more SARS-CoV-2 testing and contact tracing is needed to stop the pandemic, and provide insights on immunity and reinfection from seasonal CoVs, the problems with antibody tests, and what to expect in the coming months. Hosts: Vincent Racaniello and Rich Condit Guest: Jeff Shaman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 findings and simulations (Shaman Lab) Reconciling diverse estim
Evidence-based science and medicine for COVID-19
Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by our discussion of tests of an inactivated vaccine, results of serological surveys, an inhibitor of the cell protease needed for virus entry, and answers to listener questions. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Inactivated SARS-CoV-2 vaccine protect
READDI for the next pandemic
Ralph Baric, Mark Heise and Nat Moorman discuss their non-profit initiative READDI, Rapidly Emerging Antiviral Drug Discovery Initiative, to start making drugs now for the next pandemic virus. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Ralph Baric, Mark Heise, and Nat Moorman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode READDI.org CEPI DNDi Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your
Oral poliovaccine to prevent SARS-CoV-2 infection
Kostya Chumakov discusses the hypothesis that oral poliovirus vaccine can provide non-specific protection against many other viruses, and might prevent infection with SARS-CoV-2. Host: Vincent Racaniello Guest: Kostya Chumakov Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Nonpathogenic enteroviruses to prevent human disease (pdf) OPV for COVID-19 (pdf) Enteroviruses to prevent human infections (pdf) Timestamps by Jolene. Thanks! Intro mus
Cloudy with a chance of coronavirus
Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by results of seroprevalence studies, analysis of CpG dinucleotide frequencies in the SARS-CoV-2 genome, and answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode CpG frequency in SARS-CoV-2 genome (Mol
Coronavirus immunology with Stanley Perlman
Stanley Perlman joins TWiV to discuss immune responses to coronaviruses, including seasonal CoV, MERS, SARS, and SARS-CoV-2, including prospects for a vaccine. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Stanley Perlman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Perlman Laboratory An Iowa Caucus of Viruses (TWiV 538) Anti-SARS-CoV spike IgG and acute lung injury (JCI Insight) T cell responses to re
Das coronavirus with Christian Drosten
Coronavirus expert Christian Drosten joins Vincent to provide a view from Germany on COVID-19 and SARS-CoV-2. Host: Vincent Racaniello Guest: Christian Drosten Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Das Coronavirus podcast Identification of SARS-CoV in Germany (NEJM) 29 nt deletion in genome of SARS-CoV (Sci Rep) 382 nt deletion in genome of SARS-CoV-2 (bioRxiv) Virological assessment of COVID-19 patients (Nature) Timestamps by Jole
SARS-CoV-2 - enter the Coronials
Daniel Griffin joins TWiV to update on the clinical situation, then we discuss a 382 nucleotide deletion in the SARS-CoV-2 genome, a scenario for emergence of the virus from a bat, followed by answers to listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode 382 nt deletion in genome of SARS-CoV-2 (bioRxiv
Coronavirus update - we need a plan
Doris Cully joins TWiV to discuss inhibition of SARS-CoV-2 in cell culture by ivermectin, followed by continuing analysis of the coronavirus pandemic caused by SARS-CoV-2 including COVID-19 in Nadia the tiger, and prediction of respiratory failure by levels of IL-6. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Guest: Doris Cully Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Ivermectin inhibits SARS-CoV-2 in cell
Who was that masked man? Coronavirus update with Daniel Griffin
Daniel Griffin MD returns to TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, followed by our coverage of the coronavirus pandemic caused by SARS-CoV-2. Hosts: Vincent Racaniello, Dickson Despommier,Rich Condit, and Kathy Spindler Guest: Daniel Griffin, MD Download TWiV 598 (70 MB .mp3, 115 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Restricted dispensing of Plaquenil
A lot of immunology and some COVID-19 with Jon Yewdell
Immunologist Jon Yewdell joins Vincent and Rich to discuss immune responses in the context of infection with SARS-CoV-2. Hosts: Vincent Racaniello and Rich Condit Guest: Jon Yewdell Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
COVID-19 - an ounce of prevention
TWiV covers trials of hydroxychloroquine and convalescent plasma therapy for COVID-19, and answers listener questions on blood tests for antibodies, cross-protection among coronaviruses, acquiring infection from food or the gas pump, face masks containing copper, and much more. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Emergency use of hydroxychloroquine (FDA) Trial of hydroxycholo
Coronavirus update - Daniel Griffin MD in the parking lot
Daniel Griffin MD joins TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, and then the TWiV team continues coverage of the coronavirus pandemic caused by SARS-CoV-2. Hosts: Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Daniel Griffin, MD Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Tocilizumab (Wiki) Nares swab for SARS-CoV-
Conversation with a COVID-19 patient, Ian Lipkin
Ian Lipkin joins Vincent to talk about his experience as a COVID-19 patient, and issues surrounding the disease and SARS-CoV-2 including limiting transmission, antivirals, vaccines, and much more. Hosts: Vincent Racaniello Guest: W. Ian Lipkin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Center for Infection and Immunity Control the Contagion videos Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology ques
Coronavirus update with Mark Denison, MD
Pediatric infectious disease physician and coronavirologist Mark Denison joins Vincent for a discussion of COVID-19 and SARS-CoV-2 with an emphasis on antiviral therapeutics. Hosts: Vincent Racaniello Guest: Mark Denison Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Coronavirus update - Shelter in place
A TWiV foursome provides an update on the SARS-CoV-2 pandemic, including antibody testing kits, FDA emergency approval of convalescent sera, and answer listener questions about the dangers of mail delivery and take out foods, decontamination of PPE, diagnostic testing, and much more. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Coronavirus test kit Rapid SARS-CoV-2 s
Coronavirus update - flatten the curve
Daniel Griffin joins Ori and the TWiV team an update on the SARS-CoV-2 pandemic, including gastrointestinal illness associated with infection, use of hydroxychloroquine and other antivirals, his experiences treating many patients in the New York area, and much more. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guests: Daniel Griffin, Ori Lieberman, and Valeria Cagno Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron
Coronavirus update - dangerous curve ahead
Ori joins TWiV for an update on the SARS-CoV-2 pandemic, including scary modeling, clinical trials for antivirals and vaccines, asymptomatic transmission, and much more inspired by listener email. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Guest: Ori Lieberman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Scary modeling (Imperial College London) Avigan vs SARS-CoV-2 (NHK) SARS-CoV-2 mRNA vaccine (Clinical Trials) SARS-CoV-2
SARS-CoV-2 epidemiology with Stephen Morse
Epidemiologist Stephen Morse joins Vincent to discuss epidemiology of SARS-CoV-2 and preparedness for the COVID-19 pandemic. Hosts: Vincent Racaniello Guest: Stephen Morse Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
A medical student perspective on COVID-19
Ori Lieberman joins Vincent to discuss COVID-19, the disease caused by SARS-CoV-2, gleaned from his experience during clinical rotations in medical school. Hosts: Vincent Racaniello Guest: Ori Lieberman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Coronavirus update with Ralph Baric
Ralph Baric joins TWiV to dissect the coronavirus pandemic caused by SARS-CoV-2, including discussion on community spread, asymptomatic infections, origin of the virus, transmission, vaccine development, and much more. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Ralph Baric Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Aerosol and surface stability of SARS-CoV-2 (medRxiv) Clinical cour
COVID-19 and coronavirus - we have mail
The TWiV trio continues in-depth coverage of COVID-19 and SARS-CoV-2, including discussion on genome mutation and circulating lineages, handwashing, facemasks, cruise ship outbreaks, the South Korean situation, and much more. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Stanley Perlman answers CoV questions (Boston Globe) Fist bump (Am J Infect Control) Joint WHO-China report (
Coronavirus SARS-CoV-2 and COVID-19 update
Infectious disease physician Daniel Griffin and virologist Valeria Cagno join Vincent to provide updates on the situation with SARS-CoV-2 and COVID-19 in New York and Italy. Host: Vincent Racaniello Guests: Daniel Griffin and Valeria Cagno Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Coronavirus update - it could be bad
Vincent and Rich update the current situation with COVID-19 and SARS-CoV-2, including fatality ratios, virus spreading outside of China, immunity to infection, vaccines, antivirals and much more. Hosts: Vincent Racaniello and Rich Condit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode WHO CoV sitreps How to Prepare for the Coronavirus (NY Times) Multiple shedding routes of SARS-CoV-2 (Emerg Microbes Inf) Cruise ship a/c could promote vir
Coronavirus update - Save the pangolin!
The TWiV team returns this week to SARS-CoV-2019 coverage to review the latest epi curves, the fatality rate, furin cleavage site and receptor binding domain in the spike glycoprotein, related CoV recovered from pangolins, evidence that the virus did not escape from a laboratory, and many more questions sent in by listeners. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this
One bite is all it takes
Vincent and Rich return to the University of Texas Medical Branch at Galveston to speak with Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver about their work on viruses transmitted by mosquitoes and ticks. Hosts: Vincent Racaniello and Rich Condit Guests: Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Measles virus vectored chikungunya vaccine (J Inf Dis) World
Coronavirus update: wash your hands
In this week's coverage of the coronavirus epidemic, the TWiV team discusses the fatality rate, China's initial reaction to the outbreak, conspiracy theories, how long the virus remains infectious on surfaces, and evidence for virus in the intestinal tract. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Download TWiV 586 (72 MB .mp3, 119 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode China reacted
The coronavirus epidemic
The TWiVerers continue their coverage of the new coronavirus outbreak in China, as the number of cases increase dramatically and the virus begins person-to-person transmission in other countries. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2020 Real time tracking of 2019-nCoV (JHU) Estimation of 2019-nCoV R0 (Int J Inf Dis)
Year of the coronavirus
Coronavirus expert Ralph Baric joins TWiV to explain the virology and epidemiology of the recent zoonotic outbreak spreading across China and overseas. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove,Rich Condit, Kathy Spindler Guest: Ralph Baric Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2020 WHO coronavirus sitreps CIDRAP article on coronavirus vaccines Phylogenetic analysis of 2019-nCoV ACE2 is 2019-nCoV receptor (bi
Galveston virus hunters
Vincent and Rich travel to Galveston National Laboratory to speak with Jim LeDuc, Tom Ksiazek, and Bob Tesch about their long careers as virus hunters. Hosts: Vincent Racaniello and Rich Condit Guests: Jim LeDuc, Tom Ksiazek, and Bob Tesh Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
This little virus went to market
TWiV provides updates on the new coronavirus causing respiratory disease in China, the current influenza season, and the epidemic of African swine fever, including determination of the three-dimensional structure of the virus particle. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Download TWiV 582 (71 MB .mp3, 118 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2020 NJ ready to remo
Alimentary particles
For the first TWiV of 2020 we reveal that microbiome depletion with antibiotics alters the immune response to influenza vaccine, and how successive blood meals facilitate virus dissemination in mosquitoes and transmission potential. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2020 Vaccines are safe and effective (Science) Microbiome perturba
Noncoding RNA with Chris Sullivan
From the University of Texas at Austin, Vincent and Rich speak with Chris Sullivan about his work on miRNAs encoded in the genomes of polyomaviruses and papillomaviruses, and how an RNA triphosphatase restricts hepatitis C virus replication. Hosts: Vincent Racaniello and Rich Condit Guest: Chris Sullivan Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Sullivan lab Virus-encoded miRNAs in papillomaviruses (PLoS Path) Murine polyomavirus miR
Reno viral
Vincent speaks with virologists at the University of Nevada at Reno about their careers and their work on herpesviruses, arboviruses, and the development of diagnostics for infectious diseases. Host: Vincent Racaniello Guests: Dave AuCoin, Cyprian Rossetto, Claudia Rückert, and Subhash Verma Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode PAN's labyrinth (Viruses) KSHV SOX protein DNAse activity (J Virol) Vertical flow immunoassay for patho
Prometheus project
Vincent speaks with members of Prometheus, a team of academic and industrial scientists assembled to develop antibody-based therapeutics against infections caused by tick-borne Crimean-Congo hemorrhagic fever virus and rodent-borne hantaviruses, for which no approved vaccines or specific drugs are available. Host: Vincent Racaniello Guests: Kartik Chandran, Zachary Bornholdt, Steven Bradfute, John Dye, Matthias Forsell, Jason McLellan, Laura Walker, and Cecelia Vial. Subscribe (free): iTunes,
Virologie structurale with Félix Rey
Vincent speaks with Félix Rey about his career and his work on solving structures of a variety of viruses and the insights learned about viral membrane fusion and antibody-mediated neutralization. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Unité de Virologie Structurale Tick-borne encephalitis glycoprotein structure (Nature) HCV RNA polymerase structure (PNAS) Flavivirus structural heterogeneity (Curr Op Viral) Antibody responses to fla
Big data in virology and public health
From the 22nd meeting of the European Society for Clinical Virology in Copenhagen, Vincent speaks with Thea, Heli, Kim, Caroline and Irma about big data and its increasing use in virology diagnostics, epidemiology, and public health. Host: Vincent Racaniello Guests: Thea Kølsen Fischer, Kim Benschop, Caroline Brown, Heli Harvala, and Irma Salimovic-Besic Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode 22nd ESCV meeting Timestamps by Jolene
Endless giant virus forms most beautiful
From the Fourth Symposium on Giant Virus Biology in Germany, Vincent, Rich, and Nels speak with Assaf, Stephen, and Alexandra about their careers and their work on giant viruses that infect ocean hosts: Emiliana huxleyi, Aureococcus anophagefferans, and a choanoflagellate. Hosts: Vincent Racaniello, Rich Condit, and Nels Elde Guests: Assaf Vardi, Stephen Wilhelm, and Alexandra Worden Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode 4th Ringb
How economics shapes science
From Georgia State, Vincent speaks with economics professor Paula Stephan about the ways science is supported in the US, how universities offload risks, the absence of risk-taking, and much more. Hosts: Vincent Racaniello Guest: Paula Stephan Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode How Economics Shapes Science Coalition for Next Generation Life Science Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virolog
Inventing viruses
William Summers joins the TWiV team to discuss some virology history, including the ever-changing concept of 'virus' and the contribution of phage research to the study of animal viruses. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guest: William Summers Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Bill’s ASV 2019 talk (PPT download) Inventing viruses (Ann Rev Virol) Timestamps by Jolene. Thanks! Weekly Sci
Your EV-D68th nervous breakdown
Amy joins the TWiV team to review evidence that enterovirus D68 is an etiologic agent of childhood paralysis, and her finding that the ability of the virus to infect cells of the nervous system is not a recently acquired property. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode EV-D68 antibodies in humans before 2014 outbreak (Emerg Inf Dis)
Piwi koalas
The League of Extraordinary Virologists celebrate the eradication of wild poliovirus type 3, and consider the effectiveness of an influenza vaccine produced in insect cells, and how small RNAs are protecting the Koala germline from retroviral invasion. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Flublok (CDC) Adjuvant study of flu vaccines (NIH
Aarhus viral
At Aarhus University in Denmark, Vincent speaks with Trine Mogensen, Søren Paludan, Ole Søgaard, and Madalina Carter-Timofte about their careers and their work on sensing herpesviral DNA, immunodeficiencies that predispose to severe viral infections, and the path to a cure for HIV/AIDS. Hosts: Vincent Racaniello Guests: Trine Mogensen, Søren Paludan, Ole Søgaard, and Madalina Carter-Timofte Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode A
Smolt'in iron
The TWiV pro-vaxxers reveal viruses that infect endangered wild salmon, and how iron in host serum modulates dengue virus acquisition by mosquitoes. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode New viruses that infect endangered wild salmon (eLife) Host serum iron modulates dengue virus acquisition by mosquitoes (Nat Micro) Image credit Letters read on TWiV 569 T
Karolinska viral
In the second episode from the Karolinska Institute in Stockholm, Vincent speaks with Jan Albert, Petter Brodin, and Anna Smed-Sörensen about their work on enterovirus D68, systems immunology, and human pulmonary viral infection and inflammation. Hosts: Vincent Racaniello Guests: Jan Albert, Petter Brodin, and Anna Smed-Sörensen Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Karolinska Huddinge Evolution of enterovirus D68 (Virus Evol) Ma
Outbreaks and a breakout
The TWiV team covers outbreaks of eastern equine encephalitis virus in the US and poliovirus in the Philippines, and explain how a chemokine induced by HIV-1 infection helps release more virus particles from cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Poliomyelitis returns to the Philippines (Mashable, virology blog) EEE in
Chicken gumbo and a corona
The TWiV team reveals the protein corona that surrounds virus particles and influences infectivity and amyloid aggregation, and a proofreading-impaired herpesvirus that produces quasispecies-like populations. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Guest: Kiki Warren Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Human fetal tissue research restrictions (The Scientist) Viral protein corona (Nat Commun) Proofreading-impaired
Karolinska virology
From the Karolinska Institute in Stockholm, Vincent speaks with Niklas Björkström, Ali Mirazimi, and Matti Sällberg about their work on the impact of chronic hepatitis C virus infection on NK cells, Crimean-Congo hemorrhagic fever virus vaccines, and immunotherapy to block entry of hepatitis B and D viruses. Hosts: Vincent Racaniello Guests: Niklas Björkström, Ali Mirazimi, and Matti Sällberg Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode K
Virology Nobel Prizes with Erling Norrby
From the 16th Smögen Summer Symposium on Virology, Vincent speaks with Erling Norrby about how he has used archival material to provide insight into early Nobel Prizes for research on viruses. Hosts: Vincent Racaniello Guest: Erling Norrby Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Swedish Society for Virology Nobel Prizes and Life Sciences by Erling Norrby Nobel Prizes and Nature's Surprises by Erling Norrby Nobel Prizes and Notable Di
Call me David Tuller
David Tuller returns to talk about his efforts of the past year to expose the methodological and ethical problems with the PACE and Lightning trials for therapy of ME/CFS. Host: Vincent Racaniello Guest: David Tuller Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
BLT on mice
The TWiVologists consider whether to receive an influenza vaccine in August (in the northern hemisphere), and mice implanted with human lung fragments for studying microbial pathogens. Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Waning of influenza vaccine protection (Clin Inf Dis) Precision mouse models for microbial pathogenesis (Nat Biotech) Letters read on TWiV
Take a breath
TWiV travels to Rutgers University to speak with Brad, Kay, Siobain, and Kim about their careers and their work on viruses of plants, fungi, bacteria, diatoms, and coccolithophores. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Guests: Brad Hillman, Kay Bidle, Siobain Duffy, and Kim Thamatrakoln Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Viruses of plant-interacting fungi (Adv Virus Res) Why are RNA virus mutation r
Hot or not
The Autonomous CollecTWiVe reveal two effective treatments for Ebolavirus infection, how a virus in a fungus confers heat tolerance to a plant, and dampened inflammation as a mechanism for bat tolerance to viral infection. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Two new and effective Ebolavirus treatments (NIH, Nature) A virus in a fungus in a plant (Science) Dampened NLRP3-med
CEIRS, influenza and company
From the meeting of the Centers of Excellence for Influenza Research and Surveillance, Vincent speaks with Alan, Florian and Jennifer about their careers, the purpose of CEIRS, universal influenza vaccines, and cellular responses to infection in pediatric populations. Host: Vincent Racaniello Guests: Alan Embry, Florian Krammer, and Jennifer Nayak Become a patron of TWiV! Links for this episode NIAID CEIRS 12th CEIRS meeting summary (pdf) Antibody response to influenza virus (Nat Rev Micro) In
Nectin connection what's your infection?
The complete TWiV team give a report on the Ebola virus outbreak in DRC, and reveal that cell surface nectin proteins cause the transfer of cytoplasmic cargo, including measles virus, between cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Fire Alarm at ASV Ebola outbreak sitrep(WHO) Ebola outbreak dashboard(WHO) Ebola outbreak
Joklik's legacy
From ASV 2019 at the University of Minnesota, TWiV explores the origins of the American Society for Virology with Sid Grossberg and Pat Spear. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guests: Sid Grossberg and Pat Spear Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode American Society for Virology Bill Joklik, 92 How ASV was founded (Virology) Signatures at the Chicago meeting (page one, page two) Timel
Congress in Rotterdam
From the European Congress of Virology in Rotterdam, Vincent and local co-host Ben Berkhout speak with Ron Fouchier, Rosina Girones, and Marie-Paule Kieny about their careers and their work on influenza virus, environmental virology, and developing an Ebola virus vaccine during an epidemic. Hosts: Vincent Racanielloand Ben Berkhout Guests: Ron Fouchier, Rosina Girones, and Marie-Paule Kieny Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode
Glycolyl's not for the birds
TWiV minus one reveals delayed neurological deficits in children without microcephaly born to Zika virus infected mothers, and N-glycolyl-neuraminic acid as a receptor for influenza A viruses. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Deficits in children born to Zika virus infected mothers (Nat Med) Zika virus is still a threat (NY Times) N-gl
Fidelity and the single cell
From ASM Microbe 2019, Vincent, Brianne and Calvin meet up with Craig Cameron to discuss his career and his work exploring RNA-dependent RNA synthesis and single cell virology. Hosts: Vincent Racaniello, Brianne Barker, and Calvin Yeager Guest: Craig Cameron Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Cameron laboratory Curioscity podcast Ribavirin is an RNA virus mutagen (Nat Med) RNA virus error catastrophe: test using ribavirin (PNAS)
Full fathom five thy viromes lie
A trio TWiVers reports on influenza in Australia, how a host protein impacts bird to human movement of influenza virus, and marine DNA viral diversity in the oceans from pole to pole. Hosts: Vincent Racaniello, Kathy Spindler, and Alan Dove Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Australian Influenza Surveillance Real-time tracking of influenza H3N2 ANP32B, or not to be (eLife) ANP32B on TWiV 377 Species specific differences in ANP
Polio with David Oshinsky
Vincent speaks with David Oshinsky, the Pulitzer Prize-winning author of Polio: An American Story, about the history of poliovirus vaccines. Host: Vincent Racaniello Guest: David Oshinsky Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Delta and the amazing technicolor dreamcoat
Team TWiV reveals DNA polymerases that do not require a primer, and packaging of hepatitis delta virus by the envelope glycoproteins of diverse viruses. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Kiki Warren Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Bacteriophage DNA polymerase is primer-independent (PNAS) Primer-independent DNA polymerase from mobile elements (Cell Rep) Non-HBV he
Golden hands
At Retroviruses 2019 in Cold Spring Harbor, Vincent speaks with virologist Bryan Cullen about his work and his career, together with former associates Ann Skalka, Paul Bieniasz, and Michael Malim. Host: Vincent Racaniello Guests: Bryan Cullen, Paul Bieniasz, Michael Malim, and Ann Skalka Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Covering up the shiny parts
TWiV explains the use of a neuronal cell line to study herpes simplex virus latency and reactivation, and a strategy for creating vaccines that induce antibodies against specific epitopes. Hosts: Vincent Racaniello, Dickson Despommier,Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Neuronal cell line supports herpes simplex virus latency (J Virol) Protect, modify, deprotect (PNAS) Timestamps by Jol
The church of protocadherin
Kartik and Rohit join the TWiV team to present their identification of protocadherin-1 as a cell receptor for New World hantaviruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guests: Kartik Chandran and Rohit Jangra Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Einstein goes viral (TWiV 314) Michael Rossmann, 88 (virology blog) Protocadherin-1 essential for New World hantavirus entry (Nature) Image credit Time
Mice, shrews, and caterpillars
Vincent travels to the European Congress of Virology in Rotterdam and with local co-host Marion Koopmans speak with Martin Beer, Stephan Gunther, and Vera Ross about their careers and their work on Lassa virus, Borna virus, and insect viruses. Hosts: Vincent Racanielloand Marion Koopmans Guests: Martin Beer, Stephan Gunther, and Vera Ros Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ECV2019 Partnerships not parachutes (TWiV 413) Fatal Bo
Upstate virology
Vincent travels to the University at Albany to speak with Cara, Rachel, and Alex about their careers and their work on stress granules, epitranscriptomics, and arboviruses. Host: Vincent Racaniello Guests: Cara Pager, Rachel Netzband, and Alex Ciota Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Five postdocs in North America (TWiV 194) Zika virus subverts stress granules (J Virol) DDX68 modulates miR-122 interaction with HCV RNA (Virol) (
Delta blues and chitlins
The un-encapsidated TWiV Humans discuss finding hepatitis D virus-related sequences in birds and snakes, and fatal swine acute diarrhoea syndrome caused by a coronavirus of bat origin. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Virus Archive ASV early bird registrationends 15 May FDA approves Dengvaxia Divergent hepatitis D-like agentin
Biocrimes and misdemeanors
Jens Kuhn returns to TWiV to explain Select Agents, Priority Pathogens, Australia List Pathogens, Risk Group Agents, biosafety, biosecurity, and biosurety. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Guest: Jens Kuhn Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Bioweapon (TWiV 508) Bioterrorism and Biocrimes by W. Seth Carus Select Agents (selectagents.gov) BMBL Manual 5th Edition (pdf) Threading the NE
Immunogaga
The TWiV team reveals the repertoire of anti-viral antibodies in newborn humans, and a complement protein that binds the adenovirus capsid and prevents release of the viral DNA. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Maternal anti-viral antibodies in newborns (Nat Med) Complement protein blocks adenovirus uncoating (Cell Host Micr) Antibodies neutralize vir
Stoned and senile
The TWiV team discusses Medusavirus, isolated from a hot spring in Japan, and induction of neurodegeneration by recurrent herpes simplex virus 1 infection of mice. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Medusavirus (J Virol) Recurrent herpes simplex virus-1 and Alzheimer's (PLoS Path) Image credit Letters read on TWiV 543 Time
Inside Microbiotix
Vincent travels to Microbiotix, Inc, a biopharmaceutical company in Worcester, MA to speak with four members of the company about their discovery and development of small molecule drugs that target serious infectious diseases. Host: Vincent Racaniello Guests: Terry Bowlin, Zach Aron, Grace Lui, and Islam Hussein Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Microbiotix, Inc. MBX-400 Microbiotix pipeline Microbiotix publications Timestamps
Cloaking devices
The TWiVers present mitoviruses, which infect mitochondria, and how quasi-enveloped hepatitis A virus gets naked again. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Evidence for plant mitoviruses (Virology) Uncoating of quasi-enveloped HAV (eLife) Image credit Letters read on TWiV 541 Timestamps by Jolene. Thanks! Weekly Science Picks Alan- Where and when to se
Wascally wiruses
The TWiVstars reveal the diversity of herpes simplex virus type 2 in a neonatal population, and parallel adaptation of rabbits in three countries to myxoma virus. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Diversity of HSV2 in neonates (mSphere) Adaptation of rabbits to myxoma virus (Science) Principal component analysis (YouTube) Image credit Le
TWiV 539: Multitudes contain me
The TWiV hosts present two potentially seminal papers, on long-distance chemoattraction of a host by a chlorovirus, and replication of a nanovirus across multiple cells in a plant. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Paul Has Measles now in German (virology blog) Chloroviruses lure hosts (J Virol) Multicellular replication in plants (eLif
An Iowa caucus of viruses
TWiV travels to the University of Iowa to speak with Wendy Maury and Stanley Perlman about their research on Ebolavirus entry and coronavirus pathogenesis. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Wendy Mauryand Stanley Perlman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode TIM-1 is receptorfor Ebolaviruses (Proc Natl Acad Sci) TIM-1 is receptor for Lassa virus (J Virol) SARS coronavirus causes neuronal death (J V
Boundary issues
The Scholars of the Podcast reveal ribosomal proteins encoded in viral genomes, and a protein cell receptor for bat influenza viruses. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Roald Dahl endorses measles vaccine Viruses encode ribosomal proteins (Na
A flock of seagulls, a herd of seals
Vincent and Alan travel to Tufts Veterinary School where they meet up with members of the Runstadler lab to talk about their work on influenza virus circulation in water birds and seals. Hosts: Vincent Racaniello and Alan Dove Guests: Jonathan Runstadler, Nichola Hill, Wendy Puryear, and Kate Sawatzki Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Cummings School of Veterinary Medicine Influenza virus in North Atlantic grey seals (Emerg Mic
Miles to go before I leak
The TWiV team discuss the use of quantum dots to study uncoating of influenza virus in real time, and induction of endothelial dysfunction by flavivirus NS1 proteins in a tissue-specific manner. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Quantum dots to visualize infl
Portal to the METTL
The TWiV crew reveal a unique portal on the calcivirus capsid formed upon receptor engagement, and the regulation of interferon responses in virus-infected cells by methylation of mRNA. Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Calicivirus portal visualized (Nature
Recurring threads
The TWiVosophers review the Chinese plasma virome revealed by non-invasive prenatal testing, and a new filovirus genome from bats in China. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2019 European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Jerard Hurwitz age 90 RIP Paul has Measles now in French (virology blog) Chines
Morbillivirus had a little lamb
The TWiVers discuss the spread of African swine fever virus and its threat to pig farming, and the zoonotic potential of peste des petits ruminants virus. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed ASV in Poland does not let go (A
Circ du RNA
Patrick Moore returns to TWiV to discuss the discovery from the Chang-Moore laboratory of circular RNAs in cells infected with herpesviruses. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Guest: Patrick Moore Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Cancer virology at
Quiet please!
Steve Goff returns to TWiV to discuss the work of his laboratory on how retroviral genomes are silenced in infected cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Guest: Steve Goff Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! 🎼 They’ll histone you when you start to transcribe, And they’ll histone you just for tryin’ to get by, So be careful when you uncoat your genome, ‘Cause everybody must histone. Links for this episode P
Rueckert Road
At the University of Wisconsin-Madison, Vincent meets up with one of his virology heroes, Roland R. Rueckert, to talk about his research and his second career as a forest manager. Host: Vincent Racaniello Guest: Roland R. Rueckert Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Video of this episode (YouTube) Roland's first paper (Anesthesiol) Purification of phiX174 (Virology) Studies on viral structure (Virology) Automated gel fractionator
Our annual recapsidation
In the first episode for 2019, the TWiV team reviews the amazing virology stories of the past year. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research TWiV World Tour 2018 t-shirt (Amazon) Cool virology from 2018 Viruses behind AD? TWiV 505, TWiV 519, clini
City mouse, country mouse
The TWiV team summarizes the discovery of Sin Nombre virus, and presents evidence that neurotropic flaviviruses can cause intestinal dysmotility syndromes after systemic infection of mice. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research Outbreak (exhibit,
In the beginning there was pol
The TWiV hosts discuss the distribution of prions in the eyes of patients with sporadic Creutzfeldt-Jacob disease, and the origins and evolution of RNA viruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research Aaron Klug, 1926-2018 (Nature) Prions in sCJD eyes (mBio) Evolution of
Vaccines Did Not Cause Rachel's Autism
Vaccine scientist, pediatrician, and autism dad Peter Hotez talks about his new book, Vaccines Did Not Cause Rachel's Autism. Host: Vincent Racaniello Guest: Peter Hotez Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Peter Hotez at Baylor College of Medicine Peter Hotez on Twitter Vaccines Did Not Cause Rachel's Autism (Amazon) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to t
The A Bee Cs of bee viruses
Michelle Flenniken joins TWiV to talk about honeybees and the work of her laboratory on honeybee viruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Michelle Flenniken Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MSU Pollinator Health Center Honeybee antiviral defenses (Sci Rep) The buzz about honeybee viruses (PLoS Path) Recently identified bee viruses (Curr Op Insect Sci) Videos on
Slicing and dicing with Raul
Raul Andino joins Vincent and Amy to talk about the finding that a cricket paralysis virus protein restricts RNA-based immunity in insects by regulating the activity and stability of the Argonaute protein. Hosts: Vincent Racaniello and Amy Rosenfeld Guest: Raul Andino Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode TWiV 138: RISCy business with Raul Andino TWiV 33: Live in Philly Viral protein restricts insect immunity (Cell Host Micr) Time
Virology in Zürich
At the University of Zürich, Vincent speaks with virologists Cornel Fraefel, Urs Greber, and Silke Stertz about their careers and their work on AAV2, adenovirus entry, and influenza virus. Hosts: Vincent Racaniello Guests: Cornel Fraefel, Urs Greber, and Silke Stertz Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode AAV2 and HSV1 co-infections (J Virol) Movies of HeLa Fucci cells (J Virol) Cathepsin W and influenza virus entry (mBio) Plaque 2
Readers of the lost ORF
The TWiVsters review isolation of a naturally occurring DNA virus from fruit flies, and the cell-type specific function of a small transmembrane protein encoded in an open reading frame upstream of the enterovirus polyprotein. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Genome-edited babies (Nature) Second CRISPR pregnancy? (MIT Tech Rev) Naturally occurrin
Spitting in the Allee
Team TWiV cover the discovery of another giant virus from 30,000 year old Siberian permafrost, and how viral aggregation accelerates the production of new infectious viruses and increases fitness, demonstrating an Allee effect. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode PhD and postdoctoral programs at Dept of Microbiology, Icahn School of M
This old mouse
The TWiVidae review universal influenza vaccines that are in clinical trials, and discovery of an atypical parvovirus that causes chronic kidney disease in middle aged, immunocompromised laboratory mice. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode PhD and postdoctoral programs at Dept of Microbiology, Icahn School of Medicine at Mou
Fishing for viruses in senile
The TWiVomers review a potential role for herpes simplex virus type 1 as a cause of Alzheimer's Disease, including the finding that amyloid-beta acts as an antiviral by enveloping virus particles. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Virology Comics on sale (Amazon) Clinical Trial: antiviral for AD HHV6 and HHV7 transcripts in AD brain (TWiV
Hershey's viruses
Vincent travels to Penn State College of Medicine in Hershey, PA to speak with Nick and Leslie about their careers and their work on human cytomegalovirus and retroviruses. Host: Vincent Racaniello Guests: Nicholas Buchkovich and Leslie Parent Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode HIV-1 gag membrane binding domain (J Virol) Nuclear experience for gag (PNAS) Gag in nucleolus (J Virol) YB-1 for retrovirus assembly (J Virol) HCMV con
Just in time for Halloween
Brianne and Vincent tackle two studies that utilize infectious viruses to examine zoonotic potential of Bombali virus, a new ebolavirus from an insectivorous species in Sierra Leone, and a human mumps-like virus from an African flying fox in DRC. Hosts: Vincent Racaniello and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pan American Society for Clinical Virology San Diego and Houston Regional Meetings It's not SARS 2.0 (TWi
HUSH little virus, don't you transcribe
Lonya and Jeremy take the TWiV team beTWIXt primate immunodeficiency virus proteins Vpx and Vpr and how they counteract transcriptional repression of proviruses by the HUSH complex. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Guests: Leonid Yorkovetskiy and Jeremy Luban Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pan American Society for Clinical Virology San Diego and Houston Regional M
When virus is in retrograde
The TWiV team notes the passing of Tom Steitz, an outbreak of acute flaccid myelitis in the US, a continuing Ebola virus outbreak in DRC, respiratory vaccinia due to inhalation of ground up rabbit skin, and how a human papillomavirus capsid protein directs virus-containing endosomes towards the nucleus. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode
Staying below the ADAR
The TWiVumvirate reviews this years crop of Nobel Prizes, and how cells prevent leakage of mitochondrial double-stranded RNA into the cytoplasm, which would otherwise lead to the production of interferon. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Sea Phages program and application materials Plant biologists penalized by CNRS (The Scientist) 2018 Nobel Prize i
Double-stranded in Belgium
From the 13th International Symposium on dsRNA viruses in Belgium, Vincent speaks with Harry Greenberg about his career and his work on rotaviruses, noroviruses, hepatitis B virus, and influenza virus. Host: Vincent Racaniello Guest: Harry Greenberg Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode 13th dsRNA Virus Symposium Hepatitisin blood donors (Lancet) Interferon treatmentof hepatitis B (NEJM) Mycoplasmamutantsin volunteers (PNAS) Norwal
Flexuous SUMO wrestlers
Anne Simon joins the TWiV team to talk about plant viruses, including plum pox virus that devastates nut and stone fruit trees, and a geminivirus protein that regulates viral DNA synthesis. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Brianne Barker, and Anne Simon Click arrow to play Download TWiV 512 (62 MB .mp3, 103 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support Viruses Gordon Conference3:38 Potyvi
Accessory found guilty in DC
Ned Landau joins the TWiV team to discuss restriction of HIV replication by SAMHD1, and a viral antagonist that can be used to produce a dendritic cell vaccine. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Ned Landau Become a patron of TWiV! Links for this episode Support Viruses Gordon Conference TWiV #124 September 2008 SAMHD1 restricts HIV-1 replication (Nature) SAMHD1 restricts diverse retroviruses (Retrovirology) Vpx degradation of SAMH
Retroviruses at Cold Spring Harbor
Vincent and Dickson travel to the 44th Retrovirus meeting at Cold Spring Harbor Laboratories, where they speak with John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata about the meeting and their work on HIV-1. Hosts: Vincent Racaniello and Dickson Despommier Guests: John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata Become a patron of TWiV! Links for this episode Cold Spring Harbor Retrovirus Meeting 2018 Retroviruses and cranberries (TWiV 320) Identical proviruses in HIV-1 reservoir
41,103 bases under the sea
The TWiV team considers whether those who can do, can't teach, and newly discovered viruses of planarians and Aplysia with the largest RNA genomes. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses Gordon Conference KNAW Beijerinck Prize Bioterrorism and Biocrimes by Seth Carus (free pdf) History of Biological Warfare by Seth Carus (free) Those Who Can Do, Can't Teach (NYTimes) Planarian
Bioweapon
Jens returns to present a brief history of bioweapons, with a focus on the program in the Soviet Union, the largest ever undertaken, and his experience working in the decommissioned Soviet bioweapons laboratory known as Vector. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Jens Kuhn Become a patron of TWiV! Links for this episode Russia's Bioweapons Labs (Nature) Medical Aspects of Biological Warfare The Soviet Biological Weapons Program by Leitenberg, Zi
The fusion of form and function
The TWiV team discuss the biology of Ebola viruses, and how localization of the membrane proteins of vaccinia virus drive function: the fusion machinery sits at the tips of virions, and binding proteins are at the sides. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses & Cells Gordon Conference Outbreak at the Smithsonian Outbreak (TWiV 501) Latest Ebola virus outbreak, DRC (
David Tuller is PACEman
David Tuller returns to provide an update of his investigative work to expose the methodological and ethical problems with the PACE trial for ME/CFS. Host: Vincent Racaniello Guest: David Tuller Become a patron of TWiV! Links for this episode Articleby Lubet and Tuller (STAT) David's Australian trip (virology blog) Sir Simon scores own goal (virology blog) Lightning process (virology blog) Letter to Parliament (virology blog) Crowdfunding is not conflict of interest (virology blog) Open letter
A Cafeteria full of jelly rolls
The TWiVniks explain how the three-dimensional structure of the giant Cafeteria roenbergensis virus suggests a new mode of assembly, and the apparent elimination of dengue fever in an Australian city by release of mosquitoes harboring Wolbachia. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses & Cells Gordon Conference New DRC Ebola strains distinct (Outbreak News) Immunizations for new DRC Ebola outbrea
Rosebola
The TWiV hosts review persistence of Ebola virus after the end of the Liberian outbreak, and the potential role of two herpesviruses in the pathogenesis of Alzheimer's disease. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses & Cells Gordon Conference Trump picks science advisor (Scientist) Hendra vaccine: no effect on horses racing (Aust Vet J) Persistence of Ebola virus (Lan
Flying foxes and barking pigs
The TWiVerinos discuss Nipah virus and the recent outbreak in India, and the first cast of polio in Papua New Guinea in 18 years. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses & Cells Gordon Conference TWiV 501: Outbreak Nipah virus infection (JCM) Anatomy of an outbreak (The Hindu) Do we need to worry about Nipah virus? (Tufts Now) Nipah virus infection of bats (EID) Papua New Guinea no
The greening of TWiV
Vincent, Rich and Kathy travel to ASV 2018 at the University of Maryland to speak with Svetlana Folimonova and Anne Simon about their work on viruses that infect plants. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Svetlana Folimonova and Anne Simon Become a patron of TWiV! Links for this episode Simon laboratory Folimonova laboratory CTV superinfection exclusion (Virol) 3'-CITEs in viral genome (J Virol) Video of this episode (YouTube) Intro music is by Ronald Jenkees. S
Texas road phage
The TWiV team travels to Texas A&M University, home of the Center for Phage Technology, where they speak with Ry Young and Jason Gill about their work on viruses that infect bacteria. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guests: Jason Gill and Ry Young Become a patron of TWiV! Links for this episode Center for Phage Technology at TAMU Personalized phage therapy (PNAS) Phage for biolipid extraction (Sci Rep) Viral protein antibiotic (Nat Micro) Acinetobacter phag
Outbreak
Vincent visits the Smithsonian Institution and speaks with Sabrina Sholts, Jon Epstein, and Ed Niles about the exhibit Outbreak: Epidemics in a Connected World. Host: Vincent Racaniello Guests: Sabrina Sholts, Jon Epstein, and Ed Niles Become a patron of TWiV! Links for this episode Sabrina Sholts Jonathan Epstein EcoHealth Alliance Outbreak at the Smithsonian ASM partners with Smithsonian (bLog Phase) Vincent as museum object (AMNH) Video of this episode (YouTube) Intro music is by Ronald Jen
Keep virology weird
The entire TWiV team visits The University of Texas in Austin to record episode #500 with guests Jinny Suh, Jason McClellan, and Jon Huibregtse. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guests: Jinny Suh, Jason McClellan, and Jon Huibregtse Become a patron of TWiV! Links for this episode A big list of science podcasts Immunize Texas McClellan Lab Huibregtse Lab John Ring LaMontagne Center for Infectious Disease Video of this episode (YouTube) We
Good virologists go to Halifax
Vincent and Alan travel to the Canadian Society for Virology meeting in Halifax, Nova Scotia to speak with Nathalie and Craig about their vision for the society, and with Kate and Ryan about their careers and their research. Hosts: Vincent Racanielloand Alan Dove Guests: Nathalie Grandvaux, Craig McCormick, Kate O'Brien, and Ryan Noyce Become a patron of TWiV! Links for this episode TWiV 2018 World Tour CSV 2018 To wheeze or not to wheeze (Lancet Respir Med) Synthetic infectious horsepox (PLoS
Salivating at ASM Microbe
Vincent, Kathy and Rich travel to ASM Microbe 2018 in Atlanta where they speak with Stacy Horner and Ken Stapleford about their careers and their research. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Stacy Hornerand Ken Stapleford Become a patron of TWiV! Links for this episode TWiV 2018 World Tour RNA modifications go viral(Plos Path) N6-methyladenosinein flavivirus genomes (Cell Host Micr) Chikungunya virus evolution(Cell Host Micr) Intro music is by Ronald Jenkees. Se
Europic 2018
At Europic 2018, a meeting on picornaviruses in the Netherlands, Vincent speaks with Sasha Gorbalenya, Jim Hogle, Ann Palmenberg and Frank van Kuppeveld about their careers and their research. Hosts: Vincent Racanielloand Rich Condit Guests: Sasha Gorbalenya, Jim Hogle, Ann Palmenberg, and Frank van Kuppeveld Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Vaccines work, whether or not you believe in them
Vincent and Rich recorded this episode at Vaccines in the 21st Century, a meeting held at the University of California, Irvine, where they spoke with Stacy Schultz-Cherry, Douglas Diekema, and Andrew Noymer about vaccine facts and fiction. Hosts: Vincent Racanielloand Rich Condit Guests: Stacey Schultz-Cherry, Douglas Diekema, and Andrew Noymer Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine
Influenza virus keeps its ion channel 20
The TWiVerati follow up on the Ebola virus outbreak, virulence of Ebola-Makona, and reveal how a parasitoid is revealed to hyperparasitoids, and binding of influenza virus to a calcium ion channel to mediate influenza virus entry. Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine International dsRNA Virus Symposium Tracing Ebola virus co
Ebola Makona is the opposite of hakuna matata
Vincent, Kathy, and Alan review the ongoing outbreak of Ebola virus in the Democratic Republic of the Congo, and the finding that mutations identified in the 2015 West African epidemic do not alter pathogenesis in animals. Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine International dsRNA Virus Symposium New Ebola virus outbreakin DRC
Condit is on drugs and norovirus is lit
The TWiVerati discuss the FDA Advisory Committee deliberation on the anti-poxvirus drug tecovirimat, and immune cells in gut-associated lymphoid tissue as the major target during acute murine norovirus infection. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine FDA meeting materials for tecovirimat(FDA)
CRISPR diagnostics
The Masters of the TWiXome review the development of sensitive, portable, and field-based viral diagnostics using the CRISPR-Cas system. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine Norovirus outbreaks from nori(Emerging Inf Dis) SHERLOCK(Science) HUDSON(Science) DETECTR(Science) Letters readon TWiV
The Ileum and the Odyssey
The TWiVome deconstructs the evolutionary history of RNA viruses, and immune promortion of murine norovirus pathogenesis by replication in intestinal tuft cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine Evolutionary historyof RNA viruses (Nature) The amphioxus song Norovirus tropism for tuft cell
Shave ice and giant viruses
From the TWiV team, human cowpox infection possibly acquired from a pet cat, and a new giant mimivirus of green algae with genes encoding enzymes of fermentation. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 ASV Job Site revamped Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine Dick Courtney obit Human cowpox infection(NEJM) Mimivirus encodes fermentation ge
CD4 Hunter
Vincent visits Sandra Urdaneta-Hartmann at Drexel University College of Medicine in Philadelphia to talk about the development of the mobile video game 'CD4 Hunter'. Host: Vincent Racaniello Guest: Sandra Urdaneta-Hartmann Become a patron of TWiV! Links for this episode CD4 Hunter iOSAndroid Sandra on Twitter Carla Brown on Twitter Inactivation of HIV in breast milk(Retrovirology) Nipple shieldto inactivate HIV (Int J Pharm) Intro music is by Ronald Jenkees. Send your virology questions and
Who nose if it will work in humans
The TWiV team reveals that recent mumps virus outbreaks in the US are due to waning vaccine efficacy, and an intranasally delivered small interfering RNA that controls West Nile infection in the brain. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 ASV 2018 Microbiology Student Symposium at UC Berkeley Support Viruses & Cells Gordon Conference Waning mumps vaccinein US (Sci Trans Med) siRNA controlof
Milwaukee viral
At the Medical College of Wisconsin, Vincent talks with current and former members of the Department of Microbiology and Immunology about their work and their careers. Host: Vincent Racaniello Guests: Dominique Carter, Sid Grossberg, John Kirby, Scott Terhune, and Vera Terakanova Become a patron of TWiV! Intro music by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sean Whelan on being haploid
Sean Whelan returns to TWiV to speak with Vincent about using haploid cell lines to identify genes encoding cell receptors for viruses, including Ebolavirus, Lassa virus, and more. Host: Vincent Racaniello Guest: Sean Whelan Become a patron of TWiV! Links for this episode Ebola virus entry requires the cholesterol transporter Niemann-Pick C1 (Nature) Lassa virus entry requires a trigger-induced receptor switch (Science) Infectious Entry Pathway Mediated by the Human ERV K Envelope Protein (J Vi
Fishing with defective flies
The TWiV posse considers viral insulin-like peptides encoded in fish genomes, and insect antiviral immunity by production of viral DNA from defective genomes of RNA viruses. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Become a patron of TWiV! Links for this episode ASM Microbe 2018 Insulin-like peptides in Iridovirus genomes (PNAS) Dicer-2 dependent generation of cvDNA from defective genomes (Cell Host Micr) Carla Saleh on insect antiviral immuni
Float like a mimivirus STING like a bat
The TWiVumvirate discuss the giant Tupanvirus, with the longest tail in the known virosphere, and dampened STING dependent interferon activation in bats. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Become a patron of TWiV! Links for this episode ASM Microbe 2018 Tailed giant Tupanvirus (Nat Commun) Soda Lakes (Wikipedia) Dampened STING in bats (Cell Host Microbe) Image credit Letters read on TWiV 484 Weekly Science Picks Kathy - How to r
Every infection is unhappy in its own way
Vincent and the Virals review undermining of antiviral effectiveness by genital inflammation, and heterogeneity of influenza virus infection in single cells. Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Become a patron of TWiV! Links for this episode USA Science and Engineering Festival Genital inflammation and antiviral effectiveness (Nat Med) Single cell infection heterogeneity (eLife) Single-cell poliovirus infection (Virology) Image credit Letters read on TWiV 483 Weekl
Don't EVEome without antibody expressed
The TWiV Masters discuss serologic evidence of Ebolavirus infection in a population with no outbreaks, and the set of endogenous viral elements in the mosquito genome. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Become a patron of TWiV! Links for this episode USA Science and Engineering Festival Ebolavirus infection without an outbreak (J Inf Dis) A. aegypti EVEome (Curr Biol) One Loop to Rule Them All (Trends Biochem Sci) Image credit Letters re
And biles to go before I delete
The TWiVodrome considers the intestinal tract as an alternative infection route for MERS coronavirus, and how reduced accumulation of defective viral RNAs might lead to severe influenza. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode HaHa influenza virus (mBio) MERS coronavirus intestinal transmission (Sci Adv) Simulated gastric and intestinal fluids Stomacher Defective genomes and severe influenza (PLoS
The PFU in your achoo
Scott Hensley joins the TWiVites to review the current influenza season and presence of the virus in exhaled breath of symptomatic cases. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Scott Hensley Become a patron of TWiV! Links for this episode Weekly influenza surveillance (CDC) Influenza vaccination status (CDC) H3N2 glycosylation site and eggs (PNAS) Influenza virus in exhaled breath (PNAS) Geometric Defects and Icosahedral Viruses (Viruses
Trypsin the flight fantastic
The TWiVome explores induction of antiviral responses by repeating patterns of capsids, and a fungus in the mosquito gut that aids dengue virus replication. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode Innate immune detection of capsid patterns (mBio) Mosquito gut fungus aids dengue virus replication (eLife) Nominate MicrobeTV for a Keck award Image credit Letters read on TWiV 479 Weekly Scienc
A pox on your horse
The TWiV team explains how infectious horsepox virus - likely the ancestor of smallpox vaccines - was recovered from chemically synthesized DNA fragments. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASV 2018: asv.org, asv2018.umd.edu Potential Zika virus related birth defects, USA (MMWR) Bordering on an outbreak (Tex Obs) Horsepox virus from synthesized DNA (PLoS One) Horsepox based smallpox vaccine (N
Raiders of the lost Arc
The TWiVodrome explains how a gag-like protein from a retrotransposon forms virus-like particles that carry mRNA within vesicles across the synapse. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASV 2018: asv.org, asv2018.umd.edu Arc virus-like particles transport RNA across the synapse (mammalian, Drosophila) Chemical synapse (Wikipedia) 2 minute video on the neuron Image credit Letters read on TWiV 4
In ACOD1 we trust
Nels joins the TWiV team to talk about his work on genomic accordions in vaccinia virus, hepatitis B virus in a 439 year old mummy, and viral induction of energy synthesis by a long noncoding RNA. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Nels Elde Click arrow to play Download TWiV 476 (63 MB .mp3, 105 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV! Links for this episode ASV 2018: asv.org, asv2018.umd.edu TWiV is a must-
Everything is viral
In the first episode for 2018, the TWiV team reviews the amazing virology stories of 2017. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Become a patron of TWiV! Links for this episode ASV 2018: asv.org, asv2018.umd.edu Virology stories of 2017 - in no particular order A virologist in space - TWiV 444 Cool things viruses do: Astrovirus capsids are enterotoxins TWiV 423; giant Klosneuviruses encode lots of stuff for translation TWiV 437; Giant Noumeaviruses quick
Call me fish meal
The TWiVanguardians take on Bodo saltans virus, a leviathan which infects an abundant flagellated eukaryote in Earth's waters. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Become a patron of TWiV! Links for this episode ASV 2018: asv.org, asv2018.umd.edu Support Microbe.tv Anti-dengue antibody and disease (J Inf Dis) Bodo saltans virus (biorXiv) Kinetoplast DNA (Euk Cell) Crossword puzzle for book contest (pdf) Letters read on TWiV 474 Weekly Science Pic
Assessing a risk and infecting you twice
The Fellowship of the Virus discuss enhancement of dengue disease in humans: the contribution of antibody concentration and increased binding to Fc receptors. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASV 2018: asv.org, asv2018.umd.edu Support Microbe.tv NEIDL is approved NIH lifts GOF moratorium (Science) Blackburn steps down as head of Salk Institute (SD Union Trib) ADE of dengue disease in humans
Ray Ortega in the podcaster's studio
Vincent speaks with professional podcast producer Ray Ortega about his career and the power of the podcast. Host: Vincent Racaniello Guest: Ray Ortega Become a patron of TWiV! Links for this episode Ray on Twitter The Podcasters' Studio Produce Picker Podcast Ray's YouTube channel Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
The riddle of the skinks
The TWiV team reveal the origin of the poxvirus membrane, and how a retrovirus drove the development of the placenta of a lizard. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASV 2018: asv.org, asv2018.umd.edu Support Microbe.tv Origin of poxvirus membrane (PNAS) Poxvirus movies: Movie S1, Movie S2, Movie S3, Movie S4, Movie S5 Lizard placenta from a retrovirus (PNAS) Letters read on TWiV 472
Songs of innocence and experience
The TWiVerinos discuss restriction of dengue virus vaccine by Sanofi, and data which suggest that Dengvaxia causes enhanced disease in previously uninfected recipients. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASV 2018: asv.org, asv2018.umd.edu Sanofi update on Dengvaxia Trouble for dengue vaccine (Reuters) Sanofi restricts dengue vaccine (CIDRAP) Dengvaxia enhances disease (Vaccine) Interview with
Just a passing phage
The TWiV ninjas reveal that bacteriophage particles rapidly move across monolayers of eukaryotic cells from different tissues. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode Transcytosis of bacteriophage across cell layers (mBio) Image credit Letters read on TWiV 470 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country.
Mycovirus stuffed potatoes
The TWiV hosts discuss a plant virus that infects a fungus, and whether you need to work insane hours to succeed in science. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode Phytopathogenic fungus hosts a plant virus (PNAS) Franklin column (PNAS) Potato famine mystery solved (History) Protein Data Bank You do not need to work 80 hours per week (THE) How I Learned To Stop Worrying (Sci Am) Image credit: Trut
Zika by the slice
Amy joins the TWiV team to talk about her career and her work on Zika virus neurotropism using embryonic mouse organotypic brain slice cultures. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Amy Rosenfeld Become a patron of TWiV! Links for this episode Grad students face tax hike (Nature) House voted to bankrupt grad students (NYTimes) Neurotropism of early and late Zika virus isolates (PNAS) Zika virus blocks the neuron road (virology blog) L
Jon and Ted's Excellent Adventure
Jon and Teddy Yewdell join the TWiV team to talk about their careers, their research, and the problems with biomedical research. Hosts: Vincent Racaniello, Alan Dove,and Rich Condit Guest: Jon Yewdell and Teddy Yewdell Become a patron of TWiV! Links for this episode Jon Yewdell laboratory Chaudhuri laboratory Truth Wins by Jon Yewdell (epub or mobi download) Noncoding RNAs and class switch recombination (Int Imm) Translating DRiPs (J Leuk Biol) Lamprey VLRP response to influenza virus (eLife) T
The Capsid Club
From Indiana University, Vincent and Kathy speak with Tuli Mukhopadhyay, John Patton, and Adam Zlotnick about their careers and their work on alphaviruses, hepatitis B virus, and rotaviruses. Host: Vincent Racaniello and Kathy Spindler Guests: Tuli Mukhopadhyay, John Patton, and Adam Zlotnick Become a patron of TWiV! Links for this episode Mukhopadhyay lab Patton lab Zlotnick lab Tuli on Twitter Palmitoylation of Sindbis virus TF protein (J Virol) Hepatitis B virus structure (Ann Rev Virol) Rot
Theodora the explorer
Theodora Hatziioannou joins the TWiV team to discuss a macaque model for AIDS, and how a cell protein that blocks HIV-1 infection interacts with double-stranded RNA. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Theodora Hatziioannou Become a patron of TWiV! Links for this episode ASU-UofA Joint Virology Symposium Laboratory of Retrovirology, Rockefeller University HIV-1-induced AIDS in monkeys (Science) APOBEC3H bound to duplex RNA (Nat Comm)
Boston baked viruses
At Tufts University Dental School in Boston, Vincent speaks with Katya Heldwein and Sean Whelan about their careers and their work on herpesvirus structure and replication of vesicular stomatitis virus. Host: Vincent Racaniello Guests: Katya Heldwein and Sean Whelan Become a patron of TWiV! Links for this episode Crystal structure of HSV gB (Science) Crystal structure of HSV fusion regulator gH-gL (Nat Struct Mol Biol) Nuclear Exodus: Herpesviruses Lead the Way (Ann Rev Virol) VSV Pseudotypes B
We haven't meth but these names ring Nobel
The TWiViridae review the 2017 Nobel Prizes for cryoEM and circadian rhythms, and discuss modulation of plant virus replication by RNA methylation. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode Truth Wins by Jonathan Yewdell (epub or mobi) Gabriel Victora awarded MacArthur Prize Forty Years of mRNA Splicing (CSH) 2017 Chemistry Nobel: Jacques Dubochet, Joachim Frank, Richard Henderson 2017 Physiology or
Tear it up with David Tuller
David Tuller returns to discuss his efforts to expose the methodological and ethical problems with the PACE trial for ME/CFS. Hosts: Vincent Racaniello Guest: David Tuller Become a patron of TWiV! Links for this episode All of David's ME/CFS articles at virology blog David Tuller on Twitter Through the Shadowlands by Julie Rehmeyer Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
TWiV 462: Splicing RNA with Phillip A. Sharp
Vincent speaks with 1993 Nobel Laureate Phillip A. Sharp about his career and his seminal discovery of RNA splicing in mammalian cells, which changed our understanding of gene structure. Hosts: Vincent Racaniello Guest: Phillip A. Sharp Become a patron of TWiV! Links for this episode Meet the Microbiologist Sharp Laboratory Spliced segments of adenovirus late mRNA (PNAS) Video of this interview (YouTube) This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. De
Gotta trace them all!
The TWiVers discuss the declining readability of scientific texts, and review the use of self-inactivating rabies virus for tracing neural circuits. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Brianne Barker Become a patron of TWiV! Links for this episode Meet the Microbiologist TWiV 1: West Nile Virus Decreasing readability of scientific texts (eLife) Measure text readability Tracing neural circuits with self-inactivating rabies virus (Cell) Cre driver
Penn, a great sandbox for science
Vincent travels to the University of Pennsylvania and speaks with virologists Gary Cohen, Scott Hensley, Carolina Lopez, and Susan Weiss about their careers and their research. Host: Vincent Racaniello Guests: Gary Cohen, Scott Hensley, Carolina Lopez, and Susan Weiss Become a patron of TWiV! Links for this episode Cohen Laboratory Hensley Laboratory Lopez Laboratory Weiss Laboratory This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense,
Polio turns over a new leaf
The TWiV team reviews the first FDA approved gene therapy, accidental exposure to poliovirus type 2 in a manufacturing plant, and production of a candidate poliovirus vaccine in plants. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Conference on Viral Manipulation of Nuclear Processes ASM Public Outreach Fellowship Kymriah approved (PennMed) CAR T cells (NCBI) Cost of Kymriah (NYTimes) Accidental exp
Saliva of the fittest
The TWiVians present an imported case of yellow fever in New York City, and explain how a dengue virus subgenomic RNA disrupts immunity in mosquito salivary glands to increase virus replication. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Conference on Viral Manipulation of Nuclear Processes Roger W. Hendrix, 74 (Pittsburgh Post-Gazette) Roger Hendrix video on TWiV #135 Yellow fever in traveler ret
The Red Queen meets the White Rabbit
Brianne returns to the TWiV Gang to discuss the distribution of proteins on the influenza viral genome, and the evolution of myxoma virus that was released in Australia to control the rabbit population. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guest: Brianne Barker Become a patron of TWiV! Links for this episode First genetically engineered salmon sold in Canada Nucleoprotein on influenza virus RNA (Nucl Acids Res) Evolution of released myxoma virus in Australi
Be careful of canons
Brianne joins the TWiVMasters to explain how mutations in genes encoding RNA polymerase III predispose children to severe varicella, and detection of an RNA virus by a DNA sensor. Hosts: Vincent Racaniello and Rich Condit Guest: Brianne Barker Become a patron of TWiV! Links for this episode RNA pol III mutations underlie severe varicella (J Clin Inves) Dengue virus activates cGAS by release of mitochondrial DNA (Sci Rep) Dengue virus NS2B protein targets cGAS for degradation (Nat Micr) Image cr
Pork and Beans
Erin joins the TWiVirions to discuss a computer exploit encoded in DNA, creation of pigs free of endogenous retroviruses, and mutations in the gene encoding an innate sensor of RNA in children with severe viral respiratory disease. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Erin Garcia Become a patron of TWiV! Links for this episode DNA-based computer exploit (pdf) Inactivation of porcine endogenous retrovirus in pigs (Science) Severe viral respiratory infecti
FGCU, Zika
Sharon and Scott return to TWiV for a Zika virus update, including their work on viral evolution and spread, and whether pre-existing immunity to dengue virus enhances pathogenesis. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Guests: Sharon Isern and Scott Michael Become a patron of TWiV! Links for this episode Hurricane Zika (TWiV 410) 454 Corporation (Wikipedia) Regional Zika update, Americas (PAHO, WHO) Zika virus serum bank (pdf) Zika virus evolution and
Neurovirology with Diane Griffin
From the Vector-Borne Viruses Symposium in Hamilton, Montana, Dickson and Vincent speak with Diane Griffin about her career and her work on understanding viral infections of the central nervous system. Hosts: Vincent Racaniello and Dickson Despommier Guest: Diane Griffin Become a patron of TWiV! Links for this episode Vector-Borne Viruses Symposium Diane Griffin Adoptive immunization of immunosuppressed mice infected with Sindbis virus Role of the immune response in age-dependent resistance o
TWiV 452: Kiss that frog
Lynda Coughlan joins the weekly virtual bus companions for a discussion of a host defense peptide from frogs that destroys influenza virus, and mouse models for acute and chronic hepacivirus infection. Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Guest: Lynda Coughlan Become a patron of TWiV! Links for this episode Linda on Virus Watch and BSGCT Anti-influenza peptide from frogs (Immunity) Magainins (Wikipedia) Urumi Kathy's defensin paper (PLoS Path) World Hepatitis Day Mouse mod
TWiV 451: Expectorate the unexpected
The TWiV scientists reveal that mosquitoes transmit different West Nile virus populations with each blood meal, only to have the diversity purged in a bird host. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode Driving past a milestone (TWiP 100) Debug Fresno (Verily blog) What could possibly go wrong? (TWiV 388) Chestnut blight (ProMedMail) Hypovirus molecular biology (Adv Virus Res) Mosquitoes transmit unique WNV populatio
TWiV 450: Ben tenOever and RNA out
Ben tenOever joins the TWiVoli to discuss the evolution of RNA interference and his lab's finding that RNAse III nucleases, needed for the maturation of cellular RNAs, are an ancient antiviral RNA recognition platform in all domains of life. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Ben tenOever Become a patron of TWiV! Links for this episode RNAseIII is an ancient antiviral effector (Nature) Influenza suppression of RNAi (PNAS) Questioning
TWiV 449: The sound of non-silencing
The TWiV Council explores the finding that facial appearance affects science communication, and evidence that RNA interference confers antiviral immunity in mammalian cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Become a patron of TWiV! Links for this episode JMBE SciComm Issue Facial appearance affects science communication (PNAS) Your face matters to science (virology blog) RNA based antiviral immunity in mammals (Immunity) How mice say nodavirus (TWiV 2
TWiV 448: Mavis the Structure Maven
From ASV 2017 in Madison, Wisconsin, the complete TWiV team speaks with Mavis Agbandje-McKenna about her career and her work solving virus structures by x-ray crystallography and cryo-electron microscopy. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Mavis Agbandje-McKenna Become a patron of TWiV! This episode of TWiV is sponsored by Promega Corporation. Promega is a leader in providing innovative solutions and technical support to the life s
TWiV 447: Un-impacting an elephant
The glorious TWiVerati un-impact their email backlog, anwering questions about viruses, viruses, viruses, viruses, viruses, and more. You should listen - our fans ask great questions! Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode JMBE SciComm Issue Female role models in engineering (PNAS) Gender equity at ASM meeting (mBio) Invisible Frontiers Time, Love, Memory The Eighth Day of Creation Predatory journ
TWiV 446: Old sins die hard
The TWiV hosts review an analysis of gender parity trends at virology conferences, and the origin and unusual pathogenesis of the 1918 pandemic H1N1 influenza virus. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM grant writing online course Gender parity trends at virology meetings (J Virol) Professor gender perpetuates gender gap (NBER) Next generation researchers initiative (NIH) NIH abandons gran
TWiV 445: A nido virology meeting
From Nido2017 in Kansas City, Vincent meets up with three virologists to talk about their careers and their work on nidoviruses. Host: Vincent Racaniello Guests: Margo Brinton, Luis Enjuanes, and Linda Saif Become a patron of TWiV! Links for this episode Murine flavivirus resistance gene (PNAS) TIA-1/TIAR binding sites in West Nile virus RNA (J Virol) Infectious coronavirus DNA in BAC (PNAS) Norovirus binding to lettuce (Appl Env Micro) This episode is brought to you by Blue Apron. Blue Apron
TWiV 444: Astro Kate, The Right Stuff
From ASM Microbe 2017 at New Orleans, Vincent and Rich meet up with astronaut Kate Rubins to talk about becoming an astronaut, space travel, and doing science in space. Hosts: Vincent Racaniello and Rich Condit Guest: Kate Rubins Become a patron of TWiV! Links for this episode Live from the Space Station, NASA Astronaut Kate Rubins Kate Rubins (NASA, Wikipedia) Expedition 48-49 launches to the ISS Expedition 48-49 Crew Docks to the Space Station Expedition 48-49 Crew Welcomed to the Space Stati
TWiV Special: Trial by Error, Continued
David Tuller returns to discuss the continuing saga of the UK's PACE trial for chronic fatigue syndrome, including the accusation that he is engaging in libelous blogging. Host: Vincent Racaniello Guest: David Tuller Become a patron of TWiV! Links for this episode TWiV 397: Trial by Error All articles by David Tuller at virology blog Getting it wrong on chronic fatigue syndrome (NY Times) Esther Crawley slide (Twitter) David's fundraising page Intro music is by Ronald Jenkees. Send your viro
TWiV 443: On a leaf, no one can hear you scream
The TWiVsters reveal the puppet master: an RNA virus injected with wasp eggs that paralyzes the ladybug so that she protects the cocoon until the adult emerges. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM grant writing online course Who is the puppet master? (Proc Roy Soc B) Why ladybird? Ladybird ladybird Dinocampus coccinellae Image credit Letters read on TWiV 443 Weekly Science Picks Kathy - Science Showcase Vid
TWiV 442: The New York Tim
Freelance science journalist Tim Requarth joins the TWiVers to explain why scientists should stop thinking that explaining science will fix information illiteracy. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Tim Requarth Become a patron of TWiV! Links for this episode Neuwrite JMBE science communication issue Smallpox vaccination day The problem with facts (Fin Times) Countering antivaccination attitudes (PNAS) Effective messages in vaccine promotion (Pediatr
TWiV 441: Don't ChrY for me influenza
The Beacons of Viral Education (aka the TWiVoners) reveal a cost of being a male mouse - the Y chromosome regulates their susceptibility to influenza virus infection. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Grant Writing Online Course Giant viruses not from fourth domain of life (Virology) Nuclear envelope disruption during parvovirus infection (J Virol) Nuclear deformation during SV40 infection (Nucleus) Y chro
TWiV 440: I hardly noumeavirus
No problem being nice to Dickson in this episode, because he's absent for a discussion of a new giant virus that replicates in the cytoplasm yet transiently accesses the nucleus to bootstrap infection. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe Noumeavirus cytoplasmic replication depends on transient nuclear access (Nat Commun) Giants among viruses (TWiV 261) Image credit Letters read on TWiV 440 Weekly Sc
TWiV 439: The purloined envelope
Paul Bieniasz joins the TWiV team to talk about the co-option, millions of years ago, of an endogenous retrovirus envelope protein by hominid ancestors for host defense against viral infection. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Paul Bieniasz Become a patron of TWiV! Links for this episode ASM Grant Writing Online Course Bieniasz Laboratory Julius S. Youngner, 96 Distinguished virology career of Julius S. Youngner (TWiV 373) Recons
TWiV 438: Drs. TWiV go to Washington
On the eve of the March for Science, the TWiV team gathers at ASM Headquarters in Washington, DC with guests Stefano and Susie to talk about the state of science communication. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guests: Stefano Bertuzzi and Susan Sharp Become a patron of TWiV! Links for this episode Journal of Microbiology & Biology Education sci comm issue ASM Cultures Stefano Bertuzzi and the scientists' big picture (Washington Post) March for Science T
TWiV 437: Kathy's new spindle virus
The TWiVsters reveal new giant viruses that argue against a fourth domain of life, and discovery of viruses in the oceanic basement. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode Journal of Microbiology & Biology Education sci comm issue Mark Wainberg dies Giant viruses with many translation system components (Science) Viruses in the oceanic basement (mBio) 2-back test Photo by Judy Letters read on TWiV 437 This
TWiV 436: Virology above Cayuga's waters
Host: Vincent Racaniello Guests: Susan Daniel, Colin Parrish, and Gary Whittaker At Cornell University in Ithaca, New York, Vincent speaks with Susan, Colin, and Gary about the work of their laboratories on parvoviruses, influenza viruses, and coronaviruses that infect dogs, cats, horses and other mammals. Become a patron of TWiV! Links for this episode Daniel Laboratory Parrish Laboratory Whittaker Laboratory This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredien
TWiV 435: Two virus particles walk into a cell
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVome discuss the blood virome of 8,420 humans, and thoroughly geek out on a paper about the number of parental viruses in a plaque. Become a patron of TWiV! Links for this episode ASM Grant Writing Course Screwworm letters Blood DNA virome of 8,240 humans (PLoS Path) Plaque co-infection frequencies (mBio) Ode to a plaque (TWiV 68) Counting viruses (Virus Watch) First animal virus plaque assay (J E
TWiV 434: Live long and pupate
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler The esteemed TWiVumvirate reveal the discovery of a new negative stranded RNA virus of wasps that regulates longevity and sex ratio of its parasitoid host. Become a patron of TWiV! Links for this episode ASM Microbe 2017 Parasitoid wasp virus regulates sex ratio (PLoS Path) What is a contig? Image credit Letters read on TWiV 434 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and
TWiV 433: Poops viruses and worms
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler The lovely TWiV team explore evolution of our fecal virome, and the antiviral RNA interference response in the nematode C. elegans. Become a patron of TWiV! Links for this episode ASM Clinical Virology Symposium Evolution of the human fecal virome (PNAS) Antiviral RNAi response in C. elegans (Curr Biol) Orsay virus (TWiV 123) Broad VSV host range (J Comp Neurol) Image credit Letters read on TWiV 433 This episode is b
TWiV 432: Conjunction junction, what's your function?
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler The TWiVites discuss Zika virus seroprevalence in wild monkeys, Zika virus mRNA vaccines, and a gamete fusion protein inherited from viruses. Become a patron of TWiV! Links for this episode Nido2017 Meeting ASMCUE Seroprevalence of Zika virus in wild monkeys and baboons (mSphere) Zika virus mRNA vaccines (paper one, paper two) Gamete fusion protein is type II viral fusogen (paper one, paper two) Image credit Letters re
TWiV 431: Niemann-Pick of the weak
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVirions reveal bacteriophage genes that control eukaryotic reproduction, and the biochemical basis for increased Ebolavirus glycoprotein activity during the recent outbreak. Become a patron of TWiV! Links for this episode Nido2017 Meeting ASM Microbe 2017 Mark Buller obituary RS virus pipeline (pdf) Prophage WO genes and cytoplasmic incompatibility (Nature) Vanderbilt Virology (TWiV 332) Basis for
TWiV 430: The persistence of herpesvirus
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler The TWiX cabal discuss sexual transmission of Zika virus in mice, and how immune escape enables herpes simplex virus escape from latency. Become a patron of TWiV! Links for this episode Nido2017 Meeting ASM Clinical Virology Symposium Zika virus sexual transmission in mice (Cell Rep) Viral RNA is not infectious virus (virology blog) Methyl-phospho switch (TWiV 369) Immune escape of herpesvirus from latency (Cell Re
TWiV 429: Zika Experimental Science Team
Host: Vincent Racaniello Guests: Katie Antony, Tom Friedrich, Emma Mohr, and David O'Connor Vincent meets with members of team ZEST at the University of Wisconsin Madison to discuss their macaque model for Zika virus pathogenesis. Become a patron of TWiV! Links for this episode Badgers Go Viral (TWiV 260) Rhesus macaque model of Zika virus infection (Nat Commun) Heterologous Zika virus protection in macaques (PLoS NTD) ZEST Data Portal This episode is brought to you by Blue Apron. Blue Apron
TWiV 428: Lyse globally, protect locally
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVsters explain how superspreader bacteriophages release intact DNA from infected cells, and the role of astrocytes in protecting the cerebellum from virus infection. Become a patron of TWiV! Links for this episode Nido2017 Meeting Superspreader bacteriophages (mBio) Astrocytes, interferon, and viral infection (JCI) Viral disruption of blood brain barrier (Trends Micro) On Warts by Lewis Thomas (pd
TWiV Special: Vincent Munster on MERS-coronavirus and Ebolavirus
Host: Vincent Racaniello Guest: Vincent Munster At the Rocky Mountain Laboratory in Hamilton, Montana, Vincent speaks with Vincent Munster about the work of his laboratory on MERS-coronavirus and Ebolaviruses. Become a patron of TWiV! Links for this episode Rocky Mountain Laboratory Munster Laboratory Small town, big science (TWiM 140) Image credit Send your virology questions and comments to twiv@microbe.tv
TWiV 427: It was a DURC and UV light
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler The TWiVoids discuss the March for Science, the GOF moratorium, and a classic virology paper on mapping the gene order for vesicular stomatitis virus. Become a patron of TWiV! Links for this episode ASM 2017 election is now open - VOTE HERE ASM Election questions: Which positions are we voting for? What is the ASM Board of Directors? Organization Chart What is the Council on Microbial Sciences? Organization Chart
TWiV 426: I'm Axl, and I'll be your cervid today
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler The sages of TWiV explain how chronic wasting disease of cervids could be caused by spontaneous misfolding of prion protein, and the role of the membrane protein Axl in Zika virus entry into cells. Become a patron of TWiV! Links for this episode Register for ASV 2017 ASM 2017 election is now open - VOTE HERE ASM Election questions: Which positions are we voting for? What is the ASM Board of Directors? Organization Chart W
TWiV 425: All picornaviruses, all the time
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVaniellos discuss a thermostable poliovirus empty capsid vaccine, and two cell genes that act as a switch between entry and clearance of picornavirus infection. Become a patron of TWiV! Links for this episode Register for ASV 2017 ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens XKCD #242 Thermostable poliovirus empty capsid vaccine (PLoS Path) Switch between viral entry and cleara
TWiV 424: FLERVergnügen
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Trudy Rey Trudy joins the the TWiVlords to discuss new tests for detecting prions in the blood, and evidence showing that foamy retroviruses originated in the seas with their jawed vertebrate hosts at least 450 million years ago. Become a patron of TWiV! Links for this episode Welcome omega tau to MicrobeTV Register for ASV 2017 Oliver Smithies dies Assays for prions in the blood (one, two) Biosaf
TWiV 423: Dry, well formed, and light brown
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Jared Rice The TWiV academia discuss induction of diarrhea by the capsid protein of an astrovirus, and association of a fungal RNA virus with white-nose syndrome of North American bats. Become a patron of TWiV! Links for this episode Register for ASV 2017 ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens Astrovirus capsid protein induces diarrhea (mBio) Fungal virus associated with
TWiV 422: Watching the icosahedron drop
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVestigators wrap up 2016 with a discussion of the year's ten compelling virology stories. Become a patron of TWiV! Should auld infections be forgotAnd never T-cells primed?Will cross-reacting antigensProtect the host next time? Links for this episode Register for ASV 2017 ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens Ten virology stories from 2016 Zika virus (first covered in 2
TWiV 421: Like flies on shot
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Nathan Letts The TWiVnauts present another example of an infectious but replication incompetent vaccine, an insect specific arborvirus bearing chikungunya virus structural proteins. Become a patron of TWiV! Links for this episode Register for ASV 2017 ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens Chikungunya virus vaccine using insect virus platform (Nat Med) Ebola vaccine resul
TWiV 420: Orthogonal vectors
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiV gurus describe how to use an orthogonal translation system to produce infectious but replication-incompetent influenza vaccines. Become a patron of TWiV! Links for this episode Register for ASV 2017 Local Zika virus transmission in Texas Texaszika.org Local dengue virus transmission in Texas (EID) No more Zika virus transmission in Florida (FL DOH) Dengue virus antibodies enhance Zika virus infe
TWiV 419: The selfless gene
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVrific gang reveal how integration of a virophage into the nuclear genome of a marine protozoan enhances host survival after infection with a giant virus. Become a patron of TWiV! Links for this episode Microcephaly associated with Zika virus infection in Colombia (MMWR) Virophage genome integration and activation by superinfection (Nature) Don Nelson interview (pdf) Page view and h index for pape
TWiV 418: Of mice and MERS
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVsters describe a new animal model for MERS coronavirus-induced acute respiratory distress syndrome, produced by CRISPR/Cas9 editing of the mouse gene encoding an ortholog of the virus receptor. Become a patron of TWiV! Links for this episode New mouse model for MERS (Nat Micro) RNA-guided genome engineering (Science) Photo by Finny Letters read on TWiV 418 This episode is brought to you by Curiosi
TWiV Special: Gary Nabel on World AIDS Day 2016
Host: Vincent Racaniello Guest: Gary Nabel Vincent speaks with Gary Nabel, Chief Scientific Officer at Sanofi and former Director of the Vaccine Research Institute of NIAID, about his career and his work on HIV vaccines. Become a patron of TWiV! Links for this episode World AIDS Day Video of this interview (YouTube) Send your virology questions and comments to twiv@microbe.tv
TWiV 417: O is the loneliest letter
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The Fellowship of the Virus trace the early history of HIV in North America, based on genome sequences obtained from late 1970s archival sera, which also reveal that Gaetan Dugas was not Patient Zero. Become a patron of TWiV! Links for this episode WHO: Zika virus is no longer a PHEIC World AIDS Day Early HIV/AIDS history in North America (Nature) Dugas was not AIDS patient zero (virology blog) Image cre
TWiV 416: Scattered seeds dormant
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The multi-dimensional TWiV-brane bring you the entries in the haiku/limerick contest, and explain how a giant virus infects a host within another host (it has to do with predators!). Become a patron of TWiV! Links for this episode Predators allow virus infection of endosymbiont (PNAS) Image credit Letters read on TWiV 416 This episode is brought to you by CuriosityStream, a subscription streaming service
TWiV 415: Ebola pipettors and the philosopher's clone
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guests: Jeremy Luban, Aaron Lin, and Ted Diehl Jeremy, Aaron, and Ted join the TWiV team to discuss their work on identifying a single amino acid change in the Ebola virus glycoprotein from the West African outbreak that increases infectivity in human cells. Become a patron of TWiV! Links for this episode Ebola virus glycoprotein with increased infectivity (Cell) Effect in cells of Ebola virus mutations from West African ou
TWiV 414: Zika in the guys with Diamond
Host: Vincent Racaniello Guest: Michael Diamond Michael Diamond visits the TWiV studio to talk about chikungunya virus and his laboratory's work on a mouse model of Zika virus, including the recent finding of testicular damage caused by viral replication. Become a patron of TWiV! Links for this episode Chikungunya virus chronic joint disease caused by adaptive response (J Virol) Mouse model of Zika virus pathogenesis (Cell Host Micr) Zika virus infection during mouse pregnancy (Cell) Zika vir
TWiV 413: Partnerships not parachutes
Hosts: Vincent Racaniello, Alan Dove, and Paul Duprex Guests: Ralph Baric, Felix Drexler, Marion Koopmans, and Stacey Schultz-Cherry From the EIDA2Z conference at Boston University, Vincent, Alan and Paul meet up with Ralph Baric, Felix Drexler, Marion Koopmans, Stacey Schultz-Cherry to talk about discovering, understanding, protecting, and collaborating on emerging infectious diseases. Become a patron of TWiV! Links for this episode EIDA2Z meeting MERS-CoV infection of Alpaca (EID) Origins o
TWiV 412: WO, open the borders and rig the infection
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Mark Fuccio The TWiVome reveal the first eukaryotic genes found in a bacteriophage of Wolbachia, and how DNA tumor virus oncogenes antagonize sensing of cytoplasmic DNA by the cell. Become a patron of TWiV! Links for this episode Zika virus in vaginal secretions (EID) Zika virus in semen (EID) Eukaryotic genes in a bacteriophage (Nat Commun) Seth Bordenstein on TWiV 332 DNA tumor virus oncogenes antagonize cGAS-STING
TWiV 411: Chicken runs
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler The TWiVeroos examine a reverse spillover of Newcastle disease virus vaccines into wild birds, and identification of a protein cell receptor for murine noroviruses. Become a patron of TWiV! Links for this episode MicrobeTV Store Florida DOH Daily Zika Update Zika virus in new Miami neighborhood (CNN, NYTimes) NDV vaccine virus in wild birds (PLoS One) Protein cell receptor for murine norovirus (Science, PNAS) Poliovirus rec
TWiV 410: Hurricane Zika
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guests: Sharon Isern and Scott Michael Sharon and Scott join the TWiV team to talk about their work on dengue antibody-dependent enhancement of Zika virus infection, and identifying the virus in mosquitoes from Miami. Become a patron of TWiV! Links for this episode Live at Florida Gulf Coast University (TWiV #111) Florida DOH Daily Zika Update Regional Zika update, Americas (PAHO, WHO) NJ Zika Bill Dengue virus antibodi
TWiV 409: A Nef is enough
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Jeremy Luban Jeremy joins the TWiVeroids to tell the amazing story of how the function of the HIV-1 protein called Nef was discovered and found to promote infection by excluding the host protein SERINC from virus particles. Become a patron of TWiV! Links for this episode No recovery in PACE trial (virology blog) The real PACE data (virology blog) Contagious Thinking Florida DOH daily Zika upda
TWiV 408: Boston Quammens
Hosts: Vincent Racaniello and Alan Dove Guest: David Quammen Four years after filming 'Threading the NEIDL', Vincent and Alan return to the National Emerging Infectious Diseases Laboratory BSL4 facility at Boston University where they speak with science writer David Quammen. Watch this episode at YouTube Become a patron of TWiV! Links for this episode David Quammen's website Spillover by David Quammen Threading the NEIDL (TWiV 200) The NEIDL at Boston University This episode is brought to yo
TWiV 407: Tar Heels go viral, part two
Host: Vincent Racaniello Guests: Ralph Baric, Kristina De Paris, Tal Kafri, Helen Lazear, Mark Heise, and David Margolis In the second of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on RNA viruses, and what they would be doing if they were not scientists. View video of this episode at YouTube Become a patron of TWiV! This episode is brought to you by CuriosityStream, a subsc
TWiV 407: Tar Heels go viral, part one
Host: Vincent Racaniello Guests: Dirk Dittmer, Cary Moody, Nat Moorman, Nancy Raab-Traub, Lishan Su, and Jennifer Webster-Cyriaque In the first of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on DNA viruses, and what they would be doing if they were not scientists. View video of this episode at YouTube Become a patron of TWiV! This episode is brought to you by CuriosityStream
TWiV 406: Pow, right in the enteroids!
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiV team discussed eye infections caused by Zika virus, failure of Culex mosquitoes to transmit the virus, and replication of norovirus in stem cell derived enteroids. Become a patron of TWiV! Links for this episode Florida DOH daily Zika update Congress fails again on Zika (NY Times) Culex pipiens does not support Zika virus replication (EID) Zika virus in the eye (Cell Rep) Norovirus replication i
TWiV 405: All the world's a phage
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler The TWiXers discuss a study on vertical transmission of Zika virus by Aedes mosquitoes, and uncovering Earth's virome by mining existing metagenomic sequence data. Become a patron of TWiV! Links for this episode Roger Tsien, 64 (UC San Diego Health) CDC running out of Zika money (NYTimes) Zika virus in Miami mosquitoes (NYTimes) No Zika virus in Rio Olympics (NYTimes) Vertical transmission of Zika virus in Aedes aegy
TWiV 404: Not found
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit From the twiVivants, follow up on FluMist and Zoster vaccines, Zika virus update, and isolation of a multicomponent animal virus from mosquitoes. Become a patron of TWiV! Links for this episode FluMist problem (FDA) DA Henderson obituary (NY Times) DA Henderson, smallpox eradicator (TWiV Special) Efficacy of VZV vaccine (Ther Adv Vaccines) Zika virus burden, Puerto Rico (JAMA) Zika virus in Miami Beach (STAT) Congenital
TWiV Special: DA Henderson, smallpox eradicator
Donald “D.A.” Henderson, a physician, educator, and epidemiologist who led the World Health Organization’s campaign to eradicate smallpox, died at 87 years of age on Aug. 19, 2016. Vincent was fortunate to have the opportunity to speak with DA Henderson in 2014 about his career, the smallpox eradication effort, and what it means for the eradication of polio. Become a patron of TWiV! This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 docume
TWiV 403: It's not easy being vaccine
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit The TWiV team takes on an experimental plant-based poliovirus vaccine, contradictory findings on the efficacy of Flumist, waning protection conferred by Zostavax, a new adjuvanted subunit zoster vaccine. Become a patron of TWiV! Links for this episode Tribunal orders release of PACE trial data (Valerie Eliot Smith) Our request for PACE trial data (virology blog) GM mosquito release on ballot (NPR) Florida Keys Mosquito Control District on
TWiV 402: The plight of the bumblebee
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Polio returns to Nigeria, Zika virus spreads in Miami, and virus infection of plants attracts bumblebees for pollination, from the virus gentlepeople at TWiV. Become a patron of TWiV! Links for this episode Marian Horzinek, 80 (ProMedMail) Polio in Nigeria (Atlantic, Stat, ProMedMail) Zika virus spreads in Miami (NYTimes) More Zika virus vaccines (Science) Back to work on Zika, Congress ! (Asbury Park Press) Lack of fun
TWiV 401: Vector victorious
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Zika virus spreads in the USA, a Zika virus DNA vaccine goes into phase I trials, and how mosquito bites enhance virus replication and disease, from the friendly TWiFolk Vincent, Dickson, Alan, and Kathy. Become a patron of TWiV! Links for this episode Beverly Griffin, 86 (1 2 3) Zika virus in the US (CDC) Zika virus spreading in Miami (CDC) Zika virus in Florida (NY Times) NIH begins phase I trial of Zika virus DN
TWiV 400: Harold '400' Varmus, a scientist for all seasons
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Harold Varmus The TWiV team is together in New York City for a conversation with Nobel Laureate Harold Varmus about his remarkable career in science. Become a patron of TWiV! Links for this episode Varmus Laboratory Varmus and Kandel on Charlie Rose (transcript) Rescuing biomedical research Letters read on TWiV 400 Video of this episode at YouTube This episode is sponsored by CuriosityStream. Get
TWiV 399: Zika la femme
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit The latest Zika virus news from the ConTWiVstadors, including a case of female to male transmission, risk of infection at the 2016 summer Olympics, a DNA vaccine, antibody-dependent enhancement by dengue antibodies, and sites of replication in the placenta. Links for this episode Zika virus disease in the US (CDC) Female to male Zika virus transmission (CDC) Zika virus in female genital tract (Lancet) Zika virus transmiss
TWiV 398: Permission to be intuitive
Host: Vincent Racaniello Guest: Sandy Weller Vincent speaks with Sandy Weller about her career and her work on the mechanisms of synthesis, maturation and cleavage and packaging of viral DNA genomes. Become a patron of TWiV! Links for this episode Cell killing by avian leukosis virus (Sandy's first paper, J Virol) ND10 protein and herpes simplex virus replication (J Virol) Recombination promoted by DNA viruses (Ann Rev Micro) HSV-1 and DNA damage response (Fut Virol) Video of this episode at
TWiV 397: Trial by Error
Host: Vincent Racaniello Guest: David Tuller Vincent speaks with David Tuller about flaws in the U.K's $8 million PACE trial for chronic fatigue syndrome, and efforts to have the trial data released. Become a patron of TWiV! Links for this episode Science and journalism (TWiV 111) Chronic fatigue syndrome and the CDC (virology blog) PACE trial (Lancet) Trial by error part one, two, three (virology blog) PACE economics analysis (PLoS One) All articles by David Tuller at virology blog Valerie E
TWiV 396: Influenza viruses with Peter Palese
Host: Vincent Racaniello Guest: Peter Palese Vincent speaks with Peter Palese about his illustrious career in virology, from early work on neuraminidases to universal influenza virus vaccines. Become a patron of TWiV! Links for this episode Palese Laboratory Pig kidney neuraminidase (Hoppe Seylers Z Physiol Chem) DNAse in cytoplasmic DNA virus (Virology) Inhibitor of influenza virus neuraminidase (Virology) Influenza neuraminidase defective mutants (Virology) Swine influenza virus of 1976 RNA
TWiV 395: The cancer thief
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guest: Stephen J. Russell From ASV 2016 at Virginia Tech, Vincent, Rich and Kathy speak with Stephen Russell about his career and his work on oncolytic virotherapy - using viruses to treat cancers. Become a patron of TWiV! Links for this episode Hokies go viral (TWiV 285) MV NIS de Myelo (TWiV 298) Remission of disseminated myeloma after MV treatment (Mayo Clin Proc) miRNA detargeting (J Virol) Video of this episode at YouTube This e
TWiV 394: Cards in a hand
Hosts: Vincent Racaniello and Alan Dove Guest: Erica Ollmann Saphire Vincent and Alan speak with Erica about her career and her work on understanding the functions of proteins of Ebolaviruses, Marburg virus, and other hemorrhagic fever viruses, at ASM Microbe 2016 in Boston, MA. Become a patron of TWiV! Links for this episode Structure of antibodies bound to Ebola virus glycoprotein (PNAS) Structure of cross-reactive filovirus antibody (Cell) Multiple functions of Ebola virus VP40 protein (Ce
TWiV 393: Lovers and livers
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler The TWiVerati revisit possible sexual transmission of Zika virus, and reveal how a cell protein that allows hepatitis C virus replication in cell culture enhances vitamin E mediated protection against lipid peroxidation. Become a patron of TWiV! Links for this episode Late sexual transmission of Zika virus (Lancet) Zika virus disease in US (CDC) Zika virus lab accident (ABC News) Mosquito eradication (virology blog) Florida
TWiV 392: Zika virus!
Host: Vincent Racaniello Guests: Michael Diamond, Michaela Gack, Laura Kramer, and Charles Rice Four virologists discuss our current understanding of Zika virus biology, pathogenesis, transmission, and prevention, in this special live episode recorded at the American Society for Microbiology in Washington, DC. [powerpress url="http://traffic.libsyn.com/twiv/TWiV392.mp3"] Click arrow to play Download TWiV 392 (62 MB .mp3, 85 min) Subscribe (free): iTunes, RSS, email, Google Play Music Video of th
TWiV 391: Whiter reefs, fresh breath
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Guests: David Pride and Forest Rohwer If you have always wanted to know what coral reefs and the human oral cavity have in common, listen as guests David Pride and Forest Rohwer talk about their work on the microbiomes and viromes of these two environments, and you'll also understand why mucus is cool. Links for this episode Lytic to temperate switching of viral communities (Nature) Viromes in ancestral holobiont Hydra (PLoS One) Phage in
TWiV 390: Building a better mosquito trap
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guests: Ethan Jackson and Jonathan Carlson Project Premonition, a Microsoft Research project that uses drones to capture mosquitoes and analyze them for pathogens, preprint servers, and three mouse models for Zika virus induced birth defects are the topics of this episode hosted by the TWiumvirate and theirs guests Ethan and Jonathan. Links for this episode Project Premonition Premonition feasibility stu
TWiV 389: Alphabet hepatitis with Stan Lemon
Host: Vincent Racaniello Guest: Stan Lemon Vincent speaks with Stan Lemon about his career in virology, from early work on Epstein Barr virus, through making essential discoveries about hepatitis A virus, hepatitis C virus, and rhinoviruses. Links for this episode Live in Edmonton, Eh? (TWiV 235) Replication of EBV in epithelial cells (Nature) Returning to Carolina after 14 years Evolutionary origins of hepatitis A virus (TWiV 265) cre in rhinovirus genome (RNA) Naked viruses that aren't always
TWiV 388: What could possibly go wrong?
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Preprint servers, the structure of an antibody bound to Zika virus, blocking Zika virus replication in mosquitoes with Wolbachia, and killing carp in Australia with a herpesvirus are topics of this episode hosted by Vincent, Dickson, Alan, and Kathy. Links for this episode biorXiv preprint server Please review Vaccines and Your Child Structure of antibody bound to Zika virus E protein (Cell Host Microbe) Wolbachia bloc
TWiV 387: Quaxxed
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and
Kathy Spindler
Guest: Nina Martin
Nina Martin joins the TWiV
team to talk about the movie Vaxxed, her bout with dengue fever,
and the latest research on Zika virus.
Links for this episode
Public Health United
Fifty Shades of Science (TEDx)
Parents convicted in death of toddler (Science Based Medicine)
CDC: Zika virus causes microcephaly (NEJM)
Dengue virus antibodies enhance Zika virus infection
(biorXiv)
Zika virus in Brazilian no
TWiV 386: The dolphins did it
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Ted Diehl and Welkin Johnson
Ted and Welkin inform the TWiV team how the evolution of ancient retroviruses can be inferred by studying their sequences in the genomes of modern mammals, and join in a discussion of virus dispersal during different methods for drying hands.
Links for this episode
More fun than a monkey full of viruses (TWiV 122)
Tracking ancient retrovirus evolution in mammals (eLife)
Virus dispersal during hand
TWiV 385: Failure
Hosts: Vincent Racaniello and Dickson Despommier
Guest: Stuart Firestein
Stuart joins Vincent and Dickson to talk about his sequel to Ignorance, a book called Failure, which seeks to make science more appealing by revealing its faults.
Links for this episode
Stuart Firestein's site
Ignorance with Stuart Firestein (TWiV Special)
The pursuit of ignorance (TED)
Ignorance by Stuart Firestein
Failure by Stuart Firestein
This episode is sponsored by ASM Agar Art Contest and ASV 2016
Send your viro
TWiV 384: Agent 003, a view to a fish kill
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove and Rich Condit
Guests: Nischay Mishra and Ian Lipkin
Nischay and Ian join the TWiVions to discuss mass die-offs of tilapia by a novel orthomyxo-like virus, Ian's editorial on the movie Vaxxed, and new vaccines to prevent dengue virus infections, including a human challenge model.
Links for this episode
Novel orthomyxo-like virus in Tilapia die-offs (mBio)
Fish flu (TWiV 41)
Anti-vaccination lunacy won't stop (WSJ)
Single-dose dengue v
TWiV 383: A zillion Zika papers and a Brazilian
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove and Kathy Spindler
Guest: Esper Kallas
Esper and the Merry TWiXters analyze the latest data on Zika virus and microcephaly in Brazil, and discuss publications on a mouse model for disease, infection of a fetus, mosquito vector competence, and the cryo-EM structure of the virus particle.
Links for this episode
Zika virus in the Americas (Science)
Co-circulation of dengue, Zika, chik in Brazil (Medicine)
Murine model for Zika virus infect
TWiV 382: Everyone's a little bit viral
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove and Kathy Spindler
Guests: Nels Elde and Edward Chuong
Nels and Ed join the TWiV team to talk about their observation that regulation of the human interferon response depends on regulatory sequences that were co-opted millions of years ago from endogenous retroviruses.
Links for this episode
Endogenous retroviruses and regulation of innate immunity (Science)
Placenta is viral (Nature)
An ERV that maintains pluripotency of human embryoni
TWiV 381: Add viruses and Zimmer
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Carl Zimmer
Carl Zimmer joins the TWiV team to talk about his career in science writing, the real meaning of copy-paste, science publishing, the value of Twitter, preprint servers, his thoughts on science outreach, and much more.
Links for this episode
Carlzimmer.com
All Carl's articles at NYTimes
Carl at Stat
The Loom
Staying afloat in the rising tide of science (Cell)
Parasite Rex
Planet of Viruse
TWiV 380: Viruses visible in le microscope photonique
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVeroos deliver the weekly Zika Report, then talk about a cryoEM structure of a plant virus that reveals how the RNA genome is packaged in the capsid, and MIMIVIRE, a CRISPR-like defense system in giant eukaryotic viruses.
Links for this episode
First worms, then viruses, now dormant cyber pathogens (Zdziarski blog)
Guillain-Barré with Zika virus in urine (Eurosurveillance)
Zika virus in urine, Bra
TWiV 379: A mouse divided
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Scott Tibbetts
Scott Tibbetts joins the TWiVists to describe his work on the role of a herpesviral nocoding RNA in establishment of peripheral latency, and then we visit two last minute additions to the Zika virus literature.
Links for this episode
Noncoding RNA required for establishment of latency (mSphere) 17:20
Lessons learned from in vivo studies of a viral noncoding RNA (mSphere) 1:05:05
Zika
TWiV 378: Herpes plays DUBstep
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Guests: Greg Smith and Mark Fuccio
Greg Smith joins the TWiVirate to reveal how his lab discovered a switch that controls herpesvirus neuroinvasion, and then we visit the week's news about Zika virus.
Links for this episode
Dynamic ubiquitination drives herpesvirus neuroinvasion (PNAS)
Releasing Zika virus data in real time (Nature)
Zika virus infection and stillbirths (PLoS NTD)
Zika virus infection, imported, Italy
TWiV 377: Chicken with a side of Zika
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVniks review the past week's findings on Zika virus and microcephaly, and reveal a chicken protein that provides insight on the restriction of transmission of avian influenza viruses to humans.
Links for this episode
Larvicide not involved in microcephaly (CBS News)
Obama seeks $1.8b for Zika virus (Guardian)
Zika virus in Puerto Rico (MMWR)
Zika virus in semen (EID)
Zika virus in Indonesia (EID)
TWiV 376: The flavi of the month is Zika
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Jeremy Luban
The TWiV team discusses the latest data on Zika virus, including ocular defects in infants with microcephaly, and isolation of the entire viral genome from fetal brain tissue.
Links for this episode
Ocular findings in infants with microcephaly (JAMA and Arq Bras Oft)
Evidence of Zika virus infection in brain and placenta (MMWR)
Zika virus associated with microcephaly (NEJM)
Hard-core
TWiV 375: Zika and you will find
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guests: Carolyn Coyne, Helen Lazear, and Jeremy Luban
The TWiVziks present everything you want to know about Zika virus, including association of infection with microcephaly and Guillain-Barré syndrome, transmission, epidemiology, and much more.
Links for this episode
Zika outbreak in Brazil (EID) 13:40
Zika summary (ProMedMail) 19:30
Zika and microcephaly (MMWR) 27:30
Facts about microcephaly (CDC)
Brazil Ministry of Healt
TWiV 374: Discordance in B
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVniks consider the role of a cell enzyme that removes a protein linked to the 5'-end of the picornavirus genome, and the connection between malaria, Epstein-Barr virus, and endemic Burkitt's lymphoma.
Links for this episode
Divergent requirements for removing VPg (mBio)
Bond, covalent bond (TWiV 210)
Link between malaria and endemic Burkitt's lymphoma (PLoS Path)
Multifactorial role of malaria in
TWiV 373: The distinguished virology career of Julius S. Youngner
Host: Vincent Racaniello
Guest: Julius S. Youngner
Vincent speaks with Julius about his long career in virology, including his crucial work as part of the team at the University of Pittsburgh that developed the Salk inactivated poliovirus vaccine.
Links for this episode
Trypsin for cell cultures (Proc Soc Exp Biol Med)
Interferon induction by nonviral stimuli (J Gen Physiol)
Interferons of different molecular weight (Proc Soc Exp Biol Med)
Poliovirus thermal mutants (J Bacteriol)
Combination
TWiV 372: Latent viral tendencies
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV-osphere introduces influenza D virus, virus-like particles encoded in the wasp genome which protect its eggs from caterpillar immunity, and a cytomegalovirus protein counters a host restriction protein that prevents establishment of latency.
Links for this episode
Ebolavirus update (ProMedMail)
Influenza D virus (mBio)
Vincent's influenza C virus paper (J Virol)
Virus-like particles protect wasp eggs (Sci Adv)
CMV
TWiV 371: Sympathy for the devil
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVologists discuss the finding of a second transmissible cancer in Tasmanian devils, and development of new poliovirus strains for the production of inactivated vaccine in the post-eradication era.
Links for this episode
Second transmissible cancer in Tasmanian Devils (PNAS)
New strains for production of IPV (PLoS Path)
Synchronized switch to bivalent OPV (polioeradication.org)
Virologists, start you
TWiV 370: Ten out of 15
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
The TWiVomics review ten captivating virology stories from 2015.
Ten virology stories from 2015
Recoding to make vaccines and study viral functions: TWiV 351: The dengue codeTWiV 362: Gotta catch ’em all and new paper
Defining the virome: TWiV 365: Blood, feuds, and a foodborne disease, TWiV 362: Gotta catch ’em all, TWiV 356: Got viruses?, TWiV 355: Baby’s first virome, TWiV 342: Public epitope #1, TWiV 323: A skid loader full of viromes
TWiV 369: Camel runny noses and other JNK
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
A swarm of virologists discusses testing of a MERS coronavirus vaccine for camels, and how a neuronal stress pathway reactivates herpes simplex virus.
Links for this episode
MERS coronavirus vaccine for camels (Science)
WHO MERS summary
Neuronal stress pathway and herpes simplex virus reactivation (Cell Host Micr)
Stress flips a chromatin switch (Cell Host Micr)
How herpes simplex virus reactivates (UNC press release)
Histone antibodies d
TWiV 368: Infected, you will be
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
A plaque of virologists explores the biology of Zika virus and recent outbreaks, and the contribution of a filamentous bacteriophage to the development of biofilms.
Links for this episode
More cowbell (Wikipedia)
Microcephaly in Brazil (Outbreak News)
Non-vector borne Zika transmission (EID)
Zika virus outside Africa (EID)
Zika virus possible sexual transmission (EID)
Zika virus in saliva (J Clin Virol)
Dengue's cousin Zika (
TWiV 367: Two sides to a Coyne
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guests: Carolyn Coyne and Coyne Drummond
Two Coynes join the TWiV overlords to explain their three-dimensional culture model of polarized intestinal cells for studying enterovirus infection.
Links for this episode
Carolyn and placentas on TWiV 193
Three-dimensional cell culture model (mSphere)
Bioreactor video (JoVE)
Neurovirologist Richard T. Johnson, 84 (Hopkins and virology blog)
Tardigrade HGT disput
TWiV 366: Doctorates down under
Host: Vincent Racaniello
Guests: Carla Giles, Zoe Dyson, Brianna McLean, and Caitlin O'Brien
In Melbourne, Australia, Vincent speaks with four PhD students about their research projects and what it's like to get a doctorate down under.
Video of this episode: view at YouTube
This episode is sponsored by ASM Microbe and ASM Biodefense.
Send your virology questions and comments to twiv@twiv.tv
TWiV is a MicrobeTV Production
TWiV 365: Blood, feuds, and a foodborne disease
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
For a TWiV Thanksgiving, Vincent, Alan, and Kathy trace the feud over genome editing, a new virus discovered in human blood, and the origins of hepatitis A virus.
Links for this episode
Battle over genome editing (Wired) 10:05
First description of CRISPR in E. coli (J Bacteriol) 14:00
Cas genes identified (Mol Micro) 14:20
CRISPR-Cas provides immunity to bacterial viruses (Science) 15:35
Cas9-crRNA complex mediates DNA cleavage (PNAS) 16:
TWiV 364: It's not SARS 2.0
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Ralph Baric and Vineet Menachery
Vincent, Rich, and Kathy speak with Ralph and Vineet about their research on the potential of SARS-like bat coronaviruses to infect human cells and cause disease in mice.
Links for this episode
Zoonotic potential of SARS-like bat viruses (Nature)
SARS-CoV susceptibility loci via collaborative cross (PLoS Genetics) 47:00, 57:25
Ebright and Wain-Hobson quotes (Nature) 1:17:20
Misleading press re
TWiV 363: Eat flu and dyad
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVers reveal influenza virus replication in the ferret mammary gland and spread to a nursing infant, and selection of transmissible influenza viruses in the soft palate.
Links for this episode
Photos of my visit to OHSU (Facebook) 6:30
Folta departs (Facebook) 9:25
T-VEC approved for melanoma (FDA) 14:45
Talimogene laherparepvec (Wikipedia) 15:10
T-VEC phase III trial (J Clin Oncol) 17:35
How drugs are named (PopSci)
TWiV 362: Gotta catch 'em all
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
With their usual verve, the virus virtuosos illuminate a new method to identify all the viral nucleic acids in a sample, and regulation of viral gene expression by codon usage.
Links for this episode
Virome capture sequencing (mBio) 15:40
Codon usage regulates viral gene expression (PNAS) 40:00
Harold S. Ginsberg (Wikipedia) 7:15
Letters read on TWiV 362 6:50, 1:03:20
This episode is sponsored by ASM Edu
TWiV 361: Zombie viruses on the loose
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
The TWiVsters discuss Frederick Novy's return from retirement to recover a lost rat virus, and evidence for persistence of Ebolavirus in semen.
Links for this episode
Frederick Novy and the rat virus (Ann Int Med) 18:20
The rat virus (J Inf Dis) 22:55
Recovery of the rat virus (J Inf Dis) 35:20
Ebola sitrep 42:25
Meningitis in Glaswegian Ebolavirus nurse (ProMedMail, Medscape) 45:50
Sexual transmission of Ebolavirus (NE
TWiV 360: From Southeastern Michigan
Hosts: Vincent Racaniello and Kathy Spindler
Guests: Michael Imperiale, Adam Lauring, and Akira Ohno
Vincent visits the University of Michigan where he and Kathy speak with Michael, Adam, and Akira about polyomaviruses, virus evolution, and virus assembly, on the occasion of naming the department of Microbiology & Immunology a Milestones in Microbiology site.
Links for this episode
World Polio Day 3:20
Mole Day 5:25
The rat virus (J Inf Dis) 20:00
Polyomavirus miRNAs (Curr Op Virol) 39:30
Costs
TWiV 359: A Blossom by any other name
Host: Vincent Racaniello
Guest: Blossom Damania
Vincent speaks with Blossom about her laboratory's research on Kaposi's sarcoma-associated herpesvirus, including how it transforms cells, the switch between lytic and latent replication, and its interaction with the innate immune system of the host.
Links for this episode
Damania Laboratory
Modulation of cGAS-STING by KSHV (PNAS)
KSHV vIRF1 interacts with ISG15 pathway member (J Virol)
KSHV NLR homolog inhibits inflammasome (Science)
KSHV inhib
TWiV 358: Virology and proteomics with Ileana Cristea
Host: Vincent Racaniello
Guest: Ileana Cristea
Vincent meets up with Ileana at Princeton University to talk about how her laboratory integrates molecular virology, mass spectrometry-based proteomics, and bioinformatics to unravel the interplay between virus and host.
Links for this episode
Cristea Laboratory
Ileana's work previously on TWiV 269
Blowing off steam (Cell Host Micr)
Nuclear viral DNA sensors (J Biol Chem)
mSystems
Video of this episode - view at YouTube (coming soon!)
Send your
TWiV 357: Mistletoe on the Tree of Life
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Jens Kuhn
Jens joins the TWiVomics to discuss the strengths and weaknesses of viral taxonomy, including its history and evolution, how viruses are ordered, and why T. rex was classified without having a living isolate.
Links for this episode
Jens' previous TWiV (283) 5:15
International Committee on the Taxonomy of Viruses (ICTV) 27:50
ICTV 9th Report 32:55
Classifying viruses by capsid architectur
TWiV 356: Got viruses?
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Stephanie Neal
Stephanie joins the super professors to discuss the gut virome of children with serious malnutrition, caterpillar genes acquired from parasitic wasps, and the effect of adding chemokines to a simian immunodeficiency virus DNA vaccine.
Links for this episode
Invitrogen Science Hero Awards 15:05
Gut DNA viromes of twins with severe malnutrition (PNAS) 34:30
Random forests 48:00
Wasps
TWiV 355: Baby's first virome
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team considers the effect of a Leishmaniavirus on the efficacy of drug treatment, and the human fecal virome and microbiome in twins during early infancy.
Links for this episode
Announcing mSphere 5:50
Leishmania virus influences drug outcome (paper 1, paper 2) 25:15
Human gut virome and microbiome in infants (Nat Med) 46:00
Multiple displacement amplification (Wiki) 46:00
Virome of adult twins (N
TWiV 354: The cat in the HAART
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The esteemed doctors of TWiV review a new giant virus recovered from the Siberian permafrost, why influenza virus gain of function experiments are valuable, and feline immunodeficiency virus.
Links for this episode
Non-viral proteins in vaccinia virus particles (Arch Virol) 8:15
Thing a week (Jonathan Coulton, downloads) 23:20
Immortal Life pornographic? Not! (HuffPost) 25:25
Mollivirus sibericum (PNAS) 2
TWiV 353: STING and the antiviral police
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The TWiVniacs discuss twenty-eight years of poliovirus shedding by an immunodeficient patient, and packaging of the innate cytoplasmic signaling molecule cyclic GMP-AMP in virus particles.
Links for this episode
28 years of poliovirus shedding (PLoS Path) 36:50
NOT a rare poliovirus (Wash Post) 44:35
Ukraine polio outbreak (ProMedMail) 41:00
Virus particle transfer of cGAMP (Science one, two) 47:50
cGAS on TWiV 222 47:
TWiV 352: Science art with Michele Banks
Host: Vincent Racaniello
Guest: Michele Banks
Vincent meets up with Michele Banks in Washington, DC to discuss her career as a creator of science-themed art.
Links for this episode
Michele Banks on Twitter
Artologica
Michele's blog
The Finch and the Pea
Joseph Cornell
Not Exactly Rocket Science (Ed Yong)
Tree of Life (Jonathan Eisen)
Home Microbiome Study
Kitten Microbiome Project
Science Online
The Vexed Muddler
Luke Jerram
A Daily Dish (Klari Reis)
Neuroscience art (Greg Dunn)
Ai Weiwei
Vid
TWiV 351: The dengue code
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The Masters of the ScienTWIVic Universe discuss a novel poxvirus isolate from an immunosuppressed patient, H1N1 and the gain-of-function debate, and attenuation of dengue virus by recoding the genome.
Links for this episode
Paula Pitha-Rowe (Balt Sun)
Novel poxvirus (CID)
H1N1 and gain-of-function debate (mBio)
Recoding dengue virus genome (PNAS)
Attenuation by dinucleotide frequency change (PNAS)
Codon pa
TWiV 350: Viral gene therapy with Katherine High
Host: Vincent Racaniello
Guest: Katherine A. High
Vincent speaks with Katherine High about her career and her work on using viral gene therapy to treat inherited disorders.
This episode is drawn from one of twenty-six video interviews with leading scientists who have made significant contributions to the field of virology, part of the new edition of the textbook Principles of Virology.
Links for this episode
Katherine A. High, MD
AAV gene therapy for congenital blindness (Sci Trans Med)
Gene
TWiV 349: One ring to vaccinate them all
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan and Rich explain how to make a functional ribosome with tethered subunits, and review the results of a phase III VSV-vectored Ebolavirus vaccine trial in Guinea.
Links for this episode
Social media specialist position at ASM
WHO dismisses Catholic church on vaccine safety
U of T Dean resigns over anti-vaccine course (Tor Star)
Vaccine Adverse Event Reporting System (VAERS)
Countering anti-vaccination attitudes (PNAS)
Designer
TWiV 348: Chicken shift
Hosts: Vincent Racaniello and Rich Condit
Vincent and Rich discuss fruit fly viruses, one year without polio in Nigeria, and a permissive Marek's disease viral vaccine that allows transmission of virulent viruses.
Links for this episode
Virology tenure-track position at NCI (pdf)
ASM Agar Art Contest
Nigeria on brink of polio eradication (Nature)
Dengue in Africa (Tyler Sharp)
Permissive vaccines and virulence (PLoS Biol)
Marek's disease vaccines and virulence (Ed Yong)
Image credit
Letters r
TWiV 347: Rose rosette and squirrel roulette
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan, and Rich discuss the virus behind rose rosette disease, and fatal human encephalitis caused by a variegated squirrel bornavirus.
Links for this episode
Virology tenure-track position at NIH (pdf) 7:00
Voinnet investigation is a Swiss Federal secret (twitter) 12:25
Rose rosette disease in Ft. Worth (Star Telegram) 29:35
Rose rosette virus discovered (J Gen Virol) 34:25
Emeravirus (ViralZone) 33:55
Eriophyid mites (MI Botanical
TWiV 346: A double helical career
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guest: Joan Steitz
This episode was recorded at the 34th Annual Meeting of the American Society for Virology, where Vincent, Rich, and Kathy spoke with Joan Steitz, a tireless promoter of women in science and one of the greatest scientists of our generation.
Links for this episode
ASV annual meeting, Western University
Steitz Laboratory at Yale University
Steitz Laboratory on Twitter
Panoramic photo of ASV TWiV by Matt Evans
Photos of A
TWiV 345: How a vaccine got the nod
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The TWiVonauts review how the weather affects West Nile virus disease in the US, benefit of B cell depletion for ME/CFS patients, and an autoimmune reaction induced by influenza virus vaccine that leads to narcolepsy.
Links for this episode
Virology faculty position, University of Toledo
Weather and West Nile virus disease (AJTMH)
B cell depletion benefits ME/CFS patients (PLoS One)
Antibodies to influenza nucleoprotei
TWiV 344: Glasgwegians go viral
Host: Vincent Racaniello
Guests: Ruth Jarrett, Glen Nemerow, and Esther Schnettler
At the Glasgow Science Festival microTALKS, Vincent speaks with Ruth, Glen, and Esther about their research on viruses and Hodgkin lymphoma, adenovirus structure and entry into cells, and interactions between arthropod borne viruses and their hosts.
Links for this episode
Glasgow Science Festival microTALKS
Hodgkin lymphoma (Histopath)
HHV-6 and Hodgkin lymphoma (PLoS One)
Adenovirus entry (PLoS Path)
Adenovirus
TWiV 343: The silence of the turnips
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVerinoes discuss the potential for prion spread by plants, global circulation patterns of influenza virus, and the roles of Argonautes and a viral protein in RNA silencing in plants.
Links for this episode
Prions in plants (Cell Rep) 11:35
Global influenza virus circulation (Nature) 20:40
Rough patch for plant RNA silencing (Lab Times) 29:50
Role of Argonaute proteins in plant viral defense (PLoS Pa
TWiV 342: Public epitope #1
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVniks discuss the structure of a virus that reproduces in an extreme environment, long-term consequences of Ebolavirus infection, and VirScan, a method to identify the different virus infections you have had in your lifetime.
Links for this episode
Virus with A-form DNA (Science)
Viruses in the extreme (virology blog)
Sequelae of Ebolavirus infection (Lancet Inf Dis)
Long term Ebolavirus effects (vi
TWiV 341: Ebolavirus experiences
Host: Vincent Racaniello
Guests: Adam Kucharski, Gillian Slack, and Emma Thomson
Vincent returns to the University of Glasgow MRC-Center for Virus Research and speaks with Emma, Gillian, and Adam about their ebolavirus experiences: caring for an infected patient, working in an Ebola treatment center in Sierra Leone, and making epidemiological predictions about the outbreak in west Africa.
Links for this episode
Tribute to Richard Elliott
Donate to mesothelioma research for Richard Elliott
CVR s
TWiV 340: No shift, measles
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV teams reviews a MERS-coronavirus serosurvey and an outbreak in South Korea, and constraints on measles virus antigenic variation.
Links for this episode
Richard Elliott on TWiV 177
MERS-CoV outbreak, South Korea (ProMedMail)
MERS-CoV serosurvey (Lancet Inf Dis)
Biolabs in your backyard (USA Today)
Constraints on measles virus antigenic variation (Cell Rep)
Selection bias and bombers (John D. Cook)
TWiV 339: Herpes and the sashimi plot
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Tre TWiV amici present three snippets and a side of sashimi: how herpesvirus inhibits host cell gene expression by disrupting transcription termination.
Links for this episode
Searching for Steamer in the oceans
Lassa fever death in NJ (CDC and NYTimes)
Transgenic mouse model for MERS-CoV (J Virol)
First West Nile virus disease case in Texas
Herpesvirus disrupts host transcription termination (Nat Comm)
Sashimi plots
Broad benefits of mea
TWiV 338: Coyotes have sushi
Hosts: Vincent Racaniello and Kathy Spindler
Guest: Laura Newcomb
Vincent and Kathy visit Laura Newcomb at California State University San Bernardino, where they talk about Laura's viral tatoos, and a protein that protects the mosquito brain from lethal flavivirus infection.
Links for this episode
Neuron-specific mosquito antiviral mechanism (PLoS Path)
Letters read on TWiV 338
Photos of our visit
Video of this episode - view at YouTube
Weekly Science Picks
Laura - NP siRNA inhibits different
TWiV 337: Steamer
Host: Vincent Racaniello
Guests: Michael Metzger and Steve Goff
Vincent meets up with Michael and Steve to discuss their finding of a transmissible tumor in soft shell clams associated with a retrovirus-like element in the clam genome.
Links for this episode
Hemocytic leukemia in soft shell clam (Sci Total Environ)
Activation of Steamer in neoplastic hemocytes (PNAS)
Transmission of clonal cancer cells in clams (Cell)
Steve Goff on TWiV #76
Image credit
Timestamps by Jennifer. Thank you!
Send
TWiV 336: Brought to you by the letters H, N, P, and Eye
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVsters explore mutations in the interferon pathway associated with severe influenza in a child, outbreaks of avian influenza in North American poultry farms, Ebolavirus infection of the eye weeks after recovery, and Ebolavirus stability on surfaces and fluids.
This episode is sponsored by @ASM Conferences and ASM Microbe
Links for this episode
Life threatening influenza and IRF7 deficiency (Science)
TWiV 335: Ebola lite
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVumvirate discusses a whole Ebolavirus vaccine that protects primates, the finding that Ebolavirus is not undergoing rapid evolution, and a proposal to increase the pool of life science researchers by cutting money and time from grants.
This episode is sponsored by ASM Microbe and ICAAC/ICC
Links for this episode
Possible sexual transmission of Ebolavirus (MMWR)
Ebolavirus whole-virus vaccine protec
TWiV 334: In vino virus
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVles talk about endogenous viruses in plants, sex and Ebolavirus transmission, an outbreak of canine influenza in the US, Dr. Oz, and doubling the NIH budget.
This episode is sponsored by SciMed Solutions and ASM Education.
Links for this episode
Pinot noir and viruses (Wine Spectator) 35:00
Endogenous florendoviruses (Nat Commun) 35:30
Sex and Ebolavirus transmission (WHO, CDC, NYTimes) 54:10
Ebola
TWiV 333: Naturally curious chimeras
Host: Vincent Racaniello
Guests: Ben Fensterheim, Megan Freeman, Bobak Parang, and Meredith Rogers
Vincent returns to Vanderbilt University and meets up with Ben, Megan, Bobak, and Meredith to learn about life in the Medical Scientist Training Program.
Links for this episode
MTGR1 and intestinal secretory lineage allocation (Faseb J)
Coronaviruses induce macropinocytosis (mBio)
PD-1 and respiratory virus reinfection (J Immunol)
Vanderbilt MSTP on Facebook
Video of this episode: view at YouTube
TWiV 332: Vanderbilt virology
Host: Vincent Racaniello
Guests: Seth Bordenstein, James Crowe, and Mark Denison
Vincent visits Vanderbilt University and meets up with Seth, Jim, and Mark to talk about their work on a virus of Wolbachia, anti-viral antibodies, and coronaviruses.
Links for this episode
SARS-CoV error correction (PLoS Path) 19:00
Marburg virus neutralization by a human antibody (Cell one and two) 56:35
Phage WO, Wolbachia and Drosophila (Peer J) 1:02:00
Seth's blog Symbionticism 1:31:30
Seth on Twitter
Video
TWiV 331: Why is this outbreak different from all other outbreaks?
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team discusses the possible association of the respiratory pathogen enterovirus D68 with neurological disease.
This episode is sponsored by SciMed Solutions and ASM Education.
Links for this episode
Clusters of AFP associated with enterovirus D68 (Lancet) 31:35
Novel outbreak enterovirus D68 strain (Lancet Inf Dis) 53:00
Enterovirus D68 in Norway (Euro Surveill) 1:12:00
Unknown enemy (Nature) 1:10
TWiV 330: A swinging gate
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVers explain how a protein platform assists the hepatitis C virus RNA polymerase to begin the task of making viral genomes.
Links for this episode
NYAS Afterschool STEM Mentoring Program
Concerns about editing the human germline (Science, Nature)
Engineering the perfect baby (MIT Tech Rev)
RNA recognition by HCV polymerase (Science)
Kickstarting an RNA polymerase (Science)
A protein platform for pri
TWiV 329: Pox in the balance
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team reviews identification of immune biomarkers in CFS/ME patients, and how a cell nuclease controls the innate immune response to vaccinia virus infection.
Links for this episode
Immune signatures in ME/CFS (Science Adv) 11:15
Systemic exertion intolerance disease (Lancet) 19:50
Cell nuclease controls anti-viral responses (Cell Host Micr) 25:10
Poxvirus decapping enzymes prevent innate responses
TWiV 328: Lariat tricks in 3D
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVocateurs discuss how the RNA polymerase of enteroviruses binds a component of the splicing machinery and inhibits mRNA processing.
Links for this episode
Viral polymerase binds Prp8 to inhibit mRNA splicing (PLoS Path)
Prp8 protein of the spliceosome (RNA)
Nuclear entry of poliovirus RdRp (Virol)
RNA processing (TWiV 216)
Measles in USA (CDC)
Principles of Microbial Diversity
Journal of Microbiol
TWiV 327: Does a gorilla shift in the woods?
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The eTWiVicators review evidence that the HIV-1 group O epidemic began with a single cross-species transmission of virus from western lowland gorillas.
Links for this episode
Traces of ATCV-1 associated with laboratory contamination (PNAS)
ATCV-1 findings not explained by contamination (PNAS)
Origin of HIV-1 group O epidemic in western lowland gorillas (PNAS)
INNO-LIA
Principles of Microbial Diversity
Imag
TWiV 326: Giving HIV a flat tyr
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
The sternutating TWiVers discuss preventing infection of cells and animals by a soluble CD4-CCR5 molecule that binds to HIV-1 virus particles.
Links for this episode
Dif-tor heh smusma (NY Times)
Immunization preterm premature infants (Thanks, Johnye!)
HIV and SHIV protection conferred by eCD4-Ig (Nature)
Tyrosine sulfation (Wikipedia)
GBV-C and Ebolavirus infection (J Virol)
Letters read on TWiV 326
Weekly Science Picks
Alan - Toms River b
TWiV 325: Wildcats go viral
Host: Vincent Racaniello
Guests: Rollie Clem and Lorena Passarelli
Vincent visits the 'Little Apple' and speaks with Rollie and Lorena about their work on mosquito-born viruses and baculoviruses.
Links for this episode
Apoptosis inhibition in A. aegypti (Apop)
Initiator caspase in armyworm (Insect Bioc Mol Biol)
Manipulating apoptosis in A. aegypti (J Virol)
Viral inhibitors of apoptosis (Sem Cell Dev Biol)
Baculoviruses: Sophisticated pathogens (PLoS Path)
Baculovirus morphogenesis (Virol)
Bar
TWiV 324: Viruses in the miR may appear more numerous
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Lee Feinman
Lee joins the TWiV team to discuss the value of post-doctoral training, and how a cellular microRNA assists in the replication of hepatitis C virus.
Links for this episode
Spin by Robert Charles Wilson
Immunization of preterm infants (Dev Period Med)
miR-122 alters HCV translation-replication balance (Cell Host Micr)
Holding a miR to HCV (TWiV 180)
Treating hepatitis C by blocking miR-12
TWiV 323: A skid loader full of viromes
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The family TWiVidae discuss changes in the human fecal virome associated with Crohn's disease and ulcerative colitis.
Links for this episode
Enteric virome changes in inflammatory bowel disease (Cell)
Gov. Christie stumbles on vaccination (NY Times)
Anti-vax psychology (NPR)
Vaccine skeptic changes her mind (NPR)
Ebolavirus sitrep (WHO)
Letters read on TWiV 323
Weekly Science Picks
Alan - SitesuckerRich - Snake picked
TWiV 322: Postcards from the edge of the membrane
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The TWiVodes answer listener email about hantaviruses, antivirals, H1N1 vaccine and narcolepsy, credibility of peer review, Bourbon virus, influenza vaccine, careers in virology, and much more.
Links for this episode
Bourbon virus (NY Times)
Thogotovirus (ViralZone)
Drug induced apoptosis and HIV infection (PLoS One)
Mumps cases and outbreaks (CDC)
Opossums as pets? (doc)
Cat found
Letters read on TWiV 322
Weekly Scie
TWiV 321: aTRIP and a pause
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Guest: Paul Duprex
Paul joins the TWiV team to discuss the current moratorium on viral research to alter transmission, range and resistance, infectivity and immunity, and pathogenesis.
Links for this episode
Wain-Hobson objects (one, two, three, four)
Influenza H7N1 transmission experiments (J Virol)
Epistemological perspective on aTRIP experiments (mBio)
Limited scientific value and risk (mBio)
Reply to limited scient
TWiV 320: Retroviruses and cranberries
Host: Vincent Racaniello
Guest: John Coffin
Vincent speaks with John Coffin about his career studying retroviruses, including working with Howard Temin, endogenous retroviruses, XMRV, chronic fatigue syndrome and prostate cancer, HIV/AIDS, and his interest in growing cranberries.
Links for this episode
John Coffin (Wikipedia)
Specific HIV integration sites (Science)
Novel retrovirus in modern birds (J Virol)
Recombinant origin of XMRV (Science)
Cranberry harvest (jpg)
Send your virology questi
TWiV 319: Breaking breakbone
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVers review the outcomes of two recent phase 3 clinical trials of a quadrivalent dengue virus vaccine in Asia and Latin America.
Links for this episode
Efficacy of dengue vaccine (NEJM)
Preventing dengue (NEJM)
Dengue viruses (Scitable)
Intention to treat (Wikipedia)
Image credit: Jean-Yves Sgro
Letters read on TWiV 319
Weekly Science Picks
Alan - The Toaster Project by Thomas ThwaitesRich - Spac
TWiV 318: Last year in virology
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV gang reviews ten fascinating, compelling, and riveting virology stories from 2014.
Ten virology stories of 2014
Ebola virus outbreak (TWiV 314, 309, 308, 307, 306, 305, 304, 303, 302, 298, 297, 283)
Directional uncoating of rhinovirus RNA (TWiV 267)
Pandemic pathogen controversy (TWiV 287)
Viral evolution (TWiV 275)
Borna virus inhibition by endogenous DNA (TWiV 303)
MERS-CoV in dromedary camels (TWiV special, TWiV
TWiV 317: Brazil goes viral
Host: Vincent Racaniello
Guests: Eurico Arruda, Gustavo Acrani, Cintia Bittar, Tatiana Domitrovic, and Suellen Galvino-Costa
On his second trip to Brazil, Vincent joins Eurico to speak with three young virologists, Gustavo, Cintia, Tatiana, and Suellen, about their work and their prospects for careers in science.
Video of this episode: view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
TWiV 316: The enemy of my enemy is not my friend
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich and Kathy discuss how interleukin 10 modulation of Th17 helper cells contribute to alphavirus pathogenesis.
Links for this episode
IL10 modulation of Th17 cells during alphavirus pathogenesis (PNAS)
Th17 cells involved in influenza mediated gut injury (J Exp Med)
Helper T cells
2014-15 flu season (CDC)
Key facts about flu & flu vaccine (CDC)
Does the flu vaccine work? (Turbid plaque)
Effectiveness of flu v
TWiV 315: Must be something in the water
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich and Kathy association of a virus with sea star melting disease, and the finding of a phycodnavirus in the oropharynx of humans with altered cognitive functions.
Links for this episode
National Influenza Immunization Week (CDC)
Densovirus associated with sea star wasting disease (PNAS)
A virus that melts sea stars (virology blog)
Chlorovirus in human oropharynx (PNAS)
Algal virus in humans (virology blog)
I
TWiV 314: Einstein goes viral
Host: Vincent Racaniello
Guests: Kartik Chandran, Ganjam Kalpana, and Margaret Kielian
Vincent travels to Albert Einstein College of Medicine where he speaks with Kartik, Ganjam, and Margaret about their work on Ebolavirus entry, a tumor suppressor that binds the HIV-1 integrase, and the entry of togaviruses and flaviviruses into cells.
Links for this episode
Antibodies that protect against Sudan virus (ACS Chem Biol)
Ebola virus entry requires NPC1 (EMBO J)
A toggle switch for virus entry (Nat
TWiV 313: With viruses like these, who needs enemas?
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan, and Rich discuss how norovirus, an enteric virus, can replace the functions of the gut microbiome.
Links for this episode
Ebola virus update (WHO)
Norovirus can replace functions of gut microbiome (Nature)
Post-vaccinal distemper encephalitis (N Z Vet J)
Novel sea otter poxvirus (J Wildl Dis)
Poliovirus escapes antibodies (virology blog)
CDC whistleblower saga (Sci Based Med)
Snopes on CDC whistleblower
Image credit
Letters re
TWiV 312: She sells B cells
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVbolans discuss the finding that human noroviruses, major causes of gastroenteritis, can for the first time be propagated in B cell cultures, with the help of enteric bacteria.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this depart
TWiV 311: Bulldogs go viral
Host: Vincent Racaniello
Guests: Zhen Fu and Biao He
Vincent visits the University of Georgia where he speaks with Zhen Fu and Biao He about their work on rabies virus and paramyxoviruses.
Links for this episode
Blood-brain permeability and rabies survival (Antiviral Res)
Rabies induces blood-brain permeability (J Virol)
Virus neutralizing antibodies in CNS of non-lethal rabies (PLoS Neg Trop Dis)
RSV vaccine based on PIV5 (Vaccine)
New mumps vaccine (J Virol)
PIV5-based influenza virus vaccine
TWiV 310: From bacteriophage to retroviruses with Ann Skalka
Hosts: Vincent Racaniello and Glenn Rall
Guest: Ann Skalka
Vincent and Glenn meet up with Ann and talk about her long and productive career in virology, from biochemistry to bacteriophage lambda to retroviruses.
Links for this episode
Skalka laboratory
Asilomar Conference on recombinant DNA
Unexpected inheritance (PLoS Path)
Viral sequences in vertebrate genomes (J Virol)
Assembly of integrase multimers (J Biol Chem)
Cell cycle and retrovirus integration (J Cell Bioch)
Video of this episode -
TWiV 309: Ebola email
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVocytes answer questions about Ebola virus, including mode of transmission, quarantine, incubation period, immunity, and much more.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an inte
TWiV 308: The Running Mad Professor
Host: Vincent Racaniello
Guest: Tom Solomon
Tom talks with Vincent about viral central nervous system infections of global importance, Ebola virus, and running the fastest marathon dressed as a doctor.
Links for this episode
World's biggest brain
Tom's YouTube channel
Sex, drugs, and emerging viruses (TedX)
The Running Mad Professor
Image credit: ClickLiverpool
Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
TWiV 307: Ebola aetiology
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Guest: Tara C. Smith
Tara Smith joins the TWiEBOVsters to discuss the Ebola virus outbreak in west Africa, spread of the disease to and within the US, transmission of the virus, and much more.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit
TWiV 306: This Week in Ebolavirus
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
The Grand Masters of the TWiV discuss Ebola virus transmission, air travel from West Africa, Ebola virus infectivity on surfaces, the Dallas Ebola virus patient, and Ebola virus in dogs.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyo
TWiV 305: Rhymes with shinola
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy continue their coverage of the Ebola virus outbreak in West Africa, with a discussion of case fatality ratio, reproductive index, a conspiracy theory, and spread of the virus to the United States.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this d
TWiV 304: Given X, solve for EBOV
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Guest: Jeff Shaman
The TWiV team consults an epidemiologist to forecast the future scope of the Ebola virus epidemic in West Africa.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing v
TWiV 303: Borna this way
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The TWiV team discusses transmission of Ebola virus, and inhibition of Borna disease virus replication by viral DNA in the ground squirrel genome.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest
TWiV 302: The sky is falling
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVers discuss the growing Ebola virus outbreak in West Africa, and an epidemic of respiratory disease in the US caused by enterovirus D68.
Links for this episode
Cancer patient saved by measles virus
Ebola virus genome sequences (Science)
Robert Garry on Ebola outbreak
Aerosol transmission
WHO Ebola outbreak summary
CDC Ebola outbreak page
Ebola outbreak epi curve
CED Ebola outbreak info graphic
Ebol
TWiV 301: Marine viruses and insect defense
Host: Vincent Racaniello
Guests: Carla Saleh and Curtis Suttle
At the International Congress of Virology in Montreal, Vincent speaks with Carla and Curtis about their work on RNA interference and antiviral defense in fruit flies, and viruses in the sea, the greatest biodiversity on Earth.
Links for this episode
Greatest biodiversity on Earth (Genome)
Cafeteria roenbergensis virus (PNAS)
Marine viruses (Nat Rev Micro)
RNAi and reverse transcription is antiviral in flies (Nat Imm)
Friendly persis
TWiV 300: So happy together
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Recording together for the first time, the TWiV team celebrates their 300th recording at the American Society for Microbiology headquarters in Washington, DC, where Vincent speaks with Dickson, Alan, Rich, and Kathy about their careers in science.
Links for this episode
So Happy Together (The Turtles)
Viral Hemorrhagic Fever Consortium
Support Kenema VHFC program
Letters read on TWiV 298
Video of this epi
TWiV 299: Rocky Mountain virology
Host: Vincent Racaniello
Guests: Marshall Bloom, Sonja Best, and Byron Caughey
Vincent visits the Rocky Mountain Laboratories in Hamilton, Montana and speaks with Marshall, Sonja, and Byron about their work on tick-born flaviviruses, innate immunity, and prion diseases.
Links for this episode
Rocky Mountain Laboratories, NIH
Flavivirus persistence (Path Dis)
Flaviviruses antagonize IRF1 (J Imm)
Prion test using nasal brushings (NEJM)
Video of this episode - view at YouTube
Send your virology q
TWiV 298: MV-NIS de myelo
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV gang answer follow-up questions about the Ebola virus outbreak in West Africa, then discuss treatment of disseminated multiple myeloma with oncolytic measles virus.
Links for this episode
Use of unregistered interventions for Ebola virus disease (WHO)
Response to anthrax and H5N1 incidents (CDC)
Remission of disseminated cancer after treatment with oncolytic measles virus (Mayo Clin Proc)
New viruses for cancer ther
TWiV 297: Ebola! Don't panic
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVites present an all-ebolavirus episode, tackling virology, epidemiology, and approaches to prevention and cure that are in the pipeline.
Links for this episode
Risks and benefits of gain-of-function experiments (mBio)
Scientists for Science
US Policy for oversight of DURC (pdf)
US framework for guiding H5N1 transmission expts (pdf)
Extra oversight for H7N9 experiments (Science)
TWiV 283: No Reston for the weary
Is it
TWiV 296: The real Batman, Linfa Wang
Host: Vincent Racaniello
Guest: Linfa Wang
Vincent visits the Australian Animal Health Laboratory in Geelong, Australia and speaks with Linfa about his work on bats and bat viruses.
Links for this episode
Hendra virus vaccine (Emer Inf Dis)
Comparison of bat genomes (Science)
Endogenous retroviruses in bats (Retrovirol)
The Bat Pack
Bats in Geelong (YouTube)
Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
TWiV 295: A nonslip grippe and Lassa's LAMP
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
The TWiVome discusses an miRNA based strategy to mitigate risk of gain of function studies, and identification of a second receptor required for Lassa virus entry.
Links for this episode
miRNA strategy to minimize risk (Nat BioT)
NIH Office of Science Policy
NIH recombinant DNA guidelines
Second receptor for Lassa virus entry (Science)
Lassa fever (Wikipedia)
Fever! The discovery of Lassa virus (TWiV 9)
Letters read on TW
TWiV 294: Smallpox and anthrax and flu, oh my!
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
The TWiV team reviews the discovery of old vials of smallpox virus at NIH, anthrax and influenza mishaps at CDC, the baby who was not cured of HIV, Cambridge Working Group, and sacking of NSABB members.
Links for this episode
Newly discovered smallpox (CDC)
Infectious smallpox in FDA storage (FDA)
Report on potential anthrax exposure (pdf, CDC)
CDC Director on unsafe practices (NY Times)
HIV returns to baby (NY Times)
Ori
TWiV 293: Virology Down Under
Host: Vincent Racaniello
Guests: Melissa Churchill, Alex Khromykh, Gilda Tachedjian, and Paul Young
Vincent visits Melbourne, Australia and speaks with Melissa, Alex, Gilda, and Paul about their work on HIV infection of the central nervous system, West Nile virus, microbicides for HIV, and the Koala retrovirus.
Links for this episode
Where does HIV hide? (Curr Op HIV AIDS)
Subgenomic flavivirus RNA (Viruses)
Vaginal lactic acid and HIV (J Antimicro Chem)
Koala retroviruses (Retrovirology)
Comin
TWiV 292: Medimmune goes viral
Host: Vincent Racaniello
Guests: Wade Blair, Matt Dickson, Nicole Kallewaard-Lelay, and Ken Miller
Vincent visits Medimmune and speaks with Wade, Matt, Nicole, and Ken about why they work in industry and their daily roles in a biotechnology company.
Links for this episode
Medimmune, LLC
Medimmune on Twitter
Medimmune history and products
Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
TWiV 291: Ft. Collins abuzz with virologists
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Clodagh O'Shea and Ron Fouchier
Vincent, Rich, and Kathy and their guests Clodagh and Ron recorded this episode at the 33rd annual meeting of the American Society for Virology at Colorado State University in Ft. Collins, Colorado.
Links for this episode
Viral polymer that inactivates tumor suppressors (Cell)
Mutations driving airborne transmission of influenza H5N1 virus (Cell)
Transmission of influenza H7N1 virus in ferrets (J
TWiV 290: Baylor goes viral
Host: Vincent Racaniello
Guests: Janet Butel and Rick Lloyd
Vincent meets up with Janet Butel and Rick Lloyd at Baylor College of Medicine to talk about their work on polyomaviruses and virus induced stress.
Links for this episode
SV40 microRNAs (PLoS Path)
SV40 seroprevalence (J Infect)
Viruses and stress granules (PLoS Path)
Viral inhibition of stress granule formation (Cell Host Micr)
Video of this episode - view below or at YouTube
Send your virology questions and comments (email or mp3 fi
TWiV 289: Vinny and the capsids
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Vinny and the capsids answer listener questions about the definition of life, state vaccination laws, the basic science funding problem, viral ecology, inactivation of viruses by pressure, and much more.
Links for this episode
Varun's research poll
Letters read on TWiV 289
Weekly Science Picks
Alan - The Science of Good Cooking Vincent - The Shooter Report (pdf)Kathy - Daily overviewDickson - Girl rising
Listener Pick
TWiV 288: ebircsnart esreveR
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The Twivsters discuss how reverse transcriptase encoded in the human genome might produce DNA copies of RNA viruses in infected cells.
Links for this episode
Should variola virus be destroyed? (poll at virology blog)
DNA complementary to non-retroviral RNA viruses (Sci Rep)
Integration of arenavirus DNA into cell genome (virology blog)
Infectious respiratory syncytial DNA (PNAS)
Tysabri and PML
JC and PML
TWiV 287: A potentially pandemic podcast
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Matt Frieman
Matt updates the TWiV team on MERS-coronavirus, and joins in a discussion of whether we should further regulate research on potentially pandemic pathogens.
Links for this episode
MERS stories at CIDRAP
MERS at CDC
MERS in the US (CDC)
MERS-CoV map
MERS-CoV infection after camel exposure (EID)
MERS-CoV in dromedaries from Egypt, Sudan, Ethiopia (EID)
MERS-CoV antivirals (one, two, three, four)
Experiments
TWiV 286: Boston TWiV party
Hosts: Vincent Racaniello and Alan Dove
Guests: Julie Pfeiffer and Paul Duprex
Vincent and Alan meet up with Julie and Paul at the General Meeting of the American Society for Microbiology in Boston, to talk about their work on the pathogenesis of poliovirus and measles virus.
Links for this episode
Threading the NEIDL (YouTube)
Transmission of measles virus from macaques (J Gen Virol)
Tropism of green measles virus in macaques (J Virol)
Intestinal microbiota promote enteric virus replication (S
TWiV 285: Hokies go viral
Host: Vincent Racaniello
Guests: XJ Meng and Sarah McDonald
Vincent meets up with XJ and Sarah at Virginia Tech to talk about their work on viruses of swine and rotaviruses.
Links for this episode
Hepatitis E virus (Int J Env Res Pub Health)
Porcine and human anelloviruses (J Virol)
Origin of porcine epidemic diarrhea virus in US (mBio)
Distinguishing rotaviruses (J Virol)
Molecular epidemiology of rotaviruses (J Virol)
Core domains in rotavirus polymerase encapsidation (J Gen Virol)
Send you
TWiV 284: By the pricking of my thumbs, something wicked this way comes
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
The TWiV team discusses how skin scarification promotes a nonspecific immune response, and whether remaining stocks of smallpox virus should be destroyed.
Links for this episode
Skin scarification protects against vaccinia virus disease (J Virol)
Smallpox research agenda (PLoS Path)
WHO report on variola research (pdf)
Review of smallpox research program for WHO (pdf)
How I record my lectures (virology blog)
Letters
TWiV 283: No Reston for the weary
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Jens H. Kuhn
Jens speaks with the TWiV team about filoviruses, including the recent Ebola virus outbreak in Guinea.
Links for this episode
Review of Zanamavir clinical trials (Brit Med J)
Ebola virus disease in Guinea (NEJM)
Filovirus nomenclature (virology blog)
Ebola virus disease, West Africa (ProMedMail)
How lethal are ebolaviruses? (virology blog)
Letters read on TWiV 283
Weekly Science Picks
Alan - AMNH digital
TWiV 282: Tamiflu and tenure too
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team reviews a meta-analysis of clinical trial reports on using Tamiflu for influenza, and suggestions on how to rescue US biomedical research from its systemic flaws.
Links for this episode
World Malaria Day
Review of oseltamivir clinical trials (Brit Med J)
Effectiveness of Tamiflu questioned (NHS choices)
Tamiflu campaign (Brit Med J)
Rescuing US biomedical research (PNAS)
Letters read on TWiV 282
Weekly Science
TWiV 281: The Salk legacy with Peter L. Salk
Host: Vincent Racaniello
Guest: Peter L. Salk
Vincent meets up with Peter L. Salk to talk about development of the first poliovaccine, eradication of poliomyelitis, and Jonas Salk's 100th birth anniversary.
Links for this episode
Jonas Salk Legacy Foundation
The Cutter Incident by Paul Offit
Splendid Solution by Jeffrey Kluger (review)
Coming soon: Video of this episode
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
TWiV 280: Post viral
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVmeisters answer listener email about the NEIDL, negative results, patenting MERS-coronavirus, human papillomavirus transmission, canine distemper virus, and much, much more.
Links for this episode
Poxvirus viability in historical relics (EID)
TWiM 74: It came from the Siberian permafrost
How to read a scientific paper
Image credit: Not only quilts
Letters read on TWiV 280
Weekly Science Picks
Alan
TWiV 279: The missing LNC
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy reveal how a retrovirus in the human genome keeps embryonic stem cells in a pluripotent state, from where they can differentiate into all cells of the body.
Links for this episode
Retrovirus needed for stem cell identity (Nat Struc Mol Biol)
HERV-H is a marker for pluripotency (Retrovirology)
Letters read on TWiV 279
Weekly Science Picks
Alan - HeathkitVincent - How to think about autism risk and Autism prevalenc
TWiV 278: Flushing HIV down the zinc
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Vincent, Dickson, Alan, and Kathy discuss disruption of the ccr5 gene in lymphocytes of patients infected with HIV-1.
Links for this episode
Gene editing of ccr5 in AIDS patients (NEJM)
HIV gets the zinc finger (TWiV 144)
Genome engineering with zinc finger nucleases (Genetics)
Photo credit: Watty's Wall Stuff
Mice lie, monkeys exaggerate t-shirt design (thanks, Christophe)
Letters read on TWiV 278
Weekly Science Pick
TWiV 277: My podcast Vinny
Hosts: Glenn Rall, Ann Skalka, and Vincent Racaniello
Glenn and Ann meet up with Vincent to talk about his career in science and science communication.
Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
TWiV 276: Ramblers go viral
Host: Vincent Racaniello
Guests: Susan Baker and Thomas Gallagher
Vincent meets up with Susan Baker and Tom Gallagher at Loyola University to talk about their work on coronaviruses.
Links for this episode
Papain-like viral proteases (Virus Res)
MERS-CoV papain-like protease (Virology)
Mouse model for MERS-CoV (PNAS)
Receptor and MERS-CoV infection (J Virol)
Letters read on TWiV 276
Video of this episode - view at YouTube
Weekly Science Picks
Vincent - First demonstration of Macintosh, 1984
Lis
TWiV 275: Virocentricity with Eugene Koonin
Hosts: Vincent Racaniello and Rich Condit
Guest: Eugene Koonin
Vincent and Rich meet up with Eugene Koonin to talk about the central role of viruses in the evolution of all life.
Links for this episode
Virocentric view of evolution (Curr Op Virol)
Proposed order Megavirales (Arch Virol)
Pithovirus (PNAS)
Selfish virus-like elements (Virol J)
Pandoraviruses are derived Phycodnaviruses (Biol Direct)
Video of this episode - view below at YouTube
Send your virology questions and comments (email or
TWiV 274: Data dump
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team discusses recent cases of polio-like paralysis in California, and the virome of 14th century paleofeces.
Links for this episode
MERS-CoV in dromedary camels (EID)
Virologist Al Kapikian dies
Polio-like illness in CA (ProMedMail)
Acute flaccid paralysis
AFP in India (EID)
Enterovirus 68 (MMWR)
EV 68 CNS infection (Arch Path Lab Med)
Polio-free does not mean paralysis-free (The Hindu)
Viruses i
TWiV special: MERS-coronavirus in dromedary camels
Host: Vincent Racaniello
Guests: W. Ian Lipkin and Thomas Briese
Vincent meets up with Ian and Thomas to discuss their finding that MERS-coronavirus has been circulating in dromedary camels in the Kingdom of Saudi Arabia since at least 1992.
Links for this episode
MERS-CoV in dromedary camels (mBio)
TWiV 251: Don't kiss the camel
TWiV 247: Today's weather in virology
TWiV 239: Filterable camels
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
TWiV 273: Lambda is not just a phage
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
The TWiVome dissect the finding that interferon lambda alleles predict the outcome of hepatitis C virus infection.
Links for this episode
Interferon lambda and HCV outcome (Cell Host Micr)
Laser capture microdissection (Wikipedia)
HCV dependent fluorescent reporter (Nat Biotech)
Bats and viruses (PLoS Path)
White nose syndrome (PLoS Path)
Mouse phenome database
Letters read on TWiV 273
Weekly Science Picks
Rich - Th
TWiV 272: Give peas a chance
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team describes aphid control by using a viral capsid protein to deliver a spider toxin to plants, and a human endogenous retrovirus that enhances expression of a neuronal gene.
Links for this episode
Toxin delivery to plants by viral capsid protein (Nat Biotech)
Pea enation mosaic virus (ViralZone)
Image credit: Aphid membrane feeding chamber (Sci Rep)
Aphid feeding chamber (YouTube)
Parafilm (Wik
TWiV 271: To bee, or not to bee, that is the infection
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Ashlee Bennett
The TWiV crew discusses two reports on viruses that might have crossed kingdoms, from plants to honeybees and from plants to vertebrates.
Links for this episode
Tobacco ringspot virus in honeybees (mBio)
Plant virus that switched to vertebrates (PNAS)
CDC influenza activity and surveillance
With Esmeralda at ASM Biodefense (jpg)
Image credit: Virginia Tech Learning Resources Center
Letters read on TWiV 271
TWiV 270: Homeland virology
Hosts: Vincent Racaniello and Rich Condit
Guests: Dennis Hruby and Yoshihiro Kawaoka
Vincent and Rich discuss avian influenza virus and an antiviral drug against smallpox with Dennis and Yoshi at the ASM Biodefense and Emerging Diseases Research Meeting in Washington, DC.
Links for this episode
ASM Biodefense Meeting
Influenza H5N1 transmission (Virus Res)
Aerosol transmission of H5N1 virus in ferrets (Nature)
Characterization of H7N9 virus from humans (Nature)
ST-246 efficacy in primates (AAC)
TWiV 269: Herpesvirus stops a nuclear attack
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The complete TWiV team reviews evidence for sensing of herpesviral DNA in the nucleus by the cell protein IFI16.
Links for this episode
IFI16 is a nuclear pathogen sensor (Cell Host Micr)
Nuclear IFI16 sensing of and antagonism by herpesvirus (PNAS)
Acetylation regulates IFI16 location (PNAS)
Letters read on TWiV 269
Weekly Science Picks
Kathy - Female conveners and speakersAlan - SandgrainsRich - 2013 L
TWiV 268: Transmission is inevitable
Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Ashlee Bennett
Vincent, Alan, Kathy, and Ashlee discuss fomites in physicians offices, plant virus factories involved in aphid transmission, and clues from the bat genome about flight and immunity.
Links for this episode
How viruses cause disease (Coursera)
How clean is your iPad (Which?)
Meeting announcement: From emerging to pandemic viruses
CaMV virus factories involved in aphid transmission (J Virol)
Caulimovirus (ViralZone)
CaMV res
TWiV 267: Snow in the headlights
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich and Kathy review a protease essential for influenza pathogenesis in mice, and directionality of rhinovirus RNA exit from the capsid.
Links for this episode
Protease essential for influenza pathogenesis in mice (PLoS Path)
Rhinovirus uncoating is directional (PLoS Path)
Fluorescence correlation spectroscopy
Capillary electrophoresis (Wiki)
Letters read on TWiV 267
Weekly Science Picks
Kathy - Amazing mapsA
TWiV 266: A pathogenic vicious cycle
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy discuss finding viruses in outer space, varying results obtained from personal genetic testing, and depletion of CD4 cells during HIV infection by pyroptosis.
Links for this episode
We should hunt for viruses in space (New Scientist)
I had my DNA picture taken (NY Times)
CD4 cell death by pyroptosis (Nature)
Abortive HIV infection in lymphoid tissue (Cell)
IFI16 sensor required for HIV mediated cell death (Science
TWiV 265: This year in virology
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
In their final episode of the year, the TWiV team reviews ten compelling virology stories from 2013.
Links for this episode
Antiviral RNAi (TWiV 255, 256, 263)
MERS-CoV (TWiV 215, 223, 224, 233, 239, 247, 251, 258)
Placental trophoblasts confer viral resistance (TWiV 241)
Origin of REV (TWiV 248)
Phage T7 gets a cat scan (TWiV 220)
It's a cGAS! (TWiV 222)
Dual virus-host arms race (TWiV 242)
Pandoraviruses (TWiV 246, 261)
CMV
TWiV 264: We should do an all-email show some day
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVites read listener questions and comments about public engagement in science, vaccines, RNAi, reprogramming CD8 cells to treat cancer, rabies, and much more.
Links for this episode
Viral gifts
Controlling plant viruses by vector control (Ann Rev Phyto)
Flavivirus RNAi suppressor (J Virol)
Entre probetas podcast (iTunes)
Hedgehog central
Reprogramming T cells for leukemia therapy (NEJM)
Petri Dish podcast
On Your Mind
TWiV 263: Game of clones
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Ben tenOever
Ben joins the TWiV team to reveal the winner of his contest in which influenza viruses carrying different interferon-stimulated genes vie against one another in mice.
Links for this episode
Virusninja
Game of clones (Vax Rep)
Game of clones bracket
Letters read on TWiV 263
Weekly Science Picks
Kathy - The Brain Scoop, esp. Where My Ladies AtAlan - Say 'hi' to a spaceship (YouTube)Rich - Garm
TWiV 262: Wrong form, right professor
Host: Vincent Racaniello
Guest: Ann Palmenberg
Vincent returns to the University of Wisconsin - Madison to speak with Ann Palmenberg about her career in virology.
Links for this episode
Palmenberg lab website - great resources
Genome sequences of all rhinoviruses (J All Clin Imm)
Cardioviral poly(C) tracts (Arch Virol Supp)
EMCV disruption of nuclear transport (PNAS)
Picornavirus protease in replicase gene (J Virol)
Bacteriophage Qbeta replicase (J Virol)
Thanks to Jordan for the episode title!
TWiV 261: Giants among viruses
Hosts: Vincent Racaniello and James Van Etten
Guests: Chantal Abergel and Jean-Michel Claverie
Vincent meets up with Chantal and Jean-Michel at the first International Symposium on Giant Virus Biology in Tegernsee, Germany, to discuss their work on Mimivirus, Megavirus, and Pandoravirus.
Links for this episode
Unanswered giant virus questions (Adv Virus Res)
Fourth domain of life (Commun Integr Biol)
Pandoraviruses (Science)
Phaeocystis globosa virus (PNAS)
Cafeteria roenbergensis virus (PNAS)
TWiV 260: Badgers go viral
Host: Vincent Racaniello
Guests: Tom Friedrich, Tony Goldberg, and David O'Connor
Vincent visits the University of Wisconsin, Madison and speaks with Tom, Tony, and David about their work on virus discovery at the AIDS Vaccine Research Laboratory.
Links for this episode
A tick in Tony's nose (Am J Trop Med Hyg)
Two new SIV from colobus monkeys in Uganda (Biomed Cent)
Pegivirus diversity in Uganda (J Gen Virol)
Simian hemorrhagic fever virus diversity in African primates (J Virol)
Video of this
TWiV 259: Windows into the soul of a cell
Hosts: Vincent Racaniello and Rich Condit
Guest: Jaquelin Dudley
Vincent and Rich join Jackie at the University of Texas, Austin to talk about her work on mouse mammary tumor virus.
Links for this episode
Rem signal peptide processing and function (J Virol)
MMTV null mice and tumorigenesis (J Virol)
Jackie's publications (PubMed)
I want my MMTV (TWiV 242)
Live at ASV in Madison (TWiV 193)
Symbiotic safecrackers (TWiV 154)
Send your virology questions and comments (email or mp3 file) to twiv@tw
TWiV 258: Hedging our bats
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Matt Frieman
Matt joins the TWiV team to discuss the discovery of a SARS-like coronavirus in bats that can infect human cells, and what is going on with MERS-coronavirus.
Links for this episode
SARS-like virus in bats binds ACE2 (Nature)
Bat SARS-like virus that infects human cells (virology blog)
Coronavirus infections update (WHO)
Lack of MERS coronavirus antibodies in humans (EID)
Mice not susceptible to MERS-CoV (J Gen V
TWiV 257: Caveat mTOR
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team consider how the kinase mTOR modulates the antibody response to provide broad protection against influenza virus, and explore the problems with scientific research.
Links for this episode
Two lives intertwined (Ann Rev Imm)
John Holland, 83
Kinase mTOR modulates antibody response (Nat Imm)
Drug widens immunity to flu (TheScientist)
Concerto in B (TWiV 161)
How science goes wrong (Economist)
T
TWiV 256: How mice say nodavirus
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Dickson, Alan, Rich, and Kathy review two papers that present evidence for RNA interference as an antiviral immunity mechanism in mammals.
Links for this episode:
World Polio Day
Mole Day
John Holland's publications
RNAi is antiviral in mammals (Science)
Antiviral RNA interference in mammals (Science)
RNAi, antiviral after all (Science)
Is RNA interference antiviral in mammals? (Cell Host Microbe)
TWiV 255: Longhorns go viral
Hosts: Vincent Racaniello and Rich Condit
Guests: Robert Krug and Christopher Sullivan
Vincent and Rich visit the University of Texas at Austin and meet up with Bob and Chris to talk about their work on influenza virus and microRNAs.
Links for this episode:
Virus-encoded microRNAs (PLoS Path)
microRNA targetomes of polyomavirus (J Virol)
Innate and RNAi reciprocal inhibition (Cell)
ISG15 pathway (Trends Micro)
Role of viral NS1 protein (Virology)
Cap-snatching (Cell)
Weekly Science Picks
Rich
TWiV 254: Ninety-nine macaques on the wall
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Vincent, Dickson, Alan, and Kathy review clearance of simian immunodeficiency virus infection from macaques by immunization with SIV proteins encoded in a rhesus cytomegalovirus vector.
Links for this episode:
Immune clearance of SIV infection (Nature)
Rhesus CMV vectors (Nature Medicine)
Types of memory T cells (WikiPedia)
Goldilocks approach to vaccines (Scilogs)
Chimeric HA influenza vaccine (J Virol)
Influenza vacc
TWiV 253: I don't know anything about sorghum
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
In this second consecutive all-email episode, the complete TWiV team reads questions and comments from listeners about systemic antiviral responses, wild type poliovirus in Israel, Turkish scientists, viral symbiotes, and much more.
Links for this episode:
One Nation in support of biomedical research?
Bilim Kazani (The Cauldron of Science)
Science for Gezi
State of Turkish Science
Pathogenesis of feline co
TWiV 252: Who read the last email?
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The complete TWiV team reads email from listeners about anti-vaccine activists, a career in microbiology, placentas, a virology textbook, the HeLa cell genome, norovirus, and much more.
Links for this episode:
Anthropic principle
1999 vaccine article by Alan Dove (Nature)
Image credit: Jason Roberts
Letters read on TWiV 251
Weekly Science Picks
Dickson - A Sand County Almanac by Aldo LeopoldKathy - Noctil
TWiV 251: Don't kiss the camel
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The complete TWiV crew reviews work on MERS-coronavirus, including serological studies in camels, production of an infectious DNA clone, and identification of an interferon antagonist.
Links for this episode:
Stephan Chron dies (NY Times)
Philip Marcus dies (NY Times)
Philip Marcus on TWiV #197
Ellen Fanning dies (news@Vanderbilt)
Donald Low dies (CBC News)
MERS timeline
MERS-CoV seroepidemiology (Eurosurv
TWiV 250: Wookie viruses
Hosts: Vincent Racaniello and Robert Garcea
Vincent and Robert recorded this episode at the 53rd ICAAC in Denver, where they talked about polyomaviruses.
Links for this episode:
A cornucopia of human polyomaviruses (Nat Rev Micro)
Polyoma assembly factories in nucleus (PLoS Path)
Overprinting gene in Merkel cell polyomavirus (PNAS)
Human JCV as population marker (PLoS One)
Letters read on TWiV 250
Video of this episode (YouTube)
Weekly Science Picks
Robert - The Panic Virus by Seth MnookinVinc
TWiV 249: An inordinate fondness for viruses
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Vincent, Dickson, Alan and Rich discuss an estimate of the number of different mammalian viruses on Earth.
Links for this episode:
Estimate of unknown viral diversity in mammals (mBio)
How many viruses on Earth? (virology blog)
Letters read on TWiV 249
Weekly Science Picks
Alan - Extreme macrophotographyDickson - Baloney detection kitRich - Mutant silkworms spin colored silk (original article)Vincent - FlightRadar24
List
TWiV 248: TWiP infects TWiV
Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit
Vincent, Dickson, and Rich reveal how experiments with a malaria parasite lead to the introduction of a mammalian retrovirus into birds.
Links for this episode:
Scientists cast doubt on MERS origin (NY Times)
Animal reservoirs of SARS coronavirus (Virus Res)
Jo Handelsman in the White House
Origins of REV (PLoS Biology)
Inadvertent transfer (virology blog)
Mongoose, pheasant, pox, retrovirus (PLoS Biol)
Evolutionary history of REVs
TWiV 247: Today's weather in virology
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Special guest: Ian Lipkin
Ian joins Vincent, Alan, Rich, and Kathy to describe how his laboratory is searching for the origin of MERS-coronavirus.
Links for this episode:
MERS-CoV in bats (EID)
Mystery virus (NY Times)
Part of MERS-CoV found in bat (virology blog()
T. perforatus
Frag virus (Virol J)
Even Nature got it wrong! (Nature)
Bats: Important reservoirs of emerging viruses (Clin Micro Rev)
Letters read on TWiV 247
Wee
TWiV 246: Pandora, pandemics, and privacy
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich, and Kathy discuss the huge Pandoravirus, virologists planning H7N9 gain of function experiments, and limited access to the HeLa cell genome sequence.
Links for this episode:
Pandoraviruses (Science)
Unlike anything seen before (virology blog)
H7N9 gain of function experiments planned (Nature, Science)
Virologists plan H7N9 gain of function experiments (virology blog)
Creating a deadly virus? Not!! (USA T
TWiV 245: Writing Principles of Virology
Host: Vincent Racaniello
Guests: S. Jane Flint, Lynn Enquist, Glenn Rall, and Ann Skalka
The authors of the popular textbook Principles of Virology discuss how the book was conceived and written.
Links for this episode:
Principles of Virology
Lahiere's
General Virology by SE Luria
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
TWiV 244: Back in the CVVR
Hosts: Vincent Racaniello and Alan Dove
Guests: Dan Barouch and Jeff Teigler
This episode of TWiV was recorded before an audience at the Beth Israel Deaconess Medical Center, where Vincent and Alan spoke with Dan and Jeff about AIDS vaccines.
Links for this episode:
Human study of adenovirus 26 HIV-1 envelope vaccine (J Inf Dis)
Seroepidemiology of adenovirus serotypes (Vaccine)
SIV infection associated with expansion of gut virome (Cell, TWiV #204)
Global approach to HIV-1 vaccine development
TWiV 243: Live from ASV at Penn State
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Rebecca Dutch and Christiane Wobus
On this episode of TWiV, which was recorded before a large enthusiastic audience at the annual meeting of the American Society for Virology, Vincent, Rich, and Kathy speak with Rebecca and Christiane about their work on metapneumoviruses and noroviruses.
Links for this episode:
TWiV 143 with Stephanie Karst
American Society for Virology
Mouse model for human norovirus (mBio)
Paramyxovirus fusio
TWiV 242: I want my MMTV
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The complete TWiV team talks about how two different viruses shape the evolution of an essential housekeeping protein.
Links for this episode:
Dual virus-host arms race (PLoS Biology)
Dual virus-receptor duel (see comments - virology blog)
Ferritin and transferrin (Protein Data Bank)
Money for nothing (YouTube)
Letters read on TWiV 242
Weekly Science Picks
Dickson - Mantid imagesKathy - No email? (phd com
TWiV 241: The ferret looks ill
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich and Kathy review how human placental trophoblasts confer viral resistance via exosome-mediated delivery of microRNAs, and isolation of the first human influenza virus in 1933.
Links for this episode:
Human placental trophoblasts confer viral resistance (PNAS)
Placental circulation (Wikipedia)
Ovum in uterine decidua (Wikipedia)
A virus obtained from influenza patients (Lancet)
80 years ago today (the guard
TWiV 240: Virology in Vermont
Host: Vincent Racaniello
Guests: Markus Thali and Jason Botten
Vincent travels to the University of Vermont to talk with Markus and Jason about their work on HIV, influenza virus, arenaviruses and hantaviruses.
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
TWiV 239: Filterable camels
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Matt Frieman
Matt joins Vincent, Alan, and Rich to summarize what we know and what we do not know about the MERS coronavirus.
Links for this episode:
MERS-CoV update (WHO)
MERS-CoV evolution (epidemic)
Sick camel linked to MERS-CoV death (7Days)
MERS-CoV hospital outbreak (NEJM)
MERS-CoV French hospital cluster (Lancet)
MERS-CoV family cluster (NEJM)
Matt on MERS-CoV on the Voice of Russia
Letters read on TWiV 239
Weekly Science Picks
Matt
TWiV 238: Lost in translation
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Vincent, Rich and Kathy discuss mechanisms of protein synthesis and regulation in virus-infected cells.
Links for this episode:
Slides for this episode (pdf)
T7 ribosomal binding sites (CSH Symp Quant Biol)
Tinkering with translation (CSH Persp)
Translation at nexus of infection and immunity (Cell Host Microbe)
Viral subversion of protein synthesis machinery (Nat Rev Micr)
Weekly Science Picks
Kathy - Vaccine-preventable outbreaksRich
TWiV 237: Paleovirology with Michael Emerman
Hosts: Vincent Racaniello and Rich Condit
Guest: Michael Emerman
Vincent and Rich recorded this episode at the Fred Hutchinson Cancer Research Center in Seattle, WA, where they met up with Michael to talk about his work on the molecular and evolutionary basis of HIV replication and pathogenesis.
Links for this episode:
Ancient origins of SIV (PLoS Path)
Paleovirology (PLoS Biology)
Harmit Malik on TWiV 205
Sara Sawyer on TWiV 193
Listener Pick of the Week
Molly - Facts in the case of Dr. Andr
TWIV 236: Flu gets the VIP treatment
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan and Kathy review novel approaches to preventing influenza virus infection.
Links for this episode:
Ultraprotective influenza vaccine in mice (PNAS)
Vectored immunoprophylaxis of influenza in mice (Nat Biotech)
Intranasal antibody gene transfer protects agains influenza (Sci Transl Med)
Estimating influenza associated deaths (CDC)
Multistate HAV outbreak (CDC)
Subscribe to Microbeworld video (YouTube)
Save podcasting (EFF)
Le
TWiV 235: Live in Edmonton, eh?
Hosts: Vincent Racaniello and Rich Condit
Guests: Dave Evans, Stan Lemon, and Lorne Tyrrell
Vincent and Rich recorded this episode before an audience at the 2nd Li Ka Shing Institute of Virology Symposium at the University of Alberta, where they spoke with Dave, Stan, and Lorne about their work on poxvirus vaccines and recombination, an enveloped picornavirus, antivirals against hepatitis B and C viruses, and supporting virology research in Alberta.
Links for this episode:
Li Ka Shing Institut
TWiV 234: Live in Denver
Hosts: Vincent Racaniello and Kathy Spindler
Guests: Nels Elde and Tom Shenk
Vincent and Kathy recorded this episode before an audience at the 2013 General Meeting of the American Society for Microbiology in Denver, Colorado, where they spoke with Nels and Tom about their work on the evolution of virus-host conflict and how viruses influence the cell metabolome.
Links for this episode:
A cross-species view on viruses (Curr Op Virol)
Pox has got a squeeze box (TWiV 198)
Saturated fatty acids ne
TWiV 233: We're surrounded
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler
Vincent, Rich, Alan and Kathy review aerosol transmission studies of influenza H1N1 x H5N1 reassortants, H7N9 infections in China, and the MERS coronavirus.
Links for this episode:
Aerosol transmission of H1N1 x H5N1 reassortants (Science)
It's good science (virology blog)
Viral engineering dangers (Nature)
Colorblind web page filter
Influenza H7N9 update (ProMedMail)
Influenza H7N9 risk assessment (WHO, pdf)
Influenza H7N9 c
TWiV 232: Gophers go viral
Hosts: Vincent Racaniello, Roberto Cattaneo, Reuben Harris, Lou Mansky, and Leslie Schiff
Vincent meets up with Roberto, Reuben, Lou, and Leslie at the University of Minnesota to talk about their work on HIV-1, APOBEC proteins, measles virus, and teaching virology to undergraduates.
Links for this episode:
University of Minnesota virology timeline
Revisiting HIV-1 lethal mutagenesis (Trends Micro)
Exploiting HIV-1 drug repositioning (J Virol)
5-azaC induces HIV-1 lethal mutagenesis (J Virol)
H
TWiV 231: Hepaciviruses and pegiviruses in bats and rodents
Hosts: Vincent Racaniello, Amit Kapoor, Lan Quan, and Ian Lipkin
Vincent meets up with Amit, Lan, and Ian to discuss their discovery of hepaciviruses and pegiviruses in bats and rodents.
Links for this episode:
Canine hepacivirus (TWiV 137)
Rodent homologs of hepaciviruses and pegiviruses (mBio)
Bats are a reservoir of hepaciviruses and pegiviruses (PNAS)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
TWiV 230: Gene goes to Washington, flu chickens out
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler
Vincent, Rich, Alan and Kathy review H7N9 infections in China, the debate over patenting genes, and receptor-binding by ferret-transmissible avian H5 influenza virus.
Links for this episode:
Francois Jacob dies (The Loom)
WHO updates on H7N9
H7N9 is unusually dangerous (ScienceInsider)
H7N9 case imported into Taiwan
No H7N9 in poultry farms (Xinhua)
Supreme Court considers gene patents (TheScientist, Nature)
Patent my jeans,
TWiV 229: Partly cloudy with a high of H7N9
Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, and Alan Dove
Vincent, Rich, Dickson, and Alan review the current status of human infections with avian influenza H7N9 virus.
Links for this episode:
Hilary Koprowski, 96 (NY Times)
Koprowski, Kessin, Racaniello photo
Listen to the Music by Roger Vaughan
Influenza ocular infections (one, two)
H7N9 global concerns (NEJM)
Human infection with H7N9 (NEJM)
WHO Global Alert and Response, H7N9
Avian influenza A(H7N9) virus (WHO)
Novel H7N9 r
TWiV 228: Cal Bears go viral
Hosts: Vincent Racaniello, Britt Glausinger, and Eva Harris
Vincent visits the University of California at Berkeley and speaks with Britt Glaunsinger and Eva Harris about their work on Kaposi's sarcoma associated herpesvirus and dengue virus.
Thanks to the Microbiology Graduate Students for hosting me at their annual symposium, and especially to Emma, Lisa, and Zoe for their wonderful hospitality during my stay.
Links for this episode:
RNA element in IL-6 confers SOX resistance (J Virol)
Dual u
TWiV 227: Lacks security and bad poultry
Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler
The complete TWiV team reviews the controversial publication of the HeLa cell genome, a missing vial of Guanarito virus in a BSL-4 facility, and human infections with avian influenza H7N9 virus.
Links for this episode:
Containment plan for poliovirus (pdf, WHO)
Post-eradication of polio
Ocular tropism of respiratory viruses (MMBR)
Rally for medical research
HeLa genome sequence withdrawn (ScienceInsider)
I
TWiV 226: Taking the viral A train with Terry Dermody
Hosts: Vincent Racaniello, Dickson Despommier, and Terry Dermody
Vincent and Dickson speak with Terry Dermody about his career in medicine and virology.
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
TWiV 225: Transcripts from the inbox
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Rich, and Kathy read listener comments and questions on viral oncotherapy, science communication, a functional HIV cure in an infant, and much more.
Links for this episode:
Plant viruses alter insect behavior (Sci Rep)
Circovirus in Shanghai
Letters read on TWiV 225
Weekly Science Picks
Kathy - Case stories about CoV-EMC (one, two)Rich - The Self-Illusion by Bruce HoodVincent - Moving Targets
Listener Pick of the Week
Liam - eLI
TWiV 224: A wide receiver and a natural defense
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, Kathy, and Dickson discuss identification of a cell receptor for the coronavirus-EMC, and the role of interferon-epsilon in protecting the female reproductive tract.
Links for this episode:
Dipeptidyl peptidase 4 is CoV-EMC receptor (Nature)
Receptor for new coronavirus (Nature)
Broad reception for coronavirus (Nature)
SARS 10th anniversary (Science)
Interferon-epsilon protects female reproductive tract (Science)
Families f
TWiV 223: EEEV and the serpent
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy discuss new influenza virus NA inhibitors, detection of EEEV antibody and RNA in snakes, and replication of the coronavirus EMC in human airway epithelial cells.
Links for this episode:
International Women's Day 2013
Condit Dam, 6 weeks later (Vimeo)
Influenza HA assay
Covalent influenza NA inhibitors (ScienceExpress)
Defective influenza HA mutants (Virology)
New flu drug (BBC, e! Science)
EEEV antibody, RNA in sn
TWiV 222: Jumpin' Jack Flash, it's a GAS GAS GAS
Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler
The complete TWiV team discusses the amazing finding that cyclic GMP-AMP synthase is a cytosolic innate immune DNA sensor.
Links for this episode:
Zhijian J. Chen (Wikipedia)
Sensing the dark side of DNA (Science)
cGAMP is an endogenous second messenger (Science)
cGAMP synthase is a DNA sensor (Science)
Pore-forming toxin (Wikipedia)
Letters read on TWiV 222
Weekly Science Picks
Kathy - Graphene batteries
TWiV 221: Bunya there, done that
Hosts: Vincent Racaniello, Dickson Despommier, and Kathy Spindler
Vincent, Dickson, and Kathy review two emerging bunyaviruses, SFTSV and SBV.
Links for this episode:
Human transmission of SFTSV (JID)
SFTSV serosurvey (EID)
SFTSV on TWiV 147
SFTSV in Japan (ProMedMail)
SFTSV mouse model (PNAS)
SBV infectious DNA and mouse model (PLoS Path)
SBV in Sweden (ProMedMail)
Letters read on TWiV 221
Weekly Science Picks
Kathy - Winners, 2012 Science & Engineering Visualization ChallengeVincent - The O
TWiV 220: Flu watches the clock while T7 gets a CAT scan
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler
Vincent, Rich, Alan, and Kathy discuss regulation of influenza virus replication by splicing, and the bacteriophage T7 random walk.
Links for this episode:
Influenza splicing regulates infection (Cell Reports)
Reporting on flu splicing from NPR, BBC, NBC
Splicing of influenza RNA 8 (jpg)
Bacteriophage T7 remodeling during infection (Science)
Cryo-ET of intact cells (Trends Cell Biol)
T7: The Movie (YouTube)
Cry0-EM vs Cryo-ET
TWiV 219: Fauci pharmacy
Hosts: Vincent Racaniello, Rich Condit, and Anthony S. Fauci
Vincent and Rich meet up with Anthony S. Fauci, MD, Director of the National Institute of Allergy and Infectious Diseases.
Links for this episode:
Fauci history (J Clin Inves)
Fauci Pharmacy
Anthony Fauci (Wikipedia)
Anthony Fauci: Unfinished business (Lens)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
TWiV 218: Monkeys turning valves and pushing buttons
Hosts: Vincent Racaniello, Alan Dove, and Welkin Johnson
Vincent, Alan, and Welkin discuss how endogenous retroviruses in mice are held in check by the immune response.
Links for this episode:
Kuan-Teh Jeang, 54
Resurrection of ERVs (Nature)
Toll-like receptors control ERVs (Immunity)
Retroviral danger from within (Immunity)
Ancient viruses wreak havoc (The Scientist)
Letters read on TWiV 218
Weekly Science Picks
Welkin - Viruses: Essential Agents of Life (review at STC)Alan - Infinity Imagin
TWiV 217: I just flu in and my arms are shot
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Dickson Despommier
Vincent, Alan, Rich, and Dickson review influenza vaccines.
Links for this episode:
FDA licensed flu vaccines
Seasonal influenza vaccine distributed
How flu vaccine strains are selected (one, two)
WHO report on flu vaccine strain selection (pdf)
Derek Smith on antigenic mapping
Salk's 1945 influenza vaccine
TIV preparation: Fluzone, Agriflu, Fluvirin, Fluarix, Flulaval, Afluria (pdfs)
LAIV preparation (pdf)
Efficacy of f
TWiV 216: Processing VIRALGUUAACACCAGRNA
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich, and Kathy resume the virology 101 series with a discussion of RNA capping, splicing, and export.
Links for this episode:
Slides for this episode (pdf)
Spliced Ad 2 late mRNAs (Cell)
An amazing sequence arrangement (Cell)
Adenovirus late mRNA undecanucleotide (Cell)
Aaron Shatkin, 72 (virology blog)
Schrödinger's cat (Wikipedia)
Letters read on TWiV 216
Weekly Science Picks
Rich - Linus Pauling's explanat
TWiV 215: Illuminating rabies and unwrapping a SARI
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy review the finding that rabies virus infection alters but does not kill neurons, and provide an update on the novel coronavirus in the Middle East.
Links for this episode:
Neuronal survival after rabies virus infection (PLoS Path)
Clusters of coronavirus cases (Nature)
ProMedMail on novel coronavirus
Novel coronavirus outbreak news (Int J Inf Dis)
Genomic characterization of novel coronavirus (mBio)
Broad cell tro
TWiV 214: This is your brain on polyomavirus
Hosts: Vincent Racaniello, Rich Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy discuss how coagulation factor X binding to adenovirus activates the innate immune system, and a novel polyomavirus associated with brain tumors in raccoons.
Links for this episode:
Coagulation factor X activates innate immunity to adenovirus (Science)
A decorated virus cannot hide (Science)
Reflecting on goals for Science
Polyomavirus associated with raccoon brain tumors (EID)
MPNST
Moore tumor viruses - TWi
TWiV 213: Not bad for a hobby
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler
In their final episode of the year, the TWiV team reviews twelve cool virology stories from 2012.
Twelve virology stories from 2012:
H5N1 (TWiV 190, 182, 177, 173, 168)
Polymorphisms that control susceptibility (TWiV 175, 180)
New virus receptors (TWiV 166, 210)
XMRV: Last nail in the coffin (TWiV special)
Polio eradication troubles in Pakistan (NY Times one, two, three; virology blog)
Biomedical research crisis (TWiV 208, 18
TWiV Special: Ignorance with Stuart Firestein
Hosts: Vincent Racaniello and Stuart Firestein
Vincent and Stuart discuss why ignorance - all of what we don't know, and even what we don't know we don't know - is the driving force of science.
Links for this episode:
Ignorance: How it drives Science by Stuart Firestein
Ignorance website
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
TWiV 212: Apocalypse TWiV 122112 212
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler
The TWiVerers answer listener email about genetically modified chickens, a hendra vaccine for horses, online education, curing color blindness, Roosevelt and polio, Th cells, and much more.
Links for this episode:
TWiV 116: Cocaine, colonies, and chickens
Glofish
Recombinant Hendra vaccine
Gene therapy for color blindness (Nature)
FDR, polio, and Guillain-Barré
Transcript of TWiV 197: Philip Marcus (pdf)
TWiV 10: Bats, elepha
TWiV 211: Viruses r us
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler
The TWiV four discuss an mRNA-based influenza vaccine, and a phage tubulin that forms a filamentous array in the host cell that is needed for positioning viral DNA.
Links for this episode:
mRNA vaccine against influenza (Nat Biotech)
Phage tubulin assembles dynamic filaments (Cell)
Viral skeleton (The Scientist)
Not unorganized bags of enzymes (TWiM 28)
Bacterial cytoskeleton (FEMS Micro Rev)
Triangulation number (jpg)
Letter
TWiV 210: Bond, covalent bond
Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler
The complete TWiV team reviews identification of the cell receptor for hepatitis B and D viruses, and the cell enzyme that cleaves the genome-linked protein from picornaviral RNA.
Links for this episode:
HBV and HDV cell receptor (eLIFE)
Getting to grips with hepatitis (eLIFE)
Sodium taurocholate
Poliovirus hijacks DNA repair enzyme (PNAS)
Letters read on TWiV 210
Weekly Science Picks
Rich - Vendée GlobeD
TWiV 209: When the virus hits the fans
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Vincent, Dickson, Alan, and Kathy answer listener email about deformed wing virus, West Nile virus, FluMist, influenza in Canada, viruses and the tree of life, and more.
Links for this episode:
Postcard from the ultimate student athlete (pdf)
Fidelity of protein synthesis (Biochemistry, 5th ed.)
Letters read on TWiV 209
Weekly Science Picks
Dickson - Cassini web site and Mars reconnaissance orbiterAlan - OneZoom Tree
TWiV 208: The biomedical research crisis with Jon Yewdell
Hosts: Vincent Racaniello and Jon Yewdell
Vincent and is joined by special guest Jon Yewdell to discuss solutions for ending the current crisis in American biomedical research.
Links for this episode:
How to succeed in science: Taking the plunge (Nat Rev Mol Cell Biol)
How to succeed in science: Making discoveries (Nat Rev Mol Cell Biol)
How to succeed in science (YouTube)
Resources for graduate students and postdocs
Science career cartoons by Alexander Dent
Send your virology questions and co
TWiV 207: Silk sheets and viral infidelity
Hosts: Vincent Racaniello, Alan Dove, Matt Frieman, and Kathy Spindler
Vincent, Alan, Matt, and Kathy review the use of silk to stabilize antibiotics and a viral vaccine, and an impaired-fidelity vaccine against SARS coronavirus.
Links for this episode:
Silk stabilization of antibiotics and vaccines (PNAS)
Impaired-fidelity coronavirus vaccine (Nature Medicine)
Select agent status and SARS therapies (Spoonful of Medicine)
Letters read on TWiV 207
Weekly Science Picks
Matt - Virus-associated py
TWiV #206 - Viral turducken
Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Kathy Spindler
Vincent, Alan, Dickson, and Kathy discuss how the innate immune response to viral infection influences the production of pluripotent stem cells, and the diverse mobilome of giant viruses.
Links for this episode:
Innate immunity and nuclear reprogramming (Cell)
Viruses affect cell reprogramming (The Scientist)
Cell-penetrating peptides (Trends Mol Med)
Provirophages and transpovirons (PNAS)
Organic Lake photo and map
Le
TWiV 205: Genetic conflict with Harmit Malik
Hosts: Vincent Racaniello and Harmit Malik
Vincent is joined by special guest Harmit Malik to discuss his work on the evolution of genetic conflict.
Links for this episode:
Harmit on YouTube
Retroviruses and mammalian placentation (PNAS)
Paleovirology (Curr Opin Virol)
Evolution among AIM2-like receptors (J Exp Med)
Poxvirus genomic accordions (Cell)
Letters read on TWiV 205
Weekly Science Picks
Vincent - Candidates' answers to science questions
Listener Pick of the Week
Steve - Mural of Henri
TWiV 204: M m m my corona
Hosts: Vincent Racaniello, Alan Dove, Matt Frieman, and Kathy Spindler
Vincent, Alan, Matt and Kathy review isolation of a new coronavirus from two patients in the Middle East, and expansion of the enteric virome during simian AIDS.
Subscribe to TWiV (free) in iTunes, at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode:
Novel coronavirus (virology blog one, two)
PCR assay for novel CoV (Eurosurveillance)
Isolation
TWiV 203 - Mark Challberg, a cold room kind of guy
Hosts: Vincent Racaniello, Rich Condit, and Mark Challberg
Vincent and Rich meet up with Mark Challberg to talk about his scientific career studying viral DNA replication, and his transition to an NIH Program Officer.
Subscribe to TWiV (free) in iTunes, at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode:
Purification of vaccinia virus DNA polymerase (J Biol Chem)
Adenovirus DNA replication in vitro (PNAS)
Herpes
TWiV 202 - Huskers go viral
Hosts: Vincent Racaniello, T. Jack Morris, James Van Etten, and Charles Wood
Vincent travels to the University of Nebraska to meet with members of the Nebraska Center for Virology and discuss their work on algal viruses, plant viruses, HIV and Kaposi's sarcoma herpesvirus.
Links for this episode:
The Nebraska Center for Viology
Behind the scenes at TWiV 202
TWiV on Facebook
Weekly Science Picks
Charles - Rhabdovirus associated with hemorrhagic fever (PLoS Path)Vincent - Bacteriophage graffiti
TWiV 201: Rabid about viruses
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich, and Kathy answer reader email about rabies, xenotransplantation, poliovirus, Ph.D. programs, mosquitoes, and much more.
Links for this episode:
Mattias Schnell
Novel rhabdovirus from Africa (Plos Path)
Milwaukee protocol (Wikipedia)
How lethal is rabies virus? (virology blog)
Issues with polio eradication (J Gen Virol)
Vaccine-derived polioviruses (J Inf Dis)
Global pandemics with Hidde Ploegh (Vimeo)
Pol
TWiV 200: Threading the NEIDL
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Elke Mühlberger, Paul Duprex, and Ron Corley
Vincent, Alan, and Rich celebrate the 200th episode of TWiV by visiting the National Emerging Infectious Diseases Laboratories at Boston University Medical Center, where they meet with Elke, Paul, and Ron to talk about building and working in a BSL4 facility.
Links for this episode:
The NEIDL
NEIDL goes public (BU Today)
Biosafety levels (Wikipedia)
Select agents (Wikipedia)
NEIDL stalled (Boston Bus
TWiV Special: A paradigm for pathogen de-discovery
Hosts: Vincent Racaniello and W. Ian Lipkin
Vincent and Ian review a multicenter blinded analysis which finds no association between chronic fatigue syndrome/myalgic encephalomyelitis and XMRV or polytropic murine leukemia virus.
Subscribe to TWiV (free) in iTunes, at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode:
Multicenter blinded analysis of CFS and XMRV/pMLV (mBio)
Press release on multicenter study (pdf)
TWiV 199: Of mice, ticks, and pigs
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich, and Kathy discuss recent outbreaks of hantavirus pulmonary syndrome in Yosemite National Park and novel swine-origin influenza in the US midwest, and isolation of the Heartland virus from two patients in Missouri with severe febrile illness.
Subscribe to TWiV (free) in iTunes, at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episo
TWiV 198: Pox has got a squeeze-box, seals are gonna sneeze all night
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich, and Kathy review fatal avian influenza virus in harbor seals, and poxvirus deployment of genomic accordions to counter antiviral defenses.
Links for this episode:
Avian influenza virus in harbor seals (mBio)
Poxvirus genomic accordions (mBio)
Red Queen hypothesis (Wikipedia)
TWiV on Facebook
Letters read on TWiV 198
Weekly Science Picks
Alan - Getting Better: 200 Years of MedicineRich - Khan AcademyKathy
TWiV 197: Cloning HeLa cells with Professor Philip I Marcus
Hosts: Vincent Racaniello and Philip I. Marcus
Vincent travels to the University of Connecticut to meet up with Professor Philip I. Marcus to discuss his development of the single cell cloning technique in the early 1950s.
Links for this episode:
Cloning with X-irradiated feeder cells (PNAS)
Philip I. Marcus in the lab (jpg)
Cloning with capillary tubes (jpg)
Cloning platform (jpg)
VRR holding 1950s glass plate of clones (jpg)
HeLa clones (jpg)
Cloning cylinder (jpg)
TWiV on Facebook
Coming soo
TWiV 196: An arena for snakes
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, Kathy Spindler, Mark Stenglein, and Joseph DeRisi
The TWiVites meet with Mark Stenglein and Joseph DeRisi to discuss their discovery of a novel arenavirus in snakes with inclusion body disease.
Links for this episode:
Highly divergent arenaviruses in snakes (mBio)
Taryn's sick snake (NPR)
Assemblathon
Faculty position in virology, Columbia U.
Petridish.org
TWiV on Facebook
Letters read on TWiV 196
Weekly Science Picks
Mark
TWiV 195: They did it in the hot tub
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, and Ken Stedman
The complete TWiV team meets with Ken Stedman to discuss the discovery in Boiling Spring Lake of a DNA virus with the capsid of an RNA virus.
Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode:
Novel virus from an extreme environment (Biol Direct, virology blog)
Lassen Volcanic National Park
TWiV 194: Five postdocs in North America
Hosts: Vincent Racaniello, Matthew Daugherty, Jondavid deJong, Helen Lazear, Stefan Oliver, and Cara Pager.
Vincent returns to Madison, Wisconsin and meets with postdocs to discuss their science and their careers.
Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode:
TWiV 189: Five postdocs in Glasgow
ASM at the USA Science and Engineering Festival
ASV 2012 at Madison, WI
Photog
TWiV 193: Live at ASV in Madison
Hosts: Vincent Racaniello, Rich Condit, Carolyn Coyne, and Sara Sawyer
Vincent, Rich, Carolyn, and Sara recorded TWiV at the 31st Annual Meeting of the American Society for Virology in Madison, where they discussed genetic conflict between viral and human genes, and how the placenta protects the fetus against viral infection.
Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode:
TWiV 192: Viral tertulia
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan, and Rich answer listener email about bioinformatics, insects, influenza, laboratory classes, commensalism, reproducibility of data, and more.
Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode:
Vaccinia virus sequence from patient with vaccine complication (pdf)
The evolution of intellectual freedom (thanks,
TWiV 191: When two rights make a wrong
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Nissin Moussatche
Nissin joins the TWiV crew to discuss an outbreak of lethal disease among Cambodian children, and recombination among attenuated herpesvirus vaccines leading to pathogenic viruses.
Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode:
Outbreak in Cambodia (CNN)
Pathogen mix in Cambodian illness (ProMedMail)
TWiV 190: The second ferret of the Apocalypse
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy review selection of influenza H5N1 viruses that can transmit among ferrets by aerosol.
Links for this episode:
Airborne transmission of H5N1 among ferrets (Science)
Potential for H5N1 evolution (Science)
H5N1 (Science)
The ferrets of fear
Jim's podcast list (pdf)
TWiV on Facebook
Letters read on TWiV 190
Weekly Science Picks
Kathy - Wind mapVincent - The A-Z of Epidemiology (YouTube)
Listener Pick of the Week
Kri
TWiV 189: Five postdocs in Glasgow
Vincent returns to the Centre for Virus Research at the University of Glasgow and meets with postdocs to discuss their science and their careers.
Links for this episode:
MRC-University of Glasgow Centre for Virus Research
Stop CMV
Photos of my Glasgow visit (Facebook and VirusTalk)
TWiV on Facebook
TWiV 188 - Haggis, single malt, and viruses
Hosts: Vincent Racaniello, Massimo Palmarini, John MacLauchlan, Emma Thomson, and Hande Harmanci.
Vincent travels to Scotland to meet with members of the Centre for Virus Research at the University of Glasgow to discuss their work on hepatitis C virus and jaagsiekte sheep retrovirus.
Links for this episode:
MRC-University of Glasgow Centre for Virus Research
Aaron Shatkin, 77 (virology blog)
Photos of my Glasgow visit (Facebook and VirusTalk)
TWiV on Facebook
Letters read on TWiV 188
Weekly Sc
TWiV 187: The mummy
Hosts: Vincent Racaniello and Rich Condit
Vincent and Rich discuss recovery of a hepatitis B viral genome from a 16th century Korean mummy, and personal omics profiling of an individual over a 14 month period.
Links for this episode:
Tracing HBV to the 16th century (Hepatology)
HBV on TWiV
Precautions with ancient DNA (Science)
Personal omics profile over 14 months (Cell)
A geneticist's research turns personal (NY Times)
Mike Snyder on Futures in Biotech
The DASH diet
TWiV on Facebook
Letters r
TWiV 186: From Buda to stump grinding
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
The TWiV chiefs tackle reader email about how to pronounce Buda, Texas, grinding tree stumps, and much more.
Links for this episode:
Detecting antibodies or antigens by ELISA
Peter Wildy Prize
Biosafety levels
Baltimore classification at Viral Zone
TWiV on Facebook
Letters read on TWiV 186
Weekly Science Picks
Alan - World Wide Lightning Location NetworkRich - Steve Jobs by Walter IsaacsonVincent - The Ocelloid
Listener Pick of the Week
laf
TWiV 185: Dead parrots and live Wildcats
Vincent visits with members of the Department of Microbiology and Immunology at Northwestern University School of Medicine to discuss their work on herpesviruses and parainfluenzaviruses.
Links for this episode:
Longnecker laboratory
Herpesvirus deubiquitinase is neuroinvasive determinant (PLoS Path)
Paramyxovirus HN structure (PNAS)
TWiV on Facebook
Letters read on TWiV 185
Weekly Science Picks
Sarah - Breasts: A Natural and Unnatural History by Florence WilliamsAndrew - The Strangest Man by
TWiV 184: Reforming science
Vincent, Rich, and Alan consider how to reform the scientific enterprise to make it more effective and robust.
Links for this episode:
Reforming science: Methodological and cultural reforms (Infect Immun)
Reforming science: Structural reforms (Infect Immun)
Sharp rise in retractions (NY Times)
Vannevar Bush
TWiV on Facebook
Letters read on TWiV 184
Weekly Science Picks
Alan - PubMed PubReMinerRich - Intentional Blindness (YouTube)Vincent - Vaccine infographic
Listener Pick of the Week
Ken - Wa
TWiV 183: Bats out of hell
Connor joins the TWiV team to discuss bats as hosts for major mammalian paramyxoviruses.
Links for this episode:
NIH response to Osterholm letter (pdf)
Who's afraid of the big, bad bioterrorist?
Bats host major mammalian paramyxoviruses (Nature Comm)
TWiV on Facebook
Letters read on TWiV 183
Weekly Science Picks
Connor - Microbiology Twitter journal clubAlan - Where the Wild Types Are (YouTube)Rich - May 14th: Smallpox vaccination dayDickson - Searching for pore-fection (Science)Vincent - RRRe
TWiV 182: One flu over the ferrets' nest
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Michael J. Imperiale
Michael joins the TWiV crew to discuss the recently published influenza H5N1 transmission paper and how it was viewed by the NSABB.
Links for this episode:
About the NSABB
The Kawaoka paper (Nature)
Mutant flu paper published (Ed Yong)
Osterholm letter (pdf)
US policy for dual research of concern (pdf)
TWiV on Facebook
Letters read on TWiV 182
Weekly Science Picks
Alan - 18th century shipping mappedRich - Brave New Wor
TWiV 181: ORFan poxviruses and nIRFing prions
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Vincent, Rich, and Kathy discuss Cotia virus, a new poxvirus, Orf virus infections associated with handling goats and lamb, and the innate immune response to prions.
Links for this episode:
Cotia virus (J Virol)
Human Orf virus exposures (MMWR)
IRF3 protects agains prion infection (J Virol)
A mad cow in America (virology blog)
Human orf (pdf)
Space shuttle flies outside my window (YouTube)
TWiV on Facebook
Letters read on TWiV 181
Week
TWiV 180: Throwing IFIT at flu and holding a miR to HCV
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan, and Rich review association of an interferon-induced protein with severe influenza, and stabilization of HCV RNA by a microRNA.
Links for this episode:
IFITM3 and severe influenza (Nature)
Genetics of flu susceptibiligy (EurekAlert!)
Stabilization of HCV RNA by Ago2-miR-122 (PNAS)
Clinical trial of anti-mIR-122
TWiV on Facebook
Letters read on TWiV 180
Weekly Science Picks
Alan - Micro Empire (Vimeo)Rich - Census of marine li
TWiV 179: Was ist ein virus?
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Gertrud Radu
Gertrud joins the TWiVoners to review how dengue virus infection of mosquitoes alters blood feeding behavior, and gene therapy as practiced by parasitoid wasps.
Links for this episode:
Renato Dulbecco, 1914-2012 (virology blog)
William Jarrett, 83 (thanks, Lynn Enquist)
Dengue virus infection of mosquitoes alters their behavior (PLoS Path)
Does dengue make mosquitoes thirstier for blood? (NY Times)
Polydnaviruses of braconid wa
TWiV 178: T-Sharp on how tequila mosquito
The TWiValians meet up with Tyler Sharp for a discussion on the Epidemic Intelligence Service and controlling dengue.
Links for this episode:
2010 dengue epidemic in Puerto Rico
Marshall Islands dengue outbreak (one and two)
Photo of Tyler by Loren Rodgers
TWiV shout-out by NPR and CIDRAP
NSABB reverses decision on H5N1 publication
TWiV on Facebook
Letters read on TWiV 178
Weekly Science Picks
Tyler - Co-infection with dengue and Leptospira (Emerging Inf Dis)Alan - The Winged Scourge (YouTube)
TWiV 177: Live in Dublin
A discussion of avian influenza H5N1 transmission experiments in ferrets and novel bunyaviruses at the 2012 Spring Conference of the Society for General Microbiology in Dublin, Ireland.
Links for this episode:
Restricted data on H5N1 transmission (Science)
Novel bunyavirus in China (NEJM and TWiV 127)
Ten things about Schmallenberg virus (Microbiology Bytes)
NSABB reverses decision on H5N1 papers (virology blog)
TWiV on Facebook
Letters read on TWiV 177
Weekly Science Picks
Connor - Wellcome T
TWiV 176: Ave, magi virorum!
Vincent, Alan, and Rich answer listener email about MS, CFS, EBV, B cells, virii, influenza B, scientific papers, and more.
Links for this episode:
More than one way to skin a virus (comments)
Aerobie aeropress
Papers software
Vaccinia movies (one and two)
Lloyd Kozloff dies
BSL4 facilities
TWiV on Facebook
Letters read on TWiV 176
Weekly Science Picks
Rich - Alan Alda's Flame Challenge (NY Times article, Science editorial)Alan - ChronoZoomVincent - Academic Publishing is Broken by Michael P.
TWiV 175: More than one way to skin a virus
Vincent, Alan, and Matt discuss herpes simplex encephalitis in children with innate immune deficiency, and the local response to microneedle-based influenza skin immunization.
Links for this episode:
Herpes encephalitis in children with TRIF deficiency (J Clin Inv)
Toll-like receptor and cytosolic pattern recognition receptors
Skin responses to influenza microneedle vaccine (mBio)
Microneedles
Fluzone intradermal influenza vaccine
QDot nanocrystal technology
TWiV on Facebook
Letters read on TWi
TWiV 174: Dog runs and mooing miRs
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan, and Rich consider whether pet dogs might transmit human noroviruses, and an RNA virus microRNA that might be involved in oncogenesis.
Links for this episode:
Do pet dogs transmit human norovirus? (J Clin Virol)
RNA virus miRNA that mimics oncomiR (PNAS)
MicroRNA expression by an RNA virus (PNAS)
Lab safety stickers jpg (thanks, Jon!)
Amateur virologists (Zimmer, NY Times)
Genome at home (Wired)
Barbergators sing national anthe
TWiV 173: Going to bat for flu research
The TWiVites discuss seroevidence for human infection with avian influenza H5N1, and the discovery of a new influenza virus in Guatemalan bats.
Links for this episode:
Seroevidence for human H5N1 infection (Science)
Mammalian-transmissible H5N1 (mBio)
New information about ferret-adapted H5N1 (NY Times, virology blog)
New influenza virus from fruit bats (PNAS)
Elsevier abandons open access assault (The Scientist)
Le virus le plus dangereux?
TWiV on Facebook
Letters read on TWiV 173
Weekly Scie
TWiV 172: Two can be as bad as one
Hosts: Vincent Racaniello and Kathy Spindler
Vincent and Kathy discuss how a virus may cause disease distant from its replication site, then review a day in the life of a senior microbiology professor.
Links for this episode:
Celsius vs Centigrade
Neuropathogenesis during polymicrobial infection (PLoS Pathogens)
Tetramer staining (pdf)
One
TWiV on Facebook
Letters read on TWiV 172
TWiV 171: One is the loneliest number
Matt joins the TWiVarians to review virus production in single cells and single virion genomics.
Links for this episode:
H5N1 results will be published (NY Times)
Virus production in single cells then and now
Single virion genomics (PLoS One)
Multiple displacement amplification (Wikipedia)
Ranavirus killing turtles, tadpoles in Maryland (Washington Post)
Three Dog Night
TWiV on Facebook
Letters read on TWiV 171
TWiV 170: From variolous effluvia to VLPs
Alan, Rich, and Dickson discuss Edward Jenner's paper on cowpox vaccine, then move 200 years later to modern vaccines against norovirus, influenza H5N1, and more.
Links for this episode:
Norton Zinder, 83 (Reuters)
Jenner's cowpox vaccine paper (Bartleby, Gutenberg)
Norovirus VLP vaccine (NEJM)
Plant-grown H5N1 VLP vaccine (Reuters, PLoS One)
Plant-grown norovirus VLP
Hexavalent pediatric vaccine
TWiV on Facebook
Letters read on TWiV 170
TWiV 169: Epidemiology causes conclusions (p<0.05)
Michael and the TWiV team review epidemiology basics, including fatality ratios.
Links for this episode:
Michael's blog and podcast
Epidemiology literature critique (PowerPoint)
Seven mistakes in epidemiology (ETE)
Snow cholera map
TWiV on Facebook
Letters read on TWiV 169
TWiV 168: Super CalTech prophylaxis and ferret runny noses
Welkin joins the TWiV team for a discussion of HIV prophlaxis using vectored antibodies, and the influenza H5N1 virus studies in ferrets that were not redacted.
Links for this episode:
Vectored HIV immunoprophylaxis (Nature)
Vectored immunoprophylaxis - the Movie (YouTube)
Adeno-associated virus (Wikipedia)
In vitro evolution of H5N1 towards human receptor specificity (Virology)
Endogenous viral genes non-essential in chicken (Nature)
Rates of HIV transmission per coital act (J Inf Dis)
TWiV on
TWiV 167: It starts with a cough
The complete TWiVome deconstructs the movie Contagion.
TWiV 166: Breaking and entering
Vincent, Dickson, Rich, and Alan review cell proteins essential for entry of hepatitis C, Ebola, and measles viruses.
Links for this episode:
Niemann-Pick C1 is entry factor for HCV (Nature Med)
Ebola virus entry requires Niemann-Pick C1 (Nature one, two)
Nectin-4 is measles virus epithelial receptor (Nature, PLoS Pathogens)
An exit strategy for measles virus (Science)
On this day in history
TWiV on Facebook
Letters read on TWiV 166
TWiV 165: The email zone
Vincent, Dickson, Rich, and Alan answer listener questions about XMRV, cytomegalovirus, latency, shingles vaccine, myxomavirus and rabbits, and more.
TWiV 164: Six steps forward, four steps back
Vincent, Alan, and Rich review ten compelling virology stories of 2011.
TWiV 163: What Rous wrought
Vincent, Dickson, Rich, and Alan review the 100 year old finding by Peyton Rous of a transmissible sarcoma of chickens, a discovery that ushered in the era of tumor virology.
TWiV 162: Transcription
Vincent, Rich, and Alan continue Virology 101 with a discussion of transcription, the process of making mRNA from a DNA template.
TWiV #161 - Concerto in B
Vincent, Rich, Alan and Gabriel review the production of antibodies by B cells, and how high affinity antibodies are selected in the germinal centers of lymph nodes.
TWiV #160 - Moore tumor viruses
The TWiV team speaks with Patrick Moore about his discovery, with Yuan Chang, of two human tumor viruses, Kaposi's sarcoma herpesvirus and Merkel cell polyomavirus.
TWiV #159 - Flu gets the REDD light
Vincent, Alan, and Rich review concern over an influenza H5N1 transmission experiment, and a new host defense protein against RNA viruses.
TWiV #158 - Wolverines go viral
Vincent and Rich visit the Microbiology and Immunology Department at the University of Michigan Medical School, and speak with Alice and Kathy about their work on HIV genome dimerization, and packaging and pathogenesis of mouse adenovirus.
TWiV #157 - Better innate than never
A large TWiV panel remembers Ralph Steinman, and considers a new innate sensor of retroviral capsids.
TWiV #156 - Armed and targeted killer meta-analysis
Vincent, Rich, and Dickson review a meta-analysis on influenza vaccine, a killer virus in fungi that selects against RNAi, and the use of armed and targeted poxviruses for oncolytic virotherapy.
TWiV #155 - XXII Brazilian National Virology Meeting
Vincent, Grant, Eurico, Paulo, Francisco and Janice discuss their work on bocavirus, infectious bronchitis virus, begamoviruses, and circoviruses at the Brazilian Virology Society meeting in Atibaia, São Paulo, Brazil.
TWiV #154 - Symbiotic safecrackers
Vincent, Alan, and Rich are very enthusiastic about two studies that show how gut bacteria help viral invaders.
TWiV #153 - Rabid reindeer and protective prions
Vincent, Alan, and Rich review an outbreak of rabies in arctic foxes and reindeer in Norway, and a prion that makes you go antiviral.
TWiV #152 - Viromes in the effluence of society
Vincent, Alan, and Rich cover the virome of raw sewage, and a baculovirus gene that causes caterpillars to climb to their doom.
TWiV #151 - Dear TWiVers
Vincent, Alan, and Rich review questions and comments from TWiV listeners.
TWiV #150 - Contaminated
Vincent, Dickson, and Rich meant to do an all-email episode, but first they review results of the Blood XMRV Scientific Research Working Group, and partial retraction of the paper associating XMRV with chronic fatigue syndrome.
TWiV #149 - Live at ICAAC in the Windy City
Vincent, Rich, Mark, and Trine discuss science and medicine in journalism and the eradication of poliovirus at the 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC).
TWiV #148 - Retreating into Harvard virology
Vincent, Philip, David, and Priscilla recorded this episode before an audience at the Harvard Virology Program Annual Retreat, where they discussed negative strand RNA viruses, a vaccine against herpes simplex virus type 2, lipidomics of viral infection, and science communication.
TWiV #147 - Debugging dengue
The complete TWiV gang discusses the use of Wolbachia to control mosquito-borne infections.
TWiV #146 - Draco's potion
Vincent, Rich, and Abbie review a broad spectrum antiviral protein, and selective pressure applied by a failed HIV-1 vaccine.
TWiV #145 - The inVinceable TWiV
Alan and Rich tackle the discovery of bacteriophages, and treating influenza by calming the cytokine storm.
TWiV #144 - HIV gets the (zinc) finger
Vincent, Rich, and Alan discuss live blogging of scientific meetings, the current outbreak of Hendra virus is Australia, and using zinc finger nucleases to make HIV-resistant CD4 cells.
TWiV #143 - Live at ASV in Minneapolis
Vincent, Rich, Julie and Stacey recorded TWiV at the 30th Annual Meeting of the American Society for Virology in Minneapolis, where they discussed the role of neutralizing antibodies in protection against HIV-1 infection, and astroviruses, agents of gastroenteritis.
TWiV #142 - Viral oinkotherapy
Vincent, Rich, and Alan discuss a method for identifying viruses of individual environmental bacteria, and the using a picornavirus for oncotherapy.
TWiV #141 - Mickey gets HCV
Matt Evans joins Vincent, Dickson, Alan, and Rich to deconstruct a mouse model for hepatitis C virus infection.
TWiV #140 - An aptitude for microbicides
Vincent, Alan, Rich, and Judy Lieberman review the use of CD4 aptamer-siRNA chimeras to inhibit HIV transmission.
TWiV #139 - Honey, I shrunk the virus
Vincent, Alan, and Dickson discuss the reduction in genome size of Mimivirus upon passage in amoeba, and analysis of the microbiome of honeybees.
TWiV #138 - RISCy business with Raul Andino
Vincent meets up with Raul Andino in San Francisco to discuss the RNAi-based antiviral defense system of Drosophila, the fruit fly, and how it is antagonized by viruses.
TWiV #137 - Look what the dog dragged in
The TWiV team speaks with Amit Kapoor and Ian Lipkin about how they discovered canine hepacivirus, and its implications for the origin and evolution of hepatitis C virus.
TWiV #136 - Exit XMRV
Retrovirologist Stephen Goff joins Vincent, Rich, and Alan for a discussion of recent papers on the retrovirus XMRV and its association with chronic fatigue syndrome and prostate cancer.
TWiV #135 - Live in the Big Easy
Vincent and guests Rachel Katzenellenbogen, Roger Hendrix, and Harmit Malik recorded TWiV #135 live at the 2011 ASM General Meeting in New Orleans, where they discussed transformation and oncogenesis by human papillomaviruses, the amazing collection of bacteriophages on the planet, and the evolution of genetic conflict between virus and host.
TWiV #134 - Meet Ralph, your cruise director
Vincent, Rich, Alan, and Dickson review noroviruses with Stephanie Karst, PhD.
TWiV #133 - The HIV hideout
Vincent, Rich, Alan, and Dickson discuss the cellular reservoir of HIV-1 with Kathleen Collins, MD, PhD.
TWiV #132 - Virology 911
Vincent, Rich, Alan, and Dickson speak with Alfred Sacchetti, MD, Chief of Emergency Services at Our Lady of Lourdes Medical Center, about viral infections encountered in the emergency room.
TWiV #131 - A REOstat for cancer
Vincent, Alan, and Dickson chat with Brad Thompson, CEO of Oncolytics Biotech, about using reovirus to treat cancer.
TWiV #130 - Rhino tracking, wrestling pox, and HCV in the crosshairs
Vincent, Alan, and Rich discuss growth in culture of newly identified rhinovirus C, vaccinia transmission among wrestlers and martial artists, and results of phase III clinical trial of boceprevir, a new inhibitor of hepatitis C virus replication.
TWiV #129 - We've got mail
Vincent, Alan, Dickson and Rich answer listener questions about XMRV, yellow fever vaccine, virus-like particles, West Nile virus, amyotrophic lateral sclerosis and human endogenous retroviruses, multiplicity of infection, and how to make a poxvirus.
TWiV #128 - Virologists in the mist
Vincent, Alan, Dickson and Welkin review how a virus regulates the severity of mucocutaneous leishmaniasis, virophage control of antarctic algal host-virus dynamics, and human metapneumovirus infection in gorillas.
TWiV #127 - Viruses are no joke
Vincent, Alan, and Rich explore a novel bunyavirus isolated in China, the recent polio outbreak in Republic of the Congo, and cell to cell transmission of a retrovirus by biofilm-like extracellular assemblies.
TWiV #126 - Wart's up, doc?
Virologist Michelle Ozbun and the TWiV team review the biology of human papillomaviruses.
TWiV #125 - TWiV infects FiB
This Week in Virology and Futures in Biotech join together in a science mashup to talk about a virophage at the origin of DNA transposons, and unintended spread of a recombinant retrovirus.
TWiV #124 - Viruses that make you better
Vincent, Dickson, Alan, Rich, and Grant discuss a tanapoxvirus protein that inhibits tumor necrosis factor, purging tumors with myxoma virus, and destruction of the last known stocks of smallpox virus.
TWiV #123 - Contaminated prostates, absolute truth, and bleached worms
Vincent, Alan, and Rich talk about XMRV integration sites in prostate tumor DNA, the decline effect and scientific method, and the first virus of Caenorhabditis nematodes.
TWiV #122 - More fun than a monkey full of viruses
The complete TWiV crew teams up with Welkin Johnson to explore the other AIDS epidemic, infection of monkeys with simian immunodeficiency virus, and its restriction by the cellular protein TRIM5.
TWiV #121 - Huskies go viral
A conversation about careers in virology, systems biology, innate immunity, and antiviral research recorded at the University of Washington in Seattle.
Ed Niles, a Km Vmax kind of guy
Hosts: Vincent Racaniello, Rich Condit, and Ed Niles Vincent, Rich, and Ed discuss the transition from academic scientist to government work, the general program of drug and vaccine development in the biodefense world and at BARDA, and career opportunities for scientists in government. Become a patron of TWiV! Links for this episode: ACAM2000smallpox vaccine Bavarian Nordic's smallpox vaccine Imvamuneand phase II trial Rich and Ed's paper on bacteriophage T7 mRNAs Quandaries of dengue vaccine d
TWiV #119 - Science and journalism with David Tuller
Vincent and journalist David Tuller converse about the state of science reporting by the press.
TWiV #118 - The virus always rings twice
Vincent, Alan, and Rich answer listener questions about vaccinia virus, fungal viruses, synthetic viruses, influenza vaccine, HeLa cells, multiplicity of infection, and much more.
TWiV #117 - The Panic Virus with Seth Mnookin
Vincent and Rich converse with Seth Mnookin, author of The Panic Virus, about vaccines, autism, thimerosal, and a contagion of human unreason run wild.
TWiV #116 - Cocaine, colonies, and chickens
Vincent, Dickson, Alan, and Rich review an adenovirus-based vaccine strategy against drug addiction, a field trial of RNAi to prevent Israeli acute paralysis virus infection in honeybees, and suppression of avian influenza transmission in transgenic chickens.
TWiV #115 - Color me infected
Vincent, Alan, Rich and Marc discuss the finding that a limited number of incoming herpesviral genomes can replicate and express in a cell, and controlling viral replication inAedes aegypti with a Wolbachia symbiont.
TWiV #114 - Ten out of '10
Vincent, Alan, and Rich revisit ten compelling virology stories of 2010.
TWiV #113 - Alan Rein on XMRV
Vincent, Alan, and Rich discuss the retrovirus XMRV with retrovirologist Alan Rein of the National Cancer Institute.
TWiV #112 - Creating a killer poxvirus
Vincent, Alan, and Rich review the making of a virulent poxvirus by insertion of the gene encoding IL-4, and severe 2009 H1N1 influenza due to pathogenic immune complexes.
TWiV #111 - Live at Florida Gulf Coast University
The TWiV crew meets with members of the Florida Keys Mosquito Control District at Florida Gulf Coast University to discuss dengue in Florida and how to control it.
TWiV #110 - CSI virology
Vincent, Alan, Rich, and Dickson discuss bacteria that can utilize arsenic in place of phosphorus, the passing of Frank Fenner, polio outbreak in The Congo, solving criminal cases of HIV transmission, and classifying viruses by capsid structure.
TWiV #109 - Virologia en México
Vincent visits Mexico City and speaks with Rosa Maria del Angel and Ana Lorena Gutiérrez about virology in Mexico, and their work on dengue and caliciviruses.
TWiV #108 - Barking up the right Tre
Vincent, Alan, Rich, and Saul review the evolution of HIV-1 specific recombinases, and down-regulation of a host microRNA by a viral noncoding RNA.
TWiV #107 - Warning - this virus contains email
Vincent, Dickson, Alan, and Rich answer listener questions about poliovirus, social media, dengue, influenza, evolution, gel filtration, and much more.
TWiV #106 - Making viral DNA II
Vincent, Dickson, and Rich continue Virology 101 with a second installment of their discussion of how viruses with DNA genomes replicate their genetic information.
TWiV #105 - Finches score again
Vincent, Dickson, Alan, and Rich review eradication of rinderpest, endogenous hepatitis B virus in the zebra finch genome, and identification of the cell receptor for an extinct retrovirus.
TWiV #104 - The colony-collapse blues
The entire TWiV family reviews the latest ideas about colony collapse disorder of honeybees, and resurgence of monkeypox in Africa.
TWiV #103 - Shots with LJ Tan
Vincent and Alan discuss influenza vaccines with LJ Tan of the American Medical Association.
TWiV #102 - Catch me if you can in Munich
A conversation about the RNA sensor RIG-I, adenovirus gene therapy, a universal influenza vaccine, and rabies virus, recorded in Munich, Germany at the SFB455 symposium ‘Viral offense and immune defense’.
TWiV #101 - Sizing up adenovirus
Vincent, Alan, Rich, Dickson, and Hamish review the three-dimensional structure of adenovirus, and the role of adenovirus type 36 in obesity.
TWiV #100 - TWiV catches a big fish
Vincent, Alan, and Rich celebrate the 100th episode of TWiV by talking about viruses with Nobel Laureate David Baltimore.
TWiV #99 - ICAAC Boston 2010
On episode #99 of the podcast This Week in Virology, Vincent tours the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), speaking with exhibitors and visitors, including Professors Derek Smith, Michael Schmidt, Frederick Hayden, and Myra McClure.
Host links Vincent Racaniello
Links for this episode:
50th ICAAC
ICAAC daily press conference videos (including Prof. Myra McClure)
Antigenic cartography
Antimicrobial properties of copper
TWiV #98 - Murine musings, electric shirts, and rabid pathologists
On episode #98 of the podcast This Week in Virology, Vincent, Alan, and Rich review the finding of murine leukemia virus-related sequences in the blood of CFS patients and healthy donors, laboratory inventories for wild poliovirus containment, weaving high-performance viral batteries into fabric for the military, and a case of human rabies in Indiana.
TWiV #97 - California virology
On episode #97 of the podcast This Week in Virology, Vincent visited Peter Sarnow and Bert Semler during a trip to California, and spoke with them about their work on internal ribosome entry, and the requirement for a cellular microRNA for hepatitis C virus replication.
TWiV #96 - Making viral DNA
On episode #96 of the podcast This Week in Virology, Vincent, Dickson, and Rich continue Virology 101 with a discussion of how viruses with DNA genomes replicate their genetic information.
TWiV #95 - Does a virus shift in the woods?
On episode #95 of the podcast This Week in Virology, Vincent, Dickson, Alan, and Rich consider the end of the influenza H1N1 pandemic, dengue in Florida, vaccinia virus infection in Brazilian monkeys, and viruses in the faecal microbiota.
Host links Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Links for this episode:
WHO declares end of influenza H1N1 pandemic
CDC's FluView
WHO global monitoring of influenza
Locally acquired dengue in Key West, Florida (MMWR)
CDC page o
TWiV #94 - XMRV with Dr. Ila Singh
On episode #94 of the podcast This Week in Virology, Vincent, Alan, and Rich speak with Ila Singh about the new human retrovirus XMRV, and how her laboratory is studying its association with prostate cancer and chronic fatigue syndrome.
Host links Vincent Racaniello, Alan Dove, Rich Condit, and Ila Singh
Links for this episode:
CFIDS Association of America
Discovery of XMRV (PLoS Pathogens)
Detection of XMRV in CFS patients (Science)
Presence of XMRV in malignant prostate (PNAS)
Inhibition o
TWiV #93 - Our infectious inbox
On episode #93 of the podcast This Week in Virology, Vincent, Alan, and Rich answer listener questions about lab procedures, prokaryotes, endogenous retroviruses, the iPad and teaching, prions, mimivirus, splitting water with viruses, and the polio outbreak in Tajikistan.
Host links Vincent Racaniello, Alan Dove, and Rich Condit
Links for this episode:
Biomedical Advanced Research and Development Authority (BARDA)
SIGA responds to BARDA request for smallpox antiviral
BARDA contract for filo
TWiV #92 - Live at ASV in Bozeman
Vincent, Rich, Karla, and Marilyn recorded TWiV at the 29th Annual Meeting of the American Society for Virology in Bozeman, where they discussed plant viruses and how they make plants resistant to adverse conditions, and identification of dominant negative drug targets.
Host links Vincent Racaniello, Rich Condit, Karla Kirkegaard, and Marilyn Roosinck
Links for this episode:
Lifestyles of plant viruses
Using pyrosequencing to understand virus ecology
A virus in a fungus in a plant
Trans-domi
TWiV #91 - You're an ERVous wreck
On episode #91 of the podcast This Week in Virology, Vincent, Dickson, Alan, Rich and Welkin discuss the nature, origin, and evolution of endogenous retroviruses (ERVs), and the recent finding of endogenous filovirus genomes in mammals.
Host links Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Welkin Johnson
Links for this episode:
Welkin blogs at Small Things Considered
Constructing primate phylogenies from ancient retrovirus sequences (PNAS)
Filoviruses are ancient and
TWiV #90 - Guano happens
On episode #90 of the podcast This Week in Virology, Vincent, Alan, Rich and Eric discuss identification of viruses in Northeastern American bats, vaccinia virus infection after sexual contact with a military vaccinee, and identification of a new flavivirus from an Old World bat in Bangladesh.
Host links Vincent Racaniello, Alan Dove, Rich Condit, and Eric F. Donaldson
Links for this episode:
Vaccinia virus infection after sexual contact with vaccinee
Smallpox vaccination overview
Smallpox
TWiV #89 - Where do viruses vacation?
On episode #89 of the podcast This Week in Virology, Vincent and Alan review recent findings on the association of the retrovirus XMRV with ME/CFS, reassortment of 2009 pandemic H1N1 influenza virus in swine, and where influenza viruses travel in the off-season.
Host links Vincent Racaniello and Alan Dove
Links for this episode:
Conflicting XMRV papers on hold
Leak of PNAS paper
CDC study on XMRV in CFS patients (Retrovirology) and Science update
Where influenza viruses travel in the off sea
TWiV #88 - A bug fix, an AIDS treatment, and an undead retrovirus
On episode #88 of the podcast This Week in Virology, Vincent, Alan, and Marc discuss using a virus for beetle control, RNA based gene therapy for AIDS, and reconstitution of a endogenous human retrovirus.
Host links Vincent Racaniello, Alan Dove, and Marc Pelletier
Links for this episode:
Controlling the palm rhinoceros beetle with a virus
The virologist in the Hawaiian shirt
Information on Orcytes rhinocerus nudivirus (one, two, three)
RNA based gene therapy for AIDS
Reconstitution of an in
TWiV #87 - A PHIREside chat with Professor Graham Hatfull
On episode #87 of the podcast This Week in Virology, Vincent, Alan, and Rich hear from Professor Graham Hatfull how students in the Phage Hunters Integrating Research and Education (PHIRE) program learn about scientific inquiry by doing research on bacteriophages.
Host links Vincent Racaniello, Rich Condit, Alan Dove, and Graham Hatfull
Links for this episode:
Bacteriophage Research: Gateway to learning science
Mycobacterium smegmatis at NCBI
Prof. Steve Cresawn
Scientist infected with com
TWiV #86 - Dark matter with Dr. Eric Delwart
On episode #86 of the podcast This Week in Virology, Vincent and Rich travel to the Blood Systems Research Institute in San Francisco to speak with Eric Delwart about his work on virus discovery.
Host links Vincent Racaniello, Rich Condit, and Eric Delwart
Links for this episode:
List of Dr. Delwart's open-access journal articles (pdf) - to find each one, type PMID # into PubMed
CDC says don't give rotavirus vaccines to infants with SCID
The Brighton Collaboration
Product sheet for RotaTeq (pdf
TWiV #85 - Hepatitis C virus with Professor Michael Gale
On episode #85 of the podcast This Week in Virology, Vincent and Michael Gale discuss the origin, pathogenesis, prevention, of hepatitis C virus, and how it evades innate immune responses.
Host links Vincent Racaniello and Michael Gale
Links for this episode:
The Gale Laboratory at the University of Washington
Incredible view from the Gale laboratory (jpg)
Evasion and disruption of innate immune signalling by hepatitis C and West Nile viruses (review)
New potent HCV inhibitor
HCV virion and g
TWiV #84 - Gators go viral
On episode #84 of the podcast This Week in Virology, Vincent and Rich spoke with Dave Bloom and Grant McFadden about their work on herpesviruses and poxviruses in this episode recorded before an audience at the University of Florida, Gainesville - home of the Gators.
Host links Vincent Racaniello, Rich Condit, Dave Bloom, and Grant McFadden
Links for this episode:
Epigenetic modulation of herpes simplex virus gene expression (thanks, Matthew!)
The Red Queen and Tierra virtual environment: ar
TWiV #83 - An hour with Dr. Kiki
On episode #83 of the podcast This Week in Virology, Vincent, Alan, Rich, and special guest Dr. Kirsten Sanford talk about her career in science media, then consider whether smallpox eradication led to the AIDS pandemic, high fidelity RNA synthesis, and a new Ebola virus vaccine.
Host links Vincent Racaniello, Alan Dove, Rich Condit, and Kirsten Sanford
Links for this episode:
Does smallpox vaccine protect against HIV? (thanks, Srinivas; Washington Post and BMC Immunology)
Was the deltaCRR5
TWiV #82 - Immunology in silico
On episode #82 of the podcast This Week in Virology, Vincent and Rich talk about how thymic selection of T cells might lead to better control of HIV-1 infection, and a mouse model for severe antibody-induced dengue virus disease.
Host links Vincent Racaniello and Rich Condit
Links for this episode:
Effect of thymic selection of T-cells on control of AIDS
Mouse model of antibody-induced severe dengue virus disease
Natural antibody protects against viral infection
Kary Mullis idea for fighting
TWiV #81 - Be a virus, see the world
On episode #81 of the podcast This Week in Virology, Vincent and Rich answer listener questions on viruses and gluten allergy, RNA silencing, influenza virus, herpes simplex virus, HIV/AIDS, chronic fatigue syndrome, manicure salons, and the koala tea of Marseilles.
Host links Vincent Racaniello and Rich Condit
Links for this episode:
Virus infections and gluten intolerance on TWiS (thanks Jesper!)
Viral small RNAs in PLoS Pathogens (thanks Jason!)
Canadian Summit Awards (thanks Jim!)
Experi
TWiV #80 - How much X could a woodchuck chuck?
On episode #80 of the podcast This Week in Virology, Vincent, Alan, and Rich speak with Michael Bouchard about hepatitis B virus discovery, replication, and pathogenesis.
Host links Vincent Racaniello, Alan Dove, Rich Condit, and Michael Bouchard
Links for this episode:
The enigmatic X gene of hepatitis B virus
Tableau public (thanks Ricardo!)
Molecular phylogeny of Archaea from soil (thanks Etienne!)
Habitats of Archaea (thanks Cedric!)
Timer remote controls (thanks Bill!)
Letters read in epis
TWiV #79 - Red hot chili viruses
On episode #79 of the podcast This Week in Virology, Vincent and Alan converse about making published science accessible to everyone, global eradication of poliomyelitis, and whether a plant virus can cause disease in humans.
Host links Vincent Racaniello and Alan Dove
Links for this episode:
Making published science accessible to everyone (Nature News)
Federal Research Public Access Act
Is disease eradication a waste of money?
Do we have an ethical obligation to eradicate polio?
Signs of pr
TWiV #78 - Darwin gets weird
On episode #78 of the podcast This Week in Virology, Vincent, Alan, Dickson, and Rich talk about treating arthritis with a tanapox virus protein, Darwinian evolution of prions in cell culture, and the connection between cold weather fronts and outbreaks of avian H5N1 influenza in Europe.
Host links Vincent Racaniello, Alan Dove, Dickson Despommier, and Rich Condit
Links for this episode:
Treating arthritis with a tanapox virus protein that antagonizes TNF (press release and research article
TWiV #77 - Non-nuclear proliferation
On episode #77 of the podcast This Week in Virology, Vincent, Alan, and Rich revisit circovirus contamination of Rotarix, then discuss poxvirus-like replication of mimivirus in the cell cytoplasm, and whether seasonal influenza immunization increases the risk of infection with the 2009 H1N1 pandemic virus.
Host links Vincent Racaniello, Alan Dove, and Rich Condit
Links for this episode:
Contamination of Rotarix vaccine with porcine circovirus 1 DNA
Do you want to know what is in your vaccin
TWiV #76 - XMRV with Professor Stephen Goff
On episode #76 of the podcast This Week in Virology, Vincent speaks with Stephen Goff about the origin of the retrovirus XMRV and its association with prostate cancer and chronic fatigue syndrome.
Host links Vincent Racaniello and Stephen Goff
Links for this episode:
Discovery of XMRV in prostate tumors
Association of XMRV with chronic fatigue syndrome
Enhanced infection of prostate cells by XMRV
XMRV and xenotransplantation
TWiV #75 - Rabies rampant
On episode #75 of the podcast This Week in Virology, Vincent, Alan, and Matt review contamination of Rotarix with circovirus DNA, antigenic similarity between 1918 and 2009 H1N1 influenza, a collection of rabies reports, and chicken pox mistaken for smallpox in Uganda.
Host links Vincent Racaniello, Alan Dove, and Matthew Frieman
Links for this episode:
Contamination of Rotarix vaccine with porcine circovirus 1 DNA
Beak and feather disease circovirus (BFDV) threatens parrots
Antigenic simila
TWiV #74 - Influenza with Professor Adolfo Garcia-Sastre
On episode #74 of the podcast This Week in Virology, Vincent speaks with Adolfo Garcia-Sastre about the origin, pathogenesis, and prevention of the 2009 pandemic influenza H1N1 virus.
Host links Vincent Racaniello and Adolfo Garcia-Sastre
Links for this episode:
Influenza virus receptor specificity and disease
PB1-F2 expression by 2009 H1N1 strain does not increase virulence
Protection against 2009 H1N1 infection by immunization with older strains
Passage in eggs changes influenza receptor sp
TWiV #73 - Entering the ends
On episode #73 of the podcast This Week in Virology, Vincent, Dickson, and Rich discuss multipotent progenitor bone marrow cells as a reservoir of HIV-1, integration of HHV-6 into telomeres, and dispersal of West Nile virus across the US by mosquitoes.
Host links Vincent Racaniello, Dickson Despommier, and Rich Condit
Links for this episode:
HIV-1 infects multipotent progenitor cells
HHV-6 genome integrates into telomeres
A role for mosquito-mediated dispersal of West Nile virus across the U
TWiV #72 - Bucket of bolts
On episode #72 of the podcast This Week in Virology, Vincent, Dickson, Alan and Rich explain CRISPR/Cas, the immune system of bacteria and archaea, how novel viruses are discovered by deep sequencing of small RNAs, and the relationship between dry weather and outbreaks of West Nile virus infection.
Host links Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Links for this episode:
Review on the CRISPR/cas system of bacteria and archaea
Virus discovery by sequencing small v
TWiV #71 - Please Mr. Postman
On episode #71 of the podcast This Week in Virology, Vincent, Dickson, Alan and Rich answer listener questions about maternal infection and fetal injury, viral gene therapy, eyeglasses and influenza, filtering prions from blood, eradication of rinderpest, Tamiflu resistance of H1N1 influenza, bacteriophages and the human microbiome, H1N1 vaccine recalls, human tumor viruses, RNA interference, and junk DNA.
Host links Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Links
TWiV #70 - Hacking aphid behavior
On episode #70 of the podcast This Week in Virology, Vincent, Dickson, and Alan consider a broad spectrum antiviral against enveloped viruses, how a plant virus induces chemical signals in the host to maximize its spread, a new way to preserve viral vaccines at tropical temperatures, and the continuing story of XMRV and chronic fatigue syndrome.
Host links Vincent Racaniello, Dickson Despommier, and Alan Dove
Links for this episode:
Broad spectrum antiviral against enveloped viruses
Chemic
TWiV #69 - They're all safecrackers
On episode #69 of the podcast This Week in Virology, Vincent, Alan, and Rich review recent outbreaks of mumps in the UK, US, and Israel, protection of mice against 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 vaccines, and a virus-like particle vaccine for chikungunya virus.
Host links Vincent Racaniello, Alan Dove, and Rich Condit
Links for this episode:
Mumps outbreak in Israel (ProMedMail and Eurosurveillance; thanks Lenn!) and Iowa
Retraction of Wakefield vaccines-
TWiV #68 - Ode to a plaque
On episode #68 of the podcast This Week in Virology, Vincent, Alan, and Rich are enthralled by movies of vaccinia virus plaque formation, then consider how repulsion of superinfection virions leads to rapid virus spread, and a therapeutic prostate cancer vaccine.
Host links Vincent Racaniello, Alan Dove, and Rich Condit
Links for this episode:
Rapid virus spread by repulsion of superinfection virions
Movie of vaccinia virus plaque formation (.mov)
Movie of GFP-vaccinia virus plaque formation
TWiV #67 - Wasting deer and the Hulk rabbit
On episode #67 of the podcast This Week in Virology, Vincent, Alan, and Marc Pelletier talk about chronic wasting disease of deer caused by prions, blocking the semen-derived enhancer of HIV infection with surfen, and making green transgenic rabbits using a lentiviral vector.
Host links Vincent Racaniello, Alan Dove, and Marc Pelletier
Links for this episode:
Chronic wasting disease in West Virginia
Chronic wasting disease alliance and CDC webpage
Semen-derived inhibitor of viral infection
TWiV #66 - Reverse transcription
On episode #66 of the podcast This Week in Virology, Vincent and Dickson continue virology 101 with a discussion of information flow from RNA to DNA, a process known as reverse transcription, which occurs in cells infected with retroviruses, hepatitis B virus, cauliflower mosaic virus, foamy viruses, and even in uninfected cells.
Host links Vincent Racaniello and Dickson Despommier
Links for this episode:
Discovery of RNA tumor viruses
Reverse transcriptase found by Temin and Baltimore (pdf
TWiV #65 - Matt's bats
On episode #65 of the podcast This Week in Virology, Vincent, Alan, and Matthew Frieman Vincent, Alan, and Matt discuss a project to study the RNA virome of Northeastern American bats, failure to detect XMRV in UK chronic fatigue syndrome patients, and DNA of bornavirus, an RNA virus, in mammalian genomes.
Host links Vincent Racaniello, Alan Dove, and Matthew Frieman
Links for this episode:
Mist net Indigo Tunnel, Western Maryland Railway (jpg)
Eric Donaldson and Amy Haskew with bat in holdi
TWiV #64 - Ten virology stories of 2009
On episode #64 of the podcast This Week in Virology, Vincent, Alan, and Rich discuss ten compelling virology stories of 2009.
Host links Vincent Racaniello, Alan Dove, and Rich Condit
Ten virology stories of 2009:
Pandemic influenza: Swine-origin H1N1 virus (TWiV 36)
XMRV, prostate cancer, and chronic fatigue syndrome (TWiV 50, 55)
AIDS vaccine 'success' (TWiV 51)
Colony collapse disorder (TWiV 46, 49)
AIDS-like disease in wild chimps (TWiV 45)
Diverse viral community in Antarctic lake (TWiV 58
TWiV #63 - Melting pot virus
On episode #63 of the podcast This Week in Virology, Vincent, Alan, and Rich talk about US government contract for freeze-dried smallpox vaccine, red squirrels in the UK threatened by poxvirus, and Marseillevirus, another DNA virus from amoebae built for comfort and speed.
Host links Vincent Racaniello, Alan Dove, and Rich Condit
Links for this episode:
US Government awards contract to Bavarian Nordic for freeze-dried smallpox vaccine (pdf and clinical trial)
UK red squirrels threatened by
TWiV #62 - Persistence of West Nile virus
On episode #62 of the podcast This Week in Virology, Vincent, Dickson, and Alan discuss STEP HIV-1 vaccine failure caused by the adenovirus vector, presence of West Nile virus in kidneys for years after initial infection, adaptation of the influenza viral RNA polymerase for replication in human cells, and the significance of the D225G change in the influenza HA protein.
Host links Vincent Racaniello, Dickson Despommier, and Alan Dove
Links for this episode:
HIV vaccine failure probably ca
TWiV #61 - Original antigenic sin
On episode 61 of the podcast "This Week in Virology", Vincent and Dick muse about the symbiotic bacterium,Wolbachia, that protects flies from viral infection, the origin of 2009 influenza H1N1 virus, and the lure of original antigenic sin.
Host links Vincent Racaniello and Dickson Despommier
Links for this episode:
Variation in antiviral protection mediated by different Wolbachia strains in Drosophila simulans
Wolbachia induces resistance to RNA virus infections in Drosophila
Wolbachia reduces
TWiV #60 - Making viral RNA
Vincent and Dickson continue Virology 101 with a discussion of how RNA viruses produce mRNA and replicate their genomes.
Host links Vincent Racaniello and Dickson Despommier
Links for this episode:
Diagrams of viral RNA synthesis
Animations of influenza virus and HIV-1 replication
TWiV #59 - Dog bites virus
A TWiV panel of five considers the finding of Streptococcus pneumoniae in fatal H1N1 cases in Argentina, hysteria in the Ukraine over pandemic influenza, and human vaccinia infection after contact with a raccoon rabies vaccine bait.
Host links Vincent Racaniello, Alan Dove, Rich Condit, Gustavo Palacios, and Mady Hornig
Links for this episode:
Argentine flu death mystery
H1N1 influenza outbreak in Ukraine (article one and two, and WHO statement)
Human vaccinia infection after contact with rab
TWiV #58 - Nipah virus in ferrets
Vincent, Dick, and Alan are joined by emergency medicine physician Dr. Joshua Stillman to talk about passive antibody therapy for Nipah infection in ferrets, annual influenza immunization of children, facemasks to prevent influenza, predicting dengue outbreaks by the weather, and the amazing viral communities in an icy Antarctic lake.
Host links Vincent Racaniello, Dick Despommier, Alan Dove, and Joshua Stillman
Links for this episode:
Post-exposure passive antibody therapy for Nipah virus
TWiV #57 - Virology in high school
Vincent visits Scotch Plains – Fanwood High School and talks about viruses with high school biology students.
Host links: Vincent Racaniello
Links for this episode:
Vincent’s presentation (pdf)
Thank you letters
Oncolytic reovirus
Does rhinovirus interfere with influenza?
TWiV #56 - Perspicuously perspicacious
Vincent, Dick, Alan, and Cliff answer questions from listeners on swine influenza origins, transmission, virulence, and vaccines, HIV and AIDS, and more.
Host links: Vincent Racaniello, Dick Despommier, Alan Dove, and Cliff Mintz
Links for this episode:
Physicists propose 'Schrödinger's Virus' experiment (thanks Duncan)
Nanoparticle adjuvant (ScienceDaily and Journal of Controlled Release - thanks Jim)
Hand washing won't stop H1N1 at Newsweek (thanks Jim)
Newsweek's virus quiz
TWiV timeline
TWiV #55 - Mice lie, monkeys exaggerate
The largest TWiV panel ever assembled takes on XMRV and chronic fatigue syndrome, 2009 chemistry Nobel prizes for ribosome structure, finding new poxvirus vaccine candidates, a brouhaha over leaked Canadian data on flu susceptibility, and transmission of H1N1 influenza to a pet ferret.
Hosts: Vincent Racaniello, Dick Despommier, Alan Dove, Jason Rodriguez, and Rich Condit
Links for this episode:
XMRV and chronic fatigue syndrome
XMRV not found in German prostate cancer
2009 Chemistry Nobel
TWiV #54 - Professor Lynn Enquist, virology luminary
Vincent speaks with Lynn Enquist about his career in virology, moving from academia to industry and back. Along the way he did pioneering research on bacteriophage, participated in the birth of recombinant DNA technology, and studied herpesviruses.
Links for this episode:
Holliday junction
Asilomar Conference on Recombinant DNA
Restriction enzymes
Movies of herpesvirus movement in nerve cells
The 'other' Enquist lab
Can you find the TWiV 54 hosts in this photo?
Weekly Science Picks
Lynn Fra
TWiV #53 - The ends justify the means
Vincent, Dick, and Alan talk about Nobel prizes for telomere research, bacteriophages that protect aphids from wasps, salicylates and pandemic influenza mortality, and hand washing.
Links for this episode:
Bacteriophages encode toxins that protect aphids from wasps
14 year old dies after receiving HPV vaccine
Salicylates and pandemic influenza mortality
Canadian microbiologist says hand washing is not proven to prevent influenza
Surgical mask vs N95 respirator for preventing influenza
America
TWiV #52 - Scott Hammer, MD on AIDS vaccines
Vincent and Dr. Scott Hammer talk about different types of AIDS vaccines and how they are tested in clinical trials.
Links for this episode:
PAVE 100 trial cancelled
HIV vaccine shows promise for the first time
Description of the Thailand AIDS program
NEJM review on why AIDS vaccine is difficult (pdf)
Arguments for the AIDS vaccine trial in Thailand
International AIDS Vaccine Initiative (IAVI)
TWiV #51 - ALVAC-HIV and AIDSVAX BE
Vincent, Dick, and Alan (with a cameo appearance by Rich Condit) review the world’s largest Phase III study of a complex HIV vaccine candidate in Thailand, immunization of salmon against infectious salmon anemia virus, and an outbreak of blueberry shock virus in Michigan.
Links for this episode:
HIV vaccine shows promise for the first time - description of the program, FDA background document (pdf), NEJM review on why AIDS vaccine is difficult (pdf), and arguments for the trial
Chile immuniz
TWiV #50 - XMRV
Vincent and Jason review influenza 2009 H1N1 vaccine trials and protection against the virus conferred by the 1976 swine flu vaccine, then move on to a virus called XMRV and its possible role in prostate cancer.
Links for this episode:
One dose of influenza 2009 H1N1 vaccine without adjuvant is enough
Partially completed study on influenza 2009 H1N1 vaccine with MF59 adjuvant
1976 swine flu vaccine induces cross-reactive antibodies against influenza 2009 H1N1 strain
Explanation of hemaggluti
TWiV #49 - Viral genomes
Vincent and Dick continue Virology 101 with a discussion of the seven different types of viral genomes, and how to use the pathway to mRNA to understand viral replication.
Links for this episode:
Dick talks about hookworm on Radio Lab
Dick's video page at BigThink
The seven types of viral genome
Animation of HIV replication (thanks axiomatically atypical!)
Changes in transcript abundance relating to colony collapse disorder in honey bee (thanks Judi!)
Weekly Science Picks
Dick Discovery Chan
TWiV #48 - Outbreaks near you
Vincent, Dick, Alan and Rich revisit a vaccinia virus lab accident and viral vaccines produced in plants, then talk about an iPhone app to track infectious diseases, flying foxes, and an inhaled measles vaccine.
Links for this episode:
Laboratory acquired vaccinia infection
Medicago (investor presentation, pdf) and Fraunhofer produce vaccines in plants
iPhone app Outbreaks near me
No culling of flying foxes in Australia
Inhaled powdered measles virus vaccine
Herpesvirus latency confers symbio
TWiV #47 - Vertical vaccine farm
Vincent and Dick discuss influenza virus-like particle vaccines produced in insect and plant cells, rapid sharing of influenza research, and answer listener questions about cytomegalovirus, viral evolution and symbiosis and much more.
Links for this episode:
A Farm on Every Floor
Influenza virus-like particles in insect and plant cells
PLoS Currents: Influenza
Transmission of 2009 H1N1 influenza virus to turkeys [Thanks Debbie!]
Baxter produces Vero cell H1N1 vaccine [Thanks Peter!]
Boundari
TWiV #46 - Virus entry into cells
Vincent and Dick continue virology 101 with a discussion of virus entry into cells, then answer reader email on colony collapse disorder and viruses that confer a benefit to their host.
Links for this episode:
Illustrations of virus entry into cells
Nice reference for biological items (thanks Jim!)
Colony collapse disorder: PBS program, descriptive study, metagenomic study, genetic analysis (thanks Swiss compass!)
Potato virus Y and Alzheimer's disease (thanks Jennifer!)
A virus in a fungus
TWiV #45 - Hendra and polio are back
Vincent, Dick, Alan, and Jennifer Drahos tackle the Hendra virus disease outbreak in Australia, AIDS-like disease in wild chimps, return of polio type 2 in Nigeria, the influenza pandemic wave, and rabies in three countries.
Links for this episode:
Hendra virus killing horses in Australia
AIDS-like disease in wild chimps [ NY Times ]
Polio type 2 returns in Nigeria
Influenza pandemic wave [Branswell ]
Rabies in Ukraine , South Africa , and USA
Cell phones turned into fluorescen
TWiV #44 - No hysteria
Vincent, Dick, Alan, and Jennifer Drahos consider Marburg virus in Egyptian fruit bats, bacterial citrus pathogen found in shipping facility, canine parvovirus in Michigan, Relenza-resistant influenza virus, new HIV from gorillas, and public engagement on H1N1 immunization program.
Links for this episode:
Isolation of Marburg virus from Egyptian fruit bats
Inspectors find bacterial citrus pathogen in California
Parvovirus killing hundreds of dogs in Michigan
Relenza-resistant H1N1 identif
TWiV #43 - Virus classification
Vincent and Dick explain virus classification, and revisit the 1976 swine flu immunization campaign and Guillain-Barré syndrome.
Links for this episode:
International Committee on the Taxonomy of Viruses (ICTV)
CBS 60 Minutes on 1976 swine flu vaccine (thanks Gus and Swiss compass!)
Vaccines and Guillain-Barré
NINDS Guillain-Barré Information
Reflections on the 1976 swine flu vaccination program
Swine influenza outbreak at Fort Dix, 1976
Weekly Science Picks
Dick Five Kingdoms: An Illust
TWiV #42 - Bats and ticks
Vincent, Dick, Alan, and Delthia Ricks discuss a new influenza virus-like particle vaccine, dog flu, ultrasensitive pen-sized virus detector, imported rabies in the US, Crimean-Congo hemorrhagic fever, and next season’s flu vaccines.
Hosts Vincent Racaniello, Dick Despommier, Alan Dove, and Delthia Ricks
Links for this episode:
Trivalent virus-like particle vaccine
Canine flu virus vaccine
Ultrasensitive virus detector
Rabies imported into the US
Crimean-Congo hemorrhagic fever in Kazakhst
TWiV #41 - Fish flu
In episode 41 of "This Week in Virology", Vincent Racaniello, Dick Despommier, Alan Dove and Rich Condit chat about infectious salmon anemia virus, virus-resistant grapevines, virulence of pandemic H1N1 influenza virus, origin of 1918 influenza virus, holy water ban to halt influenza, frequency of human WU and KI polyomavirus infection, rabies in China, and host species of sin nombre virus.
Links for this episode
Wal-Mart stops buying Chile salmon on virus outbreak
Virus-resistant grapevine
TWiV #40 - Tamiflu in the water
In episode 40 of "This Week in Virology", hosts Vincent Racaniello, Dick Despommier, and Alan Dove consider Reston ebolavirus in swine, historical perspective of H1N1 influenza virus emergence and circulation, Tamiflu-resistant H1N1, Tamiflu in Japanese river waters, transmission of H1N1 virus in ferrets, and pneumonia and respiratory failure from H1N1 in Mexico.
Links for this episode
Reston ebolavirus in Philippine swine
Historical perspective on H1N1 virus
Salk's 1947 article on flu vac
TWiV #39 - Virus structure
In episode 39 of This Week in Virology, hosts Vincent Racaniello and Dick Despommier discuss virus structure and answer listener questions.
Links for this episode
Diagrams of virus structures
Boston Globe article on Genzyme
FDA warning letter to Genzyme (thanks Peter!)
Public Health Reports July - December 1918 (thanks Lenn!)
Amateur scientists working with professionals (thanks Ennio!)
Influenza H1N1 and computer analogies (thanks swiss compass!)
Bone marrow transplant to cure AIDS not rep
TWiV #38 - Measles
In episode 38 of This Week in Virology, hosts Vincent Racaniello and Glenn Rall chat about koi herpesvirus, H1N1 influenza vaccine produced in insect cells, attack by a rabid raccoon, and measles.
Links for this episode:
Virus suspected in carp die-off: koi herpesvirus
H1N1 influenza vaccine produced in insect cells with baculovirus vectors
Outbreak of measles in Wales
Production of influenza vaccines in cell cultures: MDCK, Vero, PER.C6, EB66, insect (thanks Peter!)
Weekly Science Pick
TWiV #37 - Open access
In episode 37 of This Week in Virology, hosts Vincent Racaniello, Alan Dove and guest Eric Freed talk about vesivirus contamination of bioreactors, pandemic influenza, maximizing the effect of vaccination by targeting children, chikungunya virus, and open access scientific journals.
Links for this episode:
Genzyme shuts down manufacturing of two enzyme drugs because of vesivirus contamination
Brazilian H1N1 isolate is not novel
WHO interactive H1N1 map
Targeting children maximizes the effe
TWiV #36 - Pandemic
In episode 36 of This Week in Virology, hosts Vincent Racaniello, Alan Dove, Dick Despommier and guest Hamish Young discuss the 2009 influenza pandemic, first 2009 H1N1 vaccine, hunting mosquitoes with midges, vaccine-associated polio in India, and adenoviruses.
Links for this episode:
WHO calls it a pandemic
Novartis produces test run of H1N1 vaccine
Midge keeps invasive mosquito in check
Two cases of vaccine-associated polio in India
BBC interactive map of influenza cases
Outbreak of adenovir
TWiV #35 - Much achoo about nothing
In episode 35 of This Week in Virology, hosts Vincent Racaniello, Alan Dove, Dick Despommier and guest Richard Kessin talk about Lujo virus, a new arenavirus, influenza, WHO rewriting pandemic rules, adjuvants, and a brief history of microbiology.
Links for this episode:
Lujo virus, a new arenavirus
Is CDC too optimistic about influenza?
WHO to rewrite pandemic rules
Adjuvant at wikipedia
Avery, MacLeod, McCarty 50th anniversary ( pdf)
Weekly Science Picks
Dick Three papers on orig
TWiV #34 - Arsenic and facemasks
In episode 34 of This Week in Virology, hosts Vincent Racaniello, Alan Dove, and guest Stephen Morse discuss progressive vaccinia in a smallpox vaccinee, arsenic and influenza in mice, facemasks and flu transmission, and antigenic and genetic analyses of the new H1N1 influenza virus.
Links for this episode:
Progressive vaccinia in a military smallpox vaccinee
Arsenic compromises the immune response to influenza in mice
Facemasks prevent flu transmission in a mathematical model
Serum cross-r
TWiV #33 - Live in Philly
Vincent, Alan, Dick, and Raul Andino live at ASM discussed cytomegalovirus infection and blood pressure, restriction of avian influenza viral replication at low temperature, first isolation of West Nile virus in PA, and current status of influenza.
Hosts: Vincent Racaniello, Alan Dove, Dick Despommier, and Raul Andino
Links for this episode:
Cytomegalovirus infection causes an increase of arterial blood pressure Avian influenza virus glycoproteins restrict virus replication at low temperature Fi
TWiV #32 - Influenza in silico
In episode 32 of This Week in Virology, hosts Vincent Racaniello, Alan Dove and guest Raul Rabadan converse about polio survivors in iron lungs, bocavirus, structure of mimivirus, and genome sequence analysis of influenza H1N1 viruses.
Links for this episode: Death of Marsha Mason, who lived 60 years in an iron lung First discovery of bocavirus in human stool Structural studies of the giant mimivirus Pandemic potential of H1N1 influenza virus Was swine flu a lab accident? Bloomberg and NY Times